17,814 research outputs found

    The impacts for stone curlews of increased traffic on the A11. Model and predictions

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    Stone curlew nest density in the Breckland region of Eastern England was shown to be negatively related to ‘nearby’ housing density and ‘nearby’ trunk road traffic (based on new traffic data for the period 1988-2006). However, no statistically significant additional relationship with non-trunk A-road traffic could be detected. We recommend using the statistical modelling predictions in the report Table 5 as the best currently available estimates of the potential effect of a 70% increase in A11 average daily (March-August)two-way traffic above the average All traffic levels in 2002-06. The predicted effect of a 70% increase in A11 traffic is for a reduction from current observed nest numbers on suitable arable land of 3.7% with no changes in housing density or 4.9% when combined with the predicted effect of housing options. A reduction of 7.3% is predicted for semi-natural grassland and SSSI habitats. Taking both semi-natural grassland/SSSI and arable habitats together, the observed total average nest numbers for the period 2002-2006 was 221.4, and the prediction following a 70% increase in traffic on the A11 is 210.8, a reduction of 10.6 nests (4.8%)

    Are We Worthy Leaders?

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    Today as never before America stands as the champion of democracy. Again we have successfully defended our democratic ideals against the forces of oppression. Not only have we protected them for ourselves, but it is now our aim to spread this freedom to the less fortunate people of the world who have never enjoyed it before. Our ancestors drenched this land of ours with their own blood in order that we might be a free nation. Now it is our noble purpose to make this freedom universal. Before we set ourselves up as an example, let us look over our record and make sure that we are really worthy of leadership. If we carefully examine some of our very recent history, we might detect certain distasteful elements which other nations would not want to adopt

    Studies in upper and lower atmosphere coupling

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    The theoretical and data-analytic work on upper and lower atmosphere coupling performed under a NASA Headquarters contract during the period April 1978 to March 1979 are summarized. As such, this report is primarily devoted to an overview of various studies published and to be published under this contract. Individual study reports are collected as exhibits. Work performed under the subject contract are in the following four areas of upper-lower atmosphere coupling: (1) Magnetosphere-ionosphere electrodynamic coupling in the aurora; (2) Troposphere-thermosphere coupling; (3) Ionosphere-neutral-atmosphere coupling; and (4) Planetary wave dynamics in the middle atmosphere

    Smart helmet: wearable multichannel ECG & EEG

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    Modern wearable technologies have enabled continuous recording of vital signs, however, for activities such as cycling, motor-racing, or military engagement, a helmet with embedded sensors would provide maximum convenience and the opportunity to monitor simultaneously both the vital signs and the electroencephalogram (EEG). To this end, we investigate the feasibility of recording the electrocardiogram (ECG), respiration, and EEG from face-lead locations, by embedding multiple electrodes within a standard helmet. The electrode positions are at the lower jaw, mastoids, and forehead, while for validation purposes a respiration belt around the thorax and a reference ECG from the chest serve as ground truth to assess the performance. The within-helmet EEG is verified by exposing the subjects to periodic visual and auditory stimuli and screening the recordings for the steady-state evoked potentials in response to these stimuli. Cycling and walking are chosen as real-world activities to illustrate how to deal with the so-induced irregular motion artifacts, which contaminate the recordings. We also propose a multivariate R-peak detection algorithm suitable for such noisy environments. Recordings in real-world scenarios support a proof of concept of the feasibility of recording vital signs and EEG from the proposed smart helmet

    Voltage imaging of waking mouse cortex reveals emergence of critical neuronal dynamics.

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    Complex cognitive processes require neuronal activity to be coordinated across multiple scales, ranging from local microcircuits to cortex-wide networks. However, multiscale cortical dynamics are not well understood because few experimental approaches have provided sufficient support for hypotheses involving multiscale interactions. To address these limitations, we used, in experiments involving mice, genetically encoded voltage indicator imaging, which measures cortex-wide electrical activity at high spatiotemporal resolution. Here we show that, as mice recovered from anesthesia, scale-invariant spatiotemporal patterns of neuronal activity gradually emerge. We show for the first time that this scale-invariant activity spans four orders of magnitude in awake mice. In contrast, we found that the cortical dynamics of anesthetized mice were not scale invariant. Our results bridge empirical evidence from disparate scales and support theoretical predictions that the awake cortex operates in a dynamical regime known as criticality. The criticality hypothesis predicts that small-scale cortical dynamics are governed by the same principles as those governing larger-scale dynamics. Importantly, these scale-invariant principles also optimize certain aspects of information processing. Our results suggest that during the emergence from anesthesia, criticality arises as information processing demands increase. We expect that, as measurement tools advance toward larger scales and greater resolution, the multiscale framework offered by criticality will continue to provide quantitative predictions and insight on how neurons, microcircuits, and large-scale networks are dynamically coordinated in the brain

    Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal.

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    Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the Golgi. Norwalk virus nonstructural protein p22 contains a YXΦESDG motif that mimics a di-acidic ER export signal in both sequence and function. However, unlike normal ER export signals, the ER export signal mimic of p22 is necessary for apparent inhibition of normal COPII vesicle trafficking, which leads to Golgi disassembly and antagonism of Golgi-dependent cellular protein secretion. This is the first reported function for p22. Disassembly of the Golgi apparatus was also observed in cells replicating Norwalk virus, which may contribute to pathogenesis by interfering with cellular processes that are dependent on an intact secretory pathway. These results indicate that the ER export signal mimic is critical to the antagonistic function of p22, shown herein to be a novel antagonist of ER/Golgi trafficking. This unique and well-conserved human norovirus motif is therefore an appealing target for antiviral drug development

    Northern New Hampshire Youth in a Changing Rural Economy: A Ten-Year Perspective

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    The Coös Youth Study was a ten-year research project about growing up in a rural county undergoing transformative economic and demographic changes. The study addressed how these changes affected youths’ well-being as well as their plans to stay in the region, pursue opportunities elsewhere, permanently relocate, or return to their home communities with new skills and new ideas. In this report, the authors describe their findings and point to specific areas for action to support and retain North Country youth. The study was sponsored by the Neil and Louise Tillotson Fund of the New Hampshire Charitable Foundation as one component of the long-term research collaboration Tracking Change in the North Country
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