726 research outputs found
Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy
It is generally believed that increase in adult contractile cardiac mass can be accomplished only by hypertrophy of existing myocytes. Documentation of myocardial regeneration in acute stress has challenged this dogma and led to the proposition that myocyte renewal is fundamental to cardiac homeostasis. Here we report that in human aortic stenosis, increased cardiac mass results from a combination of myocyte hypertrophy and hyperplasia. Intense new myocyte formation results from the differentiation of stem-like cells committed to the myocyte lineage. These cells express stem cell markers and telomerase. Their number increased >13-fold in aortic stenosis. The finding of cell clusters with stem cells making the transition to cardiogenic and myocyte precursors, as well as very primitive myocytes that turn into terminally differentiated myocytes, provides a link between cardiac stem cells and myocyte differentiation. Growth and differentiation of these primitive cells was markedly enhanced in hypertrophy, consistent with activation of a restricted number of stem cells that, through symmetrical cell division, generate asynchronously differentiating progeny. These clusters strongly support the existence of cardiac stem cells that amplify and commit to the myocyte lineage in response to increased workload. Their presence is consistent with the notion that myocyte hyperplasia significantly contributes to cardiac hypertrophy and accounts for the subpopulation of cycling myocytes
Imaging high-dimensional spatial entanglement with a camera
The light produced by parametric down-conversion shows strong spatial
entanglement that leads to violations of EPR criteria for separability.
Historically, such studies have been performed by scanning a single-element,
single-photon detector across a detection plane. Here we show that modern
electron-multiplying charge-coupled device cameras can measure correlations in
both position and momentum across a multi-pixel field of view. This capability
allows us to observe entanglement of around 2,500 spatial states and
demonstrate Einstein-Podolsky-Rosen type correlations by more than two orders
of magnitude. More generally, our work shows that cameras can lead to important
new capabilities in quantum optics and quantum information science.Comment: 5 pages, 4 figure
Pixel-z: Studying Substructure and Stellar Populations in Galaxies out to z~3 using Pixel Colors I. Systematics
We perform a pixel-by-pixel analysis of 467 galaxies in the GOODS-VIMOS
survey to study systematic effects in extracting properties of stellar
populations (age, dust, metallicity and SFR) from pixel colors using the
pixel-z method. The systematics studied include the effect of the input stellar
population synthesis model, passband limitations and differences between
individual SED fits to pixels and global SED-fitting to a galaxy's colors. We
find that with optical-only colors, the systematic errors due to differences
among the models are well constrained. The largest impact on the age and SFR
e-folding time estimates in the pixels arises from differences between the
Maraston models and the Bruzual&Charlot models, when optical colors are used.
This results in systematic differences larger than the 2{\sigma} uncertainties
in over 10 percent of all pixels in the galaxy sample. The effect of
restricting the available passbands is more severe. In 26 percent of pixels in
the full sample, passband limitations result in systematic biases in the age
estimates which are larger than the 2{\sigma} uncertainties. Systematic effects
from model differences are reexamined using Near-IR colors for a subsample of
46 galaxies in the GOODS-NICMOS survey. For z > 1, the observed optical/NIR
colors span the rest frame UV-optical SED, and the use of different models does
not significantly bias the estimates of the stellar population parameters
compared to using optical-only colors. We then illustrate how pixel-z can be
applied robustly to make detailed studies of substructure in high redshift
galaxies such as (a) radial gradients of age, SFR, sSFR and dust and (b) the
distribution of these properties within subcomponents such as spiral arms and
clumps. Finally, we show preliminary results from the CANDELS survey
illustrating how the new HST/WFC3 data can be exploited to probe substructure
in z~1-3 galaxies.Comment: 37 pages, 21 figures, submitted to Ap
Domain size effects on the dynamics of a charge density wave in 1T-TaS2
Recent experiments have shown that the high temperature incommensurate (I)
charge density wave (CDW) phase of 1T-TaS2 can be photoinduced from the lower
temperature, nearly commensurate (NC) CDW state. Here we report a time-resolved
x-ray diffraction study of the growth process of the photoinduced I-CDW
domains. The layered nature of the material results in a marked anisotropy in
the size of the photoinduced domains of the I-phase. These are found to grow
self-similarly, their shape remaining unchanged throughout the growth process.
The photoinduced dynamics of the newly formed I-CDW phase was probed at various
stages of the growth process using a double pump scheme, where a first pump
creates I-CDW domains and a second pump excites the newly formed I-CDW state.
We observe larger magnitudes of the coherently excited I-CDW amplitude mode in
smaller domains, which suggests that the incommensurate lattice distortion is
less stable for smaller domain sizes.Comment: 8 pages, 8 figure
Amino acid concentrations in fluids from the bovine oviduct and uterus and in KSOM-based culture media.
