12 research outputs found
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1
- Author
- Abecasis Gonçalo R.
- Absher Devin
- Adrienne Cupples L.
- Aherrahrou Zouhair
- Allayee Hooman
- Allione Alessandra
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Angelica Merlini Pier
- Ardissino Diego
- Ardlie Kristin
- Assimes Themistocles L.
- Aulchenko Yurii S.
- Baas Annette F.
- Badger Stephen A.
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Bandinelli Stefania
- Barbalic Maja
- Barnes Timothy A.
- Barroso Inês
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Benediktsson Rafn
- Bengtsson Boström Kristina
- Bennett Amanda J.
- Berger Klaus
- Berglund Göran
- Bergman Richard N.
- Bingham Sheila A.
- Bis Joshua C.
- Blagieva Roza
- Blair Ross D.
- Blankenberg Stefan
- Blankensteijn Jan D.
- Bochud Murielle
- Boehm Bernhard O.
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Bots Michiel L.
- Bown Matthew J.
- Bradley Declan T.
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris
- Bumpstead Suzannah
- Burnand Kevin
- Burton Paul R.
- Burtt Noël P.
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Chambers John C.
- Charpentier Guillaume
- Chen Li
- Child Anne H.
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Clough Rachel E.
- Cockerill Gillian
- Codd Veryan
- Coin Lachlan
- Connell John M.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Crawford Gabriel J.
- Daly Mark J.
- Davies Robert W.
- de Faire Ulf
- de Graaf Jacqueline
- de Jong Paul E.
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- Devaney Joseph M.
- Di Gregorio Alessandra
- Diemert Patrick
- Dina Christian
- Do Ron
- Doering Angela
- Dominiczak Anna
- Doney Alex S. F.
- Dupuis Josée
- Döring Angela
- Dörr Marcus
- Edkins Sarah
- Eifert Sandra
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eriksson Per
- Ernst Florian
- Eyheramendy Susana
- Farrall Martin
- Felix Stephan B.
- Ferreira Teresa
- Ferrucci Luigi
- Fischer Marcus
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forouhi Nita G.
- Fox Caroline S.
- Franco-Cereceda Anders
- Franklin Christopher S.
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Frikke-Schmidt Ruth
- Froguel Philippe
- Futers Simon
- Galan Pilar
- Ganser Martha
- Gateva Vesela
- Gerry Hill B.
- Gieger Christian
- Gigante Bruna
- Girelli Domenico
- Gloyn Anna L.
- Goel Anuj
- Golledge Jonathan
- Goodall Alison H.
- Grallert Harald
- Grarup Niels
- Green Todd
- Gretarsdottir Solveig
- Griffin Simon
- Grobbee Diederick E.
- Groop Leif
- Groves Christopher J.
- Guarrera Simonetta
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gut Ivo G.
- Gwilliam Rhian
- Gyllensten Ulf
- Hadjadj Samy
- Hadley David
- Hafez Hany
- Hall Alistair S.
- Halperin Eran
- Hammond Naomi
- Hamsten Anders
- Hansen Torben
- Harrison Seamus C.
- Hartikainen Anna-Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Hazen Stanley L.
- Heath Simon C.
- Hengstenberg Christian
- Hercberg Serge
- Herder Christian
- Hide Winston A.
- Hill Andrew A.
- Hitman Graham A.
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Horne Benjamin D.
- Hu Frank B.
- Hua Zhao Jing
- Hughes Anne E.
- Humphries Steve E.
- Hunt Sarah E.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Illig Thomas
- Iribarren Carlos
- Isomaa Bo
- Jackson Anne U.
- Jarvelin Marjo-Riitta
- Johnson Anne
- Johnson Paul R. V.
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jørgensen Torben
- Kaiser Michael A.
- Kao Wen H. L.
- Kaplan Lee M.
- Kastelein John J. P.
- Kathiresan Sekar
- Khaw Kay-Tee
- Kiemeney Lambertus A.
- Klopp Norman
- Knowles Joshua W.
- Kolovou Genovefa
- Kong Augustine
- Kooner Jaspal S.
- Kraft Peter
- Kuusisto Johanna
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laan Maris
- Lakatta Edward G.
- Lambrechts Diether
- Langenberg Claudia
- Lauritzen Torsten
- Leander Karin
- Lettre Guillaume
- Lewis David R.
- Li Mingyao
- Lieb Wolfgang
- Lieverse Aloysius
- Lim Noha
- Lindgren Cecilia M.
- Lindholt Jes S.
- Loley Christina
- Loos Ruth J. F.
- Lorbeer Roberto
- Lotery Andrew J.
- Lourdes Sampietro M.
- Luan Jian'an
- Luben Robert N.
- Lucas Gavin
- Lyssenko Valeriya
- Mannucci Pier M.
- Maouche Seraya
- Mark Lathrop G.
