KAZA İLE GAZ YAĞI İÇİMİ SONRASI BİR ÇOCUKTA AKCİĞER APSESİ VE PNÖMOTOSEL

Hydrocarbon compounds are easily accessible products. Exposure to hydrocarbons is usually by accidental ingestion especially in children younger than 5 years. Pneumonitis is the most common complication of hydrocarbon ingestion. However; formation of lung abscess and pneumatoceles is believed to be a very rare event. Herein; we report a four year old child with hydrocarbon pneumonitis who had developed lung abscess and pneumotocele.Hidrokarbon bileşikleri kolaylıkla ulaşılabilen ürünlerdir. Hidrokarbonlara maruziyet genellikle kaza sonucu içme ile özellikle 5 yaş altı çocuklarda olur. Pnömonit hidrokarbon alımının en sık komplikasyonudur. Bununla birlikte akciğer apsesi ve pnömotosel oluşumunun oldukça nadir bir olay olduğuna inanılır. Burada akciğer apsesi ve pnömotosel gelişen hidrokarbon pnömonitli dört yaşında bir çocuk sunuldu

KARTAGENER SYNDROME

Kartagener sendromu otozomal resesif geçişli sinüzit, bronşektazi, situs inversus ile karakterize ender görülen bir hastalıktır. Bu makalede, kliniğimizde Kartagener sendromu tanısı ile izlediğimiz iki olgunun klinik ve radyolojik bulguları verilmiştir. Olgular kronik rinosinüzit ve bronşektazisi olan çocuklarda Kartagener sendromunun olası bir tanı olarak akılda tutulması gerekliliğini vurgulamak amacıyla takdim edilmiştir. The Kartagener syndrome is a rare autosomal recessive disorder characterized by bronchiectasis, sinusitis, sinus inversus. Clinical and radiological features of two cases followed in our clinic are given in this article. These cases are presented to emphasize that Kartagener syndrome should be considered as a possible diagnosis in children with chronic rhinosinusitis and bronchiectasis

Characteristics of food allergy in children: National multicenter study

Conference: Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) Location: Lisbon, PORTUGAL Date: JUN 01-05, 2019Background : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study.European Academy of Allergy and Clinical Immunolog

Eveluation of apoptosis with annexin V test on normospermic people's spermatozoa before and after sperm cryoprezervation

Sperm kriyoprezervasyonu, onkolojik veya immünolojik hastalıklar ve tedavilerinden kaynaklanabilecek fertilizasyon problemlerinde, ileride eşlerin çocuk isteme durumunda kullanılmak üzere hastanın spermlerinin saklanması işlemidir. Kriyoprezervasyon sonrası spermlerde bazı hasarlar meydana gelebilir. Bu hasarların oluş mekanizması hala tam olarak anlaşılamamıştır. Bu amaçla 20 normospermik numune çalışma kapsamına alınmıştır. Bu normospermik numuneler kriyoprezervasyon uygulanan ve uygulanmayan olmak üzere iki gruba ayrılmıştır. Kriyoprezervasyon uygulanan örnekler 1 saat sonra çözülmüştür ve her iki gruba da Annexin V testi uygulanarak spermatozoa membranındaki PS?nin translokasyonundan kaynaklanan apoptozise gitme oranları istatistiksel olarak değerlendirilmeye çalışılmıştır. Bu çalışmada kriyoprezervasyon öncesi ve kriyoprezervasyon sonrası semen örneklerinin erken apoptozis sayılarında anlamlı bir fark olduğu saptandı (p<0.05). Kriyoprezervasyon öncesi ve kriyoprezervasyon sonrası semen örneklerinin geç apoptozis sayılarında ileri derecede anlamlı bir fark olduğu saptandı (p<0.05) ve son olarak kriyoprezervasyon öncesi ve kriyoprezervasyon sonrası semen örneklerinin nekroz sayılarında anlamlı bir fark olmadığı saptandı (p<0.05). Sonuç olarak elde ettiğimiz bulgular kriyoprezervasyonun apoptotik sperm oranında bir artış ile ilişkili olduğunu göstermiştir.Sperm cryopreservation is a process if keeping sperms of the patient to be used when the couples wish to have children in the future in fertilization problems resulting from oncologic or immunologic problems and their treatments. In post- cryopreservation period, same deformities may be encountered in the nature of sperms, and the mechanisms of such deformities still remain unknown. Twenty normospermic specimens were included into the study due to the uncertainity of the condition. The normospermic specimens were grouped into two as those with cryopreservation and others without. One hour after the process, cryopreservation exposed specimens were melted and, by performing Annexin V test, the rate of their apoptozis arising from the translocation of PS on spermatozoa membrane was tried to be evaluated statistically. In our study, a significant difference was found in the number of early apoptozis in semen samples of pre-and post cryopreservation periods. A higher rate of significant difference was found between the late number of pre and post cryopreservation semen samples. Finally it was found that there is no significant difference between pre and post cryopreservation necrosis number of semen samples. In conclusion, our findings indicated that cryopreservation is associated with an increase at the rate of apoptotic sperm number

