Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Effective porosity and pore-throat sizes of mudrock saprolite from the Nolichucky Shale within Bear Creek Valley on the Oak Ridge Reservation: Implications for contaminant transport and retardation through matrix diffusion

Specimens of saprolite developed from mudrock of the Nolichucky Shale (Upper Cambrian, Conasauga Group) from the Whiteoak Mountain thrust sheet on the Oak Ridge Reservation (ORR) were analyzed. Petrophysical techniques include helium porosimetry and mercury porosimetry. Petrophysical data obtained from the laboratory experiments include effective porosity, pore-throat sizes and their distribution, specimen bulk-density, and specimen grain-density. It is expected that the data from this study will significantly contribute to constraining the modeling of the hydrologic behavior of saprolite developed from mudrock of the Conasauga Group in general and from the Nolichucky Shale specifically

Effective porosity and pore-throat sizes of Conasauga Group mudrock: Application, test and evaluation of petrophysical techniques

Effective porosity (specifically referring to the interconnected pore space) was recently recognized as being essential in determining the effectiveness and extent of matrix diffusion as a transport mechanism within fractured low-permeability rock formations. The research presented in this report was performed to test the applicability of several petrophysical techniques for the determination of effective porosity of fine-grained siliciclastic rocks. In addition, the aim was to gather quantitative data on the effective porosity of Conasauga Group mudrock from the Oak Ridge Reservation (ORR). The quantitative data reported here include not only effective porosities based on diverse measurement techniques, but also data on the sizes of pore throats and their distribution, and specimen bulk and grain densities. The petrophysical techniques employed include the immersion-saturation method, mercury and helium porosimetry, and the radial diffusion-cell method

Electromagnetic image of the Trans-Hudson orogen — THO94 transect

Author Posting. © National Research Council Canada, 2005. This article is posted here by permission of National Research Council Canada for personal use, not for redistribution. The definitive version was published in Canadian Journal of Earth Sciences 42 (2005): 479-493, doi:10.1139/E05-016.The North American Central Plains (NACP) anomaly in enhanced electric conductivity and its relationship with the Paleoproterozoic Trans-Hudson orogen (THO) has been studied under the auspices of Lithoprobe for over a decade. The NACP anomaly was the first geophysical evidence of the existence of the THO beneath the Phanerozoic sediments of the Central Plains. This anomaly, detected geomagnetically in the late 1960s, has been the subject of a number magnetotelluric studies from the early 1980s. The PanCanadian and Geological Survey of Canada experiments in the 1980s and the Lithoprobe experiments in the 1990s together comprise four east–west and one north–south regional-scale profiles in Saskatchewan perpendicular to the strike of the orogen. In this paper, data from the northernmost line, coincident with seismic line S2B, are analysed and interpreted, and are shown to be key in determining the northern extension of the NACP anomaly. Dimensionality analysis confirms the rotation of deep crustal structures eastward to Hudson Bay, as earlier proposed on the basis of broad-scale geomagnetic studies. On this profile, as with the profile at the edge of the Paleozoic sediments, the NACP anomaly is imaged as lying within the La Ronge domain, in contact with the Rottenstone domain, and structurally above the Guncoat thrust, a late compressional feature. The location of the anomaly together with the surface geology suggests that the anomaly is caused either by sulphide mineralization concentrated in the hinges of folds, by graphite, or by a combination of both. Our interpretation of the data is consistent with that from other profiles, and suggests that the NACP anomaly was formed as a consequence of subduction and collisional processes involving northward subduction of the internides of the THO beneath the Hearne craton. On the southern part of this profile, a resistive structure is identified as the Sask craton, suggesting that Proterozoic rocks are above Archean rocks in the THO.XG was supported by a fellowship of the Spanish Ministry of Science: PB92-0808