6,978 research outputs found
Geometry of intensive scalar dissipation events in turbulence
Maxima of the scalar dissipation rate in turbulence appear in form of sheets
and correspond to the potentially most intensive scalar mixing events. Their
cross-section extension determines a locally varying diffusion scale of the
mixing process and extends the classical Batchelor picture of one mean
diffusion scale. The distribution of the local diffusion scales is analysed for
different Reynolds and Schmidt numbers with a fast multiscale technique applied
to very high-resolution simulation data. The scales take always values across
the whole Batchelor range and beyond. Furthermore, their distribution is traced
back to the distribution of the contractive short-time Lyapunov exponent of the
flow.Comment: 4 pages, 5 Postscript figures (2 with reduced quality
Crack Front Waves and the dynamics of a rapidly moving crack
Crack front waves are localized waves that propagate along the leading edge
of a crack. They are generated by the interaction of a crack with a localized
material inhomogeneity. We show that front waves are nonlinear entities that
transport energy, generate surface structure and lead to localized velocity
fluctuations. Their existence locally imparts inertia, which is not
incorporated in current theories of fracture, to initially "massless" cracks.
This, coupled to crack instabilities, yields both inhomogeneity and scaling
behavior within fracture surface structure.Comment: Embedded Latex file including 4 figure
Some exact results for the velocity of cracks propagating in non-linear elastic models
We analyze a piece-wise linear elastic model for the propagation of a crack
in a stripe geometry under mode III conditions, in the absence of dissipation.
The model is continuous in the propagation direction and discrete in the
perpendicular direction. The velocity of the crack is a function of the value
of the applied strain. We find analytically the value of the propagation
velocity close to the Griffith threshold, and close to the strain of uniform
breakdown. Contrary to the case of perfectly harmonic behavior up to the
fracture point, in the piece-wise linear elastic model the crack velocity is
lower than the sound velocity, reaching this limiting value at the strain of
uniform breakdown. We complement the analytical results with numerical
simulations and find excellent agreement.Comment: 9 pages, 13 figure
Cold Stowage Flight Systems
The International Space Station (ISS) provides a test bed for researchers to perform science experiments in a variety of fields, including human research, life sciences, and space medicine. Many of the experiments being conducted today require science samples to be stored and transported in a temperature controlled environment. NASA provides several systems which aid researchers in preserving their science. On orbit systems provided by NASA include the Minus Eighty Laboratory freezer for ISS (MELFI), Microgravity Experiment Research Locker Incubator (MERLIN), and Glacier. These freezers use different technologies to provide rapid cooling and cold stowage at different temperature levels on board ISS. Systems available to researchers during transportation to and from ISS are MERLIN, Glacier, and Coldbag. Coldbag is a passive cold stowage system that uses phase change materials to maintain temperature. Details of these current technologies are provided along with operational experience gained to date. This paper discusses the capability of the current cold stowage hardware and how it may continue to support NASA s mission on ISS and in future exploration missions
p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels.
BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease with few treatment options other than renal replacement therapy. p21, a cyclin kinase inhibitor which has pleiotropic effects on the cell cycle, in many cases acts to suppress cell cycle progression and to prevent apoptosis. Because defects in cell cycle arrest and apoptosis of renal tubular epithelial cells occur in PKD, and in light of earlier reports that polycystin-1 upregulates p21 and that the cyclin-dependent kinase inhibitor roscovitine arrests progression in a mouse model, we asked whether (1) p21 deficiency might underlie ADPKD and (2) the mechanism of the salutary roscovitine effect on PKD involves p21.Methodsp21 levels in human and animal tissue samples as well as cell lines were examined by immunoblotting and/or immunohistochemisty. Apoptosis was assessed by PARP cleavage. p21 expression was attenuated in a renal tubular epithelial cell line by antisense methods, and proliferation in response to p21 attenuation and to roscovitine was assessed by the MTT assay.ResultsWe show that p21 is decreased in human as well as a non-transgenic rat model of ADPKD. In addition, hepatocyte growth factor, which induces transition from a cystic to a tubular phenotype, increases p21 levels. Furthermore, attenuation of p21 results in augmentation of cell cycle transit in vitro. Thus, levels of p21 are inversely correlated with renal tubular epithelial cell proliferation. Roscovitine, which has been shown to arrest progression in a murine model of PKD, increases p21 levels and decreases renal tubular epithelial cell proliferation, with no affect on apoptosis.ConclusionThe novelty of our study is the demonstration in vivo in humans and rat models of a decrement of p21 in cystic kidneys as compared to non-cystic kidneys. Validation of a potential pathogenetic model of increased cyst formation due to enhanced epithelial proliferation and apoptosis mediated by p21 suggests a mechanism for the salutary effect of roscovitine in ADPKD and supports further investigation of p21 as a target for future therapy
