Towards manufacture of ultralow loss hollow core photonic bandgap fiber

Hollow core photonic bandgap fibers (HC-PBGFs) are a class of optical fibers which guide light in a low index core region surrounded by a triangular lattice of air holes separated by a delicate silica web. The precise nature of this cladding structure requires extremely fine control of the fabrication parameters. While HC-PBGFs have found wide range of exciting research applications the initially anticipated potential for ultralow loss below that of single mode fiber (SMF) has yet to be realized. To date loss figures as low as 1.7 dB/km have been reported, however surface roughness at the core cladding interface limited further loss reduction. The loss of HC-PBGFs can potentially be decreased further by increasing the core dimensions and through optimisation of the fabrication process. To date, the manufacture of HC-PBGFs is reliant upon the two stage stack and draw process. To target ultralow loss below what has been reported to date it has become necessary to ensure repeatability and uniformity in the labor intensive stack and draw process. Repeatability is ensured through rigorous cleanliness throughout preform preparation and by precise fabrication control at each stage of manufacture. Figure 1. a) Scanning electron micrograph of a 19 cell core defect HC-PBGF, b) Attenuation scaling of the photonic bandgap (PBG) versus central guidance wavelength of 19 cell core defect HC-PBGF.Greater than 1 km lengths of HC-PBGF (Fig. 1a) can now be drawn with typical attenuations of the order of 2-3 dB/km and with significantly improved optical bandwidth (~ 100 nm) compared with previously reported. These developments open up HC-PBGF for a range of applications such as telecommunications, laser power delivery, gas sensing and strong light matter interactions, for which they have a clear advantage over conventional fibers. The attenuation scaling of the photonic bandgap (PBG) (solid curves) with central operating wavelength has been investigated in 19 cell core defect fibres (Fig. 1b). The expected attenuation proportional to lambda[-3] relationship (dashed red curve) is observed until the infrared absorption edge of silica (black dot dash curve) is breached and the attenuation increases (green curve). Through strategic fabrication improvements we have achieved repeatable low loss manufacture of HC-PBGFs. Future developments in fabrication control and fiber design will allow the realization of ultralow loss HC-PBGF

P,T-Violating Nuclear Matrix Elements in the One-Meson Exchange Approximation

Expressions for the P,T-violating NN potentials are derived for $\pi$, $\rho$ and $\omega$ exchange. The nuclear matrix elements for $\rho$ and $\omega$ exchange are shown to be greatly suppressed, so that, under the assumption of comparable coupling constants, $\pi$ exchange would dominate by two orders of magnitude. The ratio of P,T-violating to P-violating matrix elements is found to remain approximately constant across the nuclear mass table, thus establishing the proportionality between time-reversal-violation and parity-violation matrix elements. The calculated values of this ratio suggest a need to obtain an accuracy of order $5 \times 10^{-4}$ for the ratio of the PT-violating to P-violating asymmetries in neutron transmission experiments in order to improve on the present limits on the isovector pion coupling constant.Comment: 17 pages, LaTeX, no figure

Organic Pollutants, Heavy Metals and Toxicity in Oil Spill impacted Salt Marsh Sediment Cores, Staten Island, New York City, USA

Sediment cores from Staten Island's salt marsh contain multiple historical oil spill events that impact ecological health. Microtox solid phase bioassay indicated moderate to high toxicity. Multiple spikes of TPH (6524 to 9586 mg/kg) and Σ16 PAH (15.5 to 18.9 mg/kg) were co-incident with known oil spills. A high TPH background of 400–700 mg/kg was attributed to diffuse sources. Depth-profiled metals Cu (1243 mg/kg), Zn (1814 mg/kg), Pb (1140 mg/kg), Ni (109 mg/kg), Hg (7 mg/kg), Cd 15 (mg/kg) exceeded sediment quality guidelines confirming adverse biological effects. Changes in Pb206/207 suggested three metal contaminant sources and diatom assemblages responded to two contamination events. Organic and metal contamination in Saw Mill Creek Marsh may harm sensitive biota, we recommend caution in the management of the 20–50 cm sediment interval because disturbance could lead to remobilisation of pre-existing legacy contamination into the waterway

Antiresonant hollow core fiber with an octave spanning bandwidth for short haul data communications

We report an effectively single mode tubular antiresonant hollow core fiber with minimum loss of ~25 dB/km at ~1200 nm, and an extremely wide low loss transmission window (lower than 30 dB/km loss from 1000 nm to 1400 nm and 6 dB bandwidth exceeding 1000 nm). Despite the relatively large mode field diameter of 32 µm, the fiber can be interfaced to SMF28 to produce fully connectorized samples. Exploiting an excellent modal purity arising from large modal differential loss and low intermodal coupling, we demonstrate penalty-free 10G on-off keying data transmission through 100m of fiber, at wavelengths of 1065, 1565 and 1963nm

Novel salinity tolerance loci in chickpea identified in glasshouse and field environments

A better understanding of the genetics of salinity tolerance in chickpea would enable breeding of salt tolerant varieties, offering potential to expand chickpea production to marginal, salinity-affected areas. A Recombinant Inbred Line population was developed using accelerated-Single Seed Descent of progeny from a cross between two chickpea varieties, Rupali (salt-sensitive) and Genesis836 (salt-tolerant). The population was screened for salinity tolerance using high-throughput image-based phenotyping in the glasshouse, in hydroponics, and across 2 years of field trials at Merredin, Western Australia. A genetic map was constructed from 628 unique in-silico DArT and SNP markers, spanning 963.5 cM. Markers linked to two flowering loci identified on linkage groups CaLG03 and CaLG05 were used as cofactors during genetic analysis to remove the confounding effects of flowering on salinity response. Forty-two QTL were linked to growth rate, yield, and yield component traits under both control and saline conditions, and leaf tissue ion accumulation under salt stress. Residuals from regressions fitting best linear unbiased predictions from saline conditions onto best linear unbiased predictions from control conditions provided a measure of salinity tolerance per se, independent of yield potential. Six QTL on CaLG04, CaLG05, and CaLG06 were associated with tolerance per se. In total, 21 QTL mapped to two distinct regions on CaLG04. The first distinct region controlled the number of filled pods, leaf necrosis, seed number, and seed yield specifically under salinity, and co-located with four QTL linked to salt tolerance per se. The second distinct region controlled 100-seed weight and growth-related traits, independent of salinity treatment. Positional cloning of the salinity tolerance-specific loci on CaLG04, CaLG05, and CaLG06 will improve our understanding of the key determinants of salinity tolerance in chickpea.Judith Atieno, Timothy D. Colmer, Julian Taylor, Yongle Li, John Quealy, Lukasz Kotula ... et al

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P<10(-6) in 19,979 additional individuals. We identify five loci robustly associated (P<5 × 10(-8)) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health

Meta-analysis of type 2 Diabetes in African Americans Consortium

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)<P<5 × 10(-8), odds ratio (OR)  = 1.09 to 1.36). Fine-mapping revealed that 88 of 158 previously identified T2D or glucose homeostasis loci demonstrated nominal to highly significant association (2.2 × 10(-23) < locus-wide P<0.05). These novel and previously identified loci yielded a sibling relative risk of 1.19, explaining 17.5% of the phenotypic variance of T2D on the liability scale in African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.Peer reviewe

Erratum: "A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo" (2021, ApJ, 909, 218)

[no abstract available