785 research outputs found
The prolate-to-oblate shape transition of phospholipid vesicles in response to frequency variation of an AC electric field can be explained by the dielectric anisotropy of a phospholipid bilayer
The external electric field deforms flaccid phospholipid vesicles into
spheroidal bodies, with the rotational axis aligned with its direction.
Deformation is frequency dependent: in the low frequency range (~ 1 kHz), the
deformation is typically prolate, while increasing the frequency to the 10 kHz
range changes the deformation to oblate. We attempt to explain this behaviour
with a theoretical model, based on the minimization of the total free energy of
the vesicle. The energy terms taken into account include the membrane bending
energy and the energy of the electric field. The latter is calculated from the
electric field via the Maxwell stress tensor, where the membrane is modelled as
anisotropic lossy dielectric. Vesicle deformation in response to varying
frequency is calculated numerically. Using a series expansion, we also derive a
simplified expression for the deformation, which retains the frequency
dependence of the exact expression and may provide a better substitute for the
series expansion used by Winterhalter and Helfrich, which was found to be valid
only in the limit of low frequencies. The model with the anisotropic membrane
permittivity imposes two constraints on the values of material constants:
tangential component of dielectric permittivity tensor of the phospholipid
membrane must exceed its radial component by approximately a factor of 3; and
the membrane conductivity has to be relatively high, approximately one tenth of
the conductivity of the external aqueous medium.Comment: 17 pages, 6 figures; accepted for publication in J. Phys.: Condens.
Matte
Brown dwarfs in the Hyades and beyond?
We have used both the Low-Resolution Imaging Spectrograph and the HIRES
echelle spectrograph on the Keck telescopes to obtain spectra of twelve
candidate members of the Hyades cluster identified by Leggett and Hawkins
(1988, 1989). All of the objects are chromospherically-active, late-type
M-dwarfs, with H equivalent widths varying from 1 to 30\AA. Based on
our measured radial velocities, the level of stellar activity and other
spectroscopic features, only one of the twelve stars has properties consistent
with cluster membership. We consider how this result affects estimates of the
luminosity and mass function of the Hyades cluster. Five of the eleven field
stars have weak K I 7665/7699\AA and CaH absorption as compared with M-dwarf
standards of the same spectral type, suggesting a lower surface gravity. Two of
these sources, LH0416+14 and LH0419+15, exhibit significant lithium 6708 \AA
absorption. Based partly on parallax measurements by the US Naval Observatory
(Harris et al, 1998), we identify all five as likely to be young, pre-main
sequence objects in or near the Taurus-Auriga association at distances of
between 150 and 250 parsecs. A comparison with theoretical models of pre-main
sequence stars indicates masses of less than 0.05 M.Comment: to appear in AJ, January 1999; 34 pages, (Latex format), including 10
embedded postscript figures and two table
BCAT1 redox function maintains mitotic fidelity
The metabolic enzyme branched-chain amino acid transaminase 1 (BCAT1) drives cell proliferation in aggressive cancers such as glioblastoma. Here, we show that BCAT1 localizes to mitotic structures and has a non-metabolic function as a mitotic regulator. Furthermore, BCAT1 is required for chromosome segregation in cancer and induced pluripotent stem cells and tumor growth in human cerebral organoid and mouse syngraft models. Applying gene knockout and rescue strategies, we show that the BCAT1 CXXC redox motif is crucial for controlling cysteine sulfenylation specifically in mitotic cells, promoting Aurora kinase B localization to centromeres, and securing accurate chromosome segregation. These findings offer an explanation for the well-established role of BCAT1 in promoting cancer cell proliferation. In summary, our data establish BCAT1 as a component of the mitotic apparatus that safeguards mitotic fidelity through a moonlighting redox functionality
The 10 Meter South Pole Telescope
The South Pole Telescope (SPT) is a 10 m diameter, wide-field, offset
Gregorian telescope with a 966-pixel, multi-color, millimeter-wave, bolometer
camera. It is located at the Amundsen-Scott South Pole station in Antarctica.
The design of the SPT emphasizes careful control of spillover and scattering,
to minimize noise and false signals due to ground pickup. The key initial
project is a large-area survey at wavelengths of 3, 2 and 1.3 mm, to detect
clusters of galaxies via the Sunyaev-Zeldovich effect and to measure the
small-scale angular power spectrum of the cosmic microwave background (CMB).
