Sugar Alcohols Have a Key Role in Pathogenesis of Chronic Liver Disease and Hepatocellular Carcinoma in Whole Blood and Liver Tissues.

The major risk factors for hepatocellular carcinoma (HCC) are hepatitis C and B viral infections that proceed to Chronic Liver Disease (CLD). Yet, the early diagnosis and treatment of HCC are challenging because the pathogenesis of HCC is not fully defined. To better understand the onset and development of HCC, untargeted GC-TOF MS metabolomics data were acquired from resected human HCC tissues and their paired non-tumor hepatic tissues (n = 46). Blood samples of the same HCC subjects (n = 23) were compared to CLD (n = 15) and healthy control (n = 15) blood samples. The participants were recruited from the National Liver Institute in Egypt. The GC-TOF MS data yielded 194 structurally annotated compounds. The most strikingly significant alteration was found for the class of sugar alcohols that were up-regulated in blood of HCC patients compared to CLD subjects (p < 2.4 × 10-12) and CLD compared to healthy controls (p = 4.1 × 10-7). In HCC tissues, sugar alcohols were the most significant (p < 1 × 10-6) class differentiating resected HCC tissues from non-malignant hepatic tissues for all HCC patients. Alteration of sugar alcohol levels in liver tissues also defined early-stage HCC from their paired non-malignant hepatic tissues (p = 2.7 × 10-6). In blood, sugar alcohols differentiated HCC from CLD subjects with an ROC-curve of 0.875 compared to 0.685 for the classic HCC biomarker alpha-fetoprotein. Blood sugar alcohol levels steadily increased from healthy controls to CLD to early stages of HCC and finally, to late-stage HCC patients. The increase in sugar alcohol levels indicates a role of aldo-keto reductases in the pathogenesis of HCC, possibly opening novel diagnostic and therapeutic options after in-depth validation

Food consumption and lifestyle habits among university students in Saudi Arabia

Food consumption and lifestyle habits can have a positive or negative direct impact on an individual’s health. University students tend to have poor eating habits that are influenced mainly by sensory perceptions. This survey was done to evaluate the status of food consumption and lifestyle habits among Taif university students (males and females). A total of 600 students aged from 18 to 24 years participated in the survey and responded to questions on socio-demographic characteristics, lifestyle habits, eating habits, food consumption frequency, attitude, health and food awareness knowledge. The randomly selected students were from various levels in university representing wide categories and living conditions in Taif Region, Saudi Arabia. The examined students efficiently completed the survey with the help of the university staff. Weight and height were evaluated by a portable standing electronic scale and a portable stadiometer (Seca 879, Germany) to calculate the Body mass index (BMI) classes. Female students recorded 28% of underweight cases, which was higher than the male students (11%) with none significant at p>0.05. The rate of overweight in male students was 30% compared with the female students’ 26%. The study reported 49% and 64% for normal waist circumference for male and female students, respectively. A higher frequency of moderate physical exercise was reported among male students at 60% compared to that among female students (57%). The number of students who did physical exercise regularly was reported to be higher in females (15%) than males (8%). A percentage of 15% and 7% of the male and female students, respectively were smokers. Male students recorded higher sleeping hours than females. Male students reported high media consumption frequency of more than 3 hours a day 67%, followed by 21% between 3-6 hours a day for female students. About 46% and 55% of male and female students, respectively, reported fast-food consumption at least once a week and about 30% of males and 24% females took only 1 to 2 fast food meals in a month. The major meals skipped were breakfast, followed by lunch and dinner; however, this was not significant p>0.05. Meal skipping was high among female students (72%). It was noted that high percentage of male students (72%) reported low consumption levels of vegetables and fruits. The main reason for fast-food consumption was convenience (31%) for males, while females recorded 32% for choices. Female students had a higher score than males in nutrition knowledge. There is a need for awareness creation concerning better food choices, lifestyle habits and weight management that might create a helpful impact on the university student health

