The AdS(5)xS(5) Semi-Symmetric Space Sine-Gordon Theory

The generalized symmetric space sine-Gordon theories are a series of 1+1-integrable field theories that are classically equivalent to superstrings on symmetric space spacetimes F/G. They are formulated in terms of a semi-symmetric space as a gauged WZW model with fermions and a potential term to deform it away from the conformal fixed point. We consider in particular the case of PSU(2,2|4)/Sp(2,2)xSp(4) which corresponds to AdS(5)xS(5). We argue that the infinite tower of conserved charges of these theories includes an exotic N=(8,8) supersymmetry that is realized in a mildy non-local way at the Lagrangian level. The supersymmetry is associated to a double central extension of the superalgebra psu(2|2)+psu(2|2) and includes a non-trivial R symmetry algebra corresponding to global gauge transformations, as well as 2-dimensional spacetime translations. We then explicitly construct soliton solutions and show that they carry an internal moduli superspace CP(2|1)xCP(2|1) with both bosonic and Grassmann collective coordinates. We show how to semi-classical quantize the solitons by writing an effective quantum mechanical system on the moduli space which takes the form of a co-adjoint orbit of SU(2|2)xSU(2|2). The spectrum consists of a tower of massive states in the short, or atypical, symmetric representations, just as the giant magnon states of the string world sheet theory, although here the tower is truncated.Comment: 39 pages, references adde

The Relativistic Avatars of Giant Magnons and their S-Matrix

The motion of strings on symmetric space target spaces underlies the integrability of the AdS/CFT correspondence. Although these theories, whose excitations are giant magnons, are non-relativistic they are classically equivalent, via the Polhmeyer reduction, to a relativistic integrable field theory known as a symmetric space sine-Gordon theory. These theories can be formulated as integrable deformations of gauged WZW models. In this work we consider the class of symmetric spaces CP^{n+1} and solve the corresponding generalized sine-Gordon theories at the quantum level by finding the exact spectrum of topological solitons, or kinks, and their S-matrix. The latter involves a trignometric solution of the Yang-Baxer equation which exhibits a quantum group symmetry with a tower of states that is bounded, unlike for magnons, as a result of the quantum group deformation parameter q being a root of unity. We test the S-matrix by taking the semi-classical limit and comparing with the time delays for the scattering of classical solitons. We argue that the internal CP^{n-1} moduli space of collective coordinates of the solitons in the classical theory can be interpreted as a q-deformed fuzzy space in the quantum theory. We analyse the n=1 case separately and provide a further test of the S-matrix conjecture in this case by calculating the central charge of the UV CFT using the thermodynamic Bethe Ansatz.Comment: 33 pages, important correction to S-matrix to ensure crossing symmetr

Strong and Tunable Nonlinear Optomechanical Coupling in a Low-Loss System

A major goal in optomechanics is to observe and control quantum behavior in a system consisting of a mechanical resonator coupled to an optical cavity. Work towards this goal has focused on increasing the strength of the coupling between the mechanical and optical degrees of freedom; however, the form of this coupling is crucial in determining which phenomena can be observed in such a system. Here we demonstrate that avoided crossings in the spectrum of an optical cavity containing a flexible dielectric membrane allow us to realize several different forms of the optomechanical coupling. These include cavity detunings that are (to lowest order) linear, quadratic, or quartic in the membrane's displacement, and a cavity finesse that is linear in (or independent of) the membrane's displacement. All these couplings are realized in a single device with extremely low optical loss and can be tuned over a wide range in situ; in particular, we find that the quadratic coupling can be increased three orders of magnitude beyond previous devices. As a result of these advances, the device presented here should be capable of demonstrating the quantization of the membrane's mechanical energy.Comment: 12 pages, 4 figures, 1 tabl

Quantum finite-size effects for dyonic magnons in the AdS_4 x CP^3

We compute quantum corrections to finite-size effects for various dyonic giant magnons in the AdS_4 x CP^3 in two different approaches. The off-shell algebraic curve method is used to quantize the classical string configurations in semi-classical way and to compute the corrections to the string energies. These results are compared with the F-term L\"uscher formula based on the S-matrix of the AdS_4 / CFT_3. The fact that the two results match exactly provides another stringent test for the all-loop integrability conjecture and the exact S-matrix based on it.Comment: 21 pages, No figures, corrected typos, added some reference

The complete mitochondrial genome of the foodborne parasitic pathogen Cyclospora cayetanensis

