Heparin-containing block copolymers, Part I: Surface characterization

Newly synthesized heparin-containing block copolymers, consisting of a hydrophobic block of polystyrene (PS), a hydrophilic spacer-block of poly(ethylene oxide) (PEO) and covalently bound heparin (Hep) as bioactive block, were coated on aluminium, glass, polydimethylsiloxane (PDMS), PS or Biomer substrates. Surfaces of coated materials were characterized by transmission electron microscopy (TEM), contact angle measurements and X-ray photoelectron spectroscopy for chemical analysis (XPS). It was demonstrated by TEM that thin films of PS-PEO and PS-PEO-Hep block copolymers consisted of heterogeneous microphase separated structures. Using sessile-drop and Wilhelmy plate dynamic contact angle measurements, insight was provided into the hydrophilicity of the surfaces of the coatings. Measurements with hydrated coatings of PS-PEO and PS-PEO-Hep block copolymers revealed that the surfaces became more hydrophilic during immersion in water, due to relaxation/reorientation, or swelling of PEO or PEO-Hep domains, respectively. XPS results for PS, PEO, heparin and PS-PEO as powder agreed well with qualitative and quantitative predictions. XPS results for films of PS-PEO and PS-PEO-Hep block copolymers showed enrichments of PEO in the top layers of the coatings. This effect was more pronounced for hydrated surfaces. Only small amounts of heparin were detected at the surface of coatings of PS-PEO-Hep block copolymers

A Detailed Analysis of the Dust Formation Zone of IRC+10216 Derived from Mid-IR Bands of C2H2 and HCN

A spectral survey of IRC+10216 has been carried out in the range 11 to 14 um with a spectral resolution of about 4 km s^-1. We have identified a forest of lines in six bands of C2H2 involving the vibrational states from the ground to 3nu5 and in two bands of HCN, involving the vibrational states from the ground up to 2nu2. Some of these transitions are observed also in H13CCH and H13CN. We have estimated the kinetic, vibrational, and rotational temperatures, and the abundances and column densities of C2H2 and HCN between 1 and 300 R* (1.5E16 cm) by fitting about 300 of these ro-vibrational lines. The envelope can be divided into three regions with approximate boundaries at 0.019 arcsec (the stellar photosphere), 0.1 arcsec (the inner dust formation zone), and 0.4 arcsec (outer dust formation zone). Most of the lines might require a large microturbulence broadening. The derived abundances of C2H2 and HCN increase by factors of 10 and 4, respectively, from the innermost envelope outwards. The derived column densities for both C2H2 and HCN are 1.6E19 cm^-2. Vibrational states up to 3000 K above ground are populated, suggesting pumping by near-infrared radiation from the star and innermost envelope. Low rotational levels can be considered under LTE while those with J>20-30 are not thermalized. A few lines require special analysis to deal with effects like overlap with lines of other molecules.Comment: 8 pages, 16 figures, 2 machine-readable tables, accepted in the Astrophysical Journa

Stellar Inversion Techniques

Stellar seismic inversions have proved to be a powerful technique for probing the internal structure of stars, and paving the way for a better understanding of the underlying physics by revealing some of the shortcomings in current stellar models. In this lecture, we provide an introduction to this topic by explaining kernel-based inversion techniques. Specifically, we explain how various kernels are obtained from the pulsation equations, and describe inversion techniques such as the Regularised Least-Squares (RLS) and Optimally Localised Averages (OLA) methods.Comment: 20 pages, 8 figures. Lecture presented at the IVth Azores International Advanced School in Space Sciences on "Asteroseismology and Exoplanets: Listening to the Stars and Searching for New Worlds" (arXiv:1709.00645), which took place in Horta, Azores Islands, Portugal in July 201

Solar-like oscillations in the G8 V star tau Ceti

We used HARPS to measure oscillations in the low-mass star tau Cet. Although the data were compromised by instrumental noise, we have been able to extract the main features of the oscillations. We found tau Cet to oscillate with an amplitude that is about half that of the Sun, and with a mode lifetime that is slightly shorter than solar. The large frequency separation is 169 muHz, and we have identified modes with degrees 0, 1, 2, and 3. We used the frequencies to estimate the mean density of the star to an accuracy of 0.45% which, combined with the interferometric radius, gives a mass of 0.783 +/- 0.012 M_sun (1.6%).Comment: accepted for publication in A&

Detection of Solar-like Oscillations in the G7 Giant Star xi Hya

We report the firm discovery of solar-like oscillations in a giant star. We monitored the star xi Hya (G7III) continuously during one month with the CORALIE spectrograph attached to the 1.2m Swiss Euler telescope. The 433 high-precision radial-velocity measurements clearly reveal multiple oscillation frequencies in the range 50 - 130 uHz, corresponding to periods between 2.0 and 5.5 hours. The amplitudes of the strongest modes are slightly smaller than 2 m/s. Current model calculations are compatible with the detected modes.Comment: 4 pages, 4 figures, accepted for publication as a letter in A&

p-mode frequencies in solar-like stars : I. Procyon A

As a part of an on-going program to explore the signature of p-modes in solar-like stars by means of high-resolution absorption lines pectroscopy, we have studied four stars (alfaCMi, etaCas A, zetaHer A and betaVir). We present here new results from two-site observations of Procyon A acquired over twelve nights in 1999. Oscillation frequencies for l=1 and l=0 (or 2) p-modes are detected in the power spectra of these Doppler shift measurements. A frequency analysis points out the dificulties of the classical asymptotic theory in representing the p-mode spectrum of Procyon A

