1,484 research outputs found
Quantum finite-size effects for dyonic magnons in the AdS_4 x CP^3
We compute quantum corrections to finite-size effects for various dyonic
giant magnons in the AdS_4 x CP^3 in two different approaches. The off-shell
algebraic curve method is used to quantize the classical string configurations
in semi-classical way and to compute the corrections to the string energies.
These results are compared with the F-term L\"uscher formula based on the
S-matrix of the AdS_4 / CFT_3. The fact that the two results match exactly
provides another stringent test for the all-loop integrability conjecture and
the exact S-matrix based on it.Comment: 21 pages, No figures, corrected typos, added some reference
The Relativistic Avatars of Giant Magnons and their S-Matrix
The motion of strings on symmetric space target spaces underlies the
integrability of the AdS/CFT correspondence. Although these theories, whose
excitations are giant magnons, are non-relativistic they are classically
equivalent, via the Polhmeyer reduction, to a relativistic integrable field
theory known as a symmetric space sine-Gordon theory. These theories can be
formulated as integrable deformations of gauged WZW models. In this work we
consider the class of symmetric spaces CP^{n+1} and solve the corresponding
generalized sine-Gordon theories at the quantum level by finding the exact
spectrum of topological solitons, or kinks, and their S-matrix. The latter
involves a trignometric solution of the Yang-Baxer equation which exhibits a
quantum group symmetry with a tower of states that is bounded, unlike for
magnons, as a result of the quantum group deformation parameter q being a root
of unity. We test the S-matrix by taking the semi-classical limit and comparing
with the time delays for the scattering of classical solitons. We argue that
the internal CP^{n-1} moduli space of collective coordinates of the solitons in
the classical theory can be interpreted as a q-deformed fuzzy space in the
quantum theory. We analyse the n=1 case separately and provide a further test
of the S-matrix conjecture in this case by calculating the central charge of
the UV CFT using the thermodynamic Bethe Ansatz.Comment: 33 pages, important correction to S-matrix to ensure crossing
symmetr
Scattering of Giant Magnons in CP^3
We study classical scattering phase of CP^2 dyonic giant magnons in R_t x
CP^3. We construct two-soliton solutions explicitly by the dressing method.
Using these solutions, we compute the classical time delays for the scattering
of giant magnons, and compare them to boundstate S-matrix elements derived from
the conjectured AdS_4/CFT_3 S-matrix by Ahn and Nepomechie in the strong
coupling limit. Our result is consistent with the conjectured S-matrix. The
dyonic solutions play an essential role in revealing the polarization
dependence of scattering phase.Comment: 29 pages; v2: minor corrections; v3: minor corrections, references
added ; v4: minor corrections ; v5: minor corrections based on the published
versio
Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer:a nested case-control study
Vitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer
Giant magnons and non-maximal giant gravitons
We produce the open strings on that correspond to
the solutions of integrable boundary sine-Gordon theory by making use of the
-magnon solutions provided in \cite{KPV} together with explicit moduli.
Relating the two boundary parameters in a special way we describe the
scattering of giant magnons with non-maximal giant gravitons and
calculate the leading contribution to the associated magnon scattering phase.Comment: 34 pages, 8 figure
Near-field examination of perovskite-based superlenses and superlens-enhanced probe-object coupling
A planar slab of negative index material works as a superlens with
sub-diffraction-limited imaging resolution, since propagating waves are focused
and, moreover, evanescent waves are reconstructed in the image plane. Here, we
demonstrate a superlens for electric evanescent fields with low losses using
perovskites in the mid-infrared regime. The combination of near-field
microscopy with a tunable free-electron laser allows us to address precisely
the polariton modes, which are critical for super-resolution imaging. We
spectrally study the lateral and vertical distributions of evanescent waves
around the image plane of such a lens, and achieve imaging resolution of
wavelength/14 at the superlensing wavelength. Interestingly, at certain
distances between the probe and sample surface, we observe a maximum of these
evanescent fields. Comparisons with numerical simulations indicate that this
maximum originates from an enhanced coupling between probe and object, which
might be applicable for multifunctional circuits, infrared spectroscopy, and
thermal sensors.Comment: 20 pages, 6 figures, published as open access article in Nature
Communications (see http://www.nature.com/ncomms/
The Importance of LDL and Cholesterol Metabolism for Prostate Epithelial Cell Growth
