Self-dual instanton and nonself-dual instanton-antiinstanton solutions in d=4d=4 Yang-Mills theory

Subjecting the SU(2) Yang--Mills system to azimuthal symmetries in both the $x-y$ and the $z-t$ planes results in a residual subsystem described by a U(1) Higgs like model with two complex scalar fields on the quarter plane. The resulting instantons are labeled by integers $(m,n_1,n_2)$ with topological charges $q=\frac12 [1-(-1)^m]n_1n_2$. Solutions are constructed numerically for $m=1,2,3$ and a range of $n_1=n_2=n$. It is found that only the $m=1$ instantons are self-dual, the $m>1$ configurations describing composite instanton-antiinstanton lumps.Comment: 12 pages, 5 Figure

Warm-Mix Asphalt Study: Test Track Construction and FirstLevel Analysis of Phase 3b HVS and Laboratory Testing (Rubberized Asphalt, Mix Design #2)

This is one of two reports describing the third phase of a warm-mix asphalt study that compares the performance of two rubberized asphalt control mixes with that of seven mixes produced with warm-mix technologies. The control mixes were produced and compacted at conventional hot-mix asphalt temperatures (>300 F [150°C]), while the warm-mixes were produced and compacted at temperatures between 36°F (20°C) and 60°F (35°C) lower than the controls. The mixes, test track, Heavy Vehicle Simulator (HVS) and laboratory testing are discussed. Key findings from the study include: Adequate compaction can be achieved on rubberized warm-mixes at lower temperatures. Optimal compaction temperatures will differ. Equal and potentially better rutting performance can be achieved provided that standard specified limits for hot-mix asphalt are met. Test results indicate that use of the warm-mix technologies did not significantly influence performance when compared to control specimens. However, the mixes produced with chemical surfactant technologies did appear to be influenced in part by the lower mix production and construction temperatures, which would have resulted in less oxidation of the binder and consequent lower stiffness of the mix. Rutting performance, fatigue performance and moisture sensitivity did not appear to be affected. The warm-mixes produced using water-foaming technologies appeared to have lower moisture resistance compared to the other warm-mixes. Smoke and odors are significantly reduced on warm-mixes compared to hot-mixes, while workability is considerably better on warm-mixes compared to hot-mixes. The HVS and laboratory testing completed in this phase have provided no results to suggest that warm-mix technologies should not be used in rubberized asphalt in California

Numerical and Experimental Investigation of Residual Stress and Bond Strength in Friction Surface Cladding Process

The bond strength is an essential property of cladded products, which are produced by deposition processes such as friction surface cladding (FSC). Friction and severe plastic deformation of the deposited material cause the process to take place at elevated temperatures, and inhomogeneous cooling after the deposition process can lead to the formation of residual stresses that influence the remaining bond strength. A novel simulation method for the evaluation of the residual stress distribution in clad layer and substrate after the cladding of AA6060 onto an AA2024 substrate is proposed in this study. The effect of residual stresses on the bond strength was correlated with data gathered from 3-point bending tests aimed at the determination of the mechanical properties at the clad layer–substrate interface. The results show that on the one side, the occurrence of a higher compressive residual stress magnitude increases the bond strength, but on the other side, this relationship is not always true for average tool temperature, tool rotating speed, normal force, and tool tilt angle. Therefore, it is necessary to investigate the effect of average tool temperature, tool rotating speed, normal force, and tool tilt angle parameters on the residual stress to find the best process window for carrying out the process to have optimal bond strength.</p

Do HIV treatment eligibility expansions crowd out the sickest? Evidence from rural South Africa

OBJECTIVE: The 2015 WHO recommendation to initiate all HIV patients on antiretroviral therapy (ART) at diagnosis could potentially overextend health systems and crowd out sicker patients, mitigating the policy's impact. We evaluate whether South Africa's prior eligibility expansion from CD4 ≤200 to CD4 ≤350 cells/μL reduced ART uptake in the sickest patients. METHODS: Using data on all patients presenting to the Hlabisa HIV Treatment and Care Program in KwaZulu-Natal from April 2010 - June 2012 (n=13,809), we assessed the impact of the August 2011 eligibility expansion on the number of patients seeking care, number initiating ART, and time from HIV diagnosis to ART initiation among patients always eligible (CD4 0-200), newly eligible (CD4 201-350), and not yet eligible by CD4 count (>350). We used interrupted time series methods to control for long-run trends and isolate the effect of the policy. RESULTS: Expanding ART eligibility led to an increased number of patients initiating ART per month [+95.5; 95% CI (-1.3; 192.3)]. Newly eligible patients (CD4 201-350) initiated treatment 47% faster than before (95% CI 19%; 82%), while the sickest patients (CD4 ≤200) saw no decline in the monthly number of patients initiating treatment or the rate of treatment uptake. CONCLUSION: The Hlabisa program successfully extended ART to patients with CD4 ≤350 cells/μL, while ensuring that the sickest patients did not experience delays in ART initiation. Treatment programs must be vigilant to maintain quality of care for the sickest as countries move to treat all patients irrespective of CD4 count. This article is protected by copyright. All rights reserved

A Map of the Inorganic Ternary Metal Nitrides

Exploratory synthesis in novel chemical spaces is the essence of solid-state chemistry. However, uncharted chemical spaces can be difficult to navigate, especially when materials synthesis is challenging. Nitrides represent one such space, where stringent synthesis constraints have limited the exploration of this important class of functional materials. Here, we employ a suite of computational materials discovery and informatics tools to construct a large stability map of the inorganic ternary metal nitrides. Our map clusters the ternary nitrides into chemical families with distinct stability and metastability, and highlights hundreds of promising new ternary nitride spaces for experimental investigation--from which we experimentally realized 7 new Zn- and Mg-based ternary nitrides. By extracting the mixed metallicity, ionicity, and covalency of solid-state bonding from the DFT-computed electron density, we reveal the complex interplay between chemistry, composition, and electronic structure in governing large-scale stability trends in ternary nitride materials

Design Space Exploration for Distributed Cyber-Physical Systems: State-of-the-art, Challenges, and Directions

Computer Systems, Imagery and Medi

Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart

The muscular ventricular septum separates the flow of oxygenated and de-oxygenated blood in air-breathing vertebrates. Defects within it, termed muscular ventricular septal defects (VSDs), are common, yet less is known about how they arise than rarer heart defects. Mutations of the cardiac transcription factor NKX2-5 cause cardiac malformations, including muscular VSDs. We describe here a genetic interaction between Nkx2-5 and Sarcospan (Sspn) that affects the risk of muscular VSD in mice. Sspn encodes a protein in the dystrophin-glycoprotein complex. Sspn knockout (Sspn(KO)) mice do not have heart defects, but Nkx2-5(+/−)/Sspn(KO) mutants have a higher incidence of muscular VSD than Nkx2-5(+/−) mice. Myofibers in the ventricular septum follow a stereotypical pattern that is disrupted around a muscular VSD. Subendocardial myofibers normally run in parallel along the left ventricular outflow tract, but in the Nkx2-5(+/−)/Sspn(KO) mutant they commonly deviate into the septum even in the absence of a muscular VSD. Thus, Nkx2-5 and Sspn act in a pathway that affects the alignment of myofibers during the development of the ventricular septum. The malalignment may be a consequence of a defect in the coalescence of trabeculae into the developing ventricular septum, which has been hypothesized to be the mechanistic basis of muscular VSDs