359 research outputs found

    Scaling Properties of Paths on Graphs

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    Let GG be a directed graph on finitely many vertices and edges, and assign a positive weight to each edge on GG. Fix vertices uu and vv and consider the set of paths that start at uu and end at vv, self-intersecting in any number of places along the way. For each path, sum the weights of its edges, and then list the path weights in increasing order. The asymptotic behaviour of this sequence is described, in terms of the structure and type of strongly connected components on the graph. As a special case, for a Markov chain the asymptotic probability of paths obeys either a power law scaling or a weaker type of scaling, depending on the structure of the transition matrix. This generalizes previous work by Mandelbrot and others, who established asymptotic power law scaling for special classes of Markov chains.Comment: 23 pages, 2 figure

    Presence of Acinetobacter species among the predominant bacteria found in a contaminated metal-working fluid

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    The distribution of Acinetobacter species among the bacteria isolated from an unusually heavily contaminated petroleum-based water-soluble metal-working fluid used in a large North American automotive machining operation was investigated. It had been found previously1 that, in laboratory cultures with metal-working fluids as the sole carbon source, these species grew more rapidly and to much higher densities than any other types of bacteria isolated from this system. Thus, it was expected that they would dominate the population and would be difficult to control. It is shown here that, contrary to expectation, over a one-year period Acinetobacter species usually accounted for only a few percent of the total population. Factory fluids did not contain substances that selectively inhibited the growth of these species. In mixed-cultures grown in the laboratory with metal-working fluid as the carbon source, Acinetobacter species accounted for less than 1% in the initial inocolum, nearly 70% during the mid-exponential-phase, and only a few percent in the stationary-phase. These experiments suggest, as a working hypothesis, that the Acinetobacter species `govern' the contamination in the sense that they first colonize the fluid and their presence is necessary to maintain the other strains.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26622/1/0000163.pd

    The marketing firm and co‐creation: An empirical study of marketer and customer's co‐creation process

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    This study empirically investigates the marketer and customer's co‐creation process within the context of the marketing firm. Based on principles from bilateral contingencies, findings from a conjoint study (n = 98) indicate that utilitarian and informational reinforcing consequences from the marketer have a stronger impact on customers' co‐creation behavior relative to informational reinforcing consequences from other customers. Consequently, analyzing the impact of important reinforcing contingencies through the lens of bilateral contingencies expands our understanding of how and why co‐creation outcomes might occur. Also, a good co‐creation process may increase the business companies' research and intelligence and, as a consequence, strengthen their competitiveness.The marketing firm and co‐creation: An empirical study of marketer and customer's co‐creation processacceptedVersio

    Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

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    Naïve FoxP3-expressing regulatory T-cells (Tregs) are essential to control immune responses via continuous replenishment of the activated-Treg pool with thymus-committed suppressor cells. The mechanisms underlying naïve-Treg maintenance throughout life in face of the age-associated thymic involution remain unclear. We found that in adults thymectomized early in infancy the naïve-Treg pool is remarkably well preserved, in contrast to conventional naïve CD4 T-cells. Naïve-Tregs featured high levels of cycling and pro-survival markers, even in healthy individuals, and contrasted with other circulating naïve/memory CD4 T-cell subsets in terms of their strong γc-cytokine-dependent signaling, particularly in response to IL-7. Accordingly, ex-vivo stimulation of naïve-Tregs with IL-7 induced robust cytokine-dependent signaling, Bcl-2 expression, and phosphatidylinositol 3-kinase (PI3K)-dependent proliferation, whilst preserving naïve phenotype and suppressive capacity. Altogether, our data strongly implicate IL-7 in the thymus-independent long-term survival of functional naïve-Tregs, and highlight the potential of targeting the IL-7 pathway to modulate Tregs in different clinical settings.This work was supported by Fundação para a Ciência e Tecnologia (FCT; POCI2010/IC/83068/2007 to RMMV; PTDC/SAU-MIC/109786/2009 to AES), and Gulbenkian Foundation (96526/2009 to JF; P132532/2013 to AES). SLS, ASA, RBF, ARP, PM and SMF received FCT scholarships

    The theory of the marketing firm

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    The theory of the marketing firm locates the rationale of the modern business enterprise that lies in its responding profitably to the imperatives of marketing orientation. Economic theories of the firm generally fail to recognize these imperatives, enhanced consumer choice and sophistication, which entail marketing orientation as the rationale of the firm. The paper propose a competence theory of the firm as a metacontingency and examines the bilateral contingencies by which firms link to their consumerates, which indicate their capacities for customer orientation. The marketing firm emerges as a means of encapsulating entrepreneurship, economizing on transaction costs, and enabling the management of marketing specialization

    Effective risk relievers for dimensional perceived risks on mail-order purchase: a case study on speciality foods in the UK

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    This article examines the effective risk relievers for different dimensions of perceived risk on mail-order purchase of food products. The sample comprised 1,600 active and inactive mail-order specialty food shoppers in the UK. The analysis focused on the correlation coefficients between consumers' levels of perceived risk and their weight on the importance of the risk relievers. Amongst 15 risk relievers, the results implied that there are certain risk relievers attached to higher levels of importance by consumers, who perceive higher levels of risks in certain aspects of mail-order purchase. Therefore, mail-order companies should promote the effective risk relievers to reduce specific dimensions of perceived risks

    SMEs' purchasing habits : A procurement maturity model for stakeholders

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    Although micro companies overpower the small and medium enterprise (SME) segment, generalizations are often with medium size companies, and therefore, there are many unknowns, especially when it comes to its buying behavior. Conformist studies and industry practices assume SMEs to be “normative” or “conservative” buyers; however, this hypothesis is untested. This article aims to scrutinize the reality, and proposes a unified model that rejects pre-containerization in buying behavior typologies, as well as selectiveness in terms of audience type, whether it is corporate, SME, or consumer. While replacing researchers’ perceptions with the audience’s, the model yields actual knowledge that can lead to audience’s beliefs in lieu of the opposite, which is used to mislead stakeholders. The study shows that SMEs also buy like individuals and spend in a similar way to consumers’, including not only “normative” and “conservative” but also “negligent” and “impulse” zones. From the research-implications perspective, future studies by behaviorists can explore why SMEs purchase in this way. Marketers may benefit from the finding that SMEs buy like individuals. In addition, SMEs may want to be conscious of their purchasing habits, and—utilizing the newly introduced “risk score” frontier—policymakers should assess the consequences of these habits at the macro level
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