1,578 research outputs found
Galaxy Cluster Scaling Relations between Bolocam Sunyaev-Zel'dovich Effect and Chandra X-ray Measurements
We present scaling relations between the integrated Sunyaev-Zel'dovich Effect
(SZE) signal, , its X-ray analogue, , and total mass, , for the 45 galaxy clusters in
the Bolocam X-ray-SZ (BOXSZ) sample. All parameters are integrated within
. values are measured using SZE data collected with
Bolocam, operating at 140 GHz at the Caltech Submillimeter Observatory (CSO).
The temperature, , and mass, , of the intracluster
medium are determined using X-ray data collected with Chandra, and is derived from assuming a constant gas mass fraction. Our
analysis accounts for several potential sources of bias, including: selection
effects, contamination from radio point sources, and the loss of SZE signal due
to noise filtering and beam-smoothing effects. We measure the
-- scaling to have a power-law index of , and
a fractional intrinsic scatter in of at fixed , both of which are consistent with previous analyses. We also measure the
scaling between and , finding a power-law index of
and a fractional intrinsic scatter in at fixed mass of
. While recent SZE scaling relations using X-ray mass proxies have
found power-law indices consistent with the self-similar prediction of 5/3, our
measurement stands apart by differing from the self-similar prediction by
approximately 5. Given the good agreement between the measured
-- scalings, much of this discrepancy appears to be caused
by differences in the calibration of the X-ray mass proxies adopted for each
particular analysis.Comment: 31 pages, 15 figures, accepted by ApJ 04/11/2015. This version is
appreciably different from the original submission: it includes an entirely
new appendix, extended discussion, and much of the material has been
reorganize
The design-by-adaptation approach to universal access: learning from videogame technology
This paper proposes an alternative approach to the design of universally accessible interfaces to that provided by formal design frameworks applied ab initio to the development of new software. This approach, design-byadaptation, involves the transfer of interface technology and/or design principles from one application domain to another, in situations where the recipient domain is similar to the host domain in terms of modelled systems, tasks and users. Using the example of interaction in 3D virtual environments, the paper explores how principles underlying the design of videogame interfaces may be applied to a broad family of visualization and analysis software which handles geographical data (virtual geographic environments, or VGEs). One of the motivations behind the current study is that VGE technology lags some way behind videogame technology in the modelling of 3D environments, and has a less-developed track record in providing the variety of interaction methods needed to undertake varied tasks in 3D virtual worlds by users with varied levels of experience. The current analysis extracted a set of interaction principles from videogames which were used to devise a set of 3D task interfaces that have been implemented in a prototype VGE for formal evaluation
Calculating the transfer function of noise removal by principal component analysis and application to AzTEC observations
Instruments using arrays of many bolometers have become increasingly common
in the past decade. The maps produced by such instruments typically include the
filtering effects of the instrument as well as those from subsequent steps
performed in the reduction of the data. Therefore interpretation of the maps is
dependent upon accurately calculating the transfer function of the chosen
reduction technique on the signal of interest. Many of these instruments use
non-linear and iterative techniques to reduce their data because such methods
can offer improved signal-to-noise over those that are purely linear,
particularly for signals at scales comparable to that subtended by the array.
We discuss a general approach for measuring the transfer function of principal
component analysis (PCA) on point sources that are small compared to the
spatial extent seen by any single bolometer within the array. The results are
applied to previously released AzTEC catalogues of the COSMOS, Lockman Hole,
Subaru XMM-Newton Deep Field, GOODS-North and GOODS-South fields. Source flux
density and noise estimates increase by roughly +10 per cent for fields
observed while AzTEC was installed at the Atacama Submillimeter Telescope
Experiment and +15-25 per cent while AzTEC was installed at the James Clerk
Maxwell Telescope. Detection significance is, on average, unaffected by the
revised technique. The revised photometry technique will be used in subsequent
AzTEC releases.Comment: 14 pages, 4 figure
siRNA inhibition of endocytic pathways to characterize the cellular uptake mechanisms of folate-functionalized glycol chitosan nanogels
Glycol chitosan nanogels have been widely used in gene, drug, and contrast agent delivery in an effort to improve disease diagnosis and treatment. Herein, we evaluate the internalization mechanisms and intracellular fate of previously described glycol chitosan nanogels decorated with folate to target the folate receptor. Uptake of the folate-decorated nanogel was impaired by free folate, suggesting competitive inhibition and shared internalization mechanisms via the folate receptor. Nanogel uptake was shown to occur mainly through flotillin-1 and Cdc42-dependent endocytosis. This was determined by inhibition of uptake reduction observed upon siRNA depletion of these two proteins and the pathways that they regulate. The data also suggest the involvement of the actin cytoskeleton in nanogel uptake via macropinocytosis. After 7 h of incubation with HeLa cells, approximately half of the nanogel population was localized in endolysosomal compartments, whereas the remaining 50% of the material was in undefined regions of the cytoplasm. Glycol chitosan nanogels may thus have potential as drug delivery vectors for targeting different intracellular compartments.BioHealth - Biotechnology
and Bioengineering approaches to improve health quality, Ref.
