Association of Typical versus Atypical Antipsychotics with Symptoms and Quality of Life in Schizophrenia

BACKGROUND: Several reports on patients with chronic schizophrenia suggest that atypical versus typical antipsychotics are expected to lead to better quality of life (QOL) and cognitive function. Our aim was to examine the association of chronic treatment with typical or atypical antipsychotics with cognitive function, psychiatric symptoms, QOL, and drug-induced extrapyramidal symptoms in long-hospitalized patients with schizophrenia. METHODOLOGY AND PRINCIPAL FINDINGS: The Hasegawa Dementia Scale-Revised (HDS-R), Brief Psychiatric Rating Scale (BPRS), the Schizophrenia Quality of Life Scale, translated into Japanese (JSQLS), and the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS) were used to evaluate cognitive function, psychiatric symptoms, QOL, and drug-induced extrapyramidal symptoms. We examined the correlation between the dose of antipsychotics and each measure derived from these psychometric tests. The student t-test was used to compare scores obtained from psychometric tests between patients receiving typical and atypical antipsychotics. Results showed significant correlations between chlorpromazine (CPZ)-equivalent doses of typical antipsychotics and atypical antipsychotics, and the total BPRS score and BPRS subscale scores for positive symptoms. CPZ-equivalent doses of typical antipsychotics were correlated with the JSQLS subscale score for dysfunction of psycho-social activity and DIEPSS score. Furthermore, the total BPRS scores, BPRS subscale score for positive symptoms, the JSQLS subscale score for dysfunction of psycho-social activity, and the DIEPSS score were significantly higher in patients receiving typical antipsychotics than atypical antipsychotics. CONCLUSION AND SIGNIFICANCE: These findings suggest that long-term administration of typical antipsychotics has an unfavorable association with feelings of difficulties mixing in social situations in patients with chronic schizophrenia

Structural Study of Silica Coating Thin Layers Prepared from Perhydropolysilazane: Substrate Dependence and Water Penetration Structure

The structure of perhydropolysilazane (PHPS)-derived silica (PDS) waterproof thin layers synthesized by curing at 60 °C for 1 h and allowed to stand for 48 h at 20 °C on various kinds of substrates was studied. Neutron reflectivity (NR) analysis suggested that uniform PDS thin layers were synthesized on the substrates, and the density of the layers varied depending on the type of substrate. Additionally, since the change in PDS density is correlated with the pKa value of the OH group on the substrate, it can be suggested that the acidity of the substrate would be one of the main factors determining the density of the coated PDS thin layers. For the water penetration structure study, NR analysis revealed that the depth of water penetration into the PDS layers was below 500 Å, and the hydration number of the SiO2 molecule was estimated to be 8.0–9.0. From these results, we concluded that water penetration occurred by the formation of water-pool structures in the PDS layers, and the randomly formed nano-air holes lead to a reduction in the probability of water penetration into the deep regions of the PDS layers

Anomalous depth dependency of the stress field in the 2007 Noto Hanto, Japan, earthquake: Potential involvement of a deep fluid reservoir

We have elucidated depth variations in the stress field associated with the 2007 Noto Hanto, Japan, earthquake by stress tensor inversion using high-quality aftershock data obtained by a dense seismic network. Aftershocks that occurred above 4 km in depth indicated a strike-slip stress regime. By contrast, aftershocks in deeper parts indicated a thrust faulting stress regime. This depth variation in the stress regime correlates well with that in the slip direction derived from a finite source model using geodetic data. Furthermore, the maximum principal stress (σ1) axis was stably oriented approximately W20°N down to the depth of the mainshock hypocenter, largely in agreement with the regional stress field, but, below that depth, the σ1 axis had no definite orientation, indicating horizontally isotropic stress. One likely cause of these drastic changes in the stress regime with depth is the buoyant force of a fluid reservoir localized beneath the seismogenic zone

