EXPRESSION OF THE TUMOR-ASSOCIATED PROTEINS IN THE OVARIAN CANCER

With the help of monoclonal antibodies (MCA-1, MCA-3, G1 class immunoglobulins) and polyspecific antiserum (As) by means of immunoblotting (IB) the increase of the expression of the tumor-associated proteins (TAP) in the samples of the tumor tissues (in 94, 55 and 38% respectively), metastatic lymph nodes — LN(m+) and sera of the patients with ovarian cancer (OC) (in 82, 77 and ~100% of the cases, respectively), was detected. The important feature of As was the reactivity with the samples of the LN (m+) on the numerous proteins (>5-10) in 78% of the patients. The statistical analysis of the data using Student t-criterion revealed the significant differences (MCA-1, MCA-3) in the expression of the markers in the tumor tissues and blood sera of the oncological patients compar- ing with the samples of the adjacent tissues, blood sera of the patients with the other tumor localization and healthy donors (p<0,05). The further research using a larger amount of the clinical material and development of the more precise quantitative immunoenzyme analysis to measure TAP, is needed. It is possible that detection of TAP using MCA-1 and As may serve a basis for the creation of the test-system for the immunodiagnostics of the OC and determination of the stage of the tumor process

Clinical and morphological characteristic of the case of secondary enucleation of the eye with retinoblastoma

Purpose: To analyze case of secondary enucleation of a child’s eye with recurrent retinoblastoma (RB) developing due to parents’ failure to take the child to surveillance appointments after salvage eye therapy. Material and Methods: Observation and treatment of a 10-month child diagnosed with bilateral RB. The right eye was diagnosed with RB at stage T1N0M0, and the left eye, with RB at stage T3cN0M0 complicated by secondary glaucoma. Results: Salvage eye therapy was performed which included six cycles of combined multiagent chemotherapy (with systemic intravitreal chemoreduction melphalan injection), followed by three courses of laser coagulation of tumor focus in the right eye and additional seventh local chemotherapy in the left eye. As a result, type 4 RB regression pattern in the right eye, and was developed incomplete type 2 RB regression pattern (“fish-flesh” appearance) in the left eye. However, after the child did not visit the medical care facility for surveillance and treatment during seven months, tumor regrowth developed. Secondary enucleation of the left eye was performed due to big tumor size, anterior chamber involvement blindness, and the absence of visual functions without prospects for their improvement. Histopathology found undifferentiated retinoblastoma with invasion into the episclera, the child was administered two cycles of chemoreduction as well as external beam radiotherapy of the left orbit using a medical linear accelerator system. Conclusion: Should tumor recurrence occur or if there is no tumor control, urgent secondary enucleation with eye ball histopathology and, if indicated, further adjuvant therapy are recommended to prevent metastasis and save child’s life

MHD simulations of plasma dynamics in pinch discharges in capillary plasmas

Magnetohydrodynamic simulation results related to the capillary discharge dynamics are presented. The main physical process that should be taken into account is the ablation of the capillary wall material evaporated by the heat flux from the capillary plasma. The possible applications of the capillary discharges related to the physics of the X-ray lasers and the use of the capillary plasma to provide a guiding for ultrashort high-intensity laser pulses over a distance greater than the defocusing length are discussed

Collisionless current sheet equilibria

Current sheets are important for the structure and dynamics of many plasma systems. In space and astrophysical plasmas they play a crucial role in activity processes, for example by facilitating the release of magnetic energy via processes such as magnetic reconnection. In this contribution we will focus on collisionless plasma systems. A sensible first step in any investigation of physical processes involving current sheets is to find appropriate equilibrium solutions. The theory of collisionless plasma equilibria is well established, but over the past few years there has been a renewed interest in finding equilibrium distribution functions for collisionless current sheets with particular properties, for example for cases where the current density is parallel to the magnetic field (force-free current sheets). This interest is due to a combination of scientific curiosity and potential applications to space and astrophysical plasmas. In this paper we will give an overview of some of the recent developments, discuss their potential applications and address a number of open questions

On production and asymmetric focusing of flat electron beams using rectangular capillary discharge plasmas

A method for the asymmetric focusing of electron bunches, based on the active plasma lensing technique is proposed. This method takes advantage of the strong inhomogeneous magnetic field generated inside the capillary discharge plasma to focus the ultrarelativistic electrons. The plasma and magnetic field parameters inside the capillary discharge are described theoretically and modeled with dissipative magnetohydrodynamic computer simulations enabling analysis of the capillaries of rectangle cross-sections. Large aspect ratio rectangular capillaries might be used to transport electron beams with high emittance asymmetries, as well as assist in forming spatially flat electron bunches for final focusing before the interaction point.Comment: 16 pages, 7 figures, 1 tabl