NORTE-07-0124-FEDER-000027, cofunded by the Programa
Operacional Regional do Norte (ON.2 − O Novo Norte),
QREN, FEDER. P.P. was funded through an FCT Ph.D. grant
(SFRH/BD/64977/2009). Funding is also acknowledged from
a Cancer Research UK studentship (C36040/A11652), EPSRC Grant (EP/J021334/1 to A.T.J. and E.S.
Construction of challenging proline–proline junctions via diselenide–selenoester ligation chemistry
Polyproline sequences are highly abundant in prokaryotic 10 and eukaryotic proteins, where they serve as key components of 11 secondary structure. To date, construction of the proline−proline motif 12 has not been possible owing to steric congestion at the ligation junction, 13 together with an n → π* electronic interaction that reduces the 14 reactivity of acylated proline residues at the C-terminus of peptides. 15 Here, we harness the enhanced reactivity of prolyl selenoesters and a 16 trans-γ-selenoproline moiety to access the elusive proline−proline 17 junction for the first time through a diselenide−selenoester ligation− 18 deselenization manifold. The efficient nature of this chemistry is 19 highlighted in the high-yielding one-pot assembly of two proline-rich 20 polypeptide targets, submaxillary gland androgen regulated protein 3B 21 and lumbricin-1. This method provides access to the most challenging of ligation junctions, thus enabling the construction of 22 previously intractable peptide and protein targets of increasing structural complexity
Microwave Kinetic Inductance Detector (MKID) Camera Testing for Submillimeter Astronomy
Developing kilopixel focal planes for incoherent submm- and mm-wave detectors remains challenging due to either the large hardware overhead or the complexity of multiplexing standard detectors. Microwave kinetic inductance detectors (MKIDs) provide a efficient means to produce fully lithographic background-limited kilopixel focal planes. We are constructing an MKID-based camera for the Caltech Submillimeter Observatory with 576 spatial pixels each simultaneously sensitive in 4 bands at 230, 300, 350, and 400 GHz. The novelty of MKIDs has required us to develop new techniques for detector characterization. We have measured quasiparticle lifetimes and resonator Qs for detector bath temperatures between 200 mK and 400 mK. Equivalent lifetime measurements were made by coupling energy into the resonators either optically or by driving the third harmonic of the resonator. To determine optical loading, we use both lifetime and internal Q measurements, which range between 15,000 and 30,000 for our resonators. Spectral bandpass measurements confirm the placement of the 230 and 350 GHz bands. Additionally, beam maps measurements conform to expectations. The same device design has been characterized on both sapphire and silicon substrates, and for different detector geometries. We also report on the incorporation of new shielding to reduce detector sensitivity to local magnetic fields
The discovery of lensed radio and x-ray sources behind the frontier fields cluster MACS J0717.5+3745 with the JVLA and Chandra
© 2016. The American Astronomical Society. All rights reserved.. We report on high-resolution JVLA and Chandra observations of the Hubble Space Telescope (HST) Frontier Cluster MACS J0717.5+3745. MACS J0717.5+3745 offers the largest contiguous magnified area of any known cluster, making it a promising target to search for lensed radio and X-ray sources. With the high-resolution 1.0-6.5 GHz JVLA imaging in A and B configuration, we detect a total of 51 compact radio sources within the area covered by the HST imaging. Within this sample, we find seven lensed sources with amplification factors larger than two. None of these sources are identified as multiply lensed. Based on the radio luminosities, the majority of these sources are likely star-forming galaxies with star-formation rates (SFRs) of 10-50 yr -1 located at . Two of the lensed radio sources are also detected in the Chandra image of the cluster. These two sources are likely active galactic nuclei, given their 2-10 keV X-ray luminosities of ∼10 43-44 erg s -1 . From the derived radio luminosity function, we find evidence for an increase in the number density of radio sources at , compared to a sample. Our observations indicate that deep radio imaging of lensing clusters can be used to study star-forming galaxies, with SFRs as low as ∼10 M o yr -1 , at the peak of cosmic star formation history
