Trick or Heat? Manipulating Critical Temperature-Based Control Systems Using Rectification Attacks

Temperature sensing and control systems are widely used in the closed-loop control of critical processes such as maintaining the thermal stability of patients, or in alarm systems for detecting temperature-related hazards. However, the security of these systems has yet to be completely explored, leaving potential attack surfaces that can be exploited to take control over critical systems. In this paper we investigate the reliability of temperature-based control systems from a security and safety perspective. We show how unexpected consequences and safety risks can be induced by physical-level attacks on analog temperature sensing components. For instance, we demonstrate that an adversary could remotely manipulate the temperature sensor measurements of an infant incubator to cause potential safety issues, without tampering with the victim system or triggering automatic temperature alarms. This attack exploits the unintended rectification effect that can be induced in operational and instrumentation amplifiers to control the sensor output, tricking the internal control loop of the victim system to heat up or cool down. Furthermore, we show how the exploit of this hardware-level vulnerability could affect different classes of analog sensors that share similar signal conditioning processes. Our experimental results indicate that conventional defenses commonly deployed in these systems are not sufficient to mitigate the threat, so we propose a prototype design of a low-cost anomaly detector for critical applications to ensure the integrity of temperature sensor signals.Comment: Accepted at the ACM Conference on Computer and Communications Security (CCS), 201

Non-Markovian dynamics of a microcavity coupled to a waveguide in photonic crystals

In this paper, the non-Markovian dynamics of a microcavity coupled to a waveguide in photonic crystals is studied based on Fano-type tight binding model. Using the exact master equation, we solve analytically and numerically the temporal evolution of the cavity coherent state and the associated physical observables. A critical transition is revealed when the coupling increase between the cavity and the waveguide. In particular, the cavity field becomes dissipationless when the coupling strength goes beyond a critical value, as a manifestation of strong non-Markovian memory effect. The result also indicates that the cavity can maintain in a coherent state with arbitrary small number of photons when it strongly couples to the waveguide at very low temperature. These properties can be measured experimentally through the photon current flowing over the waveguide in photonic crystals.Comment: 7 pages, 5 figure

Export efficiency of black carbon aerosol in continental outflow: Global implications

We use aircraft observations of Asian outflow from the NASA Transport and Chemical Evolution over the Pacific (TRACE-P) mission over the NW Pacific in March–April 2001 to estimate the export efficiency of black carbon (BC) aerosol during lifting to the free troposphere, as limited by scavenging from the wet processes (warm conveyor belts and convection) associated with this lifting. Our estimate is based on the enhancement ratio of BC relative to CO in Asian outflow observed at different altitudes and is normalized to the enhancement ratio observed in boundary layer outflow (0–1 km). We similarly estimate export efficiencies of sulfur oxides (SO x = SO2(g) + fine SO4 2−) and total inorganic nitrate (HNO3 T = HNO3(g) + fine NO3 −) for comparison to BC. Normalized export efficiencies for BC are 0.63–0.74 at 2–4 km altitude and 0.27–0.38 at 4–6 km. Values at 2–4 km altitude are higher than for SO x (0.48–0.66) and HNO3 T (0.29–0.62), implying that BC is scavenged in wet updrafts but not as efficiently as sulfate or nitrate. Simulation of the TRACE-P period with a global three-dimensional model (GEOS-CHEM) indicates that a model timescale of 1 ± 1 days for conversion of fresh hydrophobic to hydrophilic BC provides a successful fit to the export efficiencies observed in TRACE-P. The resulting mean atmospheric lifetime of BC is 5.8 ± 1.8 days, the global burden is 0.11 ± 0.03 Tg C, and the decrease in Arctic snow albedo due to BC deposition is 3.1 ± 2.5%.Earth and Planetary Science

Phase transition classes in triplet and quadruplet reaction diffusion models

Phase transitions of reaction-diffusion systems with site occupation restriction and with particle creation that requires n=3,4 parents, whereas explicit diffusion of single particles (A) is present are investigated in low dimensions by mean-field approximation and simulations. The mean-field approximation of general nA -> (n+k)A, mA -> (m-l)A type of lattice models is solved and novel kind of critical behavior is pointed out. In d=2 dimensions the 3A -> 4A, 3A -> 2A model exhibits a continuous mean-field type of phase transition, that implies d_c<2 upper critical dimension. For this model in d=1 extensive simulations support a mean-field type of phase transition with logarithmic corrections unlike the Park et al.'s recent study (Phys. Rev E {\bf 66}, 025101 (2002)). On the other hand the 4A -> 5A, 4A -> 3A quadruplet model exhibits a mean-field type of phase transition with logarithmic corrections in d=2, while quadruplet models in 1d show robust, non-trivial transitions suggesting d_c=2. Furthermore I show that a parity conserving model 3A -> 5A, 2A->0 in d=1 has a continuous phase transition with novel kind of exponents. These results are in contradiction with the recently suggested implications of a phenomenological, multiplicative noise Langevin equation approach and with the simulations on suppressed bosonic systems by Kockelkoren and Chat\'e (cond-mat/0208497).Comment: 8 pages, 10 figures included, Updated with new data, figures, table, to be published in PR

