1,946 research outputs found
The Stripe 82 1-2 GHz Very Large Array Snapshot Survey: Multiwavelength Counterparts
We have combined spectrosopic and photometric data from the Sloan Digital Sky
Survey (SDSS) with GHz radio observations, conducted as part of the
Stripe 82 GHz Snapshot Survey using the Karl G. Jansky Very Large Array
(VLA), which covers sq degrees, to a flux limit of 88 Jy rms.
Cross-matching the radio source components with optical data via
visual inspection results in a final sample of cross-matched objects,
of which have spectroscopic redshifts and objects have
photometric redshifts. Three previously undiscovered Giant Radio Galaxies
(GRGs) were found during the cross-matching process, which would have been
missed using automated techniques. For the objects with spectroscopy we
separate radio-loud Active Galactic Nuclei (AGN) and star-forming galaxies
(SFGs) using three diagnostics and then further divide our radio-loud AGN into
the HERG and LERG populations. A control matched sample of HERGs and LERGs,
matched on stellar mass, redshift and radio luminosity, reveals that the host
galaxies of LERGs are redder and more concentrated than HERGs. By combining
with near-infrared data, we demonstrate that LERGs also follow a tight
relationship. These results imply the LERG population are hosted by population
of massive, passively evolving early-type galaxies. We go on to show that
HERGs, LERGs, QSOs and star-forming galaxies in our sample all reside in
different regions of a WISE colour-colour diagram. This cross-matched sample
bridges the gap between previous `wide but shallow' and `deep but narrow'
samples and will be useful for a number of future investigations.Comment: 17 pages, 19 figures. Resubmitted to MNRAS after the initial comment
When membranes need an ESCRT : endosomal sorting and membrane remodelling in health and disease
Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell. Deregulation of ESCRT activity is observed in neuro-degenerative diseases, virus infection and cancer. However, the mechanisms of pathogenesis involving ESCRTs have not yet fully come into focus. Here, we review the current knowledge of ESCRT function in health and disease and provide educated guesses for future research and focused therapeutic intervention
At the crossroads of polarity, proliferation and apoptosis : The use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression
Endocytosis is an important regulator of cell-cell signaling and endocytic trafficking has been increasingly implicated in control of tumor suppression. Recent insights from Drosophila indicate that impairment of multiple trafficking steps which lead to receptor degradation can cause tumor formation in epithelial organs. These tumors are characterized by sustained activation of a number of mitogenic signaling pathways, and by subversion of epithelial polarity and the apoptotic response. Cooperation between such alterations, as well as tumor-host interactions, is also observed. The recapitulation of several hallmarks of human cancers in fly tumors provides a framework to understand the role of defective endocytosis in cancer. \ua9 2009 Federation of European Biochemical Societies
High-pressure behaviour of GeO2: a simulation study
In this work we study the high pressure behaviour of liquid and glassy GeO2
by means of molecular dynamics simulations. The interaction potential, which
includes dipole polarization effects, was parameterized from first-principles
calculations. Our simulations reproduce the most recent experimental data to a
high degree of precision. The proportion of the various GeOn polyhedra is
determined as a function of the pressure: a smooth transition from tetrahedral
to octahedral network is observed. Finally, the study of high-pressure, liquid
germania confirms that this material presents an anomalous behaviour of the
diffusivity as observed in analog systems such as silica and water. The
importance of penta-coordinated germanium ions for such behaviour is stressed.Comment: 16 pages, 4 figures, accepted as a Fast Track Communication on
Journal of Physics: Condensed Matte
Of Echo Chambers and Contrarian Clubs:Exposure to Political Disagreement Among German and Italian Users of Twitter
Scholars have debated whether social media platforms, by allowing users to select the information to which they are exposed, may lead people to isolate themselves from viewpoints with which they disagree, thereby serving as political “echo chambers.” We investigate hypotheses concerning the circumstances under which Twitter users who communicate about elections would engage with (a) supportive, (b) oppositional, and (c) mixed political networks. Based on online surveys of representative samples of Italian and German individuals who posted at least one Twitter message about elections in 2013, we find substantial differences in the extent to which social media facilitates exposure to similar versus dissimilar political views. Our results suggest that exposure to supportive, oppositional, or mixed political networks on social media can be explained by broader patterns of political conversation (i.e., structure of offline networks) and specific habits in the political use of social media (i.e., the intensity of political discussion). These findings suggest that disagreement persists on social media even when ideological homophily is the modal outcome, and that scholars should pay more attention to specific situational and dispositional factors when evaluating the implications of social media for political communication
Modulating the WNT pathway in Drosophila models of Cornelia de Lange Syndrome
