A Comparative Study Between Eruptive X-class Flares Associated with Coronal Mass Ejections and Confined X-class Flares

We examine the two kinds of major energetic phenomena that occur in the solar atmosphere: eruptive and confined events. The former describes flares with associated coronal mass ejections (CMEs), while the latter denotes flares without associated CMEs. We find that about 90% of X-class flares are eruptive, but the remaining 10% are confined. To probe why the largest energy releases could be either eruptive or confined, we investigate four X-class events from each of the two types. Both sets of events are selected to have very similar intensities (X1.0 to X3.6) and duration (rise time under 13 minutes and decay time not over 9 minutes) in soft X-ray observations, to reduce any bias due to flare size on CME occurrence. We find that the occurrence of eruption (or confinement) is sensitive to the displacement of the location of the energy release, defined as the distance between the flare site and the flux-weighted magnetic center of the source active region. The displacement is 6 - 17 Mm for confined events but as large as 22 - 37 Mm for eruptive events. This means that confined events occur closer to the magnetic center, while the eruptive events tend to occur close to the edge of active regions. We use the potential field source-surface model to infer the coronal magnetic field above the source active regions and calculate the flux ratio of low (1.1 Rs) corona. We find that the confined events have a lower ratio (<5.7) than the eruptive events (>7.1). These results imply that a stronger overlying arcade field may prevent energy releases in the low corona from being eruptive, resulting in flares, but without CMEs

Telomerase Immortalization of Human Corneal Endothelial Cells Yields Functional Hexagonal Monolayers

Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose main function is to maintain corneal clarity by regulating corneal hydration. HCEnCs are derived from neural crest and are arrested in the post-mitotic state. Thus cell loss due to aging or corneal endothelial disorders leads to corneal edema and blindness–the leading indication for corneal transplantation. Here we show the existence of morphologically distinct subpopulations of HCEnCs that are interspersed among primary cells and exhibit enhanced self-renewal competence and lack of phenotypic signs of cellular senescence. Colonies of these uniform and hexagonal HCEnCs (HCEnC-21) were selectively isolated and demonstrated high proliferative potential that was dependent on endogenous upregulation of telomerase and cyclin D/CDK4. Further transduction of HCEnC-21 with telomerase yielded a highly proliferative corneal endothelial cell line (HCEnT-21T) that was devoid of oncogenic transformation and retained critical corneal endothelial cell characteristics and functionality. This study will significantly impact the fields of corneal cell biology and regenerative medicine

On the Propagation of a Geoeffective Coronal Mass Ejection during March 15 -- 17, 2015

The largest geomagnetic storm so far in the solar cycle 24 was produced by a fast coronal mass ejection (CME) originating on 2015 March 15. It was an initially west-oriented CME and expected to only cause a weak geomagnetic disturbance. Why did this CME finally cause such a large geomagnetic storm? We try to find some clues by investigating its propagation from the Sun to 1 AU. First, we reconstruct the CME's kinematic properties in the corona from the SOHO and SDO imaging data with the aid of the graduated cylindrical shell (GCS) model. It is suggested that the CME propagated to the west $\sim$$33^\circ$$\pm$$10^\circ$ away from the Sun-Earth line with a speed of about 817 km s$^{-1}$ before leaving the field of view of the SOHO/LASCO C3 camera. A magnetic cloud (MC) corresponding to this CME was measured in-situ by the Wind spacecraft two days later. By applying two MC reconstruction methods, we infer the configuration of the MC as well as some kinematic information, which implies that the CME possibly experienced an eastward deflection on its way to 1 AU. However, due to the lack of observations from the STEREO spacecraft, the CME's kinematic evolution in interplanetary space is not clear. In order to fill this gap, we utilize numerical MHD simulation, drag-based CME propagation model (DBM) and the model for CME deflection in interplanetary space (DIPS) to recover the propagation process, especially the trajectory, of the CME from $30 R_S$ to 1 AU. It is suggested that the trajectory of the CME was deflected toward the Earth by about $12^\circ$, consistent with the implication from the MC reconstruction at 1 AU. This eastward deflection probably contributed to the CME's unexpected geoeffectiveness by pushing the center of the initially west-oriented CME closer to the Earth.Comment: 10 pages, 5 figures, 1 table, accepted by JGR - Space Physic

Clay mineral formation under oxidized conditions and implications for paleoenvironments and organic preservation on Mars

