19 research outputs found
Evidence of Non-Thermal Particles in Coronal Loops Heated Impulsively by Nanoflares
The physical processes causing energy exchange between the Sun's hot corona
and its cool lower atmosphere remain poorly understood. The chromosphere and
transition region (TR) form an interface region between the surface and the
corona that is highly sensitive to the coronal heating mechanism. High
resolution observations with the Interface Region Imaging Spectrograph (IRIS)
reveal rapid variability (about 20 to 60 seconds) of intensity and velocity on
small spatial scales at the footpoints of hot dynamic coronal loops. The
observations are consistent with numerical simulations of heating by beams of
non-thermal electrons, which are generated in small impulsive heating events
called "coronal nanoflares". The accelerated electrons deposit a sizable
fraction of their energy in the chromosphere and TR. Our analysis provides
tight constraints on the properties of such electron beams and new diagnostics
for their presence in the nonflaring corona.Comment: Published in Science on October 17:
http://www.sciencemag.org/content/346/6207/1255724 . 26 pages, 10 figures.
Movies are available at: http://www.lmsal.com/~ptesta/iris_science_mov
Inverting the model of genomics data sharing with the NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space
The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL; https://anvilproject.org) was developed to address a widespread community need for a unified computing environment for genomics data storage, management, and analysis. In this perspective, we present AnVIL, describe its ecosystem and interoperability with other platforms, and highlight how this platform and associated initiatives contribute to improved genomic data sharing efforts. The AnVIL is a federated cloud platform designed to manage and store genomics and related data, enable population-scale analysis, and facilitate collaboration through the sharing of data, code, and analysis results. By inverting the traditional model of data sharing, the AnVIL eliminates the need for data movement while also adding security measures for active threat detection and monitoring and provides scalable, shared computing resources for any researcher. We describe the core data management and analysis components of the AnVIL, which currently consists of Terra, Gen3, Galaxy, RStudio/Bioconductor, Dockstore, and Jupyter, and describe several flagship genomics datasets available within the AnVIL. We continue to extend and innovate the AnVIL ecosystem by implementing new capabilities, including mechanisms for interoperability and responsible data sharing, while streamlining access management. The AnVIL opens many new opportunities for analysis, collaboration, and data sharing that are needed to drive research and to make discoveries through the joint analysis of hundreds of thousands to millions of genomes along with associated clinical and molecular data types
Continuation of Long-Term Care for Cervical Dystonia at an Academic Movement Disorders Clinic
The Devil Is in the Details: Using Historical Methodology to Investigate Fair andd Equitable Treatmentt Clauses in Post-War United Statess Commercial Treaties.
PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease.
Charcot-Marie-Tooth disease (CMT) comprises a clinically and genetically heterogeneous group of peripheral neuropathies characterized by progressive distal muscle weakness and atrophy, foot deformities and distal sensory loss. Following the analysis of two consanguineous families affected by a medium to late-onset recessive form of intermediate CMT, we identified overlapping regions of homozygosity on chromosome 1p36 with a combined maximum LOD score of 5.4. Molecular investigation of the genes from this region allowed identification of two homozygous mutations in PLEKHG5 that produce premature stop codons and are predicted to result in functional null alleles. Analysis of Plekhg5 in the mouse revealed that this gene is expressed in neurons and glial cells of the peripheral nervous system, and that knockout mice display reduced nerve conduction velocities that are comparable with those of affected individuals from both families. Interestingly, a homozygous PLEKHG5 missense mutation was previously reported in a recessive form of severe childhood onset lower motor neuron disease (LMND) leading to loss of the ability to walk and need for respiratory assistance. Together, these observations indicate that different mutations in PLEKHG5 lead to clinically diverse outcomes (intermediate CMT or LMND) affecting the function of neurons and glial cells