Cornelia de Lange syndrome (CdLS) is a rare genetic disorder affecting neurodevelopment and the gastrointestinal and musculoskeletal systems. CdLS is caused by mutations within NIPBL, SMC1A, SMC3, RAD21, HDAC8 and BRD4 genes. These genes codify for the cohesin complex (or associated proteins), a multiprotein structure playing a role in chromatid adhesion, DNA repair and gene expression regulation. Our laboratory has shown that a strong correlation exists between cohesin complex function and WNT signalling, an intracellular pathway involved in regulation of expression of several genes controlling cell division and embryonic development. Recently, it has been observed that in nipblb- and smc1a-loss-of-function zebrafish embryos, in NIPBL- and SMC1A- mutated patient fibroblasts and in CdLS murine neural stem cells (NSCs) similar patterns of canonical WNT pathway alterations and cyclinD1 downregulation are present. Indeed, zebrafish embryos adverse phenotype was rescued by chemical activation of the WNT pathway. Drosophila melanogaster is an inexpensive model to study CdLS and to screen in vivo for therapeutic compounds. Therefore, we have used flies\u2019 strains mutated in nipped-B and hdac3 genes (respectively NIPBL and HDAC8 in humans) for assessing the existing correlation between cohesin complex and WNT pathway. Moreover, we have selected D. melanogaster mutants to screen for chemicals that revert the CdLS associated-phenotypes efficiently. In particular, we have tested WNT activators in order to investigate which effects they have on the mutated flies, assessing body weight and changes in brain structures (i.e. mushroom bodies) and possibly select compounds to test on vertebrate models. Funding: This work has been supported by Fondazione Cariplo, grant 2015-0783 to Valentina Massa
The young and happy marriage of membrane traffic and cell polarity
The ESF-EMBO meeting on Cell Polarity and Membrane Traffic took place in Poland in April 2012. It brought together scientists from two once separate fields and highlighted their emerging interdependence. The wealth of scientific insights and discoveries presented laid a path for future research
Optically variable active galactic nuclei in the 3 yr VST survey of the COSMOS field
The analysis of the variability of active galactic nuclei (AGNs) at different
wavelengths and the study of possible correlations among different spectral
windows are nowadays a major field of inquiry. Optical variability has been
largely used to identify AGNs in multivisit surveys. The strength of a
selection based on optical variability lies in the chance to analyze data from
surveys of large sky areas by ground-based telescopes. However the
effectiveness of optical variability selection, with respect to other
multiwavelength techniques, has been poorly studied down to the depth expected
from next generation surveys. Here we present the results of our r-band
analysis of a sample of 299 optically variable AGN candidates in the VST survey
of the COSMOS field, counting 54 visits spread over three observing seasons
spanning > 3 yr. This dataset is > 3 times larger in size than the one
presented in our previous analysis (De Cicco et al. 2015), and the observing
baseline is ~8 times longer. We push towards deeper magnitudes (r(AB) ~23.5
mag) compared to past studies; we make wide use of ancillary multiwavelength
catalogs in order to confirm the nature of our AGN candidates, and constrain
the accuracy of the method based on spectroscopic and photometric diagnostics.
We also perform tests aimed at assessing the relevance of dense sampling in
view of future wide-field surveys. We demonstrate that the method allows the
selection of high-purity (> 86%) samples. We take advantage of the longer
observing baseline to achieve great improvement in the completeness of our
sample with respect to X-ray and spectroscopically confirmed samples of AGNs
(59%, vs. ~15% in our previous work), as well as in the completeness of
unobscured and obscured AGNs. The effectiveness of the method confirms the
importance to develop future, more refined techniques for the automated
analysis of larger datasets.Comment: 21 pages, 10 figures; accepted for publication in A&
Unbiased large spectroscopic surveys of galaxies selected by SPICA using dust bands
The mid-infrared (IR) range contains many spectral features associated with
large molecules and dust grains such as polycyclic aromatic hydrocarbons (PAHs)
and silicates. These are usually very strong compared to fine-structure gas
lines, and thus valuable in studying the spectral properties of faint distant
galaxies. In this paper, we evaluate the capability of low-resolution mid-IR
spectroscopic surveys of galaxies that could be performed by SPICA. The surveys
are designed to address the question how star formation and black hole
accretion activities evolved over cosmic time through spectral diagnostics of
the physical conditions of the interstellar/circumnuclear media in galaxies. On
the basis of results obtained with Herschel far-IR photometric surveys of
distant galaxies and Spitzer and AKARI near- to mid-IR spectroscopic
observations of nearby galaxies, we estimate the numbers of the galaxies at
redshift z > 0.5, which are expected to be detected in the PAH features or dust
continuum by a wide (10 deg^2) or deep (1 deg^2) blind survey, both for a given
observation time of 600 hours. As by-products of the wide blind survey, we also
expect to detect debris disks, through the mid-IR excess above the photospheric
emission of nearby main-sequence stars, and we estimate their number. We
demonstrate that the SPICA mid-IR surveys will efficiently provide us with
unprecedentedly large spectral samples, which can be studied further in the
far-IR with SPICA.Comment: Paper accepted for publication on PASA on 18th October 2017, as part
of the SPICA Special Issu
- …