Clay mineral-bearing locations have been targeted for martian exploration as potentially habitable environments and as possible repositories for the preservation of organic matter. Although organic matter has been detected at Gale Crater, Mars, its concentrations are lower than expected from meteoritic and indigenous igneous and hydrothermal reduced carbon. We conducted synthesis experiments motivated by the hypothesis that some clay mineral formation may have occurred under oxidized conditions conducive to the destruction of organics. Previous work has suggested that anoxic and/or reducing conditions are needed to synthesize the Fe-rich clay mineral nontronite at low temperatures. In contrast, our experiments demonstrated the rapid formation of Fe-rich clay minerals of variable crystallinity from aqueous Fe^(3+) with small amounts of aqueous Mg^(2+). Our results suggest that Fe-rich clay minerals such as nontronite can form rapidly under oxidized conditions, which could help explain low concentrations of organics within some smectite-containing rocks or sediments on Mars

Long-term exposure to low concentrations of air pollutants and hospitalisation for respiratory diseases:A prospective cohort study in Australia

Background: Short- and long-term spatiotemporal variation in exposure to air pollution is associated with respiratory morbidity in areas with moderate-to-high level of air pollution, but very few studies have examined whether these associations also exist in areas with low level exposure. Objectives: We assessed the association between spatial variation in long-term exposure to PM and NO and hospitalisation for all respiratory diseases, asthma, chronic obstructive pulmonary disease (COPD), and pneumonia, in older adults residing in Sydney, Australia, a city with low-level concentrations. Methods: We recorded data on hospitalisations for 100,084 participants, who were aged >45 years at entry in 2006–2009 until June 2014. Annual NO and PM concentrations were estimated for the participants’ residential addresses and Cox proportional hazards regression was used to model the association between exposure to air pollutants and first episode of hospitalisation, controlling for personal and area level covariates. We further investigated the shape of the exposure-response association and potential effect modification by age, sex, education level, smoking status, and BMI. Results: NO and PM annual mean exposure estimates were 17.5 μg·m and 4.5 μg·m respectively. NO and PM was positively, although not significantly, associated with asthma. The adjusted hazard ratio for a 1 μg·m increase in PM was 1.08, 95% confidence interval 0.89–1.30. The adjusted hazard ratio for a 5 μg·m increase in NO was 1.03, 95% confidence interval 0.88–1.19. We found no positive statistically significant associations with hospitalisation for all respiratory diseases, and pneumonia while negative associations were observed with COPD. Conclusions: We found weak positive associations of exposure to air pollution with hospitalisation for asthma while there was no evidence of an association for all respiratory diseases

All-cause mortality and long-term exposure to low level air pollution in the ‘45 and up study’ cohort, Sydney, Australia, 2006–2015

Epidemiological studies show that long-term exposure to ambient air pollution reduces life expectancy. Most studies have been in environments with relatively high concentrations such as North America, Europe and Asia. Associations at the lower end of the concentration-response function are not well defined.We assessed associations between all-cause mortality and exposure to annual average particulate matte

A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases

Abstract Polyglutamine (PolyQ) diseases are progressive neurodegenerative disorders caused by both protein- and RNA-mediated toxicities. We previously showed that a peptidyl inhibitor, P3, which binds directly to expanded CAG RNA can inhibit RNA-induced nucleolar stress and suppress RNA-induced neurotoxicity. Here we report a N-acetylated and C-amidated derivative of P3, P3V8, that showed a more than 20-fold increase in its affinity for expanded CAG RNA. The P3V8 peptide also more potently alleviated expanded RNA-induced cytotoxicity in vitro, and suppressed polyQ neurodegeneration in Drosophila with no observed toxic effects. Further N-palmitoylation of P3V8 (L1P3V8) not only significantly improved its cellular uptake and stability, but also facilitated its systemic exposure and brain uptake in rats via intranasal administration. Our findings demonstrate that concomitant N-acetylation, C-amidation and palmitoylation of P3 significantly improve both its bioactivity and pharmacological profile. L1P3V8 possesses drug/lead-like properties that can be further developed into a lead inhibitor for the treatment of polyQ diseases

Disappearance of plasmaspheric hiss following interplanetary shock

Abstract Plasmaspheric hiss is one of the important plasma waves controlling radiation belt dynamics. Its spatiotemporal distribution and generation mechanism are presently the object of active research. We here give the first report on the shock-induced disappearance of plasmaspheric hiss observed by the Van Allen Probes on 8 October 2013. This special event exhibits the dramatic variability of plasmaspheric hiss and provides a good opportunity to test its generation mechanisms. The origination of plasmaspheric hiss from plasmatrough chorus is suggested to be an appropriate prerequisite to explain this event. The shock increased the suprathermal electron fluxes, and then the enhanced Landau damping promptly prevented chorus waves from entering the plasmasphere. Subsequently, the shrinking magnetopause removed the source electrons for chorus, contributing significantly to the several-hours-long disappearance of plasmaspheric hiss