High-resolution Spectroscopy of [Ne II] Emission from TW Hya

We present high-resolution echelle spectra of [Ne II] 12.81 micron emission from the classical T Tauri star (CTTS) TW Hya obtained with MICHELLE on Gemini North. The line is centered at the stellar radial velocity and has an intrinsic FWHM of 21\pm 4 km/s. The line width is broader than other narrow emission lines typically associated with the disk around TW Hya. If formed in a disk, the line broadening could result from turbulence in a warm disk atmosphere, Keplerian rotation at an average distance of 0.1 AU from the star, or a photoevaporative flow from the optically-thin region of the disk. We place upper limits on the [Ne II] emission flux from the CTTSs DP Tau and BP Tau.Comment: Accepted by ApJ. 18 pages, including 2 figures and 2 table

Far infrared CO and H2_2O emission in intermediate-mass protostars

Intermediate-mass young stellar objects (YSOs) provide a link to understand how feedback from shocks and UV radiation scales from low to high-mass star forming regions. Aims: Our aim is to analyze excitation of CO and H$_2$O in deeply-embedded intermediate-mass YSOs and compare with low-mass and high-mass YSOs. Methods: Herschel/PACS spectral maps are analyzed for 6 YSOs with bolometric luminosities of $L_\mathrm{bol}\sim10^2 - 10^3$ $L_\odot$. The maps cover spatial scales of $\sim 10^4$ AU in several CO and H$_2$O lines located in the $\sim55-210$ $\mu$m range. Results: Rotational diagrams of CO show two temperature components at $T_\mathrm{rot}\sim320$ K and $T_\mathrm{rot}\sim700-800$ K, comparable to low- and high-mass protostars probed at similar spatial scales. The diagrams for H$_2$O show a single component at $T_\mathrm{rot}\sim130$ K, as seen in low-mass protostars, and about $100$ K lower than in high-mass protostars. Since the uncertainties in $T_\mathrm{rot}$ are of the same order as the difference between the intermediate and high-mass protostars, we cannot conclude whether the change in rotational temperature occurs at a specific luminosity, or whether the change is more gradual from low- to high-mass YSOs. Conclusions: Molecular excitation in intermediate-mass protostars is comparable to the central $10^{3}$ AU of low-mass protostars and consistent within the uncertainties with the high-mass protostars probed at $3\cdot10^{3}$ AU scales, suggesting similar shock conditions in all those sources.Comment: Accepted to Astronomy & Astrophysics. 4 pages, 5 figures, 3 table

Testing particle trapping in transition disks with ALMA

We present new Atacama Large Millimeter/submillimeter Array (ALMA) continuum observations at 336GHz of two transition disks, SR21 and HD135344B. In combination with previous ALMA observations from Cycle 0 at 689GHz, we compare the visibility profiles at the two frequencies and calculate the spectral index ($\alpha_{\rm{mm}}$). The observations of SR21 show a clear shift in the visibility nulls, indicating radial variations of the inner edge of the cavity at the two wavelengths. Notable radial variations of the spectral index are also detected for SR21 with values of $\alpha_{\rm{mm}}{\sim}3.8-4.2$ in the inner region ($r<35$ AU) and $\alpha_{\rm{mm}}{\sim}2.6-3.0$ outside. An axisymmetric ring (which we call the ring model) or a ring with the addition of an azimuthal Gaussian profile, for mimicking a vortex structure (which we call the vortex model), is assumed for fitting the disk morphology. For SR21, the ring model better fits the emission at 336GHz, conversely the vortex model better fits the 689GHz emission. For HD135344B, neither a significant shift in the null of the visibilities nor radial variations of $\alpha_{\rm{mm}}$ are detected. Furthermore, for HD135344B, the vortex model fits both frequencies better than the ring model. However, the azimuthal extent of the vortex increases with wavelength, contrary to model predictions for particle trapping by anticyclonic vortices. For both disks, the azimuthal variations of $\alpha_{\rm{mm}}$ remain uncertain to confirm azimuthal trapping. The comparison of the current data with a generic model of dust evolution that includes planet-disk interaction suggests that particles in the outer disk of SR21 have grown to millimetre sizes and have accumulated in a radial pressure bump, whereas with the current resolution there is not clear evidence of radial trapping in HD135344B, although it cannot be excluded either.Comment: Minor changes after language edition. Accepted for publication in A&A (abstract slightly shortened for arXiv

The Effects of UV Continuum and Lyman alpha Radiation on the Chemical Equilibrium of T Tauri Disks

We show in this Letter that the spectral details of the FUV radiation fields have a large impact on the chemistry of protoplanetary disks surrounding T Tauri stars. We show that the strength of a realistic stellar FUV field is significantly lower than typically assumed in chemical calculations and that the radiation field is dominated by strong line emission, most notably Lyman alpha radiation. The effects of the strong Lyman alpha emission on the chemical equilibrium in protoplanetary disks has previously been unrecognized. We discuss the impact of this radiation on molecular observations in the context of a radiative transfer model that includes both direct attenuation and scattering. In particular, Lyman alpha radiation will directly dissociate water vapor and may contribute to the observed enhancements of CN/HCN in disks.Comment: 14 pages, 4 figures, accepted by ApJ Letter