- Marre Michel
- Marrugat Jaume
- Martinelli Nicola
- Matthiasson Stefan E.
- Matthijs Boekholdt S.
- Matullo Giuseppe
- McArdle Wendy L.
- McCarroll Steve A.
- McCarthy Mark I.
- McCulloch Laura J.
- McKeown Pascal P.
- McNoe Les A.
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Meneton Pierre
- Merriman Tony R.
- Midthjell Kristian
- Mohlke Karen L.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Munroe Patricia B.
- Musunuru Kiran
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Naik Dilip K.
- Najjar Samer S.
- Narisu Narisu
- Navarro Pau
- Navis Gerjan
- Nelson Christopher P.
- Newhouse Stephen J.
- Newton-Cheh Christopher
- Nilsson Peter
- Norman Paul E.
- Numans Mattijs E.
- Nöthen Markus M.
- O'Donnell Christopher J.
- O'Reilly Paul F.
- Olivieri Oliviero
- Onland-Moret N. Charlotte
- Org Elin
- Orho-Melander Marju
- Ouwehand Willem H.
- Owen Katharine R.
- Palmen Jutta
- Palmer Colin N. A.
- Panico Salvatore
- Pankow James S.
- Papadakis Konstantinos
- Patel Riyaz S.
- Patterson Chris C.
- Payne Felicity
- Peden John F.
- Pedersen Oluf
- Peltonen Leena
- Perola Markus
- Perry John R. B.
- Peters Annette
- Petersen Ann-Kristin
- Peyvandi Flora
- Pfeufer Arne
- Platou Carl
- Polidoro Silvia
- Potter Simon
- Pouta Anneli
- Powell Janet T.
- Pramstaller Peter P.
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed A.
- Rader Daniel J.
- Rallidis Loukianos S.
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Reffelmann Thorsten
- Refstrup Mette
- Reilly Muredach P.
- Rettig Rainer
- Ricceri Fulvio
- Rice Catherine
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Romanazzi Valeria
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Sacerdote Carlotta
- Salomaa Veikko
- Samani Nilesh J.
- Sampson Michael J.
- Sandhu Manjinder S.
- Sanna Serena
- Saxena Richa
- Sayers Robert D.
- Schadt Eric
- Scheet Paul
- Schillert Arne
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir Jürgen
- Schunkert Heribert
- Schwartz Stephen M.
- Schäfer Arne
- Scott D Julian A.
- Scott Laura J.
- Scuteri Angelo
- Seedorf Udo
- Segrè Ayellet V.
- Shields Beverley M.
- Shrader Peter
- Sigurdsson Gunnar
- Sijbrands Eric
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Smith Alberto
- Smith Andrew J.
- Smith Tamara B.
- Snieder Harold
- Snoep Jaapjan D.
- Sohrabi Soroush
- Song Kijoung
- Soranzo Nicole
- Sparsø Thomas
- Spector Tim D.
- Spertus John A.
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdottir Valgerdur
- Stewart Alexandre F. R.
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Stringham Heather M.
- Subirana Isaac
- Sun Qi
- Susan Burnett Mary
- Swift Amy J.
- Sylvius Nicolas
- Syvänen Ann-Christine
- Tanaka Toshiko
- Teijink Joep A. W.
- Tennstedt Stephanie
- Teumer Alexander
- Thompson John R.
- Thompson Matthew M.
- Thomson Ian A.
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Tobin Martin D.
- Tognoni Giovanni
- Tomaszewski Maciej
- Topless Ruth
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tybjærg-Hansen Anne
- Uda Manuela
- Uiterwaal Cuno S.
- Uitterlinden Andre
- Uitterlinden Andre G.
- Valle Timo T.
- van Bockxmeer Frank M.
- van Dam Rob M.
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Rij Andre
- van Rij Andre M.
- van Vliet-Ostaptchouk Jana V.
- Vasudevan Thodur M.
- Vicky Phillips L.
- Vineis Paolo
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Waeber Gerard
- Wain Louise V.
- Walker Mark
- Wallace Chris
- Waltham Matthew
- Wareham Nicholas J.
- Watanabe Richard M.
- Waterworth Dawn M.
- Watkins Hugh
- Webster John
- Weedon Michael N.
- Welch Ryan P.
- Wells George A.
- Wichmann H-Erich
- Wijmenga Cisca
- Wild John B.
- Wild Philipp S.
- Willenborg Christina
- Willer Cristen J.
- William Rayner N.
- Williams Frances M.
- Wilson Tang W. H.
- Wilson James F.
- Witteman Jaqueline C. M.
- Wouter Jukema J.
- Wright Benjamin J.
