4,606 research outputs found
The Effect of Applying Lactic Acid Bacteria to \u3ci\u3eElymus excelsus\u3c/i\u3e and \u3ci\u3eElymus sibiricus\u3c/i\u3e Gramineous Mixed Grass on Fermentation Characteristics
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Regulation of axon repulsion by MAX-1 SUMOylation and AP-3.
During neural development, growing axons express specific surface receptors in response to various environmental guidance cues. These axon guidance receptors are regulated through intracellular trafficking and degradation to enable navigating axons to reach their targets. In Caenorhabditis elegans, the UNC-5 receptor is necessary for dorsal migration of developing motor axons. We previously found that MAX-1 is required for UNC-5-mediated axon repulsion, but its mechanism of action remained unclear. Here, we demonstrate that UNC-5-mediated axon repulsion in C. elegans motor axons requires both max-1 SUMOylation and the AP-3 complex β subunit gene, apb-3 Genetic interaction studies show that max-1 is SUMOylated by gei-17/PIAS1 and acts upstream of apb-3 Biochemical analysis suggests that constitutive interaction of MAX-1 and UNC-5 receptor is weakened by MAX-1 SUMOylation and by the presence of APB-3, a competitive interactor with UNC-5. Overexpression of APB-3 reroutes the trafficking of UNC-5 receptor into the lysosome for protein degradation. In vivo fluorescence recovery after photobleaching experiments shows that MAX-1 SUMOylation and APB-3 are required for proper trafficking of UNC-5 receptor in the axon. Our results demonstrate that SUMOylation of MAX-1 plays an important role in regulating AP-3-mediated trafficking and degradation of UNC-5 receptors during axon guidance
JCMT POL-2 and ALMA polarimetric observations of 6000-100 au scales in the protostar B335: linking magnetic field and gas kinematics in observations and MHD simulations
We present our analysis of the magnetic field structures from 6000 au to 100
au scales in the Class 0 protostar B335 inferred from our JCMT POL-2
observations and the ALMA archival polarimetric data. To interpret the
observational results, we perform a series of (non-)ideal MHD simulations of
the collapse of a rotating non-turbulent dense core, whose initial conditions
are adopted to be the same as observed in B335, and generate synthetic
polarization maps. The comparison of our JCMT and simulation results suggests
that the magnetic field on a 6000 au scale in B335 is pinched and well aligned
with the bipolar outflow along the east-west direction. Among all our
simulations, the ALMA polarimetric results are best explained with weak
magnetic field models having an initial mass-to-flux ratio of 9.6. However, we
find that with the weak magnetic field, the rotational velocity on a 100 au
scale and the disk size in our simulations are larger than the observational
estimates by a factor of several. An independent comparison of our simulations
and the gas kinematics in B335 observed with the SMA and ALMA favors strong
magnetic field models with an initial mass-to-flux ratio smaller than 4.8. We
discuss two possibilities resulting in the different magnetic field strengths
inferred from the polarimetric and molecular-line observations, (1)
overestimated rotational-to-gravitational energy in B335 and (2) additional
contributions in the polarized intensity due to scattering on a 100 au scale.Comment: Accepted by Ap
In situ N-doped graphene and Mo nanoribbon formation from Mo2Ti2C3 MXene monolayers
Since the advent of monolayered 2D transition metal carbide and nitrides (MXenes) in 2011, the number of different monolayer systems and the study thereof have been on the rise. Mo2Ti2C3 is one of the least studied MXenes and new insights to this material are of value to the field. Here, the stability of Mo2Ti2C3 under electron irradiation is investigated. A transmission electron microscope (TEM) is used to study the structural and elemental changes in situ. It is found that Mo2Ti2C3 is reasonably stable for the first 2 min of irradiation. However, structural changes occur thereafter, which trigger increasingly rapid and significant rearrangement. This results in the formation of pores and two new nanomaterials, namely, N-doped graphene membranes and Mo nanoribbons. The study provides insight into the stability of Mo2Ti2C3 monolayers against electron irradiation, which will allow for reliable future study of the material using TEM. Furthermore, these findings will facilitate further research in the rapidly growing field of electron beam driven chemistry and engineering of nanomaterials.Web of Scienceart. no. 190711
Evaluation of prognostic factors and the role of chemotherapy in unfavorable carcinoma of unknown primary site: a 10-year cohort study
<p>Abstract</p> <p>Background</p> <p>Carcinoma of unknown primary site (CUP) has a poor prognosis and the prognostic factors in these patients are not well established. Furthermore, there are no selection criteria for patients who should benefit from chemotherapy.</p> <p>Methods</p> <p>The medical records of 179 CUP patients who were treated at Taipei Veterans General Hospital from 2000 to 2009 were reviewed. Factors associated with survival were determined by Kaplan-Meier analysis. Differences between the groups with and without palliative chemotherapy were analyzed.</p> <p>Results</p> <p>Univariate analysis revealed multiple prognostic factors, including performance status, lung metastasis, number of metastatic organs, serum albumin, corrected serum calcium, lactate dehydrogenase (LDH), sodium, and cholesterol levels, palliative chemotherapy, and white blood cell and lymphocyte counts. Multivariate analysis showed that performance status < 2, serum albumin level ≥ 3.5 g/dl, corrected serum calcium level < 10.7 mg/dl, single metastatic organ, and palliative chemotherapy were independent factors of better prognosis. Patients with better performance status, higher serum albumin, and lower serum LDH levels had significantly greater benefit from palliative chemotherapy.</p> <p>Conclusions</p> <p>Certain patients with unfavorable CUP will have better survival. Identification of patients with unfavorable CUP who could benefit from palliative chemotherapy warrants future prospective studies.</p
Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations
Secondary Metabolites from the Leaves of Aquilaria agallocha
Twelve compounds, including three flavonoids, 5-hydroxy-4¢,7- dimethoxyflavone (1) [22], luteolin-7,3¢,4¢-trimethyl ether (2) and 5,3¢- dihydroxy-7,4¢-dimethoxyflavone (3), five benzenoids, methylparaben (4), vanillic acid (5), p-hydroxybenzoic acid (6), syringic acid (7), and isovanillic acid (8) and four steroids, b-sitosterol (9), stigmasterol (10), b-sitostenone (11) and stigmasta-4,22-dien-3- one (12) were isolated from the leaves of Aquilaria agallocha (Thymelaeaceae). All of these compounds (1-12) were obtained for the first time from the leaves of this plant
Benchmarking Robustness to Adversarial Image Obfuscations
Automated content filtering and moderation is an important tool that allows
online platforms to build striving user communities that facilitate cooperation
and prevent abuse. Unfortunately, resourceful actors try to bypass automated
filters in a bid to post content that violate platform policies and codes of
conduct. To reach this goal, these malicious actors may obfuscate policy
violating images (e.g. overlay harmful images by carefully selected benign
images or visual patterns) to prevent machine learning models from reaching the
correct decision. In this paper, we invite researchers to tackle this specific
issue and present a new image benchmark. This benchmark, based on ImageNet,
simulates the type of obfuscations created by malicious actors. It goes beyond
ImageNet- and ImageNet- by proposing general,
drastic, adversarial modifications that preserve the original content intent.
It aims to tackle a more common adversarial threat than the one considered by
-norm bounded adversaries. We evaluate 33 pretrained models on the
benchmark and train models with different augmentations, architectures and
training methods on subsets of the obfuscations to measure generalization. We
hope this benchmark will encourage researchers to test their models and methods
and try to find new approaches that are more robust to these obfuscations
Determinants of pro-environmental behavior among excessive smartphone usage children and moderate smartphone usage children in Taiwan
Introduction Although there is evidence linking the relationships between smartphone usage with health, stress, and academic performance, there is still inadequate knowledge about the influence on pro-environmental behaviors. This study seeks to bridge this gap by adapting the theory of attribution framework to examine the effects of personal norms, social norms, perceived behavioral control on pro-environmental behavior of smartphone usage in children. Methods A total of 225 children aged between 11 to 12 from eight selected public primary schools at the Hsinchu Science and Industrial Park in Taiwan were surveyed. Two distinct groups (excessive versus moderate usage) were purposefully selected for comparison, of which 96 participants were excessive smartphone users while the remaining 129 were moderate smartphone users. Results Findings revealed significant differences between excessive and moderate smartphone usage children groups in personal norms (p  0.05), as well as social norms and pro-environmental behavior for moderate smartphone usage children (β = 0.181, t = 1.924, p > 0.05), but such a relationship could be developed through the mediating effect of perceived behavioral control (β = 0.497, t = 4.471***, p < 0.001). Discussion The results suggested that excessive smartphone usage children lack positive perceived behavioral control, and their pro-environmental behavior could only be predicted through explicit social norms, whereas pro-environmental behavior of moderate smartphone usage children was implicitly influenced by personal norms through perceived behavioral control
BAs and boride III-V alloys
Boron arsenide, the typically-ignored member of the III-V arsenide series
BAs-AlAs-GaAs-InAs is found to resemble silicon electronically: its Gamma
conduction band minimum is p-like (Gamma_15), not s-like (Gamma_1c), it has an
X_1c-like indirect band gap, and its bond charge is distributed almost equally
on the two atoms in the unit cell, exhibiting nearly perfect covalency. The
reasons for these are tracked down to the anomalously low atomic p orbital
energy in the boron and to the unusually strong s-s repulsion in BAs relative
to most other III-V compounds. We find unexpected valence band offsets of BAs
with respect to GaAs and AlAs. The valence band maximum (VBM) of BAs is
significantly higher than that of AlAs, despite the much smaller bond length of
BAs, and the VBM of GaAs is only slightly higher than in BAs. These effects
result from the unusually strong mixing of the cation and anion states at the
VBM. For the BAs-GaAs alloys, we find (i) a relatively small (~3.5 eV) and
composition-independent band gap bowing. This means that while addition of
small amounts of nitrogen to GaAs lowers the gap, addition of small amounts of
boron to GaAs raises the gap (ii) boron ``semi-localized'' states in the
conduction band (similar to those in GaN-GaAs alloys), and (iii) bulk mixing
enthalpies which are smaller than in GaN-GaAs alloys. The unique features of
boride III-V alloys offer new opportunities in band gap engineering.Comment: 18 pages, 14 figures, 6 tables, 61 references. Accepted for
publication in Phys. Rev. B. Scheduled to appear Oct. 15 200
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