Galaxy clusters discovered with a Sunyaev-Zel'dovich effect survey
The South Pole Telescope (SPT) is conducting a Sunyaev-Zel'dovich (SZ) effect
survey over large areas of the southern sky, searching for massive galaxy
clusters to high redshift. In this preliminary study, we focus on a 40
square-degree area targeted by the Blanco Cosmology Survey (BCS), which is
centered roughly at right ascension 5h30m, declination -53 degrees. Over two
seasons of observations, this entire region has been mapped by the SPT at 95
GHz, 150 GHz, and 225 GHz. We report the four most significant SPT detections
of SZ clusters in this field, three of which were previously unknown and,
therefore, represent the first galaxy clusters discovered with an SZ survey.
The SZ clusters are detected as decrements with greater than 5-sigma
significance in the high-sensitivity 150 GHz SPT map. The SZ spectrum of these
sources is confirmed by detections of decrements at the corresponding locations
in the 95 GHz SPT map and non-detections at those locations in the 225 GHz SPT
map. Multiband optical images from the BCS survey demonstrate significant
concentrations of similarly colored galaxies at the positions of the SZ
detections. Photometric redshift estimates from the BCS data indicate that two
of the clusters lie at moderate redshift (z ~ 0.4) and two at high redshift (z
>~ 0.8). One of the SZ detections was previously identified as a galaxy cluster
using X-ray data from the ROSAT All-Sky Survey (RASS). Potential RASS
counterparts (not previously identified as clusters) are also found for two of
the new discoveries. These first four galaxy clusters are the most significant
SZ detections from a subset of the ongoing SPT survey. As such, they serve as a
demonstration that SZ surveys, and the SPT in particular, can be an effective
means for finding galaxy clusters.Comment: 11 pages, 3 figures, revised to match published version, uses
emulateap
Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes
Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of common cyanine dyes Cy3 and Cy5 as vectors for targeting and delivering cargoes to mitochondria in cancer cells. Specifically, conjugation to the dyes can increase cytotoxicity by up to 1000-fold
Measurements of Secondary Cosmic Microwave Background Anisotropies with the South Pole Telescope
We report cosmic microwave background (CMB) power spectrum measurements from
the first 100 sq. deg. field observed by the South Pole Telescope (SPT) at 150
and 220 GHz. On angular scales where the primary CMB anisotropy is dominant,
ell ~< 3000, the SPT power spectrum is consistent with the standard LambdaCDM
cosmology. On smaller scales, we see strong evidence for a point source
contribution, consistent with a population of dusty, star-forming galaxies.
After we mask bright point sources, anisotropy power on angular scales of 3000
50 at both frequencies. We
combine the 150 and 220 GHz data to remove the majority of the point source
power, and use the point source subtracted spectrum to detect
Sunyaev-Zel'dovich (SZ) power at 2.6 sigma. At ell=3000, the SZ power in the
subtracted bandpowers is 4.2 +/- 1.5 uK^2, which is significantly lower than
the power predicted by a fiducial model using WMAP5 cosmological parameters.
This discrepancy may suggest that contemporary galaxy cluster models
overestimate the thermal pressure of intracluster gas. Alternatively, this
result can be interpreted as evidence for lower values of sigma8. When combined
with an estimate of the kinetic SZ contribution, the measured SZ amplitude
shifts sigma8 from the primary CMB anisotropy derived constraint of 0.794 +/-
0.028 down to 0.773 +/- 0.025. The uncertainty in the constraint on sigma8 from
this analysis is dominated by uncertainties in the theoretical modeling
required to predict the amplitude of the SZ power spectrum for a given set of
cosmological parameters.Comment: 28 pages, 11 figures, submitted to Ap
- …