Paternal kin recognition in the high frequency / ultrasonic range in a solitary foraging mammal
Background Kin selection is a driving force in the evolution of mammalian social complexity. Recognition of paternal kin using vocalizations occurs in taxa with cohesive, complex social groups. This is the first investigation of paternal kin recognition via vocalizations in a small-brained, solitary foraging mammal, the grey mouse lemur (Microcebus murinus), a frequent model for ancestral primates. We analyzed the high frequency/ultrasonic male advertisement (courtship) call and alarm call. Results Multi-parametric analyses of the calls’ acoustic parameters and discriminant function analyses showed that advertisement calls, but not alarm calls, contain patrilineal signatures. Playback experiments controlling for familiarity showed that females paid more attention to advertisement calls from unrelated males than from their fathers. Reactions to alarm calls from unrelated males and fathers did not differ. Conclusions 1) Findings provide the first evidence of paternal kin recognition via vocalizations in a small-brained, solitarily foraging mammal. 2) High predation, small body size, and dispersed social systems may select for acoustic paternal kin recognition in the high frequency/ultrasonic ranges, thus limiting risks of inbreeding and eavesdropping by predators or conspecific competitors. 3) Paternal kin recognition via vocalizations in mammals is not dependent upon a large brain and high social complexity, but may already have been an integral part of the dispersed social networks from which more complex, kin-based sociality emerged
CO-Dark Star Formation and Black Hole Activity in 3C 368 at z = 1.131: Coeval Growth of Stellar and Supermassive Black Hole Masses
We present the detection of four far-infrared fine-structure oxygen lines, as
well as strong upper limits for the CO(2-1) and [N II] 205 um lines, in 3C 368,
a well-studied radio-loud galaxy at z = 1.131. These new oxygen lines, taken in
conjunction with previously observed neon and carbon fine-structure lines,
suggest a powerful active galactic nucleus (AGN), accompanied by vigorous and
extended star formation. A starburst dominated by O8 stars, with an age of ~6.5
Myr, provides a good fit to the fine-structure line data. This estimated age of
the starburst makes it nearly concurrent with the latest episode of AGN
activity, suggesting a link between the growth of the supermassive black hole
and stellar population in this source. We do not detect the CO(2-1) line, down
to a level twelve times lower than the expected value for star forming
galaxies. This lack of CO line emission is consistent with recent star
formation activity if the star-forming molecular gas has low metallicity, is
highly fractionated (such that CO is photodissociated through much of the
clouds), or is chemically very young (such that CO has not yet had time to
form). It is also possible, though we argue unlikely, that the ensemble of fine
structure lines are emitted from the region heated by the AGN.Comment: 10 pages, 4 figures, 2 tables, accepted for publication in the
Astrophysical Journa
The X-ray luminosity function of AGN at z~3
We combine Lyman-break colour selection with ultradeep (> 200 ks) Chandra
X-ray imaging over a survey area of ~0.35 deg^2 to select high redshift AGN.
Applying careful corrections for both the optical and X-ray selection
functions, the data allow us to make the most accurate determination to date of
the faint end of the X-ray luminosity function (XLF) at z~3. Our methodology
recovers a number density of X-ray sources at this redshift which is at least
as high as previous surveys, demonstrating that it is an effective way of
selecting high z AGN. Comparing to results at z=1, we find no evidence that the
faint slope of the XLF flattens at high z, but we do find significant (factor
~3.6) negative evolution of the space density of low luminosity AGN. Combining
with bright end data from very wide surveys we also see marginal evidence for
continued positive evolution of the characteristic break luminosity L*. Our
data therefore support models of luminosity-dependent density evolution between
z=1 and z=3. A sharp upturn in the the XLF is seen at the very lowest
luminosities (Lx < 10^42.5 erg s^-1), most likely due to the contribution of
pure X-ray starburst galaxies at very faint fluxes.Comment: 16 pages, 9 figures, accepted for publication in MNRA
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