Amino acids in bovine oviductal and uterine fluids were measured and compared with those in modified simplex optimized medium (KSOM) supplemented with either fetal calf serum or Minimum Essential Medium amino acids in addition to bovine serum albumin, fetal calf serum or polyvinyl alcohol. Concentrations of cysteine, threonine, tryptophan, alanine, aspartate, glycine, glutamate, proline, beta-alanine, and citrulline were higher in oviductal fluids than in KSOM-based culture media. Nonessential and essential amino acids were present in ratios of 5:1 and 2:1 in oviductal and uterine fluids, respectively. Concentrations of alanine (3.7 mM), glycine (14.1 mM) and glutamate (5.5 mM) were high in oviductal fluids, comprising 73% of the free amino acid pool. Of the amino acids measured in uterine fluids, alanine (3.1 mM), glycine (12.0 mM), glutamate (4.2 mM), and serine (2.7 mM) were highest in concentration, and the first three comprised 43% of the free amino acid pool. In conclusion, amino acid concentrations in the bovine reproductive tract were substantially higher than those in embryo culture media. Certain amino acids, particularly alanine, glutamate, glycine and taurine, are present in strikingly high concentrations in both oviductal and uterine fluids, suggesting that they might play important roles in early embryo development. The particular pattern of amino acid concentrations may be an important factor to be considered for the improvement of embryo culture media
MASSIV: Mass Assembly Survey with SINFONI in VVDS. VI. Metallicity-related fundamental relations in star-forming galaxies at
The MASSIV (Mass Assembly Survey with SINFONI in VVDS) project aims at
finding constraints on the different processes involved in galaxy evolution.
This study proposes to improve the understanding of the galaxy mass assembly
through chemical evolution using the metallicity as a tracer of the star
formation and interaction history. Methods. We analyse the full sample of
MASSIV galaxies for which a metallicity estimate has been possible, that is 48
star-forming galaxies at , and compute the integrated values of
some fundamental parameters, such as the stellar mass, the metallicity and the
star formation rate (SFR). The sample of star-forming galaxies at similar
redshift from zCOSMOS (P\'erez-Montero et al. 2013) is also combined with the
MASSIV sample. We study the cosmic evolution of the mass-metallicty relation
(MZR) together with the effect of close environment and galaxy kinematics on
this relation. We then focus on the so-called fundamental metallicity relation
(FMR) proposed by Mannucci et al. (2010) and other relations between stellar
mass, SFR and metallicity as studied by Lara-L\'opez et al. (2010). We
investigate if these relations are really fundamental, i.e. if they do not
evolve with redshift. Results. The MASSIV galaxies follow the expected
mass-metallicity relation for their median redshift. We find however a
significant difference between isolated and interacting galaxies as found for
local galaxies: interacting galaxies tend to have a lower metallicity. The
study of the relation between stellar mass, SFR and metallicity gives such
large scattering for our sample, even combined with zCOSMOS, that it is
diffcult to confirm or deny the existence of a fundamental relation
The extended epoch of galaxy formation: age dating of ~3600 galaxies with 2<z<6.5 in the VIMOS Ultra-Deep Survey
We aim at improving constraints on the epoch of galaxy formation by measuring
the ages of 3597 galaxies with spectroscopic redshifts 2<z<6.5 in the VIMOS
Ultra Deep Survey (VUDS). We derive ages and other physical parameters from the
simultaneous fitting with the GOSSIP+ software of observed UV rest-frame
spectra and photometric data from the u-band up to 4.5 microns using composite
stellar population models. We conclude from extensive simulations that at z>2
the joint analysis of spectroscopy and photometry combined with restricted age
possibilities when taking into account the age of the Universe substantially
reduces systematic uncertainties and degeneracies in the age derivation. We
find galaxy ages ranging from very young with a few tens of million years to
substantially evolved with ages up to ~1.5-2 Gyr. The formation redshifts z_f
derived from the measured ages indicate that galaxies may have started forming
stars as early as z_f~15. We produce the formation redshift function (FzF), the
number of galaxies per unit volume formed at a redshift z_f, and compare the
FzF in increasing redshift bins finding a remarkably constant 'universal' FzF.
The FzF is parametrized with (1+z)^\zeta, with \zeta~0.58+/-0.06, indicating a
smooth 2 dex increase from z~15 to z~2. Remarkably this observed increase is of
the same order as the observed rise in the star formation rate density (SFRD).
The ratio of the SFRD with the FzF gives an average SFR per galaxy of
~7-17Msun/yr at z~4-6, in agreement with the measured SFR for galaxies at these
redshifts. From the smooth rise in the FzF we infer that the period of galaxy
formation extends from the highest possible redshifts that we can probe at z~15
down to redshifts z~2. This indicates that galaxy formation is a continuous
process over cosmic time, with a higher number of galaxies forming at the peak
in SFRD at z~2 than at earlier epochs. (Abridged)Comment: Submitted to A&A, 24 page
The XMM-Newton Wide-Field Survey in the COSMOS Field: Statistical Properties of Clusters of Galaxies
We present the results of a search for galaxy clusters in the first 36 XMM-Newton pointings on the Cosmic Evolution Survey (COSMOS) field. We reach a depth for a total cluster flux in the 0.5-2 keV band of 3 à 10^(-15) ergs cm^(-2) s^(-1), having one of the widest XMM-Newton contiguous raster surveys, covering an area of 2.1 deg^2. Cluster candidates are identified through a wavelet detection of extended X-ray emission. Verification of the cluster candidates is done based on a galaxy concentration analysis in redshift slices of thickness 0.1-0.2 in redshift, using the multiband photometric catalog of the COSMOS field and restricting the search to z S)-log S distribution compares well with previous results, although yielding a somewhat higher number of clusters at similar fluxes. The X-ray luminosity function of COSMOS clusters matches well the results of nearby surveys, providing a comparably tight constraint on the faint-end slope of α = 1.93 ± 0.04. For the probed luminosity range of (8 à 10^(42))-(2 à 10^(44)) ergs s^(-1), our survey is in agreement with and adds significantly to the existing data on the cluster luminosity function at high redshifts and implies no substantial evolution at these luminosities to z = 1.3
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