312 research outputs found
Exclusive production in proton-nucleus collisions
The exclusive meson production in a proton-nucleus collision, leading
to two body final states, is investigated in a fully covariant two-nucleon
model based on the effective Lagrangian picture. The explicit kaon production
vertex is described via creation, propagation and decay into relevant channel
of (1650), (1710) and (1720) intermediate baryonic states in the
initial collision of the projectile nucleon with one of its target counterparts
which is modeled by the one-pion exchange process. The calculated cross
sections show strong sensitivity to the medium effects on pion propagator and
to the final hypernuclear state excited in the reaction.Comment: Two new figures, version accepted for publication by Phys. Rev.
Possibility of \Lambda\Lambda pairing and its dependence on background density in relativistic Hartree-Bogoliubov model
We calculate a \Lambda\Lambda pairing gap in binary mixed matter of nucleons
and \Lambda hyperons within the relativistic Hartree-Bogoliubov model. Lambda
hyperons to be paired up are immersed in background nucleons in a normal state.
The gap is calculated with a one-boson-exchange interaction obtained from a
relativistic Lagrangian. It is found that at background density
\rho_{N}=2.5\rho_{0} the \Lambda\Lambda pairing gap is very small, and that
denser background makes it rapidly suppressed. This result suggests a
mechanism, specific to mixed matter dealt with relativistic models, of its
dependence on the nucleon density. An effect of weaker \Lambda\Lambda
attraction on the gap is also examined in connection with revised information
of the \Lambda\Lambda interaction.Comment: 8 pages, 6 figures, REVTeX 4; substantially rewritten, emphasis is
put on the LL pairing in pure neutron matte
Hyperon Single-Particle Potentials Calculated from SU6 Quark-Model Baryon-Baryon Interactions
Using the SU6 quark-model baryon-baryon interaction recently developed by the
Kyoto-Niigata group, we calculate NN, Lambda N and Sigma N G-matrices in
ordinary nuclear matter. This is the first attempt to discuss the Lambda and
Sigma single-particle potentials in nuclear medium, based on the realistic
quark-model potential. The Lambda potential has the depth of more than 40 MeV,
which is more attractive than the value expected from the experimental data of
Lambda-hypernuclei. The Sigma potential turns out to be repulsive, the origin
of which is traced back to the strong Pauli repulsion in the Sigma N (I=3/2)
^3S_1 state.Comment: 20 pages, 5 figure
A Realistic Description of Nucleon-Nucleon and Hyperon-Nucleon Interactions in the SU_6 Quark Model
We upgrade a SU_6 quark-model description for the nucleon-nucleon and
hyperon-nucleon interactions by improving the effective meson-exchange
potentials acting between quarks. For the scalar- and vector-meson exchanges,
the momentum-dependent higher-order term is incorporated to reduce the
attractive effect of the central interaction at higher energies. The
single-particle potentials of the nucleon and Lambda, predicted by the G-matrix
calculation, now have proper repulsive behavior in the momentum region q_1=5 -
20 fm^-1. A moderate contribution of the spin-orbit interaction from the
scalar-meson exchange is also included. As to the vector mesons, a dominant
contribution is the quadratic spin-orbit force generated from the rho-meson
exchange. The nucleon-nucleon phase shifts at the non-relativistic energies up
to T_lab=350 MeV are greatly improved especially for the 3E states. The
low-energy observables of the nucleon-nucleon and the hyperon-nucleon
interactions are also reexamined. The isospin symmetry breaking and the Coulomb
effect are properly incorporated in the particle basis. The essential feature
of the Lambda N - Sigma N coupling is qualitatively similar to that obtained
from the previous models. The nuclear saturation properties and the
single-particle potentials of the nucleon, Lambda and Sigma are reexamined
through the G-matrix calculation. The single-particle potential of the Sigma
hyperon is weakly repulsive in symmetric nuclear matter. The single-particle
spin-orbit strength for the Lambda particle is very small, in comparison with
that of the nucleons, due to the strong antisymmetric spin-orbit force
generated from the Fermi-Breit interaction.Comment: Revtex v2.09, 69 pages with 25 figure
Protection by the NO-Donor SNAP and BNP against Hypoxia/Reoxygenation in Rat Engineered Heart Tissue
