916 research outputs found
Head-to-head comparison of tau positron emission tomography tracers [F-18]flortaucipir and [F-18]RO948
Purpose:
[18F]flortaucipir binds to paired helical filament tau and accurately identifies tau in Alzheimerâs disease (AD). However, âoff-targetâ binding interferes with the quantification of [18F]flortaucipir in several brain regions. Recently, other tau PET tracers have been developed. Here, we compare [18F]flortaucipir with the novel tau tracer [18F]RO948 head-to-head in vivo.
Methods:
We included 18 participants with AD, three with amyloid-ÎČ-positive amnestic mild cognitive impairment, and four healthy controls. All underwent [18F]flortaucipir (80â100 min) and [18F]RO948 (70â90) PET scans within approximately 1 month. Four study participants underwent 0â100-min dynamic scanning. Standardized uptake value ratios (SUVRs) were created using an inferior cerebellar reference region.
Results:
Neocortical tracer retention was highly comparable using both SUVR and distribution volume ratio-1 values obtained from dynamic scans. However, [18F]RO948 retention was significantly higher in the entorhinal cortex and lower in the basal ganglia, thalamus, and choroid plexus compared with [18F]flortaucipir. Increased off-target binding was observed with age for both tracers. Several cases exhibited strong [18F]RO948 retention in the skull/meninges. This extra-cerebral signal, however, did not affect diagnostic accuracy and remained relatively unchanged when re-examining a subsample after 1 year. Kinetic modeling showed an increase in [18F]flortaucipir SUVR over the scanning interval, compared with a plateau for [18F]RO948.
Conclusion:
[18F]RO948 and [18F]flortaucipir bound comparably in neocortical regions, but [18F]RO948 showed higher retention in the medial temporal lobe and lower intracerebral âoff-targetâ binding. Time-dependent bias of SUVR estimates may prove less of a factor with [18F]RO948, compared with previous tau ligands
Reduction of Birth Weight Among Infants Born to Adolescents: MaternalâFetal Growth Competition
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72838/1/j.1749-6632.1997.tb48213.x.pd
Alternative Interpretation of Sharply Rising E0 Strengths in Transitional Regions
It is shown that strong 0+2 -> 0+1 E0 transitions provide a clear signature
of phase transitional behavior in finite nuclei. Calculations using the IBA
show that these transition strengths exhibit a dramatic and robust increase in
spherical-deformed shape transition regions, that this rise matches well the
existing data, that the predictions of these E0 transitions remain large in
deformed nuclei, and that these properties are intrinsic to the way that
collectivity and deformation develop through the phase transitional region in
the model, arising from the specific d-boson coherence in the wave functions,
and that they do not necessarily require the explicit mixing of normal and
intruder configurations from different IBA spaces.Comment: 6 pages, 3 figure
Transient magnetoconductivity of photoexcited electrons
Transient magnetotransport of two-dimensional electrons with
partially-inverted distribution excited by an ultrashort optical pulse is
studied theoretically. The time-dependent photoconductivity is calculated for
GaAs-based quantum wells by taking into account the relaxation of electron
distribution caused by non-elastic electron-phonon interaction and the
retardation of the response due to momentum relaxation and due to a finite
capacitance of the sample. We predict large-amplitude transient oscillations of
the current density and Hall field (Hall oscillations) with frequencies
corresponding to magnetoplasmon range, which are initiated by the instability
owing to the absolute negative conductivity effect.Comment: 21 pages, 6 fig
The CFEPS Kuiper Belt Survey: Strategy and Pre-survey Results
We present the data acquisition strategy and characterization procedures for
the Canada-France Ecliptic Plane Survey (CFEPS), a sub-component of the
Canada-France-Hawaii Telescope Legacy Survey. The survey began in early 2003
and as of summer 2005 has covered 430 square degrees of sky within a few
degrees of the ecliptic. Moving objects beyond the orbit of Uranus are detected
to a magnitude limit of =23 -- 24 (depending on the image quality). To
track as large a sample as possible and avoid introducing followup bias, we
have developed a multi-epoch observing strategy that is spread over several
years. We present the evolution of the uncertainties in ephemeris position and
orbital elements as the objects progress through the epochs. We then present a
small 10-object sample that was tracked in this manner as part of a preliminary
survey starting a year before the main CFEPS project.
