The Micro-Arcsecond Scintillation-Induced Variability (MASIV) Survey II: The First Four Epochs

We report on the variability of 443 flat spectrum, compact radio sources monitored using the VLA for 3 days in 4 epochs at ~ 4 month intervals at 5 GHz as part of the Micro-Arcsecond Scintillation-Induced Variability (MASIV) survey. Over half of these sources exhibited 2-10% rms variations on timescales over 2 days. We analyzed the variations by two independent methods, and find that the rms variability amplitudes of the sources correlate with the emission measure in the ionized Interstellar Medium along their respective lines of sight. We thus link the variations with interstellar scintillation of components of these sources, with some (unknown) fraction of the total flux density contained within a compact region of angular diameter in the range 10-50 micro-arcseconds. We also find that the variations decrease for high mean flux density sources and, most importantly, for high redshift sources. The decrease in variability is probably due either to an increase in the apparent diameter of the source, or a decrease in the flux density of the compact fraction beyond z ~ 2. Here we present a statistical analysis of these results, and a future paper will the discuss the cosmological implications in detail.Comment: 62 pages, 13 figures. Accepted for publication in the Astrophysical Journa

Interstellar scintillation, AGN physics and the SKA

A large fraction of compact, extragalactic radio sources exhibit rapid variability at centimetre wavelengths as their radio emission is scattered by electron density fluctuations in the interstellar medium of the Galaxy. Next-generation wide-field radio telescopes will have to account for this in forming deep images of the radio sky. Interstellar scintillation offers a unique probe of very small-scale structure in both the ionized interstellar medium and the compact jets of the radio sources themselves. The effective resolution is two orders of magnitude higher than achievable with very long baseline interferometry. The recent Micro-Arcsecond Scintillation-Induced Variability Survey revealed a reduction in ISS at 4.9 GHz with increasing source redshift, implying either an increase in the apparent angular size of high-redshift radio cores beyond that expected due to a cosmological decrease in brightness, or a decrease in the microarcsecond-scale core dominance towards high redshift. The result could be due either to source-intrinsic evolution in the selected sample, or to scatter-broadening in the intergalactic medium

Clinical predictors of velocardiofacial syndrome as reported in patients' charts

Objective: The velocardiofacial syndrome (VCFS) involves a deletion of part of chromosome 22 and is associated to more than 180 clinical conditions. With a high variation in clinical findings, early identification of this condition may be difficulty. The objective of this study was to compare clinical findings reported in medical charts in two groups of patients with VCFS: with positive molecular testing and without testing but with clinical sigs of VPI. Methods: A list of patients with VCFS was identified in a large craniofacial center. The first 40 patients with signs of VPI that could be grouped according to presence or absence of molecular testing were included in the study. Results: The charts from 20 patients without molecular tests, 20 patients with positive molecular test for the deletion and 2 with negative molecular test were reviewed. A total of 17 health professional areas reported signs of VCFS in one or more charts, with speech pathologists reporting in all charts, clinical geneticists in 98% and pediatrician in 83% of the charts studied. A list of 31 clinical signs were reported by these professionals. Cardiac and respiratory conditions and behavioral problems were more prevalent in the group with positive molecular test. Incomplete cleft palate was reported for 43% of the patients, submucous cleft palate for 26%, congenital velopharyngeal dysfunction for 19% and other anomalies for 12%. Conclusion: Patients with VCFS that are treated in a Cleft Palate Center are biased to presenting with cleft palate or velopharyngeal dysfunction. Presence of cardiac and respiratory conditions and behavioral problems in this population can be a sign of VCFS

THE ATLAS EXPERIMENT ON-LINE MONITORING AND FILTERING AS AN EXAMPLE OF REAL-TIME APPLICATION

The ATLAS detector, recording LHC particles’ interactions, produces events with rate of40 MHz and size of 1.6 MB. The processes with new and interesting physics phenomena arevery rare, thus an efficient on-line filtering system (trigger) is necessary. The asynchronouspart of that system relays on few thousands of computing nodes running the filtering software.Applying refined filtering criteria results in increase of processing times what may lead tolack of processing resources installed on CERN site. We propose extension to this part ofthe system based on submission of the real-time filtering tasks into the Grid

Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter.Comment: 15 pages, 11 figures. Published in European Physical Journal

Ankyrin is the major oxidised protein in erythrocyte membranes from end-stage renal disease patients on chronic haemodialysis and oxidation is decreased by dialysis and vitamin C supplementation

Chronically haemodialysed end-stage renal disease patients are at high risk of morbidity arising from complications of dialysis, the underlying pathology that has led to renal disease and the complex pathology of chronic kidney disease. Anaemia is commonplace and its origins are multifactorial, involving reduced renal erythropoietin production, accumulation of uremic toxins and an increase in erythrocyte fragility. Oxidative damage is a common risk factor in renal disease and its co-morbidities and is known to cause erythrocyte fragility. Therefore, we have investigated the hypothesis that specific erythrocyte membrane proteins are more oxidised in end-stage renal disease patients and that vitamin C supplementation can ameliorate membrane protein oxidation. Eleven patients and 15 control subjects were recruited to the study. Patients were supplemented with 2 × 500 mg vitamin C per day for 4 weeks. Erythrocyte membrane proteins were prepared pre- and post-vitamin C supplementation for determination of protein oxidation. Total protein carbonyls were reduced by vitamin C supplementation but not by dialysis when investigated by enzyme linked immunosorbent assay. Using a western blot to detect oxidised proteins, one protein band, later identified as containing ankyrin, was found to be oxidised in patients but not controls and was reduced significantly by 60% in all patients after dialysis and by 20% after vitamin C treatment pre-dialysis. Ankyrin oxidation analysis may be useful in a stratified medicines approach as a possible marker to identify requirements for intervention in dialysis patients

Minimally invasive and computer-navigated total hip arthroplasty: a qualitative and systematic review of the literature

ABSTRACT: BACKGROUND: Both minimally invasive surgery (MIS) and computer-assisted surgery (CAS) for total hip arthroplasty (THA) have gained popularity in recent years. We conducted a qualitative and systematic review to assess the effectiveness of MIS, CAS and computer-assisted MIS for THA. METHODS: An extensive computerised literature search of PubMed, Medline, Embase and OVIDSP was conducted. Both randomised clinical trials and controlled clinical trials on the effectiveness of MIS, CAS and computer-assisted MIS for THA were included. Methodological quality was independently assessed by two reviewers. Effect estimates were calculated and a best-evidence synthesis was performed. RESULTS: Four high-quality and 14 medium-quality studies with MIS THA as study contrast, and three high-quality and four medium-quality studies with CAS THA as study contrast were included. No studies with computer-assisted MIS for THA as study contrast were identified. Strong evidence was found for a decrease in operative time and intraoperative blood loss for MIS THA, with no difference in complication rates and risk for acetabular outliers. Strong evidence exists that there is no difference in physical functioning, measured either by questionnaires or by gait analysis. Moderate evidence was found for a shorter length of hospital stay after MIS THA. Conflicting evidence was found for a positive effect of MIS THA on pain in the early postoperative period, but that effect diminished after three months postoperatively. Strong evidence was found for an increase in operative time for CAS THA, and limited evidence was found for a decrease in intraoperative blood loss. Furthermore, strong evidence was found for no difference in complication rates, as well as for a significantly lower risk for acetabular outliers. CONCLUSIONS: The results indicate that MIS THA is a safe surgical procedure, without increases in operative time, blood loss, operative complication rates and component malposition rates. However, the beneficial effect of MIS THA on functional recovery has to be proven. The results also indicate that CAS THA, though resulting in an increase in operative time, may have a positive effect on operative blood loss and operative complication rates. More importantly, the use of CAS results in better positioning of acetabular component of the prosthesis