Characterization of middle‐atmosphere polar warming at Mars

We characterize middle‐atmosphere polar warming (PW) using nearly three Martian years of temperature observations by the Mars Climate Sounder. We report the observed structure of PW and share hypotheses as to possible explanations, which have yet to be tested with global dynamical models. In the data, PW manifested between p  = 15 Pa and p  = 4.8×10 –3  Pa. The latitude where PW maximized shifted poleward with decreasing pressure. The nightside magnitude was larger than the dayside magnitude. The maximum nightside magnitudes ranged from 22 to 67 K. As expected, the annual maximum magnitude in the north occurred during late‐local fall to middle‐local winter. In the south it occurred during late‐local winter. Also as expected, the maximum magnitude near MY 28's southern winter solstice was smaller than that at that same year's northern winter solstice, when a global dust storm was occurring. Unexpectedly, the maximum magnitude at southern winter solstice was comparable to that at northern winter solstice for both MY 29 and MY 30, years that did not experience global dust storms but certainly experienced greater dust loading during L s  = 270° than L s  = 90°. Another unexpected result was a hemispheric asymmetry in PW magnitude during most of the observed equinoxes. This paper also provides tables of (1) averaged temperatures as a function of latitude, pressure, and season, and (2) the maximum polar warming features as a function of pressure and season. These tables can be used to validate GCM calculations of middle‐atmosphere temperatures and constrain calculations of unobserved winds. Key Points Polar warming is characterized based on nearly three MYs of MCS temperatures Average temperatures are provided for validation of modeled temperatures Polar warming characteristics are provided for constraint of modeled windsPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97505/1/jgre20016.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/97505/2/SPICAM_temperatures_v_latitude.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/97505/3/PolarWarming_CrossSections_Dayside.pd

Solar cycle variability of Mars dayside exospheric temperatures: Model evaluation of underlying thermal balances

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95086/1/grl25450.pd

Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy

<p>Abstract</p> <p>Background</p> <p>Resistance to modern adjuvant treatment is in part due to the failure of programmed cell death. Therefore the molecules that execute the apoptotic program are potential targets for the development of anti-cancer therapeutics. The sigma-2 receptor has been found to be over-expressed in some types of malignant tumors, and, recently, small molecule ligands to the sigma-2 receptor were found to induce cancer cell apoptosis.</p> <p>Results</p> <p>The sigma-2 receptor was expressed at high levels in both human and murine pancreas cancer cell lines, with minimal or limited expression in normal tissues, including: brain, kidney, liver, lung, pancreas and spleen. Micro-PET imaging was used to demonstrate that the sigma-2 receptor was preferentially expressed in tumor as opposed to normal tissues in pancreas tumor allograft-bearing mice. Two structurally distinct sigma-2 receptor ligands, SV119 and WC26, were found to induce apoptosis to mice and human pancreatic cancer cells <it>in vitro </it>and <it>in vivo</it>. Sigma-2 receptor ligands induced apoptosis in a dose dependent fashion in all pancreatic cell lines tested. At the highest dose tested (10 μM), all sigma-2 receptor ligands induced 10–20% apoptosis in all pancreatic cancer cell lines tested (p < 0.05). In pancreas tumor allograft-bearing mice, a single bolus dose of WC26 caused approximately 50% apoptosis in the tumor compared to no appreciable apoptosis in tumor-bearing, vehicle-injected control animals (p < 0.0001). WC26 significantly slowed tumor growth after a 5 day treatment compared to vehicle-injected control animals (p < 0.0001) and blood chemistry panels suggested that there is minimal peripheral toxicity.</p> <p>Conclusion</p> <p>We demonstrate a novel therapeutic strategy that induces a significant increase in pancreas cancer cell death. This strategy highlights a new potential target for the treatment of pancreas cancer, which has little in the way of effective treatments.</p

Dysregulated Cytokine Expression by CD4+ T cells from Post-Septic Mice Modulates both Th1 and Th2-Mediated Granulomatous Lung Inflammation

Previous epidemiological studies in humans and experimental studies in animals indicate that survivors of severe sepsis exhibit deficiencies in the activation and effector function of immune cells. In particular, CD4+ T lymphocytes can exhibit reduced proliferative capacity and improper cytokine responses following sepsis. To further investigate the cell-intrinsic defects of CD4+ T cells following sepsis, splenic CD4+ T cells from sham surgery and post-septic mice were transferred into lymphopenic mice. These recipient mice were then subjected to both TH1-(purified protein derivative) and TH2-(Schistosoma mansoni egg antigen) driven models of granulomatous lung inflammation. Post-septic CD4+ T cells mediated smaller TH1 and larger TH2 lung granulomas as compared to mice receiving CD4+ T cells from sham surgery donors. However, cytokine production by lymph node cells in antigen restimulation assays indicated increased pan-specific cytokine expression by post-septic CD4+ T cell recipient mice in both TH1 and TH2 granuloma models. These include increased production of TH2 cytokines in TH1 inflammation, and increased production of TH1 cytokines in TH2 inflammation. These results suggest that cell-intrinsic defects in CD4+ T cell effector function can have deleterious effects on inflammatory processes post-sepsis, due to a defect in the proper regulation of TH-specific cytokine expression

