Reaction Rate Sensitivity of the gamma-Process Path

The location of the (gamma,p)/(gamma,n) and (gamma,alpha)/(gamma,n) line at gamma-process temperatures is discussed, using recently published reaction rates based on global Hauser-Feshbach calculations. The results can directly be compared to previously published, classic gamma-process discussions. The nuclei exhibiting the largest sensitivity to uncertainties in nuclear structure and reaction parameters are specified.Comment: 4 pages, contribution to Nuclei in the Cosmos VIII, to appear in Nucl. Phys.

Portable technology and multi-domain energy practices

This article complements the concept of embedded security by proposing disembedded security to capture consumers’ energy practices when travelling across multiple domains of energy accessibility. Consumer mobility outside the home produces misalignments between infrastructure and portable technology experienced as ‘hysteresis of the battery’. Hysteresis captures how respondents are subject to ‘unpleasant unpredictability’ about battery-based technology and infrastructure, which spurs hermeneutic reflection about energy, location and sociality. Multi-domain energy practices therefore bring energy consumers to ‘reembed’ or create a sense of psychological comfort on the move. Charge levels on battery icons not only structure daily patterns of consumer life through planning efforts but become interpretively entangled in issues of duration, distance and sociality as energy demands in portable technology push consumers to avoid disruption

Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals?

Mitochondrial unfolded protein response is a form of retrograde signaling that contributes to ensuring the maintenance of quality control of mitochondria, allowing functional integrity of the mitochondrial proteome. When misfolded proteins or unassembled complexes accumulate beyond the folding capacity, it leads to alteration of proteostasis, damages, and organelle/cell dysfunction. Extensively studied for the ER, it was recently reported that this kind of signaling for mitochondrion would also be able to communicate with the nucleus in response to impaired proteostasis. The mitochondrial unfolded protein response (UPR(mt)) is activated in response to different types and levels of stress, especially in conditions where unfolded or misfolded mitochondrial proteins accumulate and aggregate. A specific UPR(mt) could thus be initiated to boost folding and degradation capacity in response to unfolded and aggregated protein accumulation. Although first described in mammals, the UPR(mt) was mainly studied in Caenorhabditis elegans, and accumulating evidence suggests that mechanisms triggered in response to a UPR(mt) might be different in C. elegans and mammals. In this review, we discuss and integrate recent data from the literature to address whether the UPR(mt) is relevant to mitochondrial homeostasis in mammals and to analyze the putative role of integrated stress response (ISR) activation in response to the inhibition of mtDNA expression and/or accumulation of mitochondrial mis/unfolded proteins

Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells:Role of autophagy and JNK activation

Cancer cell resistance against chemotherapy is still a heavy burden to improve anticancer treatments. Autophagy activation and the development of hypoxic regions within the tumors are known to promote cancer cell resistance. Therefore, we sought to evaluate the role of autophagy and hypoxia on the taxol-induced apoptosis in MDA-MB-231 breast cancer cells. The results showed that taxol induced apoptosis after 16 h of incubation, and that hypoxia protected MDA-MB-231 cells from taxol-induced apoptosis. In parallel, taxol induced autophagy activation already after 2 h of incubation both under normoxia and hypoxia. Autophagy activation after taxol exposure was shown to be a protective mechanism against taxol-induced cell death both under normoxia and hypoxia. However, at longer incubation time, the autophagic process reached a saturation point under normoxia leading to cell death, whereas under hypoxia, autophagy flow still correctly took place allowing the cells to survive. Autophagy induction is induced after taxol exposure via mechanistic target of rapamycin (mTOR) inhibition, which is more important in cells exposed to hypoxia. Taxol also induced c-Jun N-terminal kinase (JNK) activation and phosphorylation of its substrates B-cell CLL/lymphoma 2 (Bcl(2)) and BCL2-like 1 (Bcl(XL)) under normoxia and hypoxia very early after taxol exposure. Bcl(2) and Bcl(XL) phosphorylation was decreased more importantly under hypoxia after long incubation time. The role of JNK in autophagy and apoptosis induction was studied using siRNAs. The results showed that JNK activation promotes resistance against taxol-induced apoptosis under normoxia and hypoxia without being involved in induction of autophagy. In conclusion, the resistance against taxol-induced cell death observed under hypoxia can be explained by a more effective autophagic flow activated via the classical mTOR pathway and by a mechanism involving JNK, which could be dependent on Bcl(2) and Bcl(XL) phosphorylation but independent of JNK-induced autophagy activation

Effects of Composite Rheology on Plate-Like Behavior in Global-Scale Mantle Convection

Earth's upper mantle rheology controls lithosphere-asthenosphere coupling and thus surface tectonics. Rock deformation experiments and seismic anisotropy measurements indicate that composite rheology (co-existing diffusion and dislocation creep) occurs in the Earth's uppermost mantle, potentially affecting convection and surface tectonics. Here, we investigate how the spatio-temporal distribution of dislocation creep in an otherwise diffusion-creep-controlled mantle impacts the planform of convection and the planetary tectonic regime as a function of the lithospheric yield strength in numerical models of mantle convection self-generating plate-like tectonics. The low upper-mantle viscosities caused by zones of substantial dislocation creep produce contrasting effects on surface dynamics. For strong lithosphere (yield strength > 35 MPa), the large lithosphere-asthenosphere viscosity contrasts promote stagnant-lid convection. In contrast, the increase of upper mantle convective vigor enhances plate mobility for lithospheric strength <35 MPa. For the here-used model assumptions, composite rheology does not facilitate the onset of plate-like behavior at large lithospheric strength