Cholesterol-lowering treatment has been suggested to delay progression of prostate cancer by decreasing serum LDL. We studied in vitro the effect of extracellular LDL-cholesterol on the number of prostate epithelial cells and on the expression of key regulators of cholesterol metabolism. Two normal prostatic epithelial cell lines (P96E, P97E), two in vitro immortalized epithelial cell lines (PWR-1E, RWPE-1) and two cancer cell lines (LNCaP and VCaP) were grown in cholesterol-deficient conditions. Cells were treated with 1–50 µg/ml LDL-cholesterol and/or 100 nM simvastatin for seven days. Cell number relative to control was measured with crystal violet staining. Changes in mRNA and protein expression of key effectors in cholesterol metabolism (HMGCR, LDLR, SREBP2 and ABCA1) were measured with RT-PCR and immunoblotting, respectively. LDL increased the relative cell number of prostate cancer cell lines, but reduced the number of normal epithelial cells at high concentrations. Treatment with cholesterol-lowering simvastatin induced up to 90% reduction in relative cell number of normal cell lines but a 15–20% reduction in relative number of cancer cells, an effect accompanied by sharp upregulation of HMGCR and LDLR. These effects were prevented by LDL. Compared to the normal cells, prostate cancer cells showed high expression of cholesterol-producing HMGCR but failed to express the major cholesterol exporter ABCA1. LDL increased relative cell number of cancer cell lines, and these cells were less vulnerable than normal cells to cholesterol-lowering simvastatin treatment. Our study supports the importance of LDL for prostate cancer cells, and suggests that cholesterol metabolism in prostate cancer has been reprogrammed to increased production in order to support rapid cell growth
Suppression of Stochastic Domain Wall Pinning Through Control of Gilbert Damping
Finite temperature micromagnetic simulations were used to investigate the magnetisation structure, propagation dynamics and stochastic pinning of domain walls in rare earth-doped Ni80Fe20 nanowires. We first show how the increase of the Gilbert damping, caused by the inclusion rare-earth dopants such as holmium, acts to suppress Walker breakdown phenomena. This allows domain walls to maintain consistent magnetisation structures during propagation. We then employ finite temperature simulations to probe how this affects the stochastic pinning of domain walls at notch-shaped artificial defect sites. Our results indicate that the addition of even a few percent of holmium allows domain walls to pin with consistent and well-defined magnetisation configurations, thus suppressing dynamically-induced stochastic pinning/depinning phenomena. Together, these results demonstrate a powerful, materials science-based solution to the problems of stochastic domain wall pinning in soft ferromagnetic nanowires
Beta function of k deformed AdS5 × S 5 string theory
We calculate the one loop beta function for the would-be marginal coupling on
the world sheet of the k deformed sigma models associated to a quantum group
with q=exp(i pi/k). This includes the bosonic principal chiral models and
symmetric space sigma models but also the k deformed semi-symmetric space sigma
model describing strings in a deformation of AdS_5 x S^5. The world sheet sigma
model is a current-current deformation of the gauged WZW model for the
supergroup PSU(2,2|4) with level k. In the string theory context the beta
function is shown to vanish because of the vanishing of the Killing form of
PSU(2,2|4) which is another piece of evidence that the k deformed theories
define consistent string theories.Comment: 26 pages, some typos correcte
Quercetin Inhibits IL-1β-Induced Inflammation, Hyaluronan Production and Adipogenesis in Orbital Fibroblasts from Graves' Orbitopathy
Management of Graves' orbitopathy (GO) is challenging, as no reliable, specific, and safe medical therapeutic agents have yet been developed. We investigated the effect of quercetin in primary cultured orbital fibroblasts from GO, targeting pathways of inflammation, aberrant accumulation of extracellular matrix macromolecules, and adipose tissue expansion. Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1β-induced increases in ICAM-1, IL-6, and IL-8 mRNA. Increased hyaluronan production induced by IL-1β or tumor necrosis factor-α was suppressed by quercetin in a dose- and time-dependent manner. Treatment with noncytotoxic doses of quercetin inhibited accumulation of intracytoplasmic lipid droplets and resulted in a dose-dependent decrease in expression of peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein (C/EBP) α, and C/EBPβ proteins. In conclusion, inhibition of inflammation, hyaluronan production, and adipogenesis by the natural plant product quercetin in vitro provides the basis for further study of its potential use in the treatment of GO
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