Collective Path Connecting the Oblate and Prolate Local Minima in 68Se

By means of the adiabatic self-consistent collective coordinate method and the pairing plus quadrupole interaction, we have obtained the selfconsistent collective path connecting the oblate and prolate local minima in 68Se for the first time. Along the collective path, the triaxial deformation parameter (gamma) changes between 0 and 60 (degree) keeping the axially symmetric deformation parameter (beta) approximately constant, indicating the importance of triaxial deformation dynamics in the oblate-prolate shape coexistence phenomena.Comment: 6 pages including 6 eps figure

コドモ ノ マワリ ワ キケン ガ イッパイ

Children die in most under the age of 12 months（2.8 per 1,000 person）, specially in the age of 1 month. The most causes of death are anomaly of chromosome and congenital diseases. The born of immature baby is increasing in these years, and that relate with mother’s smoking, excessive diet and late marriage. The first cause of children’s death between the age of 1 years and 14 years is accidents including suffocation, drowning, burn, traffic accident and etc. Second cause is congenital anomaly and malignant neoplasm a. The most of suffocation, drowning, burn and traffic accident are preventable by paying attention and doing first aids. The importance of prevention of child injury and death is to recognize many hazards around the children and take away those from the children. Vaccines are most effective to protect the child from common infection, However, vaccine schedule in Japan is late, comparing with the developing countries in North America and Europe. They start prevention of Rota V, MMR, human-pappiloma V, chicken pox, HBV, HAV, Hib, pneumococcus and meningococcus. Adults also should take care the hidden dangers like visual picture and animation. Because excessive use is harmful to not only eye but also mental health and lose physical exercise

Soft X-ray Absorption and Photoemission Studies of Ferromagnetic Mn-Implanted 3CC-SiC

We have performed x-ray photoemission spectroscopy (XPS), x-ray absorption spectroscopy (XAS), and resonant photoemission spectroscopy (RPES) measurements of Mn-implanted 3$C$-SiC (3$C$-SiC:Mn) and carbon-incorporated Mn$_{5}$Si$_{2}$ (Mn$_{5}$Si$_{2}$:C). The Mn 2$p$ core-level XPS and XAS spectra of 3$C$-SiC:Mn and Mn$_{5}$Si$_{2}$:C were similar to each other and showed "intermediate" behaviors between the localized and itinerant Mn 3$d$ states. The intensity at the Fermi level was found to be suppressed in 3$C$-SiC:Mn compared with Mn$_{5}$Si$_{2}$:C. These observations are consistent with the formation of Mn$_{5}$Si$_{2}$:C clusters in the 3$C$-SiC host, as observed in a recent transmission electron microscopy study.Comment: 4 pages, 3 figure

Kinematics and excitation of the ram pressure stripped ionized gas filaments in the Coma cluster of galaxies

We present the results of deep imaging and spectroscopic observations of very extended ionized gas (EIG) around four member galaxies of the Coma cluster of galaxies: RB199, IC4040, GMP2923 and GMP3071. The EIGs were serendipitously found in an H-alpha narrow band imaging survey of the central region of the Coma cluster. The relative radial velocities of the EIGs with respect to the systemic velocities of the parent galaxies from which they emanate increase almost monotonically with the distance from the nucleus of the respective galaxies, reaching -400 - -800 km/s at around 40 - 80 kpc from the galaxies. The one-sided morphologies and the velocity fields of the EIGs are consistent with the predictions of numerical simulations of ram pressure stripping. We found a very low-velocity filament (v_rel = -1300 km/s) at the southeastern edge of the disk of IC4040. Some bright compact knots in the EIGs of RB199 and IC4040 exhibit blue continuum and strong H-alpha emission. The equivalent widths of the H-alpha emission exceed 200 A, and are greater than 1000 A for some knots. The emission line intensity ratios of the knots are basically consistent with those of sub-solar abundance HII regions. These facts indicate that intensive star formation occurs in the knots. Some filaments, including the low velocity filament of the IC4040 EIG, exhibit shock-like emission line spectra, suggesting that shock heating plays an important role in ionization and excitation of the EIGs.Comment: Accepted for publication in The Astrophysical Journal. 14 pages, 23 figures, emulateapj forma

Acute superior mesenteric venous thrombosis with advanced gastric cancer: a case report

Although the advanced stages of neoplasms have a risk of superior mesenteric venous thrombosis (MVT), an initial clinical diagnosis of MVT is sometimes difficult and it can be treated as a cancer-related pain using NSAIDs and/or opioids