Extended of TEA: A 256 bits block cipher algorithm for image encryption

This paper introduces an effective image encryption approach that merges a chaotic map and polynomial with a block cipher. According to this scheme, there are three levels of encryption. In the first level, pixel positions of the image are scuffled into blocks randomly based on a chaotic map. In the second level, the polynomials are constructed by taking N unused pixels from the permuted blocks as polynomial coefficients. Finally, the third level a proposed secret-key block cipher called extended of tiny encryption algorithm (ETEA) is used. The proposed ETEA algorithm increased the block size from 64-bit to 256-bit by using F-function in type three Feistel network design. The key schedule generation is very straightforward through admixture the entire major subjects in the identical manner for every round. The proposed ETEA algorithm is word-oriented, where wholly internal operations are executed on words of 32 bits. So, it is possible to efficiently implement the proposed algorithm on smart cards. The results of the experimental demonstration that the proposed encryption algorithm for all methods are efficient and have high security features through statistical analysis using histograms, correlation, entropy, randomness tests, and the avalanche effect

Prevalence of thinness cases and dietary diversity among learners of various education stages in Taif Region, Saudi Arabia

Monitoring nutritional status during infancy, childhood, and adulthood is essential because good quality diet during growth is vital to cover the cognitive and physical demands, supply enough energy stores for illnesses and pregnancy and avoid adult nutrition-associated diseases. Thinness cases and lack of dietary diversity among learners in various education stages are common nutritional problems. A cross-sectional survey was carried out for the assessments of thinness cases and dietary diversity among the learners in various education stages in Taif Region, Saudi Arabia in August, 2020. A total of randomly selected 1602 respondents who fulfilled the exclusion and inclusion criteria (n=364 primary schools, n=410 middle schools, n=321 high schools, and n=507 university students) were examined and efficiently completed the survey. The survey comprised of socio-demographic characteristics, questions about health problems, adequate dietary diversity, habits, food item consumption, and nutritional knowledge test based on the student's theory and behaviors. The prevalence of thinness status among university students was very obvious (22%) and found to be mild followed by moderate (11%) and (0.4%) severely thin. The prevalence of severe thinness was the highest among primary school participants (28%). The prevalence of moderate thinness was reported slightly similar among middle and high school participants (29% and 32%, respectively). The highest prevalence of thinness cases was found in students from rural areas, while the lowest values were observed in those from urban areas. Students from large family size were more likely to be thin as compared to students from small size families. Students whose mothers were illiterate or had low formal education were more likely to be thin compared to those students whose mothers had completed university education or above. Further, 78% of primary school students reported meal skipping due to lack of appetite, while shape maintaining for the meal was accounted for 50% for middle school students as the main reason for the meal skipping. Snacking was also reported to be at a high rate among primary and high school students as 76% and 83% of the students mentioned having snacks, respectively. A higher frequency of light physical exercise was established for primary school pupils (81%), while university students reported (34%) as moderate. Almost all students had a low level of eating cereals, fruits and vegetables, while high schools and university students had a high-level consumption of fruits, animal-based foods and nutritional supplements. High school students had an excellent score 37% for nutrition knowledge. Education stage of learners was found to have direct influence on thinness, dietary diversity and food consumption frequency of the respondents. Consequently, nutritional education may positively affect the whole student's ability for good diet choices in the way to ensure a healthier status. The knowledge of nutrition education combined with physical exercise programmers may contribute to strengthening of the healthy eating messages at the various educationstages

Progressive internal gravity waves with bounded upper surface climbing a triangular obstacle

In this paper we discuss a theoretical model for the interfacial profiles of progressive non-linear waves which result from introducing a triangular obstacle, of finite height, attached to the bottom below the flow of a stratified, ideal, two layer fluid, bounded from above by a rigid boundary. The derived equations are solved by using a nonlinear perturbation method. The dependence of the interfacial profile on the triangular obstacle size, as well as its dependence on some flow parameters, such as the ratios of depths and densities of the two fluids, have been studied