Identification of Metabolites in the Normal Ovary and Their Transformation in Primary and Metastatic Ovarian Cancer

In this study, we characterized the metabolome of the human ovary and identified metabolic alternations that coincide with primary epithelial ovarian cancer (EOC) and metastatic tumors resulting from primary ovarian cancer (MOC) using three analytical platforms: gas chromatography mass spectrometry (GC/MS) and liquid chromatography tandem mass spectrometry (LC/MS/MS) using buffer systems and instrument settings to catalog positive or negative ions. The human ovarian metabolome was found to contain 364 biochemicals and upon transformation of the ovary caused changes in energy utilization, altering metabolites associated with glycolysis and β-oxidation of fatty acids—such as carnitine (1.79 fold in EOC, p<0.001; 1.88 fold in MOC, p<0.001), acetylcarnitine (1.75 fold in EOC, p<0.001; 2.39 fold in MOC, p<0.001), and butyrylcarnitine (3.62 fold, p<0.0094 in EOC; 7.88 fold, p<0.001 in MOC). There were also significant changes in phenylalanine catabolism marked by increases in phenylpyruvate (4.21 fold; p = 0.0098) and phenyllactate (195.45 fold; p<0.0023) in EOC. Ovarian cancer also displayed an enhanced oxidative stress response as indicated by increases in 2-aminobutyrate in EOC (1.46 fold, p = 0.0316) and in MOC (2.25 fold, p<0.001) and several isoforms of tocopherols. We have also identified novel metabolites in the ovary, specifically N-acetylasparate and N-acetyl-aspartyl-glutamate, whose role in ovarian physiology has yet to be determined. These data enhance our understanding of the diverse biochemistry of the human ovary and demonstrate metabolic alterations upon transformation. Furthermore, metabolites with significant changes between groups provide insight into biochemical consequences of transformation and are candidate biomarkers of ovarian oncogenesis. Validation studies are warranted to determine whether these compounds have clinical utility in the diagnosis or clinical management of ovarian cancer patients

Mars Global Ionosphere‐Thermosphere Model: Solar cycle, seasonal, and diurnal variations of the Mars upper atmosphere

A new Mars Global Ionosphere‐Thermosphere Model (M‐GITM) is presented that combines the terrestrial GITM framework with Mars fundamental physical parameters, ion‐neutral chemistry, and key radiative processes in order to capture the basic observed features of the thermal, compositional, and dynamical structure of the Mars atmosphere from the ground to the exosphere (0–250 km). Lower, middle, and upper atmosphere processes are included, based in part upon formulations used in previous lower and upper atmosphere Mars GCMs. This enables the M‐GITM code to be run for various seasonal, solar cycle, and dust conditions. M‐GITM validation studies have focused upon simulations for a range of solar and seasonal conditions. Key upper atmosphere measurements are selected for comparison to corresponding M‐GITM neutral temperatures and neutral‐ion densities. In addition, simulated lower atmosphere temperatures are compared with observations in order to provide a first‐order confirmation of a realistic lower atmosphere. M‐GITM captures solar cycle and seasonal trends in the upper atmosphere that are consistent with observations, yielding significant periodic changes in the temperature structure, the species density distributions, and the large‐scale global wind system. For instance, mid afternoon temperatures near ∼200 km are predicted to vary from ∼210 to 350 K (equinox) and ∼190 to 390 k (aphelion to perihelion) over the solar cycle. These simulations will serve as a benchmark against which to compare episodic variations (e.g., due to solar flares and dust storms) in future M‐GITM studies. Additionally, M‐GITM will be used to support MAVEN mission activities (2014–2016).Key PointsThe Mars Global Ionosphere‐Thermosphere Model (MGITM) is presented and validatedMGITM captures solar cycle, seasonal, and diurnal trends observed above 100 kmMGITM variations will be compared to key episodic variations in future studiesPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110830/1/jgre20354.pd

Probing the Martian atmosphere with MAVEN/IUVS stellar occultations

The first campaign of stellar occultations with the Imaging Ultraviolet Spectrograph (IUVS) instrument on board of Mars Atmosphere and Volatile EvolutioN (MAVEN) mission was executed between 24 and 26 March 2015. From this campaign 13 occultations are used to retrieve CO2 and O2 number densities in the altitude range between 100 and 150 km. Observations probe primarily the low-latitude regions on the nightside of the planet, just past the dawn and dusk terminator. Calculation of temperature from the CO2 density profiles reveals that the lower thermosphere is significantly cooler than predicted by the models in the Mars Climate Database. A systematically cold layer with temperatures of 105-120 K is seen in the occultations at a pressure level around 7 × 10-6 Pa. © 2015. American Geophysical Union. All Rights Reserved