More than a feeling: Autonomous sensory meridian response (ASMR) is characterized by reliable changes in affect and physiology

Autonomous Sensory Meridian Response (ASMR) describes the experience of tingling sensations in the crown of the head, in response to a range of audio-visual triggers such as whispering, tapping, and hand movements. Public interest in ASMR has risen dramatically and ASMR experiencers watch ASMR videos to promote relaxation and sleep. Unlike ostensibly similar emotional experiences such as “aesthetic chills” from music and awe-inspiring scenarios, the psychological basis of ASMR has not yet been established. We present two studies (one large-scale online experiment; one laboratory study) that test the emotional and physiological correlates of the ASMR response. Both studies showed that watching ASMR videos increased pleasant affect only in people who experienced ASMR. Study 2 showed that ASMR was associated with reduced heart rate and increased skin conductance levels. Findings indicate that ASMR is a reliable and physiologically-rooted experience that may have therapeutic benefits for mental and physical health

Augmentation varieties and disk potentials

We elaborate on a suggestion of Aganagic-Ekholm-Ng-Vafa, that in order for Lagrangian fillings such as the Harvey-Lawson filling to define augmentations of Chekanov-Eliashberg differential graded algebras, one should count configurations of holomorphic disks connected by gradient trajectories. We propose a definition of the Chekanov-Eliashberg dga in higher dimensions which includes as generators both Reeb chords and the space of chains on the Legendrian, similar to the definition of immersed Lagrangian Floer theory whose generators are chains on the Lagrangian as well as self-intersection points. We prove that for connected Legendrian covers of monotone Lagrangian tori, the augmentation variety in this model is equal to the image of the zero level set of the disk potential, as suggested by Dimitroglou-Rizell-Golovko. In particular, we show that Legendrian lifts of Vianna's exotic tori are not Legendrian isotopic, as conjectured in Dimitroglou-Rizell-Golovko. Using related ideas, we show that the Legendrian lift of the Clifford torus admits no exact fillings, extending the results of Dimitroglou-Rizell and Treumann-Zaslow in dimension two. We consider certain disconnected Legendrians, and show, similar to another suggestion of Aganagic-Ekholm-Ng-Vafa, that the components of the augmentation variety correspond to certain partitions and each component is defined by a (not necessarily exact) Lagrangian filling. An adaptation of the theory of holomorphic quilts shows that the cobordism maps associated to bounding chains are independent of all choices up to chain homotopy.Comment: 157 page

Lipid droplet detection by the cavity perturbation method

There are currently no point-of-care diagnosis strategies available to indicate the presence of neoplasmic growth. This research aims to develop a novel diagnostic strategy based on detecting TAG accumulation in cells. This element of the research is a preliminary experiment to prove the concept of detecting TAG lipid droplets in YEPD media. It was found that a change in mono-unsaturated concentration can be detected by the frequency shift in a resonant cavity. The dielectric constant of TAG vegetable oils was calculated at 2.34-2.39. It was also found that concentrations of lipid droplet can be differentiated up to 5% (v/v)

Legal Framework of Public Intervention in Industrial Disputes

This survey was prepared by G. R. Blakey, A.B., LL.B., and Matthew T. Hogan, A.B., LL.B., both of the class of 1960, and John J. Coffey, Thomas A. McNish and Edward O\u27Toole of THE LAWYER\u27S Senior Staff

Developmental profile of temporal binding: from childhood to adulthood

Temporal binding refers to a phenomenon whereby the time interval between a cause and its effect is perceived as shorter than the same interval separating two unrelated events. We examined the developmental profile of this phenomenon by comparing the performance of groups of children (aged 6–7, 7–8, and 9–10 years) and adults on a novel interval estimation task. In Experiment 1, participants made judgements about the time interval between (a) their button press and a rocket launch, and (b) a non-causal predictive signal and rocket launch. In Experiment 2, an additional causal condition was included in which participants made judgements about the interval between an experimenter’s button press and the launch of a rocket. Temporal binding was demonstrated consistently and did not change in magnitude with age: estimates of delay were shorter in causal contexts for both adults and children. In addition, the magnitude of the binding effect was greater when participants themselves were the cause of an outcome compared with when they were mere spectators. This suggests that although causality underlies the binding effect, intentional action may modulate its magnitude. Again, this was true of both adults and children. Taken together, these results are the first to suggest that the binding effect is present and developmentally constant from childhood into adulthood

Detection and metabolic investigations of a novel designer steroid: 3-chloro-17α-methyl-5α-androstan-17β-ol