Erratum: ``A Measurement of the Cosmic Microwave Background B-Mode Polarization Power Spectrum at Sub-degree Scales with POLARBEAR'' (2014, ApJ, 794, 171)

International audienceNot Availabl

POLARBEAR constraints on cosmic birefringence and primordial magnetic fields

We constrain anisotropic cosmic birefringence using four-point correlations of even-parity E-mode and odd-parity B-mode polarization in the cosmic microwave background measurements made by the POLARization of the Background Radiation (POLARBEAR) experiment in its first season of observations. We find that the anisotropic cosmic birefringence signal from any parity-violating processes is consistent with zero. The Faraday rotation from anisotropic cosmic birefringence can be compared with the equivalent quantity generated by primordial magnetic fields if they existed. The POLARBEAR nondetection translates into a 95% confidence level (C.L.) upper limit of 93 nanogauss (nG) on the amplitude of an equivalent primordial magnetic field inclusive of systematic uncertainties. This four-point correlation constraint on Faraday rotation is about 15 times tighter than the upper limit of 1380 nG inferred from constraining the contribution of Faraday rotation to two-point correlations of B-modes measured by Planck in 2015. Metric perturbations sourced by primordial magnetic fields would also contribute to the B-mode power spectrum. Using the POLARBEAR measurements of the B-mode power spectrum (two-point correlation), we set a 95% C.L. upper limit of 3.9 nG on primordial magnetic fields assuming a flat prior on the field amplitude. This limit is comparable to what was found in the Planck 2015 two-point correlation analysis with both temperature and polarization. We perform a set of systematic error tests and find no evidence for contamination. This work marks the first time that anisotropic cosmic birefringence or primordial magnetic fields have been constrained from the ground at subdegree scales. \ua9 2015 American Physical Society

POLARBEAR-2: a new CMB polarization receiver system for the Simons array (Conference Presentation)

International audiencePOLARBEAR-2 is a new receiver system, which will be deployed on the Simons Array telescope platform, for the measurement of Cosmic Microwave Background (CMB) polarization. The science goals with POLARBEAR-2 are to characterize the B-mode signal both at degree and sub-degree angular-scales. The degree-scale polarization data can be used for quantitative studies on inflation, such as the reconstruction of the energy scale of inflation. The sub-degree polarization data is an excellent tracer of large-scale structure in the universe, and will lead to precise constraints on the sum of the neutrino masses. In order to achieve these goals, POLARBEAR-2 employs 7588 polarization-sensitive antenna-coupled transition-edge sensor (TES) bolometers on the focal plane cooled to 0.27K with a three-stage Helium sorption refrigerator, which is ~6 times larger array over the current receiver system. The large TES bolometer array is read-out by an upgraded digital frequency-domain multiplexing system capable of multiplexing 40 bolometers through a single superconducting quantum interference device (SQUID). The first POLARBEAR-2 receiver, POLARBEAR-2A is constructed and the end-to-end testing to evaluate the integrated performance of detector, readout, and optics system is being conducted in the laboratory with various types of test equipments. The POLARBEAR-2A is scheduled to be deployed in 2018 at the Atacama desert in Chile. To further increase measurement sensitivity, two more POLARBEAR-2 type receivers will be deployed soon after the deployment (Simons Array project). The Simons Array will cover four frequency bands at 95GHz, 150GHz, 220GH and 270GHz for better control of the foreground signal. The projected constraints on a tensor-to-scalar ratio (amplitude of inflationary B-mode signal) is σ(r=0.1) = $6.0 \times 10^{-3}$ after foreground removal ($4.0 \times 10^{-3}$ (stat.)), and the sensitivity to the sum of the neutrino masses when combined with DESI spectroscopic galaxy survey data is 40 meV at 1-sigma after foreground removal (19 meV(stat.)). We will present an overview of the design, assembly and status of the laboratory testing of the POLARBEAR-2A receiver system as well as the Simons Array project overview