Herschel PACS observations of shocked gas associated with the jets of L1448 and L1157

In the framework of the WISH key program, several H2O (E_u>190 K), high-J CO, [OI], and OH transitions are mapped with PACS in two shock positions along the two prototypical low-luminosity outflows L1448 and L1157. Previous HIFI H2O observations (E_u=53-249 K) and complementary Spitzer mid-IR H2 data are also used, with the aim of deriving a complete picture of the excitation conditions. At all selected spots a close spatial association between H2O, mid-IR H2, and high-J CO emission is found, whereas the low-J CO emission traces either entrained ambient gas or a remnant of an older shock. The excitation analysis at L1448-B2 suggests that a two-component model is needed to reproduce the H2O, CO, and mid-IR H2 lines: an extended warm component (T~450 K) is traced by the H2O emission with E_u =53-137 K and by the CO lines up to J=22-21, and a compact hot component (T=1100 K) is traced by the H2O emission with E_u>190 K and by the higher-J CO lines. At L1448-B2 we obtain an H2O abundance (3-4)x10^{-6} for the warm component and (0.3-1.3)x10^{-5} for the hot component; we also detect OH and blue-shifted [OI] emission, spatially coincident with the other molecular lines and with [FeII] emission. This suggests a dissociative shock for these species, related to the embedded atomic jet. On the other hand, a non-dissociative shock at the point of impact of the jet on the cloud is responsible for the H2O and CO emission. The other examined shock positions show an H2O excitation similar to L1448-B2, but a slightly higher H2O abundance (a factor of 4). The two gas components may represent a gas stratification in the post-shock region. The extended and low-abundance warm component traces the post-shocked gas that has already cooled down to a few hundred Kelvin, whereas the compact and possibly higher-abundance hot component is associated with the gas that is currently undergoing a shock episode.Comment: Accepted for publication in Astronomy and Astrophysic

Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and TGF-beta2-/IGF-1-mediated regulation of hair cycle in male and female human hair follicles in vitro.

BACKGROUND: Caffeine reportedly counteracts the suppression of hair shaft production by testosterone in organ-cultured male human hair follicles (HFs). OBJECTIVES: We aimed at investigating the impact of caffeine a) on additional key hair growth parameters, b) on major hair growth-regulatory growth factors and c) on male versus female HFs in the presence of testosterone. METHODS: Microdissected male and female human scalp HFs were treated in serum-free organ culture for 120 h with testosterone alone (0,5 mug/ml) or in combination with caffeine (0.005-0.0005%), and effects on hair shaft elongation, HF cycling (i.e. anagen-catagen transition), hair matrix keratinocyte proliferation and expression of a key catagen inducer, transforming growth factor beta2 (TGF-beta2), and anagen-prolonging insulin-like growth factor 1 (IGF-1) were evaluated by quantitative (immuno-) histomorphometry. Caffeine effects were further investigated in human outer root sheath keratinocytes (ORSK). RESULTS: Caffeine enhanced hair shaft elongation, prolonged anagen duration and stimulated hair matrix keratinocyte proliferation. Female HFs showed higher sensitivity to caffeine compared to male HFs. Caffeine counteracted testosterone-enhanced TGF-beta2 protein expression in male HFs. In female HFs, testosterone failed to induce TGF-beta2 expression, while caffeine reduced it. In male and female HFs, caffeine enhanced IGF-1 protein expression. In ORSK, caffeine stimulated cell proliferation, inhibited apoptosis/necrosis, up-regulated IGF-1 gene expression and protein secretion, while TGF-beta2 protein secretion was down-regulated. CONCLUSIONS: This study reveals new growth-promoting effects of caffeine on human hair follicles of both genders at different (molecular, cellular and organ) levels. This article is protected by copyright. All rights reserved

X-Shooter study of accretion in Chamaeleon I: II. A steeper increase of accretion with stellar mass for very low mass stars?

The dependence of the mass accretion rate on the stellar properties is a key constraint for star formation and disk evolution studies. Here we present a study of a sample of stars in the Chamaeleon I star forming region carried out using the VLT/X-Shooter spectrograph. The sample is nearly complete down to M~0.1Msun for the young stars still harboring a disk in this region. We derive the stellar and accretion parameters using a self-consistent method to fit the broad-band flux-calibrated medium resolution spectrum. The correlation between the accretion luminosity to the stellar luminosity, and of the mass accretion rate to the stellar mass in the logarithmic plane yields slopes of 1.9 and 2.3, respectively. These slopes and the accretion rates are consistent with previous results in various star forming regions and with different theoretical frameworks. However, we find that a broken power-law fit, with a steeper slope for stellar luminosity smaller than ~0.45 Lsun and for stellar masses smaller than ~ 0.3 Msun, is slightly preferred according to different statistical tests, but the single power-law model is not excluded. The steeper relation for lower mass stars can be interpreted as a faster evolution in the past for accretion in disks around these objects, or as different accretion regimes in different stellar mass ranges. Finally, we find two regions on the mass accretion versus stellar mass plane empty of objects. One at high mass accretion rates and low stellar masses, which is related to the steeper dependence of the two parameters we derived. The second one is just above the observational limits imposed by chromospheric emission. This empty region is located at M~0.3-0.4Msun, typical masses where photoevaporation is known to be effective, and at mass accretion rates ~10^-10 Msun/yr, a value compatible with the one expected for photoevaporation to rapidly dissipate the inner disk.Comment: Accepted for publication on Astronomy & Astrophysics. Abstract shortened for arxiv constraints. Revised version after language editin