In vitro assays could replace animal experiments in drug screening and disease modeling, but have shortcomings in terms of functional readout. Force-generating engineered heart tissues (EHT) provide simple automated measurements of contractile function. Here we evaluated the response of EHTs to hypoxia/reoxygenation (H/R) and the effect of known cardiocytoprotective molecules. EHTs from neonatal rat heart cells were incubated for 24 h in EHT medium. Then they were subjected to 180 min hypoxia (93% N2, 7% CO2) and 120 min reoxygenation (40% O2, 53% N2, 7% CO2), change of medium and additional follow-up of 48 h. Time-matched controls (40% O2, 53% N2, 7% CO2) were run for comparison. The following conditions were applied during H/R: fresh EHT medium (positive control), the NO-donor S-nitroso-N-acetyl-D,L-penicillamine (SNAP, 10-7, 10-6, 10-5 M) or the guanylate cyclase activator brain type natriuretic peptide (BNP, 10-9, 10-8, 10-7 M). Frequency and force of contraction were repeatedly monitored over the entire experiment, pH, troponin I (cTnI), lactate dehydrogenase (LDH) and glucose concentrations measured in EHT medium. Beating activity of EHTs in 24 h-medium ceased during hypoxia, partially recovered during reoxygenation and reached time-control values during follow-up. H/R was accompanied by a small increase in LDH and non-significant increase in cTnI. In fresh medium, some EHTs continued beating during hypoxia and all EHTs recovered faster during reoxygenation. SNAP and BNP showed small but significant protective effects during reoxygenation. EHTs are applicable to test potential cardioprotective compounds in vitro, monitoring functional and biochemical endpoints, which otherwise could be only measured by using in vivo or ex vivo heart preparations. The sensitivity of the model needs improvement
Dietary Lactoferrin Alleviates Age-Related Lacrimal Gland Dysfunction in Mice
BACKGROUND: Decrease in lacrimal gland secretory function is related to age-induced dry eye disease. Lactoferrin, the main glycoprotein component of tears, has multiple functions, including anti-inflammatory effects and the promotion of cell growth. We investigated how oral administration of lactoferrin affects age-related lacrimal dysfunction. METHODS AND FINDINGS: Twelve-month-old male C57BL/6Cr Slc mice were randomly divided into a control fed group and an oral lactoferrin treatment group. Tear function was measured at a 6-month time-point. After euthanasia, the lacrimal glands were subjected to histological examination with 8-hydroxy-2'-deoxyguanosine (8-OHdG) antibodies, and serum concentrations of 8-OHdG and hexanoyl-lysine adduct (HEL) were evaluated. Additionally, monocyte chemotactic protein-1(MCP-1) and tumor necrosis factor-α (TNF-α) gene expression levels were determined by real-time PCR. The volume of tear secretion was significantly larger in the treated group than in the control. Lactoferrin administration reduced inflammatory cell infiltration and the MCP-1 and TNF-α expression levels. Serum concentrations of 8-OHdG and HEL in the lactoferrin group were lower than those in the control group and were associated with attenuated 8-OHdG immunostaining of the lacrimal glands. CONCLUSION: Oral lactoferrin administration preserves lacrimal gland function in aged mice by attenuating oxidative damage and suppressing subsequent gland inflammation
First observation of the hyper superheavy hydrogen 6{\Lambda}H
Three candidate events of the neutron-rich hypernucleus 6{\Lambda}H were
uniquely identified in the FINUDA experiment at DA{\Phi}NE, Frascati, by
observing {\pi}+ mesons from the (K-stop,{\pi}+) production reaction on 6Li
targets, in coincidence with {\pi}-mesons from 6{\Lambda}H \rightarrow
6He+{\pi}- weak decay. Details of the experiment and the analysis of its data
are reported, leading to an estimate of (2.9\pm2.0)\cdot10-6/K- stop for the
6{\Lambda}H production rate times the two-body {\pi}- weak decay branching
ratio. The 6{\Lambda}H binding energy with respect to 5H + {\Lambda} was
determined jointly from production and decay to be B{\Lambda} = (4.0 \pm 1.1)
MeV, assuming that 5H is unbound with respect to 3H + 2n by 1.7 MeV. The
binding energy determined from production is higher, in each one of the three
events, than that determined from decay, with a difference of (0.98 \pm 0.74)
MeV here assigned to the 0+g.s. \rightarrow 1+ excitation. The consequences of
this assignment to {\Lambda} hypernuclear dynamics are briefly discussed.Comment: 20 pages, 8 figures, version matching published Nuclear Physics A
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