The dynamical evolution of the circumstellar gas around low-and intermediate-mass stars I: the AGB

We have investigated the dynamical interaction of low- and-intermediate mass stars (from 1 to 5 Msun) with their interstellar medium (ISM). In this first paper, we examine the structures generated by the stellar winds during the Asymptotic Giant Branch (AGB) phase, using a numerical code and the wind history predicted by stellar evolution. The influence of the external ISM is also taken into account. We find that the wind variations associated with the thermal pulses lead to the formation of transient shells with an average lifetime of 20,000 yr, and consequently do not remain recorded in the density or velocity structure of the gas. The formation of shells that survive at the end of the AGB occurs via two main processes: shocks between the shells formed by two consecutive enhancements of the mass-loss or via continuous accumulation of the material ejected by the star in the interaction region with the ISM. Our models show that the mass of the circumstellar envelope increases appreciably due to the ISM material swept up by the wind (up to 70 % for the 1 Msun stellar model). We also point out the importance of the ISM on the deceleration and compression of the external shells. According to our simulations, large regions (up to 2.5 pc) of neutral gas surrounding the molecular envelopes of AGB stars are expected. These large regions of gas are formed from the mass-loss experienced by the star during the AGB evolution.Comment: 43 pages, 15 figures. Accepted for publication in the Astrophysical Journa

Photoexcitation cascade and multiple hot-carrier generation in graphene

The conversion of light into free electron–hole pairs constitutes the key process in the fields of photodetection and photovoltaics. The efficiency of this process depends on the competition of different relaxation pathways and can be greatly enhanced when photoexcited carriers do not lose energy as heat, but instead transfer their excess energy into the production of additional electron–hole pairs through carrier–carrier scattering processes. Here we use optical pump–terahertz probe measurements to probe different pathways contributing to the ultrafast energy relaxation of photoexcited carriers. Our results indicate that carrier–carrier scattering is highly efficient, prevailing over optical-phonon emission in a wide range of photon wavelengths and leading to the production of secondary hot electrons originating from the conduction band. As hot electrons in graphene can drive currents, multiple hot-carrier generation makes graphene a promising material for highly efficient broadband extraction of light energy into electronic degrees of freedom, enabling high-efficiency optoelectronic applications.United States. Office of Naval Research (Grant N00014-09-1-0724

Enteropathogenicity of Dutch and German avian reoviruses in SPF white leghorn chickens and broilers.

The enteropathogenicity of avian reoviruses (ARVs), isolated from chickens affected with malabsorption syndrome (MAS) from The Netherlands and Germany was studied. In the first trial seven different ARVs isolated from MAS cases were inoculated in 1-day-old specific pathogenic free (SPF) white leghorns. The pathogenicity was compared with 2 ARVs isolated from cases of tenosynovitis, namely reference strain S1133 and a Dutch strain. Although a difference in the severity of the clinical disease was observed, all reoviruses could induce vacuolar degeneration and sloughing of the epithelium of the small intestine at day 2 post inoculation (PI) till day 7 PI. Two Dutch and one German ARV derived from MAS causing the most severe intestinal lesions at day 2 PI, were further studied in the second trial using SPF broilers. These reoviruses did not cause weight gain depression in the broilers although lesions in the small intestine were present from day 1 up to day 4 PI and were more severe than in the white leghorn chickens. In one of the inoculated groups apical denuded villi were already present at day 1 PI. At day 7 PI the small intestine of the infected broilers appeared to be normal. Reovirus antigen was detected in the cytoplasm of the enterocytes at the tip and middle section of the affected villi both in layers and in broilers. To study the role of intestinal CD4 + and CD8 + T-cells and macrophages/monocytes in the pathogenesis of ARV, the numbers of these cells of the jejunal villi of one infected and the control broiler groups were compared. CD4 + T-cells were detected in low numbers and only in the infected broiler group at day 14 PI. The numbers of CD8 + T-cells and macrophages/monocytes were significantly higher in the infected broiler group than in the control broiler group at day 7 and 14 PI and at day 7 PI respectively. Our study indicates that the reovirus alone cannot induce intestinal lesions as found in MAS chickens. Moreover, CD8 + T-cells may play a major role in the pathogenesis and or reovirus clearance in the small intestine

Power, Connected Coalitions, and Efficiency: Challenges to the Council of the European Union

This article is concerned with challenges to reforming the voting procedures of the Council of the European Union (EU). The next major waves of EU enlargement will cause the Union to increase to a membership of first twenty-one, and then twenty-six or possibly even more states. How does enlargement affect the Council's inherent "capacity to act" under the currently used qualified majority voting rule? It is demon strated here that the expected increase in EU membership will most likely induce a larger "status quo bias" as compared to the present situation in the Council if the crucial majority decision quota is not lowered. In addition, the article is responding to some criticism that has been applied against assessing the leverage of EU governments in one of the EU's most important institutions: the Council of the EU. By resorting to techniques that capture the influence of a priori coalitions on the one hand and "connected coalitions" among EU governments on the other—applying n- person cooperative game theory—the piece illustrates how the assessment of relative voting leverage in the framework of weighted voting systems may be extended and applied to situations in which the specific distribu tion of members' preferences is known. These calculations are again relevant in the face of the upcoming rounds of EU enlargement and projects for institutional reform.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68064/2/10.1177_019251219902000404.pd