Cyclospora cayetanensis is a human-specific coccidian parasite responsible for several food and water-related outbreaks around the world, including the most recent ones involving over 900 persons in 2013 and 2014 outbreaks in the USA. Multicopy organellar DNA such as mitochondrion genomes have been particularly informative for detection and genetic traceback analysis in other parasites. We sequenced the C. cayetanensis genomic DNA obtained from stool samples from patients infected with Cyclospora in Nepal using the Illumina MiSeq platform. By bioinformatically filtering out the metagenomic reads of non-coccidian origin sequences and concentrating the reads by targeted alignment, we were able to obtain contigs containing Eimeria-like mitochondrial, apicoplastic and some chromosomal genomic fragments. A mitochondrial genomic sequence was assembled and confirmed by cloning and sequencing targeted PCR products amplified from Cyclospora DNA using primers based on our draft assembly sequence. The results show that the C. cayetanensis mitochondrion genome is 6274 bp in length, with 33% GC content, and likely exists in concatemeric arrays as in Eimeria mitochondrial genomes. Phylogenetic analysis of the C. cayetanensis mitochondrial genome places this organism in a tight cluster with Eimeria species. The mitochondrial genome of C. cayetanensis contains three protein coding genes, cytochrome (cytb), cytochrome C oxidase subunit 1 (cox1), and cytochrome C oxidase subunit 3 (cox3), in addition to 14 large subunit (LSU) and nine small subunit (SSU) fragmented rRNA genes

Scattering of Giant Magnons in CP^3

We study classical scattering phase of CP^2 dyonic giant magnons in R_t x CP^3. We construct two-soliton solutions explicitly by the dressing method. Using these solutions, we compute the classical time delays for the scattering of giant magnons, and compare them to boundstate S-matrix elements derived from the conjectured AdS_4/CFT_3 S-matrix by Ahn and Nepomechie in the strong coupling limit. Our result is consistent with the conjectured S-matrix. The dyonic solutions play an essential role in revealing the polarization dependence of scattering phase.Comment: 29 pages; v2: minor corrections; v3: minor corrections, references added ; v4: minor corrections ; v5: minor corrections based on the published versio

The South Asian genome

Genetics of disease Microarrays Variant genotypes Population genetics Sequence alignment AllelesThe genetic sequence variation of people from the Indian subcontinent who comprise one-quarter of the world's population, is not well described. We carried out whole genome sequencing of 168 South Asians, along with whole-exome sequencing of 147 South Asians to provide deeper characterisation of coding regions. We identify 12,962,155 autosomal sequence variants, including 2,946,861 new SNPs and 312,738 novel indels. This catalogue of SNPs and indels amongst South Asians provides the first comprehensive map of genetic variation in this major human population, and reveals evidence for selective pressures on genes involved in skin biology, metabolism, infection and immunity. Our results will accelerate the search for the genetic variants underlying susceptibility to disorders such as type-2 diabetes and cardiovascular disease which are highly prevalent amongst South Asians.Whole genome sequencing to discover genetic variants underlying type-2 diabetes, coronary heart disease and related phenotypes amongst Indian Asians. Imperial College Healthcare NHS Trust cBRC 2011-13 (JS Kooner [PI], JC Chambers)

Self-Compensation in Transparent Conducting F-Doped SnO2

The factors limiting the conductivity of fluorine-doped tin dioxide (FTO) produced via atmospheric pressure chemical vapor deposition are investigated. Modeling of the transport properties indicates that the measured Hall effect mobilities are far below the theoretical ionized impurity scattering limit. Significant compensation of donors by acceptors is present with a compensation ratio of 0.5, indicating that for every two donors there is approximately one acceptor. Hybrid density functional theory calculations of defect and impurity formation energies indicate the most probable acceptor-type defects. The fluorine interstitial defect has the lowest formation energy in the degenerate regime of FTO. Fluorine interstitials act as singly charged acceptors at the high Fermi levels corresponding to degenerately n-type films. X-ray photoemission spectroscopy of the fluorine impurities is consistent with the presence of substitutional F O donors and interstitial F i in a roughly 2:1 ratio in agreement with the compensation ratio indicated by the transport modeling. Quantitative analysis through Hall effect, X-ray photoemission spectroscopy, and calibrated secondary ion mass spectrometry further supports the presence of compensating fluorine-related defects

Cardiorespiratory fitness is associated with hard and light intensity physical activity but not time spent sedentary in 10–14 year old schoolchildren: the HAPPY study

Sedentary behaviour is a major risk factor for developing chronic diseases and is associated with low cardiorespiratory fitness in adults. It remains unclear how sedentary behaviour and different physical activity subcomponents are related to cardiorespiratory fitness in children. The purpose of this study was to assess how sedentary behaviour and different physical activity subcomponents are associated with 10–14 year-old schoolchildren's cardiorespiratory fitness