388 research outputs found
The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens
Repeated exposure to cocaine increases the density of dendritic spines on medium spiny neurons in the nucleus accumbens (Acb) and pyramidal cells in the medial prefrontal cortex (mPFC). To determine if this is associated with the development of psychomotor sensitization, rats were given daily i.p. injections of 15âmg/kg of cocaine (or saline) for 8âdays, either in their home cage (which failed to induce significant psychomotor sensitization) or in a distinct and relatively novel test cage (which induced robust psychomotor sensitization). Their brains were obtained 2âweeks after the last injection and processed for GolgiâCox staining. In the Acb core (AcbC) cocaine treatment increased spine density only in the group that developed psychomotor sensitization (i.e. in the Novel but not Home group), and there was a significant positive correlation between the degree of psychomotor sensitization and spine density. In the Acb shell (AcbS) cocaine increased spine density to the same extent in both groups; i.e. independent of psychomotor sensitization. In the mPFC cocaine increased spine density in both groups, but to a significantly greater extent in the Novel group. Furthermore, when rats were treated at Home with a higher dose of cocaine (30âmg/kg), cocaine now induced psychomotor sensitization in this context, and also increased spine density in the AcbC. Thus, the context in which cocaine is experienced influences its ability to reorganize patterns of synaptic connectivity in the Acb and mPFC, and the induction of psychomotor sensitization is associated with structural plasticity in the AcbC and mPFC, but not the AcbS.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73532/1/j.1460-9568.2004.03612.x.pd
Factorization Breaking in Dijet Photoproduction with a Leading Neutron
The production of dijets with a leading neutron in ep-interactions at HERA is
calculated in leading order and next-to-leading order of perturbative QCD using
a pion-exchange model. Differential cross sections for deep-inelastic
scattering (DIS) and photoproduction are presented as a function of several
kinematic variables. By comparing the theoretical predictions for DIS dijets to
recent H1 data, the pion flux factor together with the parton distribution
functions of the pion is determined. The dijet cross sections in
photoproduction show factorization breaking if compared to the H1
photoproduction data. The suppression factor is S = 0.48 (0.64) for resolved
(global) suppression.Comment: 16 pages, 5 figure
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Information (and library) science at City University London; 50 years of educational development
The development of education for information and library science at City University London over a 50-year period is described in this article. The development of the Masters course in Information Science, and the later equivalent courses in Library Science and in Information Management in the Cultural Sector are described in detail, together with shorter-lived Masters courses in pharmaceutical and health information. The rationale for changes to the courses, and the influence of the professional and educational contexts, are analysed. Issues emerging from this analysis are discussed in seven themes: the nature of the discipline; the library/information spectrum; the student group; the academic/professional balance; curriculum design; local and global issues; and teaching methods. The discussions of the courses are set in the wider context of changes in library/information education over the period in the UK and worldwide
Multimodal super-resolution optical microscopy using a transition metal-based probe provides unprecedented capabilities for imaging both nucle-ar chromatin and mitochondria
Detailed studies on the live cell uptake properties of a dinuclear membrane permeable permeable RuII cell probe show that, at low concentrations, the complex localizes and images mitochondria. At concentrations above ~20 ÎŒM the complex images nuclear DNA. Since the complex is extremely photostable, has a large Stokes shift, and displays intrinsic subcellular targeting, its compatibility with super-resolution techniques was investigated. It was found to be very well suited to image mitochondria and nuclear chromatin in two col-our, 2C-SIM; and STED and 3D-STED both in fixed and live cell. In particular, due to its vastly improved photostability compared to conventional SR probes, it can provide images of nuclear DNA at unprecedented resolution
Atmospheric Heating and Wind Acceleration: Results for Cool Evolved Stars based on Proposed Processes
A chromosphere is a universal attribute of stars of spectral type later than
~F5. Evolved (K and M) giants and supergiants (including the zeta Aurigae
binaries) show extended and highly turbulent chromospheres, which develop into
slow massive winds. The associated continuous mass loss has a significant
impact on stellar evolution, and thence on the chemical evolution of galaxies.
Yet despite the fundamental importance of those winds in astrophysics, the
question of their origin(s) remains unsolved. What sources heat a chromosphere?
What is the role of the chromosphere in the formation of stellar winds? This
chapter provides a review of the observational requirements and theoretical
approaches for modeling chromospheric heating and the acceleration of winds in
single cool, evolved stars and in eclipsing binary stars, including physical
models that have recently been proposed. It describes the successes that have
been achieved so far by invoking acoustic and MHD waves to provide a physical
description of plasma heating and wind acceleration, and discusses the
challenges that still remain.Comment: 46 pages, 9 figures, 1 table; modified and unedited manuscript;
accepted version to appear in: Giants of Eclipse, eds. E. Griffin and T. Ake
(Berlin: Springer
Limits to the sensitivity of a low noise compact atomic gravimeter
A detailed analysis of the most relevant sources of phase noise in an atomic
interferometer is carried out, both theoretically and experimentally. Even a
short interrogation time of 100 ms allows our cold atom gravimeter to reach an
excellent short term sensitivity to acceleration of g at 1s.
This result relies on the combination of a low phase noise laser system,
efficient detection scheme and good shielding from vibrations. In particular,
we describe a simple and robust technique of vibration compensation, which is
based on correcting the interferometer signal by using the AC acceleration
signal measured by a low noise seismometer.Comment: 30 pages, 14 figure
Reproductive biology of Synallaxis albescens (Aves: Furnariidae) in the cerrado of central Brazil
Energy balance measurements over a banana orchard in the Semiarid region in the Northeast of Brazil
Narrative inquiry into (re)imagining alternative schools: a case study of Kevin Gonzales.
Although there are many alternative schools that strive for the successful education for their students, negative images of alternative schools persist. While some alternative schools are viewed as âidealistic havens,â many are viewed as âdumping grounds,â or âjuvenile detention centers.â Employing narrative inquiry, this article interrogates how a student, Kevin Gonzales, experiences his alternative education and raises questions about the role of alternative schools. Kevin Gonzalesâs story is presented in a literary form of biographical journal to provide a âmetaphoric loftâ that helps us imagine other students like Kevin. This, in turn, provokes us to examine our current educational practice, and to (re)imagine ways in which alternative education can provide the best possible educational experiences for disenfranchised students who are increasingly underserved by the public education system
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