Pengaruh Konflik Peran, Konflik Kerja dan Stres Kerja terhadap Kinerja Karyawan pada PT. Air Manado

Sumber daya manusia merupakan salah satu sumber daya yang paling menentukan sukses tidaknya suatu organisasi. Dalam era globalisasi, masalah sumber daya manusia menjadi sorotan maupun tumpuan bagi Perusahaan untuk tetap dapat bertahan. Permasalahan yang dihadapi Perusahaan adalah sumber daya manusia, sebab sumber daya manusia ini terdiri dari berbagai individu dengan karakteristik yang berbeda-beda, dengan bermacam latar belakang, pendidikan, dan sifat yang berbeda sehingga perselisihan dapat muncul setiap saat. Stres kerja dan konflik kerja merupakan salah satu masalah yang mungkin timbul dalam aktifitas Perusahaan. Penelitian ini dilakukan dengan tujuan untuk melihat apakah konflik peran, konflik kerja dan stres kerja mempengaruhi kinerja karyawan, dan menjadi objek dari penelitian ini yaitu PT. Air Manado. Menggunakan alat analisis Regresi Berganda. Hasil penelitian didapati bahwa Konflik Peran, Konflik Kerja dan Stres Kerja berpengaruh secara simultan dan parsial terhadap Kinerja Karyawan pada Perusahaan. Sebaiknya pimpinan PT. Air Manado meminimalisir terjadinya konflik peran, konflik kerja dan stres kerja pada para karyawan, sehingga kinerja karyawan dapat meningkat. Kata kunci: peran konflik, konflik kerja, stress kerja, kinerja karyawa

Seasonal variation in cotyledoside concentration of Tylecodon wallichii (Harv.) Tolken subsp. wallichii sampled in a krimpsiekte-prevalent region

Krimpsiekte, an economically important neuromuscular affliction of small stock, follows upon ingestion of certain members of the Crassulaceae (plakkies) containing cumulative neurotoxic bufadienolides. Tylecodon wallichii (Harv.) Tolken subsp. wallichii is probably the most important species of the group of plants causing krimpsiekte. The growing tip of the stem and various other plant parts of T. wallichii, when available, were collected monthly. The seasonal variation in cotyledoside content of the plant was measured. Cotyledoside concentration was determined by high performance liquid chromatographic-electrospray mass spectrometry analysis (HPLC-ESMS). The cotyledoside concentration in the plant stems fluctuated substantially during the year, but tended to be higher in the cold winter months and increased again in the spring and early summer. Elevated plant stem concentrations corresponded with natural field outbreaks of krimpsiekte, which usually occur during the winter to early summer. The highest cotyledoside concentrations were detected in the flowering stalk. Cotyledoside was not the only component of this type in the plant, as mass spectrometry revealed the presence of other, possibly related, compounds.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat v.9 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.mn201

Advanced database mining integrating sequence and structure bioinformatics with microfluidics challenges enzyme engineering

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Krimpsiekte in a sheep following a single dose of Tylecodon ventricosus (Burm. f.) Toelken and the isolation of tyledoside D from this plant species

Tylecodon ventricosus induced severe respiratory distress in two penned sheep without any electrocardiographic abnormalities being recorded. Based on the results it appears as if T. ventricosus predominantly induces the neuromuscular syndrome referred to as krimpsiekte. A single, relatively large intraruminal dose of 10,0 g/kg induced krimpsiekte in one sheep. Treatment with 5,0 g/kg activated charcoal on two consecutive days did not prevent the development of krimpsiekte. A bufadienolide, tyledoside D, was isolated from semi-dried plant material.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat X Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.mn201

Krimpsiekte, associated with thalamic lesions, induced by the neurotoxic cardiac glycoside, cotyledoside, isolated from Tylecodon wallichii (Harv.) Toelken subsp. wallichii

