Four Years of Jointness at Scott Paper Company and the United Paperworkers International Union (UPIU): Background Information Submitted to the Commission on the Future of Worker-Management Relations

Includes Scott/UPIU Joint Declaration Statement.Background_Scott_Paper_091593.pdf: 376 downloads, before Oct. 1, 2020

Marrying biomolecules and nanoparticles for diagnostics and nanomedicine

Noble metal nanoparticles (NPs) such as silver and gold NPs, at the size range of 1-100 nm have attracted enormous scientific and technological interest due to their unique optical, electronic and catalytic properties, which are largely determined by their size, shape and crystal structure. Inspired by the natural biomineralization process on using biomolecular templates to form a range of sophisticated inorganic nanostructures, our current research efforts focus on the development of bioinspired metal NPs with tunable physicochemical properties that incorporate the highly specific recognition function of biomolecules for a vast plethora of biomedical applications. Firstly, I will talk about the rational design of peptide and nucleic acid-based biomolecular templates for the biomimetic synthesis of multifunctional metal NPs with different optical properties (i.e., plasmon absorption and light emission) and integrated biofunctionalities for biosensing, imaging, delivery and therapy.1-7 Recently, we have designed a unique self-assembly DNA templates to form redox-responsive photoluminescent silver nanoclusters (NCs \u3c 2 nm in size) for two-way color change detection of free radicals (red-to-blue) and antioxidants (blue-to-red) in real time. These DNA-templated AgNCs are found to have excellent antimicrobial and toxin inhibition properties towards superbugs. Using bi-functional peptide templates, AuNCs with tunable emission color from visible to near-infrared wavelength have been successfully synthesized for targeted gene delivery and bioimaging applications. We have also employed this bioinspired approach to ‘turn’ the native protein into bioactive fluorescent sensors for small molecule drug screening and photodynamic therapy. The biocompatibility and adaptability of biomolecules involved in the synthesis enable an efficient control over nanostructures morphology (size and shape) with fine-tuned properties, resulting in low energy use and environmental impact. The second part of my talk will focus on the biofunctionalization strategies of nanometals for the development of ultrasensitive biosensors, to convert ‘invisible’ biological responses into easily measurable and observable optical outputs.8-13 By exploiting the plasmonic coupling, fluorescence and/or light scattering properties of the nanometals, we have developed a series of label-free optical nanosensors to detect a wide range of bioanalytes (e.g., vitamins, small molecule drug, etc.) and for studying important biomolecular interactions such as gene transcription, DNA mutation and enzymatic reaction. These bioassays are versatile, efficient and low-cost with high throughput sensing capability, which could culminate into tangible products useful for biomedical research and clinical diagnostics. References Tan, Y. N.; Lee, J. Y.; Wang, Daniel. I. C. J. Am. Chem. Soc. 2010, 132, 5677-5686. Tan, Y. N.; Lee, J. Y.; Wang, Daniel. I. C. J. Phys. Chem. C. 2009, 113, 10887-10895 Tan, Y. N.; Lee, J. Y.; Wang, Daniel. I. C. J. Phys. Chem. C.2008, 112, 5463-5470. Yung, Y.; Luo, Z.; Teo, C.S.; Tan, Y. N.*; Xie, J.* Chem. comm., 2013, 49, 9740-9742. Yu, Y.; Li, J.; Chen, T.; Tan, Y. N.*; Xie, J.* J. Phys. Chem. C. 2015, 119, 10910–10918 Yu, Y; New, S. Y.; Xie, J.; Su, X.*; Tan, Y. N.* Chem. comm., 2014, 50, 13805-13808. Geng, J.; Goh, Walter L.P.; Zhang, C.; Lane, David.; Liu, B.; Ghadessy, Farid J*.; Tan, Y. N.* J. Mater. Chem. B. 2015,3, 5933-5937 Tan, Y. N.; Lai, A.; Su, X. Sci. Adv. Mater, 2014, 6 (7), 1460-1466. Seow N.; Tan, Y. N.*; Su, X.; Lanry Yung*, Scientific Report, 2015, 5:18293. doi: 10.1038/srep18293. Tan, Y. N.; Lee, K. H.; Su, X. RCS Advances, 2013, 3, 21604-21612. Tan, Y. N.; Lee, K. H.; Su, X. Anal. Chem. 2011, 83 (11), 4251–4257. Tan, Y. N.; Su, X.; Zhu, Y.; Lee, J. Y. ACS Nano 2010, 4, 5101–5110. Tan, Y. N.; Su, X.; Liu, Edison T.; Thomsen, J. S. Anal. Chem. 2010, 82, 2759-2765

