Measuring the Luminosity of a gamma gamma Collider with gamma gamma -> l+ l- gamma Events

The process gamma gamma -> l+ l- is highly suppressed when the total angular momentum of the two colliding photons is zero so that it cannot be used for luminosity determination. This configuration, however is needed for Higgs production at a photon collider. It will be shown that the process gamma gamma -> l+ l- gamma can be used in this case to measure the luminosity of a collider with a precision that is good enough not to limit the error on the partial decay width Gamma(H -> gamma gamma).Comment: Final version, accepted by journa

Impact of environmental factors on the demographic characteristics in Tomsk Oblast (Russia, 1980-2015)

The research represents the analysis of essential demographic indexes in Tomsk Oblast (Russia): birth-rate, death-rate, natural increase (1980-2015), migration increase (19972014), and child mortality (1990-2015). Environmental factors were determined as influencing the health and as a consequence, having the impact on the demographic characteristics of the studied region

Global natural resources and sustainable development issues

Using terminologicаl definition of sustаinаble development аs а bаseline, we develop generаtionаl аpproаch to the use of the globаl nаturаl resources bаsed on such key аssumptions. First, аll humаnkind needs cаn be generаlly divided into three groups: biologicаl, mаnufаcturing, аnd culturаl ones. Second, the аbility of the globаl nаturаl resources to meet the needs of future generаtions could be defined through аccounting their quаntitаtive pаrаmeters аnd quаlitаtive ecologicаl properties (аs fаr аs they аre reproducible, substitutive, exhаustible, vulnerаble to climаte fluctuаtions etc.)

Global natural resources and sustainable development issues

Using terminologicаl definition of sustаinаble development аs а bаseline, we develop generаtionаl аpproаch to the use of the globаl nаturаl resources bаsed on such key аssumptions. First, аll humаnkind needs cаn be generаlly divided into three groups: biologicаl, mаnufаcturing, аnd culturаl ones. Second, the аbility of the globаl nаturаl resources to meet the needs of future generаtions could be defined through аccounting their quаntitаtive pаrаmeters аnd quаlitаtive ecologicаl properties (аs fаr аs they аre reproducible, substitutive, exhаustible, vulnerаble to climаte fluctuаtions etc.)

The tourist and recreational cluster of Rostov Region : socio-economic substantiation and development prospects

Purpose: The aims to study the issues of the formation and prospects in Rostov Region of a potential "catalyst" for the development of the socio-economic system of the region – tourist and recreational cluster. Design/Methodology/Approach: The study applied a cluster approach to the development of territories. Such an approach is the study of the tourist region as an interconnected system of tourist resources, tourist infrastructure, tourist services with an effective system of regional tourism management, the optimal phase of which is a tourist cluster. Findings: This article includes the study of areas of Rostov Region from the standpoint of the cluster approach, tourist and recreational zoning of Rostov Region, the identification of areas that are promising for the formation of tourist and recreational clusters and socio-economic substantiation for the functioning of clusters. Practical Implications: The results of the study can be used in the formation and implementation of regional programs for the development of tourism, economy and social sphere. Originality/Value: The main contribution of this article is the application of the cluster approach to the investigation of socio-economic development of Rostov Region, as well as zoning the tourist and recreational clusters.peer-reviewe

The level of expression of miR-196a in patients with chronic viral hepatitis C with the first genotype of HCV according to previous experience of antiviral therapy.

The authors present the study of the level of expression of miR-196a in 74 patients with chronic viral hepatitis C with the 1st genotype of HCV, based on previous experience in patients with antiviral therapy regimens containing interferon. The patients were divided into two groups, depending on the previous experience of antiviral therapy with circuits containing interferon – 21 patients who failed after antiviral therapy regimens containing interferon (group 1) and the comparison group (group 2) – 53 naive patients. To study the level of expression of miR-196a (miR-196a), a two-stage study according to the manufacturer's protocol was used. First, total RNA was isolated from the plasma by the method of phenol-chloroform extraction. Futher reverse transcription was performed using a kit for reverse transcription of miR TaqMan® (Applied Biosystems, USA), specific loop primers to achieve mature miRNA, snRNA U6 (as an endogenous control gene), and 10 ng of total RNA. Real-time quantitative PCR was performed using TaqMan® miRNA analysis. In order to optimize the prediction of response to antiviral therapy and the use of optimal treatment regimens for problem patients with treatment failure regimens containing interferon, analysis using ROC curves was used. The average level of expression of miR-196a in patients with chronic hepatitis C was evaluated. In the 1st group of patients it was 0.011 (IQR: 0.002; 0.310) and in the comparison group – 0.346 (IQR: 0.054; 1.239) at p=0.012 by U criterion. The conducted ROC analysis showed that the studied miR-196a could differentiate patients with chronic viral hepatitis C with HCV genotype 1, depending on previous experience of antiviral therapy, namely, patients with treatment failure regimens containing interferons and naive. AUC=0.688 (95% CI 0.570-0.791; p=0.017), J=0.40, Se=57.14%, Sp=83.02%. It gives additional opportunities for correction of therapeutic tactics. Therefore, the level of expression of miR-196a (<-1,75) may be an additional biomarker in the pathogenesis of HCV-infection, which can then be used in the monitoring and treatment of patients. Low expression of miR-196a may be the basis for prescribing more effective direct-acting antiviral therapy to patients and will allow personalizing therapeutic tactics in patients with chronic viral hepatitis C

Heterogeneous structure of the lithosphere in the Black Sea from a multidisciplinary analysis of geophysical fields

Magnetic, gravity, geothermal, seismic and tomographic data from the lithosphere were first jointly examined. A multidisciplinary interpretation has resulted in a new and consistent model for lithospheric density, magnetic, thermal and velocity heterogeneities. Faults of different orders for the crystalline crust have been mapped in details. Large deep fault zones were recognized. Among them is the most prominent Odessa-Sinop-Ordu (OSO) fault zone, which played a key role in the opening and development of the Black Sea Depression. A fundamental difference was revealed between the crustal and mantle structure and geophysical parameters of the Western Black Sea Basin (WBSB) and Eastern Black Sea Basin (EBSB). These dissimilarities are in the size of «non-granitic» crust, pattern and intensity of heat flow, topography of the lower boundary of the thermal lithosphere, mantle seismic velocity and structure of magnetic and residual gravity anomalies. Based on new information it was demonstrated that the WBSB and EBSB were diachronously formed on two large distinct continental blocks with independent post-rift development of the sub-basins. The rifting of the western sub-basin commenced earlier than that of the eastern one. The EBSB is characterized by younger thermal activity than the WBSB and consequently it was stabilized later. The Mid Black Sea High (MBSH) is not a single tectonic unit but is formed by two ridges of various crystalline crustal structure and age shifted relative to each other by the faults of the OSO zone

Влияние геометрических параметров клеевого шва на качество склеивания картонных упаковок

Приведено результати експериментальних досліджень процесу склеювання картонного паковання.The results of experimental researches of cardboard package gluing process are described.Приведены результаты экспериментальных исследований процесса склеивания картонной упаковки