Efficacy of rupatadine on lung histopathology in a murine model of chronic asthma

Amaç: Rupatadin yeni, non sedatif bir antihistaminiktir. Selektif H1 antagonisti etkisinin yanı sıra diğer antihistaminiklerden farklı olarak güçlü bir PAF inhibitörüdür. PAF alerjik hastalıklarda ve astımda önemli bir mediyatördür. Bu çalışmada amacımız, rupatadinin kronik astım fare modelinde akciğer histolojisi üzerine etkilerini incelemektir. Materyal-Metod: Çalışmada 35 adet BALB/c fare kullanıldı. Fareler yedişerli gruplara ayrıldı. Grup I (kontrol), Grup II, Grup III, Grup IV, Grup V. Çalışma gruplarındaki fareler, ovalbumin uygulanarak duyarlılaştırıldı. Kontrol grubundaki farelere aynı yol ve dozlarda %0,9 NaCl solusyonu uygulandı. Duyarlaştırmanın son haftasında beş gün boyunca Grup II'e %0,9 NaCl, Grup III'e 3mg/kg rupatadin, Grup IV'e 30 mg/kg rupatadin, Grup V'e 1 mg/kg deksametazon orogastrik yolla uygulandı. Çalışma ilaçlarının son uygulamasından 24 saat sonra fareler sakrifiye edildi. Elde edilen akciğer örneklerinin histolojik özellikleri, ışık ve elektron mikroskopisi kullanılarak değerlendirildi. Bulgular: Grup II (plasebo) ve Grup III (rupatadin 3mg/kg) karşılaştırıldığında aralarında anlamlı farklılık bulunmamıştır. Grup IV (rupatadin 30 mg/kg), Grup II ile karşılaştırıldığında ise bazal membran kalınlığı, subepitelyal düz kas kalınlığı ve epitel yüksekliği parametrelerinde istatistiksel olarak anlamlı düzelme gözlenmiştir. Grup IV ve Grup V (deksametazon) ile karşılaştırıldığında ise tüm bu parametrelerdeki düzelmenin benzer olduğu bulunmuştur Sonuç: Rupatadinin kronik astım fare modelinde bazal membran kalınlığı, subepitelyal düz kas kalınlığı ve epitel yüksekliği parametreleri üzerine etkili olduğu gözlenmiştir. Rupatadinin astımda monoterapide kullanılabilmesi için yapılacak daha ileri çalışmalara ihtiyaç vardır. Introduction: Rupatadine is classified as a new second generation antihistamine. It has selective H1 antagonist effects as well as platelet activating factor antagonist properties. Platelet activating factor is proinflammatory mediator involved in the pathogenesis of asthma. Our aim is to investigate the effect of rupatadine on histologic changes in chronic murine model of asthma. Method: Thirty-five BALB/c mice were divided into five groups: Group I (as a control group), group II, group III, group IV, group V. All mice except control were sensitized and challenged with ovalbumine. Saline was administered instead of ovalbumine in control group. Mice in group II (placebo group) received saline, in group III received rupatadine at a dose of 3mg/kg per day, in group IV received rupatadine at a dose of 30mg/kg per day and in group V received dexamethasone at a dose of 1 mg/kg per day perorally via orogastric route once daily in the last 5 days of the challenge period. Animals were sacrificed by an overdose of ketamin after 24 hours from the last drug administration. Airway histopathology was evaluated by using light and electron microscopy in all groups. Results: In comparison of Group II and Group III (rupatadine 3 mg/kg), all histologic parameters were similar. When compared Group II and Group IV(rupatadin 30mg/kg), thicknesses of basement membrane, subepithelial smooth muscle layer and epithelium were significantly lower in group IV (p&lt;0.05). In comparison of Group IV (30 mg/kg rupatadin) and Group V(dexamethasone), there were no statistically significant differences of thicknesses of basement membrane, subepithelial smooth muscle layer and epithelium. Conclusion: Rupatadine has beneficial effect on histologic changes in chronic murine model of asthma. Additional studies are needed to evaluate the efficacy of rupatadine in the management of asthma as monotherapy