Levi Pennington Writing to Don Beede, February 28, 1947

Levi Pennington writing to Don Beede, who was just released by the court, telling him about the new resolutions of the Oregon Council of Churches against war, drinking, gambling, and calling for more relief. (Possible typo- could be January 28).https://digitalcommons.georgefox.edu/levi_pennington/1128/thumbnail.jp

Chemical Evaluation Of Lignocellulolytic Microbes, Yeast and Lactobacilli Addition to Rice Straw at Silage preservation

ABSTRACT Lignocelluiolytie microbial isolate, Trichoderma reseei and rumen fluid, Lactobacilli plantarum and Ithizopus sp were used as starter for rice straw silage fermentation. The fermentation have an objective to improve the nutritive value of nee straw. There were four different fermented rice straw in respect to various starter used. Fl, using T reseei - L. plontorumF2, rumen fluid isolate - L. plantarumF3 nimcn fluid and added by L. &martini as prohioticF4, T. reseei - Wrizopus sp, plantarlim. Mier three weeks fermentation, sample were taken out to the analyzed their nutritive value which were include moisture, dry matter. fat,crude protein, true protein, crude fibre, Neutral Detergen Fibre (NDF), Acid Dctcrgcn Fibre (ADF), ash, and pH. The result of the experiment showed that the fermentation improved of nutritive value (

Indiana Inspiration

Midwest shelter goes the distance to help animals in nee

Bioactive compounds from Ploiarium alternifolium (Theaceae) and Calophyllum mucigerum (Guttiferae)

Chemical and cytotoxic studies were carried out on two plant species, Caiophyllum mucigerum (Guttiferae) and Ploiarium alternifolium (Theaceae). The chemical investigations covered anthraquinones, triterpenes, xanthone and coumarins. These compounds were isolated using common chromatographic techniques and HPLC and identified using spectroscopic methods including 2-D NMR, GCMS, MS, IR andUV. Ploiarium alternifolium provided emodin, ploiariquinone A, 1,8-dihydroxy-3- methyl-6-methoxy-anthraquinone, 3 β-benzoyloxyolean-ll-en-13β,28-olide and euxanmodin C. Emodin and 1, 8-dihydroxy-3-metbyl-6-methoxy-antbraquinone have not been reported from Ploairium aiternifolium. Calophyllum mucigerum gave the common steroidal triterpenes friedelin and stigmasterol, a prenylated xanthone cudraxanthone C and two new coumarins mucigerin I and mucigerin II. The crude n-hexane, ethyl acetate and ethanol stem bark extracts of both plants were screened for their larvicidal activity against the larvae of Aedes aegypti. The crude n-hexane, ethyl acetate and ethanol extracts for both of the plants were susceptible to the larvae of Aedes aegypti with LC₅₀ values of 95.0 µg/ml, 129.4 µg/ml and 131.6 µg/ml, respectively for Ploiarium alternifolium whereas 87.9 µg/ml, 138.5 µg/ml and 147.4 µg/ml, respectively for Calophyllum mucigerum. Larvicidal activity on the pure compound, emodin gave an LCso value of 2.79 µg/ml. The cytotoxicity, antibacterial and antifungal activities test were also carried out on the three crude extracts of both plants and also on the pure compounds. Cytotoxicities were determined by performing the microtitration assay. All the crude extracts were weakly cytotoxic towards the CEM-SS cell line except hexane extracts from C. mucigerum and P. alternifolium which gave moderate activity with IC₅₀ = 16.2 µg/ml and lC₅₀ = 19.2 µg/ml, respectively. The pure compound euxanmodin C was the most sensitive against the cell line with IC₅₀ = 5.9 µg/ml. The antimicrobial activity was tested using the modified disc diffusion method. The crude extracts from both plants also showed different antimicrobial activity against the growth of four bacteria; Bacillus subtiUs mutant, Bacillus subtilis wild type, Staphyloccus aures and Pseudomonas aeruginosa. However, these crude extracts were weakly active against the bacteria with less than 10 mm diameter inhibition zone

Mathematical modeling of radiant heating of a closed rectangular area under conditions of convective heat transfer at the external boundaries

Mathematical modeling of radiant heating of a closed rectangular area under conditions of convective heat transfer at the external boundaries is passed. The fields of temperature and stream function, illustrating the unsteady nature of the heat transfer were obtained. The extent influence of convective heat transfer at the external boundaries on the circulating flows formation in the gas cavity are shown