The specific neurotoxic principle of Tylecodon wallichii (Harv.) Toelken subsp. wallichii, the cause of krimpsiekte in small stock, was isolated and identified as the previously described cumulative bufadienolide, cotyledoside. Krimpsiekte was experimentally induced in two sheep by the repeated intravenous administration of cotyledoside at the rate of 0,01-0,015 mg/kg body mass. On day 9, both animals developed clinical signs typical of krimpsiekte, which is characterized by tremors, paresis and recumbency. Both sheep had difficulty in controlling their hindquarters when attempting to lie down. No significant electrocardiograph abnormalities were detected during the experiment which confirms that cotyledoside at low doses does not overtly affect the electrical activity of the heart. No gross lesions were observed in the sheep. The most significant microscopic lesions comprised mild brain oedema and pronounced vacuolation of the white matter of thalamic nuclei. These lesions might explain some of the motor function deficiencies clinically observed in this syndrome. The previously held contention that these neurotoxic cardiac glycosides are indeed the cause of krimpsiekte is, therefore, confirmed.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat X Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

The Infrared Continuum Spectrum of VY CMa

We combine spectra of VY CMa obtained with the short- and long-wavelength spectrometers, SWS and LWS, on the Infrared Space Observatory to provide a first detailed continuum spectrum of this highly luminous star. The circumstellar dust cloud through which the star is observed is partially self-absorbing, which makes for complex computational modeling. We review previous work and comment on the range of uncertainties about the physical traits and mineralogical composition of the modeled disk. We show that these uncertainties significantly affect the modeling of the outflow and the estimated mass loss. In particular, we demonstrate that a variety of quite diverse models can produce good fits to the observed spectrum. If the outflow is steady, and the radiative repulsion on the dust cloud dominates the star's gravitational attraction, we show that the total dust mass-loss rate is $\sim 4\times 10^{-6}M_{\odot}$ yr$^{-1}$, assuming that the star is at a distance of 1.5 kpc. Several indications, however, suggest that the outflow from the star may be spasmodic. We discuss this and other problems facing the construction of a physically coherent model of the dust cloud and a realistic mass-loss analysis

Piecewise Linear Models for the Quasiperiodic Transition to Chaos

We formulate and study analytically and computationally two families of piecewise linear degree one circle maps. These families offer the rare advantage of being non-trivial but essentially solvable models for the phenomenon of mode-locking and the quasi-periodic transition to chaos. For instance, for these families, we obtain complete solutions to several questions still largely unanswered for families of smooth circle maps. Our main results describe (1) the sets of maps in these families having some prescribed rotation interval; (2) the boundaries between zero and positive topological entropy and between zero length and non-zero length rotation interval; and (3) the structure and bifurcations of the attractors in one of these families. We discuss the interpretation of these maps as low-order spline approximations to the classic ``sine-circle'' map and examine more generally the implications of our results for the case of smooth circle maps. We also mention a possible connection to recent experiments on models of a driven Josephson junction.Comment: 75 pages, plain TeX, 47 figures (available on request

METIS - the Mid-infrared E-ELT Imager and Spectrograph

METIS, the Mid-infrared ELT Imager and Spectrograph (formerly called MIDIR), is a proposed instrument for the European Extremely Large Telescope (E-ELT), currently undergoing a phase-A study. The study is carried out within the framework of the ESO-sponsored E-ELT instrumentation studies. METIS will be designed to cover the E-ELT science needs at wavelengths longward of 3um, where the thermal background requires different operating schemes. In this paper we discuss the main science drivers from which the instrument baseline has been derived. Specific emphasis has been given to observations that require very high spatial and spectral resolution, which can only be achieved with a ground-based ELT. We also discuss the challenging aspects of background suppression techniques, adaptive optics in the mid-IR, and telescope site considerations. The METIS instrument baseline includes imaging and spectroscopy at the atmospheric L, M, and N bands with a possible extension to Q band imaging. Both coronagraphy and polarimetry are also being considered. However, we note that the concept is still not yet fully consolidated. The METIS studies are being performed by an international consortium with institutes from the Netherlands, Germany, France, United Kingdom, and Belgium.Comment: 15 pages, to be published in Proc SPIE 7014: Ground-based & Airborne Instrumentation for Astronomy I

The impact of Stieltjes' work on continued fractions and orthogonal polynomials

Stieltjes' work on continued fractions and the orthogonal polynomials related to continued fraction expansions is summarized and an attempt is made to describe the influence of Stieltjes' ideas and work in research done after his death, with an emphasis on the theory of orthogonal polynomials