Estimation of functional sparsity in nonparametric varying coefficient models for longitudinal data analysis

We study the simultaneous domain selection problem for varying coefficient models as a functional regression model for longitudinal data with many covariates. The domain selection problem in functional regression mostly appears under the functional linear regression with scalar response, but there is no direct correspondence to functional response models with many covariates. We reformulate the problem as nonparametric function estimation under the notion of functional sparsity. Sparsity is the recurrent theme that encapsulates interpretability in the face of regression with multiple inputs, and the problem of sparse estimation is well understood in the parametric setting as variable selection. For nonparametric models, interpretability not only concerns the number of covariates involved but also the functional form of the estimates, and so the sparsity consideration is much more complex. To distinguish the types of sparsity in nonparametric models, we call the former global sparsity and the latter local sparsity, which constitute functional sparsity. Most existing methods focus on directly extending the framework of parametric sparsity for linear models to nonparametric function estimation to address one or the other, but not both. We develop a penalized estimation procedure that simultaneously addresses both types of sparsity in a unified framework. We establish asymptotic properties of estimation consistency and sparsistency of the proposed method. Our method is illustrated in simulation study and real data analysis, and is shown to outperform the existing methods in identifying both local sparsity and global sparsity

In Vitro Microvessel Growth and Remodeling within a Three-Dimensional Microfluidic Environment

This paper presents in vitro microvascular network formation within 3D gel scaffolds made from different concentrations of type-I collagen, fibrin, or a mixture of collagen and fibrin, using a simple microfluidic platform. Initially, microvascular network formation of human umbilical vein endothelial cells was examined using live time-lapse confocal microscopy every 90 min from 3 h to 12 h after seeding within three different concentrations of collagen gel scaffolds. Among the three collagen gel concentrations, the number of skeletons was consistently the highest at 3.0 mg/mL, followed by those of collagen gel scaffolds at 2.5 mg/mL and 2.0 mg/mL. Results demonstrated that concentration of collagen gel scaffolds, which influences matrix stiffness and ligand density, may affect microvascular network formation during the early stages of vasculogenesis. In addition, the maturation of microvascular networks in monoculture under different gel compositions within gel scaffolds (2.5 mg/mL) was examined for 7 days using live confocal microscopy. It was confirmed that pure fibrin gel scaffolds are preferable to collagen gel or collagen/fibrin combinations, significantly reducing matrix retractions during maturation of microvascular networks for 7 days. Finally, early steps in the maturation process of microvascular networks for 14 days were characterized by demonstrating sequential steps of branching, expanding, remodeling, pruning, and clear delineation of lumens within fibrin gel scaffolds. Our findings demonstrate an in vitro model for generating mature microvascular networks within 3D microfluidic fibrin gel scaffolds (2.5 mg/mL), and furthermore suggest the importance of gel concentration and composition in promoting the maturation of microvascular networks.Singapore-MIT Alliance for Research and Technolog

Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells.

Multiple myeloma (MM) is a cancer of plasma cells in the bone marrow characterized by bone lesions, hypercalcemia, anemia, and renal failure. Bortezomib (BTZ), a common treatment for MM, is a proteasome inhibitor that induces apoptosis in MM cells. However, high doses of BTZ can be very toxic, signifying a need for a synergistic drug combination to improve treatment efficacy. Resveratrol (RES), a phenolic compound found in grapes, has been shown to inhibit MM cell growth. We sought to identify a synergistic combination of BTZ with a RES derivative and analyze the effects on reducing viability and inducing apoptosis in human MM cells. BTZ as well as RES and its derivatives pinostilbene (PIN) and piceatannol (PIC) decreased MM cell viability in a dose- and time-dependent manner and increased expression of cleaved proapoptotic proteins poly(ADP-ribose) polymerase 1 (PARP1) and caspase-3 in a dose-dependent manner. The combination of 5 nM BTZ and 5 μM PIN was identified to have synergistic cytotoxic effects in MM RPMI 8226 cells. MM RPMI 8226 cells treated with this combination for 24 h showed increased cleaved PARP1 and caspase-3 expression and higher percentages of apoptotic cells versus cells treated with the individual compounds alone. The treatment also showed increased apoptosis induction in MM RPMI 8226 cells co-cultured with human bone marrow stromal HS-5 cells in a Transwell model used to mimic the bone marrow microenvironment. Expression of oxidative stress defense proteins (catalase, thioredoxin, and superoxide dismutase) in RPMI 8226 cells were reduced after 24 h treatment, and cytotoxic effects of the treatment were ameliorated by antioxidant N-acetylcysteine (NAC), suggesting the treatment impacts antioxidant levels in RPMI 8226 cells. Our results suggest that this combination of BTZ and PIN decreases MM cell viability synergistically by inducing apoptosis and oxidative stress in MM cells

A New Study on Reliability Based Design Optimization.

This paper presents a general approach for probabilistic constraint evaluation in the reliability-based design optimization (RBD