- Wu Guanming
- Ye Shu
- Yu Grace
- Yuan Xin
- Zeggini Eleftheria
- Zelenika Diana
- Zeller Tanja
- Zhai Guangju
- Zhang Feng
- Ziegler Andreas
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10-5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 × 10-5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10-10, odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression
Nikolai: Portrait of a Dilemma. By William C. Fletcher. New York: The Macmillan Company, 1968. 230 pp. $6.95.
- Author
- Publication venue
- 'JSTOR'
- Publication date
- Field of study
Anna Pavlova. By Oleg Kerensky. New York: E. P. Dutton, 1973. xvi. 161 pp. $6.95.
- Author
- Publication venue
- 'JSTOR'
- Publication date
- Field of study
Iu. A. Bakrushin, Istoriia russkogo baleta. Moscow: “Sovetskaia rossiia,” 1965. Pages 248; illustrations. - Fedor Lopukhov,Shest'desiat let v balete: Vospominaniia i zapiski baletmeistera. Edited by Iu. Slonimskii. Moscow: “Iskusstvo,” 1966. Pages 367. - Mikhail M. Mikhailov, Zhizn' v balete. Moscow: “Iskusstvo,” 1966. Pages 316. Vsë o balete: Slovar' spravochnik. Compiled by E. la. Surits. Moscowand Leningrad: “Muzyka,” 1966. Pages 454.
- Author
- Publication venue
- 'JSTOR'
- Publication date
- Field of study
The World of Diaghilev. By John Percival. London: Studio Vista. New York: Dutton Pictureback, 1971. 159 pp. $2.25, paper.
- Author
- Publication venue
- 'JSTOR'
- Publication date
- Field of study
Nationalism, satire, and Romantic ballet: Thackeray, Taglioni, and the good old (English) plan
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Minds Mad for Dancing: Polkamania on the London Stage
- Author
- Armitage Mrs
- Baker Michael
- Barnett C. Z.
- Barnett Morris
- Boucicault Dion
- Burnand Sir Francis Cowley
- Cellarius Henri
- Cellarius Henri
- Coyne J. Stirling
- Coyne J. Stirling
- Davis Tracy C.
- Gawlikowski
- Michel Arthur
- Polkarius pseud
- Richardson P[hilip] J. S.
- Scott Clement
- Selby Charles
- Stocqueler J[oachim] H.
- Swift Mary Grace
- Webster Margaret
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1
- Author
- Abecasis G.R. (Gonçalo R.)
- Abecasis Gonçalo
- Absher D. (Devin)
- Adrienne Cupples L.
- Aherrahrou Zouhair
- Allayee Hooman
- Allione Alessandra
- Altshuler David
- Altshuler David
- Altshuler David
- Amin Najaf
- Anand Sonia
- Andersen Karl
- Anderson J.L. (Jeffrey L.)
- Angelica Merlini Pier
- Ardissino Diego
- Ardlie Kristin
- Assimes T.L. (Themistocles L.)
- Assimes Themistocles
- Aulchenko Yurii
- Baas Annette
- Badger Jonathan
- Balkau Beverley
- Ball Stephen
- Balmforth Anthony
- Bandinelli Stefania
- Barbalic maja
- Barnes Timothy
- Barroso Inês
- Barroso Inês
- Becker Diane
- Becker Lewis
- Beckmann Jacques
- Benediktsson Rafn
- Bengtsson Boström Kristina
- Bennett Amanda
- Berger Klaus
- Berglund G.
- Bergman R.N. (Richard N.)
- Bergman Richard N.
- Bergmann S. (Sven)
- Bingham Sheila
- Bis Joshua
- Blagieva Roza
- Blair R.D. (Ross D.)
- Blankenberg Stefan
- Blankensteijn Jan
- Bochud Murielle
- Bockxmeer Frank
- Boehm Bernhard
- Boehnke Michael
- Boehnke Michael
- Boekholdt Matthijs
- Boerwinkle E. (Eric)
- Boerwinkle Eric
- Bonnycastle L.L. (Lori L.)
- Bonnycastle Lori
- Bots Michiel
- Bown N.
- Bradley Declan
- Bragi Walters G.
- Braund Peter
- Bravenboer Bert
- Brown M.J. (Morris J.)
- Brown Morris
- Bumpstead Suzannah
- Bumpstead Suzannah
- Burnand Kevin
- Burton Paul
- Burtt Noël
- Buysschaert Ian
- Cambien François
- Campbell Harry
- Carlquist John
- Cauchi Stephane
- Caulfield Mark
- Chambers John
- Charpentier Guillaume
- Chen L. (Li)
- Child Anne
- Chines Peter
- Cichon Sven
- Clarke Robert
- Clough Rachel
- Cockerill Gillian
- Codd Veryan
- Coin L. (Lachlan)
- Collins F.S. (Francis S.)
- Collins Francis
- Connell John
- Cornelis Marilyn
- Couper David
- Crawford G.J. (Gabriel J.)