НАВЧАЛЬНО-МЕТОДИЧНЕ ТА ОРГАНІЗАЦІЙНЕ ЗАБЕЗПЕЧЕННЯ ОСВІТНЬОГО ПРОЦЕСУ ДЛЯ АНГЛОМОВНИХ СТУДЕНТІВ НА КАФЕДРІ МІКРОБІОЛОГІЇ, ВІРУСОЛОГІЇ ТА ІМУНОЛОГІЇ ВДНЗУ “УКРАЇНСЬКА МЕДИЧНА СТОМАТОЛОГІЧНА АКАДЕМІЯ”

The aim of the work – to analyze  the status of methodical provision of the educational process with English-speaking students at the Department of Microbiology, Virology and Immunology of UMSA to determine in the future the following appropriate actions in this direction of the teaching staff of the department.The main body. In order to further improving the level of knowledge on the subject at the Department of Microbiology, Virology and Immunology systematic work is being done on the creation, refinement and modernization of methodological developments for students with English language teaching. The methodological developments of the department are aimed at facilitating students in obtaining information on the subject, successfully mastering practical skills and preparing for the independent testing of Krok-1. Also test bases for current student knowledge control are developed.Conclusion. Educational and methodological support of the educational process for English-speaking students at the Department of Microbiology, Virology and Immunology is being developed and improved in the areas of information support, organization of the process of mastering practical skills and controlling knowledge of students.Мета роботи – аналіз стану методичного забезпечення навчального процесу з англомовними студентами на кафедрі мікробіології, вірусології та імунології ВДНЗУ “УМСА” для визначення у майбутньому доцільних дій у цьому напрямку діяльності викладацького колективу кафедри.Основна частина. З метою подальшого покращення рівня знань з предмета на кафедрі мікробіології, вірусології та імунології постійно проводиться методична робота щодо створення, удосконалення та осучаснення методичних розробок для студентів з англійською мовою викладання. Методичні розробки кафедри направлені на сприяння студентам в отриманні інформації з предмета, успішне оволодіння практичними навичками та підготовку до складання незалежного тестування “Крок-1”. Також розробляються бази тестів для поточного контролю знань студентів.Висновок. Навчально-методичне забезпечення освітнього процесу для англомовних студентів на кафедрі мікробіології, вірусології та імунології розробляється та вдосконалюється у напрямках інформаційного забезпечення, організації процесу оволодіння практичними навичками та контролю знань студентів.

Hospital stage of myocardial infarction treatment in 13 Regions of Russian Federation by results of the international research

Aim: To describe the characteristics of the patient with MI who is admitted to a hospital and to characterize the main diagnostic and treatment interventions in clini

Babesia infection of small mammals from southern taiga of Omsk region

Blood samples were taken from 541 small mammal captured in 2013-2015 in Znamensky district of Omsk region from Ixodes persulcatus and Ixodes trianguliceps sympatric area and examined for the Babesia spp. presence by nested PCR with subsequent sequencing of positive samples. Babesia microti DNA was found in 31,1 % of positive samples; a proportion of infected mammals varied from 5,3 % to 61,6 % in different sampling periods. B. microti DNA was found in samples from three prevailing Myodes species as well as from a root vole (Microtus oeconomus), field voles (Microtus argestis) and Siberian chipmunks (Tamias sibiricus). It was shown that identified B. microti samples belong to two genetic groups: B. microti 'US'-type and B. microti 'Munich'-type; notably that > 90 % infected mammals contained DNA of nonpathogenic for human B. microti 'Munich'-type. We suppose that I. trianguliceps tick is the most probable vector of B. microti 'Munich'-type

The Effect of Neutral Atoms on Capillary Discharge Z-pinch

We study the effect of neutral atoms on the dynamics of a capillary discharge Z-pinch, in a regime for which a large soft-x-ray amplification has been demonstrated. We extended the commonly used one-fluid magneto-hydrodynamics (MHD) model by separating out the neutral atoms as a second fluid. Numerical calculations using this extended model yield new predictions for the dynamics of the pinch collapse, and better agreement with known measured data.Comment: 4 pages, 4 postscript figures, to be published in Phys. Rev. Let

Prospects of the «Beres plus» drops application for the generalized periodontitis treatment

Генералізований пародонтит це захворювання тканин пародонта, що характеризується прогресуючою деструкцією тканин періодонта та кістки, в патогенезі якого вирішальну роль відіграє мікробний фактор. Одним із недостатньо вивчених аспектів є вплив препаратів гомеостатичної та антибактеріальної дії на патогенну мікрофлору пародонтальних кишень хворих на генералізований пародонтит при їх місцевому застосуванні