In 2012, seized capsules containing white powder were analyzed to show the presence of unknown steroid-related compounds. Subsequent gas chromatography–mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR) investigations identified a mixture of 3α- and 3β- isomers of the novel compound; 3-chloro-17α-methyl-α-androstan-17β-ol. Synthesis of authentic reference materials followed by comparison of NMR, GC-MS and gas chromatography-tandem mass spectrometry (GC-MS/MS) data confirmed the finding of a new ‘designer’ steroid. Furthermore, in vitro androgen bioassays showed potent activity highlighting the potential for doping using this steroid. Due to the potential toxicity of the halogenated steroid, in vitro metabolic investigations of 3α-chloro-17α-methyl-α-androstan-17β-ol using equine and human S9 liver fractions were performed. For equine, GC-MS/MS analysis identified the diagnostic 3α-chloro-17α-methyl-5α-androstane-16α,17β-diol metabolite. For human, the 17α-methyl-α-androstane-3α,17β-diol metabolite was found. Results from these studies were used to verify the ability of GC-MS/MS precursor-ion scanning techniques to support untargeted detection strategies for designer steroids in anti-doping analyses.Synthesis and in vitro metabolic investigations of 3α/β-chloro-17α-methyl-5α-androstan -17β-ol was suppo rted by the Austr a-lian Research Council Linkage Grant (LP120200444) Strat egies for the detection of designer ster oids in ra cehorses

When causality shapes the experience of time: evidence for temporal binding in young children

It is well-established that the temporal proximity of two events is a fundamental cue to causality. Recent research with adults has shown that this relation is bidirectional: events that are believed to be causally related are perceived as occurring closer together in time—the so-called temporal binding effect. Here we examined the developmental origins of temporal binding. Participants predicted when an event that was either caused by a button press, or preceded by a non-causal signal, would occur. We demonstrate for the first time that children as young as four years are susceptible to temporal binding. Binding occurred both when the button press was executed via intentional action, and when a machine caused it. These results suggest binding is a fundamental, early developing property of perception and grounded in causal knowledge

Food Distribution and Consumption in Knoxville: Exploring Food-Related Local Planning Issues

Summary: City planners have traditionally made an effort to understand the interrelationships between urban activities and various support systems, such as transportation, water and sewer, waste management, communications and energy. Food is also an important urban support system with a complex system of supply, distribution, and consumption. An understanding of the nature of the food supply and distribution system seems important, but in the past has not been an area of concern for the planning profession. It was the intent of this project to develop a basis from which to seek an understanding of the Knoxville food support system and its implications for local planning policy in Knoxville. The thrust of the study was three-fold. First, food-related problems and issues were identified. Then, further work was undertaken in order to propose remedial measures or public programs that might be initiated by local units of government. Finally, the group considered the possibility of establishing some kind of public oversight of the local food supply and distribution function. The approach has been general and comprehensive. One assumption here is that before public action can be initiated, those with responsibility for maintaining the public interest must understand the system. Thus, an analysis which would describe the system comprehensively, while allowing an opportunity to detect interrelationships among system components, was utilized. Patterns of consumption, food services and programs, and marketing channels by food types were also explored. The development of information involves consultation with literature, academicians, public officials, and industry representatives

Causality influences children’s and adults’ experience of temporal order

Although it has long been known that time is a cue to causation, recent work with adults has demonstrated that causality can also influence the experience of time. In causal reordering (Bechlivanidis & Lagnado, 2013, 2016) adults tend to report the causally consistent order of events rather than the correct temporal order. However, the effect has yet to be demonstrated in children. Across four preregistered experiments, 4- to 10-year-old children (N = 813) and adults (N = 178) watched a 3-object Michotte-style “pseudocollision.” While in the canonical version of the clip, object A collided with B, which then collided with object C (order: ABC), the pseudocollision involved the same spatial array of objects but featured object C moving before object B (order: ACB), with no collision between B and C. Participants were asked to judge the temporal order of events and whether object B collided with C. Across all age groups, participants were significantly more likely to judge that B collided with C in the 3-object pseudocollision than in a 2-object control clip (where clear causal direction was lacking), despite the spatiotemporal relations between B and C being identical in the two clips (Experiments 1-3). Collision judgments and temporal order judgments were not entirely consistent, with some participants—particularly in the younger age range—basing their temporal order judgments on spatial rather than temporal information (Experiment 4). We conclude that in both children and adults, rather than causal impressions being determined only by the basic spatial–temporal properties of object movement, schemata are used in a top-down manner when interpreting perceptual displays

Environmental and Parental Influences on Offspring Health and Growth in Great Tits (Parus major)

PMCID: PMC3728352This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited