Future changes in tropical cyclone activity in the North Indian Ocean projected by high-resolution MRI-AGCMs

Open Access at publisher's web site: http://www.springerlink.com/content/b682734237171631

METODE KONJUGAT GRADIEN HIBRID BARU: METODE HS-CD UNTUK MENYELESAIKAN MASALAH OPTIMASI TAK BERKENDALA

Metode konjugat gradien adalah salah satu metode yang efektif dalam menyelesaikan permasalahan optimasi tak-berkendala dan metode ini juga termasuk salah satu metode iteratif. Pada tulisan ini, peneliti mengusulkan metode konjugat gradien hibrid baru yaitu metode new hybrid 4 yang merupakan gabungan antara metode Hestenes dan Stiefel – Conjugate Descent, dimana metode tersebut diusulkan berdasarkan ide dari metode yang telah diusulkan sebelumnya yaitu metode Polak, Ribiѐre dan Polyak - Fletcher dan Reeves atau metode NH1, metode Hestenes dan Stiefel – Dai dan Yuan atau metode NH2 dan metode Liu dan Storey – Conjugate Descent (NH3). Peneliti mengusulkan metode tersebut dengan menggabungkan antara metode HS dan CD, dimana metode tersebut memiliki kekurangan masing-masing. Dalam penelitian ini, peneliti membandingkan hasil numerik antara metode baru yaitu Metode HS-CD (NH4) dengan metode-metode sebelumnya serta membuktikan bahwa memenuhi sifat konvergen global dan memenuhi kondisi descent setiap iterasinya. Hasil numerik menunjukkan bahwa metode baru adalah sangat efisien dalam menyelesaikan fungsi nonlinear tak-berkendala. Metode tersebut juga terbukti memenuhi sifat konvergen global menggunakan kondisi Wolfe serta memenuhi kondisi descent di setiap iterasinya

Active Referral Intervention following Fragility Fractures Leads to Enhanced Osteoporosis Follow-Up Care

At one major urban academic medical center, patients aged 50 years and older with fragility fractures were identified and scheduled or assisted in referral into osteoporosis medical management appointments. We evaluated the efficacy of an active intervention program at overcoming the logistical barriers and improving proper osteoporosis follow-up for persons who have sustained a fragility fracture. Of 681 patients treated for defined fractures, 168 were eligible and consented for the study of fragility fractures. Of those enrolled, 91 (54.2%) had appropriate osteoporosis follow-up on initial interview, and overall 120 (71.4%) had successful osteoporosis follow-up following our active intervention. Seventy patients (41.7%) were deemed to have no osteoporosis follow-up, and, of these, 48 were successfully referred to a scheduling coordinator. The scheduling coordinator was able to contact 37 (77%) patients to schedule proper follow-up, and, of these, 29 (78.4%) confirmed receiving an appropriate follow-up appointment. Active intervention and assisted scheduling for patients with recent fragility fractures improved the self-reported rate of osteoporosis follow-up from 54.2% to 71.4%

Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules.

Myocardial ischemia reperfusion injury (IRI) adversely affects cardiac performance and the prognosis of patients with acute myocardial infarction. Although myocardial signal transducer and activator of transcription (STAT) 3 is potently cardioprotective during IRI, the inhibitory mechanism responsible for its activation is largely unknown. The present study aimed to investigate the role of the myocardial suppressor of cytokine signaling (SOCS)-3, an intrinsic negative feedback regulator of the Janus kinase (JAK)-STAT signaling pathway, in the development of myocardial IRI. Myocardial IRI was induced in mice by ligating the left anterior descending coronary artery for 1 h, followed by different reperfusion times. One hour after reperfusion, the rapid expression of JAK-STAT-activating cytokines was observed. We precisely evaluated the phosphorylation of cardioprotective signaling molecules and the expression of SOCS3 during IRI and then induced myocardial IRI in wild-type and cardiac-specific SOCS3 knockout mice (SOCS3-CKO). The activation of STAT3, AKT, and ERK1/2 rapidly peaked and promptly decreased during IRI. This decrease correlated with the induction of SOCS3 expression up to 24 h after IRI in wild-type mice. The infarct size 24 h after reperfusion was significantly reduced in SOCS3-CKO compared with wild-type mice. In SOCS3-CKO mice, STAT3, AKT, and ERK1/2 phosphorylation was sustained, myocardial apoptosis was prevented, and the expression of anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) was augmented. Cardiac-specific SOCS3 deletion led to the sustained activation of cardioprotective signaling molecules including and prevented myocardial apoptosis and injury during IRI. Our findings suggest that SOCS3 may represent a key factor that exacerbates the development of myocardial IRI

4f-derived Fermi Surfaces of CeRu2(Si[1-x]Ge[x])2 near the Quantum Critical Point: Resonant Soft X-ray ARPES Study

Angle-resolved photoelectron spectroscopy in the Ce 3d-4f excitation region was measured for the paramagnetic state of CeRu2Si2, CeRu2(Si0.82Ge0.18)2, and LaRu2Si2 to investigate the changes of the 4$f$ electron Fermi surfaces around the quantum critical point. While the difference of the Fermi surfaces between CeRu2Si2 and LaRu2Si2 was experimentally confirmed, a strong 4f-electron character was observed in the band structures and the Fermi surfaces of CeRu2Si2 and CeRu2(Si0.82Ge0.18)2, consequently indicating a delocalized nature of the 4$f$ electrons in both compounds. The absence of Fermi surface reconstruction across the critical composition suggests that SDW quantum criticality is more appropriate than local quantum criticality in CeRu2(Si[1-x]Ge[x])2.Comment: 4 pages, 5 figure

4′-(4-Methoxy­phen­yl)-1,1′,1′′-trimethyl­dispiro­[indoline-3,2′-pyrrolidine-3′,3′′-pyrrolidine]-2,2′′,5′′-trione

In the title compound, C24H25N3O4, the pyrrolidine ring adopts an envelope conformation while the pyrrolidine-2′′,5′′-dione ring adopts a twist conformation. The indoline unit is planar [maximum deviation of −0.050 (9) Å] and forms a dihedral angle of 40.36 (4)° with the methoxy­phenyl ring. Intra­molecular C—H⋯O hydrogen bonds are observed. In the crystal, mol­ecules are linked into a two-dimensional network parallel to the ab plane by inter­molecular C—H⋯O hydrogen bonds and C—H⋯π inter­actions

Measurement of K^+K^- production in two-photon collisions in the resonant-mass region

K^+K^- production in two-photon collisions has been studied using a large data sample of 67 fb^{-1} accumulated with the Belle detector at the KEKB asymmetric e^+e^- collider. We have measured the cross section for the process gamma gamma -> K^+ K^- for center-of-mass energies between 1.4 and 2.4 GeV, and found three new resonant structures in the energy region between 1.6 and 2.4 GeV. The angular differential cross sections have also been measured.Comment: 24 pages, 8 figures, to appear in Euro. Phys. Jour.

Search for the Electric Dipole Moment of the tau Lepton

We have searched for a CP violation signature arising from an electric dipole moment (d_tau) of the tau lepton in the e+e- -> tau+tau- reaction. Using an optimal observable method and 29.5 fb^{-1} of data collected with the Belle detector at the KEKB collider at sqrt{s} = 10.58 GeV, we find Re(d_tau) = (1.15 +- 1.70) x 10^{-17} ecm and Im(d_tau) = (-0.83 +- 0.86) x 10^{-17} ecm and set the 95% confidence level limits -2.2 < Re(d_tau) < 4.5 (10^{-17}ecm) and -2.5 < Im(d_tau) < 0.8 (10^{-17}ecm).Comment: 15 pages, LaTeX, 21 figures, submitted to Phys. Lett.

Thoracoscopic detection of occult indeterminate pulmonary nodules using bronchoscopic pleural dye marking

Background: The annual incidence of a small indeterminate pulmonary nodule (IPN) on computed tomography (CT) scan remains high. While traditional paradigms exist, the integration of new technologies into these diagnostic and treatment algorithms can result in alternative, potentially more efficient methods of managing these findings. Methods: We report on an alternative diagnostic and therapeutic strategy for the management of an IPN. This approach combines electromagnetic navigational bronchoscopy (ENB) with an updated approach to placement of a pleural dye marker. This technique lends itself to a minimally invasive wedge resection via either video-assisted thoracoscopic surgery (VATS) or a robotic approach. Results: Subsequent to alterations in the procedure, a cohort of 22 patients with an IPN was reviewed. Navigation was possible in 21 out of 22 patients with one patient excluded based on airway anatomy. The remaining 21 patients underwent ENB with pleural dye marking followed by minimally invasive wedge resection. The median size of the nodules was 13.4 mm (range: 7–29). There were no complications from the ENB procedure. Indigo carmine dye was used in ten patients. Methylene blue was used in the remaining 11 patients. In 81% of cases, the visceral pleural marker was visible at the time of surgery. In one patient, there was diffuse staining of the parietal pleura. In three additional patients, no dye was identified within the hemithorax. In all cases where dye marker was present on the visceral pleural surface, it was in proximity to the IPN and part of the excised specimen. Conclusions: ENB with pleural dye marking can provide a safe and effective method to localize an IPN and can allow for subsequent minimally invasive resection. Depending on the characteristics and location of the nodule, this method may allow more rapid identification intraoperatively

Measurements of the DsJD_{sJ} resonance properties

We report measurements of the properties of the $D_{sJ}^+(2317)$ and $D_{sJ}^+(2457)$ resonances produced in continuum $e^+ e^-$ annihilation near $\sqrt{s}=10.6 \mathrm{GeV}$. The analysis is based on an $86.9 \mathrm{fb^{-1}}$ data sample collected %at and 60 MeV below the $\Upsilon(4S)$ resonance with with the Belle detector at KEKB. We determine the masses to be $M(D_{sJ}^+(2317)) = 2317.2 \pm 0.5(\mathrm{stat}) \pm 0.9(\mathrm{syst}) \mathrm{MeV}/c^2$ and $M(D_{sJ}^+(2457))=2456.5 \pm 1.3(\mathrm{stat}) \pm 1.3(\mathrm{syst}) \mathrm{MeV}/c^2$. We observe the radiative decay mode $D_{sJ}^+(2457) \to D_s^+ \gamma$ and the dipion decay mode $D_{sJ}^+(2457) \to D_s^+ \pi^+ \pi^-$, and determine their branching fractions. No corresponding decays are observed for the $D_{sJ}(2317)$ state. These results are consistent with the spin-parity assignments of $0^+$ for the $D_{sJ}(2317)$ and $1^+$ for the $D_{sJ}(2457)$.Comment: 5 pages, 6 figures; Added content, updated and paper submitted to PR