An isolated proximal tibiofibular joint dislocation in a young male playing soccer: a case report

Isolated dislocation of the proximal tibiofibular joint is a rare injury. We present a 23-year-old caucasian man who sustained a traumatic anterolateral dislocation of the proximal tibiofibular joint. There is no consenus on definitive management, and we review the different published treatment and rehabilitation regimens for this injury. Our patient was successfully treated by open reduction and temporary Kirschner-wire fixation. The authors recommend their structured rehabilitation process involved using cast brace immobilization as allows for excellent soft tissue healing

A Feasibility Study of Methodological Issues and Short-Term Outcomes in Seriously Injured Older Adults

Background: For any given traumatic injury, older adults experience a longer hospitalization, more complications, and higher mortality than do younger patients. Objectives: To prospectively identify problems in designing follow-up studies in seriously injured older adults without head injury and to examine outcomes after serious trauma in older adults who were sent to a level I trauma center. Methods: A short-term descriptive follow-up design was used in which each patient served as his or her baseline. Eligible patients had injuries that required admission to an intensive care unit, a hospital length of stay longer than 72 hours, or surgery. Patients with isolated hip fractures, central nervous system injuries, and burn injuries were excluded. Data were collected by using standardized instruments during the acute hospital stay and 3 months after discharge from the hospital. Results: During a representative 2-month period, 21% of a potential 77 subjects died in the hospital, 44% had cognitive impairment that precluded participation, and 17% declined to participate. Twenty older adults (mean age 73.5 years) who were injured in motor vehicle crashes (45%), falls (35%), or pedestrian accidents (15%) or who had gunshot wounds (5%) were enrolled. Ten percent died after discharge. Levels of physical disability at 3 months after discharge were higher than those before the injury (score on Sickness Impact Profile physical subscale 24.5 vs 10.9, P = .02), and psychological distress (Impact of Event Scale score 20.9) remained elevated. Conclusion: Mortality, disability, and posttraumatic psychological distress after discharge are problems in seriously injured older adults

Ooligan Grease: A Nutritious Fat Used by Native People of Coastal British

ABSTRACT.-Marine fat, derived from several sources, was formerly used to great extent by Northwest Coast Indians as a flavor enhancer of many foods as well as for medicinal and ceremonial purposes. The most prominent source of food fat used by British Columbia native people has been from the ooligan (Thaleichthys pacificus Richardson, Osmeridae) a small fish which is harvested in bulk in early spring, allowed to ripen in large bins, and then rendered to give a pungent, golden, thick oil called "ooUgan grease". Samples from five preparations of this fat were made in 1981 from the Nuxalk Community of Bella Coola, B.C. and several nutrient analyses were done. Fatty acids, expressed as mean and range of percent methyl esters were: saturated at 32.2 (30-33), monounsaturated at 64.5 (63-66), and polyunsaturated at 0.9 (0.8-

A review of iron carbonate (FeCO₃) formation in the oil and gas industry

This paper reviews the information in the literature relating to FeCO₃ formation in the context of oil and gas production. Numerous factors which influence the kinetics, physical properties and protective nature of FeCO₃ are considered in addition to a review of semi-empirical models developed to predict precipitation/corrosion layer accumulation rate. The limitations of current models are discussed and the challenges of conducting deposition studies onto steel surfaces in a controlled environment using laboratory based techniques are also reviewed. Finally, more recently employed experimental techniques are considered in their potential to provide a further understanding of FeCO₃ and mixed carbonate kinetics

Fretting–corrosion at the modular tapers interface: Inspection of standard ASTM F1875-98

Interest in the degradation mechanisms at the modular tapers interfaces has been renewed due to increased reported cases of adverse reactions to metal debris and the appearance of wear and corrosion at the modular tapers interfaces at revision. Over the past two decades, a lot of research has been expended to understand the degradation mechanisms, with two primary implant loading procedures and orientations used consistently across the literature. ASTM F1875-98 is often used as a guide to understand and benchmark the tribocorrosion processes occurring within the modular tapers interface. This article presents a comparison of the two methods outlined in ASTM F1875-98 as well as a critique of the standard considering the current paradigm in pre-clinical assessment of modular tapers

