Hot water drilling and measurements beneath the grounding zone of Langhovde Glacier, East Antarctica

第3回極域科学シンポジウム　横断セッション「海・陸・氷床から探る後期新生代の南極寒冷圏環境変動」11月27日（火） 国立国語研究所 ２階講

The bryophyte flora in the alpine zone of Mt. Fuji

第3回極域科学シンポジウム/第34回極域生物シンポジウム 11月27日（火） 国立極地研究所 ３階ラウン

Impedance Matching and Power Division Algorithm Considering Cross Coupling for Wireless Power Transfer via Magnetic Resonance

Abstract-Wireless power transfer via magnetic resonant coupling has been extensively researched for various applications. Impedance matching is implemented so that the transfer system is resilient to positional changed and load changed. Recently powering multiple loads simultaneously is becoming the focus in wireless power transfer researches and designs. Apart from maintaining high efficiency, controllable power division is also an important feature in multi-receiver system. This is due to ratio of power division depends not only on the load but also on the gap of each receiver to the transmitter. On the other hand, cross coupling exists when receivers are placed relatively near to each other. In this paper, novel algorithm is proposed for impedance matching and power division considering cross coupling in between two receivers. The wireless power transfer system is first represented by equivalent circuit and the algorithm for impedance matching and power division is derived. The new method is then verified using simulations

A simple and Useful predictive Assay for evaluating the Quality of Isolated Hepatocytes for Hepatocyte transplantation

Abstract No optimal assay for assessing isolated hepatocytes before hepatocyte transplantation (HTx) has been established, therefore reliable and rapid assays are warranted. Isolated rat hepatocytes were dipped in a water bath (necrosis model), and were also cultured with Okadaic acid (apoptosis model) or vehicle, followed by cellular assessment including trypan blue exclusion (TBE) viability, ADP /ATP ratio, plating efficiency (PE), DNA quantity and ammonia elimination. Hepatocytes were transplanted into the liver of analbuminemic rats, subsequently engraftment was assessed by serum albumin and the histology of transplanted grafts. In the necrosis model, the ADP/ATP ratio was strongly and negatively correlated with the TBE (R2 = 0.559, P < 0.001). In the apoptosis model, the ADP/ATP ratio assay, PE, DNA quantification and an ammonia elimination test clearly distinguished the groups (P < 0.001, respectively). The ADP/ATP ratio, PE and DNA quantity were well-correlated and the ammonia elimination was slightly correlated with the transplant outcome. TBE could not distinguish the groups and was not correlated with the outcome. The ADP/ATP ratio assay predicted the transplant outcome. PE and DNA quantification may improve the accuracy of the retrospective (evaluations require several days) quality assessment of hepatocytes. The ADP/ATP ratio assay, alone or with a short-term metabolic assay could improve the efficiency of HTx

Έλεγχος και ανάλυση υδραυλικής αντλίας με εφαρμογές σε συστήματα άρδευσης

<p>In the HBSS model, the isolated islet yield was significantly increased in the ductal injection (gray bar: ductal group: n = 9), vascular perfusion (dotted bar: vascular group: n = 9), and ductal injection/vascular perfusion groups (squared bar: combination group: n = 10) compared with that of the cold ischemia control group (black bar: control group: n = 9). The islets isolated from pancreases with a negligible cold ischemia time (less than 10 min) served as the fresh control group (white bar: fresh group: n = 7). The islet yield of the fresh group was significantly higher than that of the other groups. No significant differences were observed among the ductal, vascular, and combination groups. *<i>P</i><0.05, **<i>P</i><0.005, ***<i>P</i><0.0001.</p

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

Flexibility of Contactless Power Transfer using Magnetic Resonance Coupling to Air Gap and Misalignment for EV

Nowadays, the establishment of the technologies of contactless power transfer (CPT) for electric vehicles (EVs) are needed. The system can provide people with a convenient charging system which can powers their EVs wirelessly and automatically when they park. Traditional CPT solutions have the problem of distance between transmitting antennas and receiving antennas (air gap), as well as from the misalignment of the antennas. Those systems cannot power at a great distance and the efficiency is very low. In this paper, CPT by magnetic resonance couplings and small antennas are proposed. These techniques more easily span air gaps and are more forgiving to antennas misalignments than traditional solutions. The Efficiencies are still high when the air gaps are longer than the diameter of the antennas. As well, the efficiencies are over 90% when the antennas are half a diameter out of alignment. For example, when the air gap and the displacement is 150mm, the efficiency is about 96%. The magnetic resonant couplings can power wirelessly even if there is a weak connection. Thus, a large air gaps with high efficiency are possible. The relation between two resonant frequencies and the coupling coefficient are described using the method of equivalent circuits. As well, the relation between resonant frequencies and the efficiencies, especially the moment of decreasing, are described