A new meta-analysis on the WTP/WTA disparity

This study reports a new meta-analysis of papers that elicit willingness-to-pay (WTP) and willingness-to-accept compensation (WTA) measures of value for the same good. We investigate the effects of type of good and several survey-design features on the WTP/WTA disparity, measured as the logarithm of the ratio of mean WTA to mean WTP. Confirming Horowitz and McConnell׳s (2002) pioneering meta-analysis, we find the disparity is smaller for ordinary private goods than for public and non-market goods, that it is not solely an artifact of using hypothetical transactions or other weak experimental or survey methods, and that it is smaller for studies using student subjects. In addition, we find that the disparity is smaller when subjects have experience valuing the good in real markets or through repeated experimental trials. In contrast to Horowitz and McConnell, we find the disparity is significantly smaller in studies using incentive-compatible elicitation mechanisms. The disparity is smaller in more recent studies, an effect that is attributable only in part to changes in study characteristics

The beneficial effect of eco-friendly chemical impregnation on the thermal stabilization process of poly(hexamethylene adipamide) multifilament

The influence of the impregnation of phosphoric acid, boric acid, and urea (in brief PBU) as eco-friendly chemicals and the thermal-oxidative stabilization (TOS) on the properties of poly(hexamethylene adipamide) or polyamide 66 multifilament were studied at temperatures up to 245 degrees C for different stabilization periods. PBU impregnation followed by a two-step TOS process in an air environment leads to major changes in the structural, physical, and mechanical properties of the polyamide 66 (PA66) multifilaments. In this study, X-ray diffraction (XRD), infrared (IR) spectroscopy techniques, thermogravimetric analysis (TGA), and optical microscopy were employed to perform structural characterization of the original, and PBU impregnated and thermally stabilized samples. Characterization of physical changes was accomplished by observing fiber burning behavior, change of color, linear density, fiber density, fiber thickness, and mechanical properties for the different stabilization periods. The outcomes showed that PBU pretreatment enhanced the thermal stability of PA66 multifilaments before the carbonization stage. Continuous loss of crystalline structure was observed from the investigation of the equatorial X-ray diffraction results. This loss is caused by disordering methods due to the breakage of hydrogen bonding (H-bonding) of the PA66 chains. The TGA thermograms revealed a comparative enhancement in thermal stability of the samples by the increased char yield percentage with an increasing stabilization period. The PBU impregnated PA66 multifilaments oxidized at 245 degrees C for 150 min showed the highest value of carbon yield of 47% at 1000 degrees C. Infrared analysis showed the steady loss of intermolecular and intramolecular H-bonding due to the concurrently occurred dehydration and dehydrogenation reactions. (C) 2022 Published by Elsevier B.V