Turn-boundary projection: Looking ahead

Coordinating with others is hard; and yet we accomplish this every day when we take turns in a conversation. How do we do this? The present study introduces a new method of measuring turn-boundary projection that enables researchers to achieve more valid, flexible, and temporally informative data on online turn projection: tracking an observer’s gaze from the current speaker to the next speaker. In this preliminary investigation, participants consistently looked at the current speaker during their turn. Additionally, they looked to the next speaker before her turn began, and sometimes even before the current speaker finished speaking. This suggests that observer gaze is closely aligned with perceptual processes of turn-boundary projection, and thus may equip the field with the tools to explore how we manage to take turns

Tectonic synthesis of the Olympic Mountains segment of the Cascadia wedge, using two-dimensional thermal and kinematic modeling of thermochronological ages

A fully coupled two-dimensional kinematic and thermal model of a steady state accretionary wedge, constrained by an extensive data set of fission track and (U-Th)/He ages for apatite and zircon, is here used to investigate the development of the Olympic Mountains segment of the Cascadia accretionary wedge. The model has two main free parameters: ε_(max), the maximum rate of erosion for a generic erosion function operating at the top of the wedge, and α, the distribution of sedimentary accretion into the wedge. The best fit values for ε_(max) and α and their confidence limits are determined through an iterative search of parameter space. This study represents the first time that such inversion methods have been used to quantify the thermal-kinematic evolution of an accretionary wedge. Our results suggest that horizontal transport plays an important role in the exhumation trajectories experienced by material passing through the Cascadia wedge. At a 95% confidence interval, 80 to 100% of the sedimentary sequence from the subducting Juan de Fuca Plate has been accreted at the front of the wedge offshore of the Olympics over the past 14 m.y. This frontally accreted material must then traverse the entire width of the wedge prior to its eventual exposure in the Olympic forearc high. Assessed in this two-dimensional framework, the fission track and (U-Th)/He age data sets from the Olympic Mountains are all best fit by ε_(max) of 0.9–1.0 mm yr^(−1), despite variation in the timescales relevant to the three chronometers. This result supports the hypothesis that the Olympic Mountains segment of the Cascadia accretionary wedge has been in a flux steady-state since ∼14 Ma. The demonstration of a flux balance across the Cascadia margin also suggests that margin-parallel transport has not had a significant role in driving uplift of the Olympic Mountains

Dust from Mars-Analog Plains (Iceland): Physico-Compositional Properties as a Function of Grain-Size Fraction

Dust is a key component of the geological and climatic systems of Earth and Mars. On Mars, dust is ubiquitous. It coats rocks and soils, and, in the atmosphere, it interacts strongly with solar and thermal radiation. Yet, key questions remain about the genesis and fate of martian dust, as well as its sources, composition, and properties. We collected wind-blown dust from basaltic plains in SW Iceland at Skjaldbreiauhraun that represent a geologic Mars-analog environment. Icelandic dust differs from the typical continental sources (e.g. Sahara, Asia) because of its basaltic volcanogenic origin, which is similar to Mars. Dust collection took place in July of 2019 as a complementary project to the SAND-E: Semi-Autonomous Navigation for Detrital Environments project. Here we report preliminary analyses of this Mars-analog dust material, with the goal of understanding the processes that control the physico-chemical proper-ties of the different grain-size fractions

No increase in radiation-induced chromosome aberration complexity detected by m-FISH after culture in the presence of 5’-bromodeoxyuridine

The thymidine analogue, 5’-bromodeoxyuridine (BrdU), is a known mutagen that is routinely introduced into culture media for subsequent Harlequin stain analysis and determination of cell cycle status. Previously, we examined the induction of chromosome aberrations in human peripheral blood lymphocytes (PBL) known to be in their 1st cell division following exposure to a low dose (0.5 Gy, average one -particle per cell) of high-LET α-particles. We found complex chromosome aberrations to be characteristic of exposure to high-LET radiation and suggested the features of complex exchange to reflect qualitatively the spatial deposition of this densely ionising radiation. To exclude the possibility that BrdU addition post-irradiation influenced the complexity of chromosomal damage observed by m-FISH, the effect of increasing BrdU concentration on aberration complexity was investigated. Comparisons between BrdU concentration (0, 10, and 40 M) and between sham- and α-particle irradiated PBL, were made both independently and in combination to enable discrimination between BrdU and high-LET radiation effects. Aberration type, size, complexity and completeness were assessed by m-FISH, and the relative progression through cell division was evaluated. We found no evidence of any qualitative difference in the complexity of damage as visualized by m-FISH but did observe an increase in the frequency of complex exchanges with increasing BrdU concentration indicative of altered cell cycle kinetics. The parameters measured here are consistent with findings from previous in vitro and in vivo work, indicating that each complex aberration visualised by m-FISH is characteristic of the structure of the high-LET α-particle track and the geometry of cell irradiated

Single neutral pion production by charged-current (nu)over-bar(mu) interactions on hydrocarbon at \u3c E-nu \u3e=3.6 GeV

Single neutral pion production via muon antineutrino charged-current interactions in plastic scintillator (CH) is studied using the MINERvA detector exposed to the NuMI low-energy, wideband antineutrino beam at Fermilab. Measurement of this process constrains models of neutral pion production in nuclei, which is important because the neutral-current analog is a background for (nu) over bar (e) appearance oscillation experiments. The differential cross sections for pi(0) momentum and production angle, for events with single observed pi(0) and no charged pions, are presented and compared to model predictions. These results comprise the first measurement of the pi(0) kinematics for this process. (C) 2015 The Authors. Published by Elsevier B.V

Increasing and decreasing droplets velocity in micro channels

This paper deals with a specific aspect of non miscible liquid-liquid systems in microfluidic. For Chemical Engineering applications, the main constraints of functioning lies in the droplets velocity and frequency. Furthermore, the material used and the composition of the fluids is often imposed by the chemistry of the system (material resistance, fluids composition) and there is no possibility of adding other compound (surfactants for example). A technique under evaluation is presented: by using secondary channels and pumps, it is possible to increase or decrease at will the droplets velocity after they have been generated. Some experimental results are presented and discussed, including the possible limits of such an approach

Influence of real-world characteristics on outcomes for patients with methicillin-resistant Staphylococcal skin and soft tissue infections:a multi-country medical chart review in Europe

BACKGROUND: Patient-related (demographic/disease) and treatment-related (drug/clinician/hospital) characteristics were evaluated as potential predictors of healthcare resource use and opportunities for early switch (ES) from intravenous (IV)-to-oral methicillin-resistant Staphylococcus aureus (MRSA)-active antibiotic therapy and early hospital discharge (ED). METHODS: This retrospective observational medical chart study analyzed patients (across 12 European countries) with microbiologically confirmed MRSA complicated skin and soft tissue infections (cSSTI), ≥3 days of IV anti-MRSA antibiotics during hospitalization (July 1, 2010-June 30, 2011), and discharged alive by July 31, 2011. Logistic/linear regression models evaluated characteristics potentially associated with actual resource use (length of IV therapy, length of hospital stay [LOS], IV-to-oral antibiotic switch), and ES and ED (using literature-based and expert-verified criteria) outcomes. RESULTS: 1542 patients (mean ± SD age 60.8 ± 16.5 years; 61.5% males) were assessed with 81.0% hospitalized for MRSA cSSTI as the primary reason. Several patient demographic, infection, complication, treatment, and hospital characteristics were predictive of length of IV therapy, LOS, IV-to-oral antibiotic switch, or ES and ED opportunities. Outcomes and ES and ED opportunities varied across countries. Length of IV therapy and LOS (r = 0.66, p < 0.0001) and eligibilities for ES and ED (r = 0.44, p < 0.0001) showed relatively strong correlations. IV-to-oral antibiotic switch patients had significantly shorter length of IV therapy (−5.19 days, p < 0.001) and non-significantly shorter LOS (−1.86 days, p > 0.05). Certain patient and treatment characteristics were associated with increased odds of ES (healthcare-associated/ hospital-acquired infection) and ED (patient living arrangements, healthcare-associated/ hospital-acquired infection, initiating MRSA-active treatment 1–2 days post cSSTI index date, existing ED protocol), while other factors decreased the odds of ES (no documented MRSA culture, ≥4 days from admission to cSSTI index date, IV-to-oral switch, IV line infection) and ED (dementia, no documented MRSA culture, initiating MRSA-active treatment ≥3 days post cSSTI index date, existing ES protocol). CONCLUSIONS: Practice patterns and opportunity for further ES and ED were affected by several infection, treatment, hospital, and geographical characteristics, which should be considered in identifying ES and ED opportunities and designing interventions for MRSA cSSTI to reduce IV days and LOS while maintaining the quality of care. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2334-14-476) contains supplementary material, which is available to authorized users