Testing the role of SNe Ia for galactic chemical evolution of p-nuclei with two-dimensional models and with s-process seeds at different metallicities

Date of Acceptance: 07/11/2014The bulk of p isotopes is created in the "gamma processes" mainly by sequences of photodisintegrations and beta decays in explosive conditions in Type Ia supernovae (SNIa) or in core collapse supernovae (ccSN). The contribution of different stellar sources to the observed distribution of p-nuclei in the solar system is still under debate. We explore single degenerate Type Ia supernovae in the framework of two-dimensional SNIa delayed-detonation explosion models. Travaglio et al. discussed the sensitivity of p-nuclei production to different SNIa models, i.e., delayed detonations of different strength, deflagrations, and the dependence on selected s-process seed distributions. Here we present a detailed study of p-process nucleosynthesis occurring in SNIa with s-process seeds at different metallicities. Based on the delayed-detonation model DDT-a of TRV11, we analyze the dependence of p-nucleosynthesis on the s-seed distribution obtained from different strengths of the 13C pocket. We also demonstrate that 208Pb seed alone changes the p-nuclei production considerably. The heavy-s seeds (140 ≤A < 208) contribute with about 30%-40% to the total light-p nuclei production up to 132Ba (with the exception of 94Mo and 130Ba, to which the heavy-s seeds contribute with about 15% only). Using a Galactic chemical evolution code from Travaglio et al., we study the contribution of SNIa to the solar stable p-nuclei. We find that explosions of Chandrasekhar-mass single degenerate systems produce a large amount of p-nuclei in our Galaxy, both in the range of light (A ≤ 120) and heavy p-nuclei, at almost flat average production factors (within a factor of about three). We discussed in details p-isotopes such as 94Mo with a behavior diverging from the average, which we attribute to uncertainties in the nuclear data or in SNIa modeling. Li et al. find that about 70% of all SNeIa are normal events. If these are explained in the framework of explosions of Chandrasekhar-mass white dwarfs resulting from the single-degenerate progenitor channel, we find that they are responsible for at least 50% of the p-nuclei abundances in the solar system.Peer reviewedFinal Accepted Versio

Nucleosynthesis in Massive Stars With Improved Nuclear and Stellar Physics

We present the first calculations to follow the evolution of all stable nuclei and their radioactive progenitors in stellar models computed from the onset of central hydrogen burning through explosion as Type II supernovae. Calculations are performed for Pop I stars of 15, 19, 20, 21, and 25 M_sun using the most recently available experimental and theoretical nuclear data, revised opacity tables, neutrino losses, and weak interaction rates, and taking into account mass loss due to stellar winds. A novel ``adaptive'' reaction network is employed with a variable number of nuclei (adjusted each time step) ranging from about 700 on the main sequence to more than 2200 during the explosion. The network includes, at any given time, all relevant isotopes from hydrogen through polonium (Z=84). Even the limited grid of stellar masses studied suggests that overall good agreement can be achieved with the solar abundances of nuclei between 16O and 90Zr. Interesting discrepancies are seen in the 20 M_sun model and, so far, only in that model, that are a consequence of the merging of the oxygen, neon, and carbon shells about a day prior to core collapse. We find that, in some stars, most of the ``p-process'' nuclei can be produced in the convective oxygen burning shell moments prior to collapse; in others, they are made only in the explosion. Serious deficiencies still exist in all cases for the p-process isotopes of Ru and Mo.Comment: 53 pages, 17 color figures (3 as separate GIF images), slightly extended discussion and references, accepted by Ap

The Karlsruhe Astrophysical Database of Nucleosynthesis in Stars Project - Status and Prospects

The KADoNiS (Karlsruhe Astrophysical Database of Nucleosynthesis in Stars) project is an astrophysical online database for cross sections relevant for nucleosynthesis in the s process and the γ process. The s-process database (http://www.kadonis.org) was started in 2005 and is presently facing its 4th update (KADoNiS v1.0). The γ-process database (KADoNiS-p, http://www.kadonis.org/pprocess) was recently revised and re-launched in March 2013. Both databases are compilations for experimental cross sections with relevance to heavy ion nucleosynthesis. For the s process recommended Maxwellian averaged cross sections for kT=5-100 keV are given for more than 360 isotopes between 1H and 210Bi. For the γ-process database all available experimental data from (p, γ), (p, n), (p, α), (α, γ), (α, n), and (α, p) reactions between 70Ge and 209Bi in or close to the respective Gamow window were collected and can be compared to theoretical predictions. The aim of both databases is a quick and user-friendly access to the available data in the astrophysically relevant energy regions. © 2014 Elsevier Inc.Peer reviewe