Geographic variation in phytochemical constituents and allelopathic potential of Pinus halepensis barks

Aqueous extracts (10, 20, 30 and 40 g/L) of Pinus halepensis barks, collected from Bizerte (B), Tabarka (T), Seliana (S) and Oueslatia (O) to elucidate the influence of ecological sites on allelopathic potential. Aqueous barks extracts from (S) and (O) have revealed a higher rate of phenolic acids than those from (T) and (B), respectively 13.23, 13.8, 11.63 and 10.37 mg/mL. Alep pin barks were analyzed using HPLC/UV for the identification and quantification of the phenolic compounds, among which in particular the catechin acetate, the gallic acid, the rutine hydrate, luteolin 7 glucoside and the cinnamic acid. In fact, the aqueous extract of barks from (S) revealed a highest level, respectively 2.61, 1.74, 1.61, 1.36, and 1.21 mg/mL. The Pinus halepensis barks was analyzed by GC and GC-MS. As a result, 29 compounds were identified representing 89% made up basically by β-caryophyllene, α-humulene. As for allelopathic activity, aqueous extracts of barks significantly delayed germination, reduced its rate and affected the seedling growth mainly the (S) and (O) extracts. The root growth of the two targets has shown a high sensibility compared to the shoot lengths. Pot cultures were conducted by the incorporation of barks powder (50 and 100 g/kg) or the irrigation with their aqueous extracts at 20 and 40 g/L. Pinus halepensis barks and its extracts have shown a high herbicide potent, particularly the one collected from (S) and (O), may be favorably used for incorporating in agricultural systems for sustainable weed managemen

Effects of dietary supplementation of soybean lecithin on growth performance, nutrients digestibility and serum profiles of broilers fed fried soybean oil

The objective of this study was to evaluate the effects of soybean lecithin in broiler diets formulated with either fried or non-fried soybean oils (as an energy source), on growth performance, digestibility, and some serum parameters. A total of 600 broilers (50% male) were assigned to 4 experimental groups (with 10 replicates of 15 birds each): (i) group (S) fed with soybean oil only, (ii) group (SL) fed with soybean oil + lecithin (0.035% in feed), (iii) group (F) fed with fried soybean oil only, and iv) group (FL) fed with fried soybean oil + lecithin (0.035% in feed). The results showed that fried soybean oil in broilers diets had the same effects on the analysed parameters as the non-fried oil. Broilers that received lecithin with fried soybean oil (group FL) exhibited significantly higher body weights (1.228 vs. 1.210, p<0.05 and 1.935 vs. 1.917 kg, p<0.05) than group F in the last two experimental periods (22-28 and 29-35 d), respectively. On the contrary, the addition of soybean lecithin to diets formulated with either fried or non-fried soybean oil resulted in a significant increase in weight of some carcass cuts (thigh, breast) and a significant decrease in some visceral organs (intestine, liver, viscera), without affecting the digestibility parameters here assessed. Our findings revealed that the addition of soybean lecithin to standard soybean oil (group SL) significantly decreased serum TG (77.16 vs. 83.46, p<0.05) compared to group S. In conclusion, it was possible to use recovered frying soybean oil in broiler diets without a negative impact on growth performance and serum triglyceride level, while these parameters were improved by the addition of soybean lecithin

Close-packed floating clusters: granular hydrodynamics beyond the freezing point?

Monodisperse granular flows often develop regions with hexagonal close packing of particles. We investigate this effect in a system of inelastic hard spheres driven from below by a "thermal" plate. Molecular dynamics simulations show, in a wide range of parameters, a close-packed cluster supported by a low-density region. Surprisingly, the steady-state density profile, including the close-packed cluster part, is well described by a variant of Navier-Stokes granular hydrodynamics (NSGH). We suggest a simple explanation for the success of NSGH beyond the freezing point.Comment: 4 pages, 5 figures. To appear in Phys. Rev. Let