Process transparency on construction sites : examples from construction companies in Brazil

Process transparency is the core concept in Visual Management (VM), which is one of the founding blocks of the Toyota Production System. This paper presents the preliminary results of a collaborative research conducted between Brazil and the UK, as part of a research effort focused on the application of Visual Management in construction. How process transparency is realized on construction sites is the main research question of the paper. The use of this concept and the implementation of the transparency theory were investigated through multiple case studies, carried out in nine different construction companies. The findings are explained through six theoretical transparency increasing approaches. The affecting parameters in the application of, the management’s perception of and several methods in process transparency in construction were identified. Further work, especially exploring the functions of process transparency on construction sites and reflecting the worker perception of the issue, is necessary to elaborate the process transparency concept

Human-induced earthquakes: E-PIE—a generic tool for Evaluating Proposals of Induced Earthquakes

The HiQuake database documents all cases of earthquake sequences proposed on scientific grounds to have been induced by anthropogenic industrial activity. Because these cases range from being highly plausible to unpersuasive, stakeholders have requested cases to be allocated plausibility grades. Since no questionnaire scheme existed that was sufficiently generalized to be applied to the diverse cases in HiQuake, we developed a new scheme for the task. Our scheme for Evaluating Proposals of Induced Earthquakes (E-PIE) comprises nine generalized questions with a simple weighting system to adjust for the variable diagnostic strength of different observations. Results are illustrated using a simple colored pie chart. We describe the E-PIE scheme and illustrate its application in detail using the example cases of the Groningen gas field in the Netherlands, the November 2017 M5.4 Pohang Enhanced Geothermal Systems-related earthquake sequence in South Korea, and the 2001 deep-penetrating bombing of Tora Bora, Afghanistan. To test the performance of E-PIE, five analysts independently applied it to a suite of 23 diverse cases from HiQuake. By far the most diagnostic questions are those concerning spatial and temporal correlations with industrial effects. Other data are diagnostically subsidiary. For individual cases, the agreement between analysts correlated positively with the strength of evidence for human induction. E-PIE results agree well with those from a specialist scheme tailored to fluid-injection cases. Its strong performance confirms its suitability to apply to the entire HiQuake database

The study of dynamic singularities of seismic signals by the generalized Langevin equation

Analytically and quantitatively we reveal that the generalized Langevin equation (GLE), based on a memory function approach, in which memory functions and information measures of statistical memory play a fundamental role in determining the thin details of the stochastic behavior of seismic systems, naturally leads to a description of seismic phenomena in terms of strong and weak memory. Due to a discreteness of seismic signals we use a finite-discrete form of the GLE. Here we studied some cases of seismic activities of Earth ground motion in Turkey with consideration of the complexity, nonergodicity and fractality of seismic signals. © 2009 Elsevier B.V. All rights reserved

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid

Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment with the antioxidant alpha-lipoic acid (LA). Methods: Cultured ONH astrocytes were treated with 1.0 ng/ml TGF-beta(2) for 24 h or 200 mu M hydrogen peroxide (H2O2) for 1 h. Lipid peroxidation was measured by a decrease in cis-pari-naric acid fluorescence. Additionally, cells were pretreated with different concentrations of LA before TGF-beta 2 or H2O2 exposure. Expressions of the heat shock protein (Hsp) alpha B-crystallin and Hsp27, the extracellular matrix (ECM) component fibronectin and the ECM-modulating protein connective tissue growth factor (CTGF) were examined with immunohistochemistry and real-time PCR analysis. Results: Both TGF-beta(2) and H2O2 increased lipid peroxidation. Treatment of astrocytes with TGF-beta(2) and H2O2 upregulated the expression of alpha B-crystallin, Hsp27, fibronectin and CTGF. Pretreatment with different concentrations of LA reduced the TGF-beta(2)- and H2O2-stimulated gene expressions. Conclusion: We showed that TGF-beta(2)- and H2O2-stimulated gene expressions could be prevented by pretreatment with the antioxidant LA in cultured human ONH astrocytes. Therefore, it is tempting to speculate that the use of antioxidants could have protective effects in glaucomatous optic neuropathy. Copyright (C) 2012 S. Karger AG, Base

Design science research in lean construction: Process and outcomes

Design science (or constructive) research is a mode of producing scientific knowledge. It differs from explanatory research whose goal is to describe, understand and eventually predict phenomena of a particular field. Alternatively, the goal of design science research is to develop scientifically grounded solutions that are able to solve real-world problems. In this way, it establishes an appropriate link between theory and practice, strengthening the relevance of academic research. This paper discusses the design science research approach and illustrates through the analysis of two Ph.D investigations how it can be adopted in lean construction. In this paper, the outcomes and the research process adopted in these investigations are presented. At the end, some conclusions concerning the outcomes achieved and the activities involved in conducting design science in lean construction are discussed