[OI]63micron jets in class 0 sources detected by Herschel

We present Herschel PACS mapping observations of the [OI]63 micron line towards protostellar outflows in the L1448, NGC1333-IRAS4, HH46, BHR71 and VLA1623 star forming regions. We detect emission spatially resolved along the outflow direction, which can be associated with a low excitation atomic jet. In the L1448-C, HH46 IRS and BHR71 IRS1 outflows this emission is kinematically resolved into blue- and red-shifted jet lobes, having radial velocities up to 200 km/s. In the L1448-C atomic jet the velocity increases with the distance from the protostar, similarly to what observed in the SiO jet associated with this source. This suggests that [OI] and molecular gas are kinematically connected and that this latter could represent the colder cocoon of a jet at higher excitation. Mass flux rates (\.M$_{jet}$(OI)) have been measured from the [OI]63micron luminosity adopting two independent methods. We find values in the range 1-4 10$^{-7}$ Mo/yr for all sources but HH46, for which an order of magnitude higher value is estimated. \.M$_{jet}$(OI) are compared with mass accretion rates (\.M$_{acc}$) onto the protostar and with \.M$_{jet}$ derived from ground-based CO observations. \.M$_{jet}$(OI)/\.M$_{acc}$ ratios are in the range 0.05-0.5, similar to the values for more evolved sources. \.M$_{jet}$(OI) in HH46 IRS and IRAS4A are comparable to \.M$_{jet}$(CO), while those of the remaining sources are significantly lower than the corresponding \.M$_{jet}$(CO). We speculate that for these three sources most of the mass flux is carried out by a molecular jet, while the warm atomic gas does not significantly contribute to the dynamics of the system.Comment: 37 pages and 12 figures, accepted for publication on Astrophysical Journa

Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man.

Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in this region. In the present study, we addressed the hypothesis that the weakening of this inhibitory testosterone feedback in elderly men coincides with enhanced KP and NKB signaling in the infundibular nucleus. This central hypothesis was tested in a series of immunohistochemical studies on hypothalamic sections of male human individuals that were divided into arbitrary "young" (21-49 yr, n = 11) and "aged" (50-67 yr, n = 9) groups. Quantitative immunohistochemical experiments established that the regional densities of NKB-immunoreactive (IR) perikarya and fibers, and the incidence of afferent contacts they formed onto GnRH neurons, exceeded several times those of the KP-IR elements. Robust aging-dependent enhancements were identified in the regional densities of KP-IR perikarya and fibers and the incidence of afferent contacts they established onto GnRH neurons. The abundance of NKB-IR perikarya, fibers, and axonal appositions to GnRH neurons also increased with age, albeit to lower extents. In dual-immunofluorescent studies, the incidence of KP-IR NKB perikarya increased from 36% in young to 68% in aged men. Collectively, these immunohistochemical data suggest an aging-related robust enhancement in central KP signaling and a moderate enhancement in central NKB signaling. These changes are compatible with a reduced testosterone negative feedback to KP and NKB neurons. The heavier KP and NKB inputs to GnRH neurons in aged, compared with young, men may play a role in the enhanced central stimulation of the reproductive axis. It requires clarification to what extent the enhanced KP and NKB signaling upstream from GnRH neurons is an adaptive response to hypogonadism or, alternatively, a consequence of a decline in the androgen sensitivity of KP and NKB neurons

The formation of planetary disks and winds: an ultraviolet view

Planetary systems are angular momentum reservoirs generated during star formation. This accretion process produces very powerful engines able to drive the optical jets and the molecular outflows. A fraction of the engine energy is released into heating thus the temperature of the engine ranges from the 3000K of the inner disk material to the 10MK in the areas where magnetic reconnection occurs. There are important unsolved problems concerning the nature of the engine, its evolution and the impact of the engine in the chemical evolution of the inner disk. Of special relevance is the understanding of the shear layer between the stellar photosphere and the disk; this layer controls a significant fraction of the magnetic field building up and the subsequent dissipative processes ougth to be studied in the UV. This contribution focus on describing the connections between 1 Myr old suns and the Sun and the requirements for new UV instrumentation to address their evolution during this period. Two types of observations are shown to be needed: monitoring programmes and high resolution imaging down to, at least, milliarsecond scales.Comment: Accepted for publication in Astrophysics and Space Science 9 figure