Response of CdWO4 crystal scintillator for few MeV ions and low energy electrons

The response of a CdWO4 crystal scintillator to protons, alpha particles, Li, C, O and Ti ions with energies in the range 1 - 10 MeV was measured. The non-proportionality of CdWO4 for low energy electrons (4 - 110 keV) was studied with the Compton Coincidence Technique. The energy dependence of the quenching factors for ions and the relative light yield for low energy electrons was calculated using a semi-empirical approach. Pulse-shape discrimination ability between gamma quanta, protons, alpha particles and ions was investigated.Comment: 20 pages, 8 figs, accepted in Nucl. Instrum. Meth.

Native NIR-emitting single colour centres in CVD diamond

Single-photon sources are a fundamental element for developing quantum technologies, and sources based on colour centres in diamonds are among the most promising candidates. The well-known NV centres are characterized by several limitations, thus few other defects have recently been considered. In the present work, we characterize in detail native efficient single colour centres emitting in the near infra-red in both standard IIa single-crystal and electronic-grade polycrystalline commercial CVD diamond samples. In the former case, a high-temperature annealing process in vacuum is necessary to induce the formation/activation of luminescent centres with good emission properties, while in the latter case the annealing process has marginal beneficial effects on the number and performances of native centres in commercially available samples. Although displaying significant variability in several photo physical properties (emission wavelength, emission rate instabilities, saturation behaviours), these centres generally display appealing photophysical properties for applications as single photon sources: short lifetimes, high emission rates and strongly polarized light. The native centres are tentatively attributed to impurities incorporated in the diamond crystal during the CVD growth of high-quality type IIa samples, and offer promising perspectives in diamond-based photonics.Comment: 27 pages, 10 figures. Submitted to "New Journal of Phsyics", NJP-100003.R

Spatial Resolution of Double-Sided Silicon Microstrip Detectors for the PAMELA Apparatus

The PAMELA apparatus has been assembled and it is ready to be launched in a satellite mission to study mainly the antiparticle component of cosmic rays. In this paper the performances obtained for the silicon microstrip detectors used in the magnetic spectrometer are presented. This subdetector reconstructs the curvature of a charged particle in the magnetic field produced by a permanent magnet and consequently determines momentum and charge sign, thanks to a very good accuracy in the position measurements (better than 3 um in the bending coordinate). A complete simulation of the silicon microstrip detectors has been developed in order to investigate in great detail the sensor's characteristics. Simulated events have been then compared with data gathered from minimum ionizing particle (MIP) beams during the last years in order to tune free parameters of the simulation. Finally some either widely used or original position finding algorithms, designed for such kind of detectors, have been applied to events with different incidence angles. As a result of the analysis, a method of impact point reconstruction can be chosen, depending on both the particle's incidence angle and the cluster multiplicity, so as to maximize the capability of the spectrometer in antiparticle tagging.Comment: 28 pages, 18 figures, submitted to Nuclear Instruments and Methods in Physics Research

Energy and angular momentum sharing in dissipative collisions

Primary and secondary masses of heavy reaction products have been deduced from kinematics and E-ToF measurements, respectively, for the direct and reverse collisions of 93Nb and 116Sn at 25 AMeV. Light charged particles have also been measured in coincidence with the heavy fragments. Direct experimental evidence of the correlation of energy-sharing with net mass transfer has been found using the information from both the heavy fragments and the light charged particles. The ratio of Hydrogen and Helium multiplicities points to a further correlation of angular momentum sharing with net mass transfer.Comment: 21 pages, 20 figures. Submitted to European Physics Journal

Micro-beam and pulsed laser beam techniques for the micro-fabrication of diamond surface and bulk structures

Micro-fabrication in diamond is involved in a wide set of emerging technologies, exploiting the exceptional characteristics of diamond for application in bio-physics, photonics, radiation detection. Micro ion-beam irradiation and pulsed laser irradiation are complementary techniques, which permit the implementation of complex geometries, by modification and functionalization of surface and/or bulk material, modifying the optical, electrical and mechanical characteristics of the material. In this article we summarize the work done in Florence (Italy) concerning ion beam and pulsed laser beam micro-fabrication in diamond.Comment: 14 pages, 5 figure

Ex vivo model predicted in vivo efficacy of CFTR modulator therapy in a child with rare genotype

Background: New drugs that target the basic defect in cystic fibrosis (CF) patients may now be used in a large number of patients carrying responsive mutations. Nevertheless, further research is needed to extend the benefit of these treatments to patients with rare mutations that are still uncharacterized in vitro and that are not included in clinical trials. For this purpose, ex vivo models are necessary to preliminary assessing the effect of CFTR modulators in these cases. Method: We report the clinical effectiveness of lumacaftor/ivacaftor therapy prescribed to a CF child with a rare genetic profile (p.Phe508del/p.Gly970Asp) after testing the drug on nasal epithelial cells. We observed a significant drop of the sweat chloride value, as of the lung clearance index. A longer follow-up period is needed to define the effects of therapy on pancreatic status, although an increase of the fecal elastase values was found. Conclusion: Drug response obtained on nasal epithelial cells correlates with changes in vivo therapeutic endpoints and can be a predictor of clinical efficacy of novel drugs especially in pediatric patients

The importance of being little: MA-XRF on manuscripts on a Venetian island

The XRF scanning spectrometer developed in the framework of CHNet-INFN (Cultural Heritage Network - National Institute of Nuclear Physics), is specifically customised for cultural heritage applications, designed with a focus on having a lightweight scanner (weighing approximately 10 kg), easy to handle and thus easily transportable in two medium-sized boxes. The research presented here deals with the study of a set of choir books preserved in the Abbey of San Giorgio Maggiore on the homonymous island in Venice. Produced for the Abbey itself from the mid-15th century onwards, the manuscripts have never left the island, making the study of the materials of particular interest as they have undergone little or no modification over time. During their history in the Abbey, however, the volumes have been disassembled and reassembled in various ways, bringing complexity to the current cataloguing work. Thus, analytical investigations of the pigments and painting techniques might help identify the original arrangement of displaced leaves and provide evidence for the attribution of individual illuminations to certain artists. Thanks to its easy transportability, it was possible to take the scanner to the small island by means of the water-based Venetian public transport. Selected results are presented, derived from the high-quality MA-XRF maps obtained