The two sides of cytokine signaling and glaucomatous optic neuropathy

The mechanistic study of glaucoma pathogenesis has shifted to seeking to understand the effects of immune responses on retinal ganglion cell damage and protection. Cytokines are the hormonal factors that mediate most of the biological effects in both the immune and nonimmune systems. CD4-expressing T helper cells are a major source of cytokine production and regulation. Type 1 helper T (Th1) cells are characterized by the production of proinflammatory cytokines such as interferon-gamma, interleukin (IL)-2, IL-12, IL-23, and tumor necrosis factor-alpha while type 2 helper T (Th2) cells are characterized by the production of IL-4, IL-5, IL-6, and IL-10. The balance of Th1/Th2 cytokine production influences many pathological processes and plays both causative and protective roles in neuron damages. Growing evidence indicates that imbalances of Th1/Th2 cytokine production are involved in neural damage or protection in many neurological diseases. In this review, we discuss the possible roles of Th1/Th2 cytokine production and imbalance of Th1/Th2 cytokines in retina, especially glaucomatous optic neuropathy

Novel role for the innate immune receptor toll-like receptor 4 (TLR4) in the regulation of the wnt signaling pathway and photoreceptor apoptosis

Recent evidence has implicated innate immunity in regulating neuronal survival in the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons in the retina that are essential for vision. In this study, we investigated the role of the innate immunity receptor TLR4 in photoreceptors. TLR4 activation by lipopolysaccharide (LPS) significantly reduced the survival of cultured mouse photoreceptors exposed to oxidative stress. With respect to mechanism, TLR4 suppressed Wnt signaling, decreased phosphorylation and activation of the Wnt receptor LRP6, and blocked the protective effect of the Wnt3a ligand. Paradoxically, TLR4 activation prior to oxidative injury protected photoreceptors, in a phenomenon known as preconditioning. Expression of TNFα and its receptors TNFR1 and TNFR2 decreased during preconditioning, and preconditioning was mimicked by TNFα antagonists, but was independent of Wnt signaling. Therefore, TLR4 is a novel regulator of photoreceptor survival that acts through the Wnt and TNFα pathways. © 2012 Yi et al

Comprehensive functional characterization of complement factor I rare variant genotypes identified in the SCOPE geographic atrophy cohort

\ua9 2024 The AuthorsRare variants (RVs) in the gene encoding the regulatory enzyme complement factor I (CFI; FI) that reduce protein function or levels increase age-related macular degeneration risk. A total of 3357 subjects underwent screening in the SCOPE natural history study for geographic atrophy secondary to age-related macular degeneration, including CFI sequencing and serum FI measurement. Eleven CFI RV genotypes that were challenging to categorize as type I (low serum level) or type II (normal serum level, reduced enzymatic function) were characterized in the context of pure FI protein in C3b and C4b fluid phase cleavage assays and a novel bead-based functional assay (BBFA) of C3b cleavage. Four variants predicted or previously characterized as benign were analyzed by BBFA for comparison. In all, three variants (W51S, C67R, and I370T) resulted in low expression. Furthermore, four variants (P64L, R339Q, G527V, and P528T) were identified as being highly deleterious with IC50s for C3b breakdown >1 log increased versus the WT protein, while two variants (K476E and R474Q) were ∼1 log reduced in function. Meanwhile, six variants (P50A, T203I, K441R, E548Q, P553S, and S570T) had IC50s similar to WT. Odds ratios and BBFA IC50s were positively correlated (r = 0.76, p < 0.01), while odds ratios versus combined annotation dependent depletion (CADD) scores were not (r = 0.43, p = 0.16). Overall, 15 CFI RVs were functionally characterized which may aid future patient stratification for complement-targeted therapies. Pure protein in vitro analysis remains the gold standard for determining the functional consequence of CFI RVs

Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study

<p>Abstract</p> <p>Background</p> <p>Normal tension glaucoma is a major subtype of glaucoma, associated with intraocular pressures that are within the statistically normal range of the population. Monogenic forms following classical inheritance patterns are rare in this glaucoma subtype. Instead, multigenic inheritance is proposed for the majority of cases. The present study tested common sequence variants in candidate genes for association with normal tension glaucoma in the German population.</p> <p>Methods</p> <p>Ninety-eight SNPs were selected to tag the common genetic variation in nine genes, namely OPTN (optineurin), RDX (radixin), SNX16 (sorting nexin 16), OPA1 (optic atrophy 1), MFN1 (mitofusin 1), MFN2 (mitofusin 2), PARL (presenilin associated, rhomboid-like), SOD2 (superoxide dismutase 2, mitochondrial) and CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1). These SNPs were genotyped in 285 cases and 282 fully evaluated matched controls. Statistical analyses comprised single polymorphism association as well as haplogroup based association testing.</p> <p>Results</p> <p>Results suggested that genetic variation in five of the candidate genes (RDX, SNX16, OPA1, SOD2 and CYP1B1) is unlikely to confer major risk to develop normal tension glaucoma in the German population. In contrast, we observed a trend towards association of single SNPs in OPTN, MFN1, MFN2 and PARL. The SNPs of OPTN, MFN2 and PARL were further analysed by multimarker haplotype-based association testing. We identified a risk haplotype being more frequent in patients and a vice versa situation for the complementary protective haplotype in each of the three genes.</p> <p>Conclusion</p> <p>Common variants of OPTN, PARL, MFN1 and MFN2 should be analysed in other cohorts to confirm their involvement in normal tension glaucoma.</p