Genetic and clinical landscape of breast cancers with germline BRCA1/2 variants

遺伝性乳癌の遺伝学的・臨床学的特徴を解明 --BRCA1/2 変異乳癌は両アレルの不活化の有無により異なった特徴を持つ--. 京都大学プレスリリース. 2020-10-26.The genetic and clinical characteristics of breast tumors with germline variants, including their association with biallelic inactivation through loss-of-heterozygosity (LOH) and second somatic mutations, remain elusive. We analyzed germline variants of 11 breast cancer susceptibility genes for 1, 995 Japanese breast cancer patients, and identified 101 (5.1%) pathogenic variants, including 62 BRCA2 and 15 BRCA1 mutations. Genetic analysis of 64 BRCA1/2-mutated tumors including TCGA dataset tumors, revealed an association of biallelic inactivation with more extensive deletions, copy neutral LOH, gain with LOH and younger onset. Strikingly, TP53 and RB1 mutations were frequently observed in BRCA1- (94%) and BRCA2- (9.7%) mutated tumors with biallelic inactivation. Inactivation of TP53 and RB1 together with BRCA1 and BRCA2, respectively, involved LOH of chromosomes 17 and 13. Notably, BRCA1/2 tumors without biallelic inactivation were indistinguishable from those without germline variants. Our study highlights the heterogeneity and unique clonal selection pattern in breast cancers with germline variants

Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study

Abstract Objective: Resting energy expenditure (REE) decreases if there is reduced energy intake and body weight (BW). The decrease in REE could make it difficult for patients with obesity to maintain decreased BW. This study aimed to investigate the correlation among changes in REE, energy intake, and BW during the weight loss process in patients with obesity. Materials and methods: We conducted a retrospective cohort study of patients hospitalized for the treatment of obesity in Japan. Patients received fully controlled diet during hospitalization and performed exercises if able. REE was measured once a week using a hand-held indirect calorimetry. Energy intake was determined by actual dietary intake. Results: Of 44 inpatients with obesity, 17 were included in the analysis. Their BW decreased significantly after 1 week (−4.7 ± 2.0 kg, P < 0.001) and 2 weeks (−5.7 ± 2.2 kg, P < 0.001). The change in REE after 1 and 2 weeks was positively correlated with the energy intake/energy expenditure ratio (r = 0.66, P = 0.004 at 1 week, r = 0.71, P = 0.002 at 2 weeks). Using a regression equation (y = 0.5257x – 43.579), if the energy intake/energy expenditure ratio within the second week was 82.9%, the REE after 2 weeks was similar to the baseline level. There was no significant correlation between the change in REE and BW. Conclusions: Our data suggest that changes in REE depend on energy intake/energy expenditure ratio and that the decrease in REE can be minimized by matching energy intake to energy expenditure, even during the weight loss process

Optimization of prediction methods for risk assessment of pathogenic germline variants in the Japanese population

Predicting pathogenic germline variants (PGVs) in breast cancer patients is important for selecting optimal therapeutics and implementing risk reduction strategies. However, PGV risk factors and the performance of prediction methods in the Japanese population remain unclear. We investigated clinicopathological risk factors using the Tyrer-Cuzick (TC) breast cancer risk evaluation tool to predict BRCA PGVs in unselected Japanese breast cancer patients (n = 1, 995). Eleven breast cancer susceptibility genes were analyzed using target-capture sequencing in a previous study; the PGV prevalence in BRCA1, BRCA2, and PALB2 was 0.75%, 3.1%, and 0.45%, respectively. Significant associations were found between the presence of BRCA PGVs and early disease onset, number of familial cancer cases (up to third-degree relatives), triple-negative breast cancer patients under the age of 60, and ovarian cancer history (all P < .0001). In total, 816 patients (40.9%) satisfied the National Comprehensive Cancer Network (NCCN) guidelines for recommending multigene testing. The sensitivity and specificity of the NCCN criteria for discriminating PGV carriers from noncarriers were 71.3% and 60.7%, respectively. The TC model showed good discrimination for predicting BRCA PGVs (area under the curve, 0.75; 95% confidence interval, 0.69-0.81). Furthermore, use of the TC model with an optimized cutoff of TC score ≥0.16% in addition to the NCCN guidelines improved the predictive efficiency for high-risk groups (sensitivity, 77.2%; specificity, 54.8%; about 11 genes). Given the influence of ethnic differences on prediction, we consider that further studies are warranted to elucidate the role of environmental and genetic factors for realizing precise prediction

Laughter and humor as complementary and alternative medicines for dementia patients

<p>Abstract</p> <p>Background</p> <p>The number of dementia patients has increased worldwide, with an estimated 13.7 million dementia patients in the Asia Pacific region alone. This number is expected to increase to 64.6 million by the year 2050.</p> <p>Discussion</p> <p>As a result of advances in research, there several pharmacological therapies available for the treatment of dementia patients. However, current treatments do not suppress the disease process and cannot prevent dementia, and it will be some time before these goals are realized. In the meantime, complementary and alternative medicine (CAM) is an important aspect in the treatment of dementia patients to improve their quality of life throughout the long course of the disease. Considering the individuality of dementia patients, applicability of laughter and humor therapy is discussed. Even though there are many things that need to be elucidated regarding the mechanisms underlying the beneficial effects of laughter and humor, both may be good CAM for dementia patients if they are applied carefully and properly.</p> <p>Summary</p> <p>In this debate article, the physiological basis and actual application of laughter and humor in the treatment of dementia patients are presented for discussion on the applicability to dementia patients.</p