Theoretical Response to the Discovery of Deeply Bound Pionic States in 208Pb(d,3He) reactions

Recently, deeply bound pionic states were found experimentally in (d, $^3$He) reactions on $^{208}$Pb. They found an isolated peak structure in the bound region below the pion production threshold. We study theoretically these excitation functions in (d, $^3$He) reactions on $^{208}$Pb at T$_d$=600 MeV. We found very good agreement with the (d, $^3$He) excitation functions and could identify the underlying structures of the pionic states. We study the energy dependence of the (d, $^3$He) reactions and the change of the excitation functions with the incident energy.Comment: 5 pages, Latex, Figures available on request, Z.Phys.A.accepte

Normal chemotactic activity of granulocytes obtained by filtration leucapheresis

The chemotactic activity of granulocytes obtained by the Terumo Filtration Leucapheresis System (F.L.) was examined by the method of Boyden's chamber. The number of cells migrating through the Millipore filter was expressed as the chemotactic activity. The mean values were 117 for the F.L. and 122 in a control, in which cells were collected from the same donor blood using dextran sedimentation. The results suggested that the in vitro chemotactic function of granulocytes obtained by F.L. was within normal limits.</p

σ\sigma Exchange in the NN Interaction within the Chiral Unitary Approach

We study the nucleon-nucleon interaction in the isoscalar-scalar channel using t he chiral unitary approach. The $t$-matrix of the pion-pion scattering in this c hannel is summed up to all orders using the B-S equation. We find that the calcu lated results at long distances are close to those of the $\sigma$-exchange inte raction. In addition, there appears a shorter range repulsion in this channel.Comment: LaTeX, 22pages 10figure

The relationship of cellular immunity to prognosis in acute leukemia

Forty-five patients with acute leukemia were compared on cellular immunity measures versus prognosis. The patients were treated according a multicombination therapy protocol. The purified protein derivative (PPD) test and dinitrochlorobenzene (DNCB) test on admission indicated low positive percentages. In acute non-lymphocytic leukemia (ANLL) patients, the 50% survival durations were 11 months in the PPD positive group and 6 months in the PPD negative group. In acute lymphocytic leukemia (ALL) patients, the 50% survival durations were 21 months in the PPD positive group and 13 months in the PPD negative group. Peripheral lymphocyte blastogenesis by phytohemagglutinin (PHA) stimulation was examined at various clinical stages. The stimulation indices were generally low, and no correlation was found between the PHA test and clinical stages. These cellular immunity measures appeared to reflect one aspect of the clinical condition in acute leukemia patients, and further studies are needed for predicting prognosis.</p

Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation.

Chemically modified mRNAs are extensively studied with a view toward their clinical application. In particular, long noncoding RNAs (lncRNAs) containing SINE elements, which enhance the translation of their target mRNAs (i.e., SINEUPs), have potential as RNA therapies for various diseases, such as haploinsufficiencies. To establish a SINEUP‐based system for efficient protein expression, we directly transfected chemically modified in vitro transcribed (mIVT) SINEUP RNAs to examine their effects on target mRNA translation. mIVT SINEUP RNAs enhanced translation of EGFP mRNA and endogenous target Sox9 mRNA in both cultured cells and a cell‐free translation system. Our findings reveal the functional role of RNA modifications in SINEUPs and suggest several broad clinical applications of such an RNA regulatory system

Role of the Carboxy-Terminal Region of the GluRε2 Subunit in Synaptic Localization of the NMDA Receptor Channel

AbstractThe synaptic localization of the N-methyl-D-aspartate (NMDA) type glutamate receptor (GluR) channel is a prerequisite for synaptic plasticity in the brain. We generated mutant mice carrying the carboxy-terminal truncated GluRε2 subunit of the NMDA receptor channel. The mutant mice died neonatally and failed to form barrelette structures in the brainstem. The mutation greatly decreased the NMDA receptor–mediated component of hippocampal excitatory postsynaptic potentials and punctate immunofluorescent labelings of GluRε2 protein in the neuropil regions, while GluRε2 protein expression was comparable. Immunostaining of cultured cerebral neurons showed the reduced punctate staining of the truncated GluRε2 protein at synapses. These results suggest that the carboxy-terminal region of the GluRε2 subunit is important for efficient clustering and synaptic localization of the NMDA receptor channel

Ground state particle-particle correlations and double beta decay

A self-consistent formalism for the double beta decay of Fermi type is provided. The particle-particle channel of the two-body interaction is considered first in the mean field equations and then in the QRPA. The resulting approach is called the QRPA with a self-consistent mean field (QRPASMF). The mode provided by QRPASMF, does not collapse for any strength of the particle-particle interaction. The transition amplitude for double beta decay is almost insensitive to the variation of the particle-particle interaction. Comparing it with the result of the standard pnQRPA, it is smaller by a factor 6. The prediction for transition amplitude agrees quite well with the exact result. The present approach is the only one which produces a strong decrease of the amplitude and at the same time does not alter the stability of the ground state.Comment: 23 pages, 7 figure

New treatment of the chiral SU(3) quark mean field model

We perform a study of infinite hadronic matter, finite nuclei and hypernuclei with an improved method of calculating the effective baryon mass. A detailed study of the predictions of the model is made in comparison with the available data and the level of agreement is generally very good. Comparison with an earlier treatment shows relatively minor differences at or below normal nuclear matter density, while at high density the improved calculation is quite different. In particular, we find no phase transition corresponding to chiral symmetry restoration in high density nuclear matter.Comment: 19 pages, 11 figure