B physics at CDF - the Beauty of hadron collisions

The CDF experiment at the Tevatron p-pbar collider established that extensive and detailed exploration of the b-quark dynamics is possible in hadron collisions, with results competitive and supplementary to those from e+e- colliders. This provides an unique, rich, and highly rewarding program that is currently reaching full maturity. I report a few recent world-leading results on rare decays, CP-violation in Bs mixing, and b-> s penguin decays.Comment: 6 pages, 5 figures. Write-up of the proceedings of the "Third Workshop on Theory, Phenomenology and Experiments in Heavy Flavour Physics" (Capri2010

Parametric study of space power systems. Volume 1 - Summary Final report

Summary of methodology and results of study of space power system

Parametric Study of Space Power Systems. Volume 2 - Technical Report Final Report

Computer program for analysis of space power system

Precise Determination of Minimum Achievable Temperature for Solid-State Optical Refrigeration

We measure the minimum achievable temperature (MAT) as a function of excitation wavelength in anti-Stokes fluorescence cooling of high purity Yb3+-doped LiYF4 (Yb:YLF) crystal. Such measurements were obtained by developing a sensitive noncontact thermometry that is based on a two-band differential luminescence spectroscopy using balanced photo-detectors. These measurements are in excellent agreement with the prediction of the laser cooling model and identify MAT of 110 K at 1020 nm, corresponding to E4-E5 Stark manifold transition in Yb:YLF crystal.Comment: 10 pages, 6 figure

ALP-Based Biosensors Employing Electrodes Modified with Carbon Nanomaterials for Pesticides Detection

Due to the growing presence of pesticides in the environment and in food, the concern of their impact on human health is increasing. Therefore, the development of fast and reliable detection methods is needed. Enzymatic inhibition-based biosensors represent a good alternative for replacing the more complicated and time-consuming traditional methods (chromatography, spectrophotometry, etc.). This paper describes the development of an electrochemical biosensor exploiting alkaline phosphatase as the biological recognition element and a chemically modified glassy carbon electrode as the transducer. The biosensor was prepared modifying the GCE surface by a mixture of Multi-Walled-Carbon-Nanotubes (MWCNTs) and Electrochemically-Reduced-Graphene-Oxide (ERGO) followed by the immobilization of the enzyme by cross-linking with bovine serum albumin and glutaraldehyde. The inhibition of the biosensor response caused by pesticides was established using 2-phospho-L-ascorbic acid as the enzymatic substrate, whose dephosphorylation reaction produces ascorbic acid (AA). The MWCNTs/ERGO mixture shows a synergic effect in terms of increased sensitivity and decreased overpotential for AA oxidation. The response of the biosensor to the herbicide 2,4-dichloro-phenoxy-acetic-acid was evaluated and resulted in the concentration range 0.04-24 nM, with a limit of the detection of 16 pM. The determination of other pesticides was also achieved. The re-usability of the electrode was demonstrated by performing a washing procedure

Synthesis and characterization of layered double hydroxides as materials for electrocatalytic applications

Layered double hydroxides (LDHs) are anionic clays which have found applications in a wide range of fields, including electrochemistry. In such a case, to display good performances they should possess electrical conductivity which can be ensured by the presence of metals able to give reversible redox reactions in a proper potential window. The metal centers can act as redox mediators to catalyze reactions for which the required overpotential is too high, and this is a key aspect for the development of processes and devices where the control of charge transfer reactions plays an important role. In order to act as redox mediator, a material can be present in solution or supported on a conductive support. The most commonly used methods to synthesize LDHs, referring both to bulk synthesis and in situ growth methods, which allow for the direct modification of conductive supports, are here summarized. In addition, the most widely used techniques to characterize the LDHs structure and morphology are also reported, since their electrochemical performance is strictly related to these features. Finally, some electrocatalytic applications of LDHs, when synthesized as nanomaterials, are discussed considering those related to sensing, oxygen evolution reaction, and other energy issues