We describe the CFEPS survey simulator, to be released in 2006, which allows
theoretical models of the Kuiper Belt to be compared with the survey
discoveries since CFEPS has a well-documented pointing history with
characterized detection efficiencies as a function of magnitude and rate of
motion on the sky. Using the pre-survey objects we illustrate the usage of the
simulator in modeling the classical Kuiper Belt.Comment: to be submitted to Icaru
The distribution of Quiet Sun magnetic field strengths from 0 to 1800 G
The quiet Sun photospheric plasma has a variety of magnetic field strengths
going from zero to 1800 G. The empirical characterization of these field
strengths requires a probability density function (PDF), i.e., a function P(B)
describing the fraction of quiet Sun occupied by each field strength B. We show
how to combine magnetic field strength measurements based on the Zeeman effect
and the Hanle effect to estimate an unbiased P(B). The application of the
method to real observations renders a set of possible PDFs, which outline the
general characteristics of the quiet Sun magnetic fields. Their most probable
field strength differs from zero. The magnetic energy density is a significant
fraction of the kinetic energy of the granular motions at the base of the
photosphere (larger than 15% or larger than 2 10^{3} erg cm^{-3}). The unsigned
flux density (or mean magnetic field strength) has to be between 130 G and 190
G. A significant part of the unsigned flux (between 10% and 50%) and of the
magnetic energy (between 45% and 85%) are provided by the field strengths
larger than 500 G which, however, occupy only a small fraction of the surface
(between 1% and 10%). The fraction of kG fields in the quiet Sun is even
smaller, but they are important for a number of reasons. The kG fields still
trace a significant fraction of the total magnetic energy, they reach the high
photosphere, and they appear in unpolarized light images. The quiet Sun
photosphere has far more unsigned magnetic flux and magnetic energy than the
active regions and the network all together.Comment: To appear in ApJ. 14 pages, 9 figure
Equilibrium and dynamical properties of two dimensional self-gravitating systems
A system of N classical particles in a 2D periodic cell interacting via
long-range attractive potential is studied. For low energy density a
collapsed phase is identified, while in the high energy limit the particles are
homogeneously distributed. A phase transition from the collapsed to the
homogeneous state occurs at critical energy U_c. A theoretical analysis within
the canonical ensemble identifies such a transition as first order. But
microcanonical simulations reveal a negative specific heat regime near .
The dynamical behaviour of the system is affected by this transition : below
U_c anomalous diffusion is observed, while for U > U_c the motion of the
particles is almost ballistic. In the collapsed phase, finite -effects act
like a noise source of variance O(1/N), that restores normal diffusion on a
time scale diverging with N. As a consequence, the asymptotic diffusion
coefficient will also diverge algebraically with N and superdiffusion will be
observable at any time in the limit N \to \infty. A Lyapunov analysis reveals
that for U > U_c the maximal exponent \lambda decreases proportionally to
N^{-1/3} and vanishes in the mean-field limit. For sufficiently small energy,
in spite of a clear non ergodicity of the system, a common scaling law \lambda
\propto U^{1/2} is observed for any initial conditions.Comment: 17 pages, Revtex - 15 PS Figs - Subimitted to Physical Review E - Two
column version with included figures : less paper waste
Magnetic Coupling in the Quiet Solar Atmosphere
Three kinds of magnetic couplings in the quiet solar atmosphere are
highlighted and discussed, all fundamentally connected to the Lorentz force.
First the coupling of the convecting and overshooting fluid in the surface
layers of the Sun with the magnetic field. Here, the plasma motion provides the
dominant force, which shapes the magnetic field and drives the surface dynamo.
Progress in the understanding of the horizontal magnetic field is summarized
and discussed. Second, the coupling between acoustic waves and the magnetic
field, in particular the phenomenon of wave conversion and wave refraction. It
is described how measurements of wave travel times in the atmosphere can
provide information about the topography of the wave conversion zone, i.e., the
surface of equal Alfv\'en and sound speed. In quiet regions, this surface
separates a highly dynamic magnetic field with fast moving magnetosonic waves
and shocks around and above it from the more slowly evolving field of high-beta
plasma below it. Third, the magnetic field also couples to the radiation field,
which leads to radiative flux channeling and increased anisotropy in the
radiation field. It is shown how faculae can be understood in terms of this
effect. The article starts with an introduction to the magnetic field of the
quiet Sun in the light of new results from the Hinode space observatory and
with a brief survey of measurements of the turbulent magnetic field with the
help of the Hanle effect.Comment: To appear in "Magnetic Coupling between the Interior and the
Atmosphere of the Sun", eds. S.S. Hasan and R.J. Rutten, Astrophysics and
Space Science Proceedings, Springer-Verlag, Heidelberg, Berlin, 200
- âŠ