The data will be used to characterize the primordial matter power spectrum and
to place constraints on the equation of state of dark energy. A
second-generation camera will measure the polarization of the CMB, potentially
leading to constraints on the neutrino mass and the energy scale of inflation.Comment: 47 pages, 14 figures, updated to match version to be published in
PASP 123 903 (May, 2011
Predicting burst pressure of radiofrequency-induced colorectal anastomosis by bio-impedance measurement
Toward a first-principles integrated simulation of tokamak edge plasmas
Performance of the ITER is anticipated to be highly sensitive to the edge plasma condition. The edge pedestal in ITER needs to be predicted from an integrated simulation of the necessary first-principles, multi-scale physics codes. The mission of the SciDAC Fusion Simulation Project (FSP) Prototype Center for Plasma Edge Simulation (CPES) is to deliver such a code integration framework by (1) building new kinetic codes XGC0 and XGC1, which can simulate the edge pedestal buildup; (2) using and improving the existing MHD codes ELITE, M3D-OMP, M3D-MPP and NIMROD, for study of large-scale edge instabilities called Edge Localized Modes (ELMs); and (3) integrating the codes into a framework using cutting-edge computer science technology. Collaborative effort among physics, computer science, and applied mathematics within CPES has created the first working version of the End-to-end Framework for Fusion Integrated Simulation (EFFIS), which can be used to study the pedestal-ELM cycles
Hereditary Hemorrhagic Telangiectasia: Success of the Osler Calendar for Documentation of Treatment and Course of Disease
Hereditary hemorrhagic telangiectasia (HHT; Rendu-Osler-Weber syndrome) affects the capillary and larger vessels, leading to arteriovenous shunts. Epistaxis is the main symptom impairing quality of life. The aim of the Osler Calendar is to offer information about the extent of the systemic disease and the current state of treatment. A care plan with information on the rare disease and self-treatment of epistaxis was created. Organ examinations and ongoing treatments were recorded. A questionnaire documents the treatment success, including patient satisfaction, frequency of hemorrhage and hemoglobin levels. The patients using the Osler Calendar for at least one year (n = 54) were surveyed. Eighty-five percent of patients (n = 46) used the calendar to gain information about HHT. Seventy-two percent (n = 39) used the Osler Calendar for instructions on the self-treatment of nosebleeds. The calendar increased patients’ understanding for the need for organ screenings from 48% (n = 26) to 81% (n = 44). Seventy-nine percent (n = 43) of patients confirmed that the Osler Calendar documented their therapeutic process either well or very well. Fifty-two percent (n = 28) saw an improvement in the therapeutic process due to the documentation. The Osler Calendar records the individual intensity of the disease and facilitates the communication between attending physicians. It is a tool for specialists to review treatment strategies. Furthermore, the calendar enhances patients’ comprehension of their condition
Non-parametric modeling of the intra-cluster gas using APEX-SZ bolometer imaging data
We demonstrate the usability of mm-wavelength imaging data obtained from the
APEX-SZ bolometer array to derive the radial temperature profile of the hot
intra-cluster gas out to radius r_500 and beyond. The goal is to study the
physical properties of the intra-cluster gas by using a non-parametric
de-projection method that is, aside from the assumption of spherical symmetry,
free from modeling bias. We use publicly available X-ray imaging data from the
XMM-Newton observatory and our Sunyaev-Zel'dovich Effect (SZE) imaging data
from the APEX-SZ experiment at 150 GHz to de-project the density and
temperature profiles for the relaxed cluster Abell 2204. We derive the gas
density, temperature and entropy profiles assuming spherical symmetry, and
obtain the total mass profile under the assumption of hydrostatic equilibrium.
For comparison with X-ray spectroscopic temperature models, a re-analysis of
the recent Chandra observation is done with the latest calibration updates.
Using the non-parametric modeling we demonstrate a decrease of gas temperature
in the cluster outskirts, and also measure the gas entropy profile. These
results are obtained for the first time independently of X-ray spectroscopy,
using SZE and X-ray imaging data. The contribution of the SZE systematic
uncertainties in measuring T_e at large radii is shown to be small compared to
the Chandra systematic spectroscopic errors. The upper limit on M_200 derived
from the non-parametric method is consistent with the NFW model prediction from
weak lensing analysis.Comment: Replaced with the published version; A&A 519, A29 (2010
Indication for the disappearance of reactor electron antineutrinos in the Double Chooz experiment
The Double Chooz Experiment presents an indication of reactor electron
antineutrino disappearance consistent with neutrino oscillations. A ratio of
0.944 0.016 (stat) 0.040 (syst) observed to predicted events was
obtained in 101 days of running at the Chooz Nuclear Power Plant in France,
with two 4.25 GW reactors. The results were obtained from a single 10
m fiducial volume detector located 1050 m from the two reactor cores. The
reactor antineutrino flux prediction used the Bugey4 measurement as an anchor
point. The deficit can be interpreted as an indication of a non-zero value of
the still unmeasured neutrino mixing parameter \sang. Analyzing both the rate
of the prompt positrons and their energy spectrum we find \sang = 0.086
0.041 (stat) 0.030 (syst), or, at 90% CL, 0.015 \sang 0.16.Comment: 7 pages, 4 figures, (new version after PRL referee's comments
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