Precision Anti-Cancer Medicines by Oligonucleotide Therapeutics in Clinical Research Targeting Undruggable Proteins and Non-Coding RNAs

Cancer incidence and mortality continue to increase, while the conventional chemotherapeutic drugs confer limited efficacy and relevant toxic side effects. Novel strategies are urgently needed for more effective and safe therapeutics in oncology. However, a large number of proteins are considered undruggable by conventional drugs, such as the small molecules. Moreover, the mRNA itself retains oncological functions, and its targeting offers the double advantage of blocking the tumorigenic activities of the mRNA and the translation into protein. Finally, a large family of non-coding RNAs (ncRNAs) has recently emerged that are also dysregulated in cancer, but they could not be targeted by drugs directed against the proteins. In this context, this review describes how the oligonucleotide therapeutics targeting RNA or DNA sequences, are emerging as a new class of drugs, able to tackle the limitations described above. Numerous clinical trials are evaluating oligonucleotides for tumor treatment, and in the next few years some of them are expected to reach the market. We describe the oligonucleotide therapeutics targeting undruggable proteins (focusing on the most relevant, such as those originating from the MYC and RAS gene families), and for ncRNAs, in particular on those that are under clinical trial evaluation in oncology. We highlight the challenges and solutions for the clinical success of oligonucleotide therapeutics, with particular emphasis on the peculiar challenges that render it arduous to treat tumors, such as heterogeneity and the high mutation rate. In the review are presented these and other advantages offered by the oligonucleotide as an emerging class of biotherapeutics for a new era of precision anti-cancer medicine

EXTRACTION of DEMS and ORTHOIMAGES from ARCHIVE AERIAL IMAGERY to SUPPORT PROJECT PLANNING in CIVIL ENGINEERING

Archive aerial photos represent a valuable heritage to provide information about land content and topography in the past years. Today, the availability of low-cost and open-source solutions for photogrammetric processing of close-range and drone images offers the chance to provide outputs such as DEM's and orthoimages in easy way. This paper is aimed at demonstrating somehow and to which level of accuracy digitized archive aerial photos may be used within a such kind of low-cost software (Agisoft Photoscan Professional®) to generate photogrammetric outputs. Different steps of the photogrammetric processing workflow are presented and discussed. The main conclusion is that this procedure may come to provide some final products, which however do not feature the high accuracy and resolution that may be obtained using high-end photogrammetric software packages specifically designed for aerial survey projects. In the last part a case study is presented about the use of four-epoch archive of aerial images to analyze the area where a tunnel has to be excavated

Are bullies more productive? Empirical study of affectiveness vs. issue fixing time

Human Affectiveness, i.e., The emotional state of a person, plays a crucial role in many domains where it can make or break a team's ability to produce successful products. Software development is a collaborative activity as well, yet there is little information on how affectiveness impacts software productivity. As a first measure of this impact, this paper analyzes the relation between sentiment, emotions and politeness of developers in more than 560K Jira comments with the time to fix a Jira issue. We found that the happier developers are (expressing emotions such as JOY and LOVE in their comments), the shorter the issue fixing time is likely to be. In contrast, negative emotions such as SADNESS, are linked with longer issue fixing time. Politeness plays a more complex role and we empirically analyze its impact on developers' productivity

Simulation and performance of an artificial retina for 40 MHz track reconstruction

We present the results of a detailed simulation of the artificial retina pattern-recognition algorithm, designed to reconstruct events with hundreds of charged-particle tracks in pixel and silicon detectors at LHCb with LHC crossing frequency of $40\,\rm MHz$. Performances of the artificial retina algorithm are assessed using the official Monte Carlo samples of the LHCb experiment. We found performances for the retina pattern-recognition algorithm comparable with the full LHCb reconstruction algorithm.Comment: Final draft of WIT proceedings modified according to JINST referee's comment