Advancing and building infodemic management training for public health : introducing the Society for Infodemic Management (SIM)

The reverberations of the pandemic, magnified by the accompanied infodemic, was and remains multifaceted for both the public, and public health staff. We have learned from this crisis, the fragility and the vulnerability the public are to misinformation, affecting health outcomes, and confidence and trust with public health programs. In addition, all health care staff struggle(d) with extreme stress, fatigue, and burnout.peer-reviewe

Granular cell ameloblastoma: Case report of a particular ameloblastoma histologically resembling oncocytoma

Granular cell ameloblastoma is classified as a histological subtype of solid/multicystic ameloblastoma. Usual granular cell ameloblastoma is histologically characterized by granular changes of stellate-like cells located in the inner portion of the epithelial follicles. Here we report a case of another type of granular cell ameloblastoma, showing predominant anastomosing double-stranded trabeculae of granular cells. This type of granular cell ameloblastoma is extremely rare, and the World Health Organization classification does not contain the entity. We tentatively termed it \u27anastomosing granular cell ameloblastoma\u27 in this report. The present case suggests the importance of differential diagnosis because the histology of \u27anastomosing granular cell ameloblastoma\u27 resembles that of salivary gland oncocytoma rather than that of usual granular cell ameloblastoma. The trabeculae observed in our case continued to the peripheral cells of a small amount of epithelial sheets of plexiform ameloblastoma, and the tumor cells were positive for CK19, which is regarded as an immunohistochemical marker of odontogenic epithelium. Similar to usual granular cell ameloblastoma, the tumor cells had CD68-positive granules. For precise diagnosis of this condition, immunohistochemistry using CK19 and CD68, as well as detailed histological observation, are recommended

The MITRE trial protocol: a study to evaluate the microbiome as a biomarker of efficacy and toxicity in cancer patients receiving immune checkpoint inhibitor therapy.

BACKGROUND: The gut microbiome is implicated as a marker of response to  immune checkpoint inhibitors (ICI) based on preclinical mouse models and preliminary observations in limited patient series. Furthermore, early studies suggest faecal microbial transfer may have therapeutic potential, converting ICI non-responders into responders. So far, identification of specific responsible bacterial taxa has been inconsistent, which limits future application. The MITRE study will explore and validate a microbiome signature in a larger scale prospective study across several different cancer types. METHODS: Melanoma, renal cancer and non-small cell lung cancer patients who are planned to receive standard immune checkpoint inhibitors are being recruited to the MITRE study. Longitudinal stool samples are collected prior to treatment, then at 6 weeks, 3, 6 and 12 months during treatment, or at disease progression/recurrence (whichever is sooner), as well as after a severe (≥grade 3 CTCAE v5.0) immune-related adverse event. Additionally, whole blood, plasma, buffy coat, RNA and peripheral blood mononuclear cells (PBMCs) is collected at similar time points and will be used for exploratory analyses. Archival tumour tissue, tumour biopsies at progression/relapse, as well as any biopsies from body organs collected after a severe toxicity are collected. The primary outcome measure is the ability of the microbiome signature to predict 1 year progression-free survival (PFS) in patients with advanced disease. Secondary outcomes include microbiome correlations with toxicity and other efficacy end-points. Biosamples will be used to explore immunological and genomic correlates. A sub-study will evaluate both COVID-19 antigen and antibody associations with the microbiome. DISCUSSION: There is an urgent need to identify biomarkers that are predictive of treatment response, resistance and toxicity to immunotherapy. The data generated from this study will both help inform patient selection for these drugs and provide information that may allow therapeutic manipulation of the microbiome to improve future patient outcomes. TRIAL REGISTRATION: NCT04107168 , ClinicalTrials.gov, registered 09/27/2019. Protocol V3.2 (16/04/2021)