- Crawford Gabe
- Daly Mark
- Dam Rob
- Davies Robert
- de Jong P.E. (Paul E.)
- Dedoussis George
- Dehghan Abbas
- Deloukas P. (Panos)
- Deloukas P. (Panos)
- Deloukas Panagiotis
- Demissie Serkalem
- Devaney Joseph
- Di Gregorio Alessandra
- Diemert Patrick
- Dina Christian
- Do Ron
- Doering Angela
- Dominiczak Anna
- Doney Alex
- Duijn Cornelia
- Dupuis Josée
- Döring Angela
- Dörr Marcus
- Edkins Ted
- Eifert Sandra
- El Mokhtari Nour Eddine
- Elliott Amanda
- Elliott K.S. (Katherine S.)
- Elliott Katherine
- Elliott P. (Paul)
- Ellis Stephen
- Elosua R. (Roberto)
- Elosua Roberto
- Engert J.C. (James C.)
- Epstein Stephen
- Erdmann Jeanette
- Erdos Michael
- Eriksson Per
- Ernst F. (Florian)
- Eyheramendy Susana
- Faire Ulf
- Farrall Martin
- Felix Stephan
- Ferreira Teresa
- Ferrucci Luigi
- Fischer M. (Marcus)
- Florez J.C. (Jose C.)
- Folkersen Lasse
- Folsom Aaron
- Forouhi Nita
- Fox Caroline
- Franco-Cereceda Anders
- Franklin Christopher
- Frayling Timothy
- Freimer Nelson B.
- Freyer Jennifer
- Frikke-Schmidt Ruth
- Froguel Philippe
- Futers Simon
- Galan Pilar
- Ganser Martha
- Gateva Vesela
- Gerry Hill B.
- Gieger C. (Christian)
- Gieger C. (Christian)
- Gieger Christian
- Gigante Bruna
- Gilst Wiek
- Girelli Domenico
- Gloyn Anna
- Goel A. (Anuj)
- Golledge Jonathan
- Goodall Alison
- Graaf Jacqueline
- Grallert Harald
- Grarup Niels
- Green T. (Todd)
- Gretarsdottir S. (Solveig)
- Gretarsdottir Solveig
- Griffin Simon
- Grobbee Diederick
- Groop Leif
- Groop Leif
- Groves Christopher
- Guarrera Simonetta
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey
- Gut Ivo
- Gwilliam Rhian
- Gyllensten U. (Ulf)
- Hadjadj Samy
- Hadley D. (David)
- Haeften Timon
- Hafez Hany
- Hall Alistair
- Halperin Eran
- Hammond Naomi
- Hamsten Anders
- Hansen T. (Torben)
- Harrison Seamus
- Harst Pim
- Hartikainen A.L.
- Hassanali Neelam
- Hattersley Andrew
- Hazen Stanley
- Heath Simon
- Hengstenberg Christian
- Hercberg Serge
- Herder Christian
- Herpt Thijs
- Hide Winston
- Hill A.A. (Andrew A.)
- Hitman Graham
- Hoek Mandy
- Hofman A. (Albert)
- Hofman Albert
- Hofmann Oliver
- Holm Hilma
- Homuth Georg
- Horne Benjamin
- Hu Frank
- Hua Zhao J. (Jing)
- Hughes Anne
- Humphries Steve
- Hunt Sarah
- Hunter D.J. (David J.)
- Huth Cornelia
- Hveem Kristian
- Illig Thomas
- Illig Thomas
- Illig Thomas
- Iribarren Carlos
- Isomaa Bo
- Jackson Anne
- Jackson Anne
- Jarvelin Marjo-Riitta
- Johnson A. (Anne)
- Johnson P.R.V. (Paul R. V.)
- Johnson Toby
- Jones G.T. (Gregory T.)
- Jones Gregory
- Jorgensen Torben
- Jousilahti Pekka
- Jukema Jan Wouter
- Kaiser Michael
- Kao Wen
- Kaplan Lee
- Kastelein John
- Kathiresan S. (Sekar)
- Kathiresan S. (Sekar)
- Khaw K.T.
- Khaw Kay-Tee
- Kiemeney Bart
- Klopp Norman
- Knowles Joshua
- Kolovou G. (Genovefa)
- Kong Augustine
- Kong Augustine
- Kooner Jaspal S.
- Kraft Peter
- Kuusisto Johanna
- König Inke
- Laakso M. (Markku)
- Laakso Markku
- Laaksonen Reijo
- Laan Maris
- Lakatta Edward
- Lambrechts Diether
- Langenberg Claudia
- Lathrop Mark
- Lauritzen Torsten
- Leander Karin
- Lettre Guillaume
- Lewis David
- Li Man
- Li X.
- Lieb Wolfgang
- Lieverse Aloysius
- Lim Noha
- Lindgren Cecilia
- Lindholt Jes
- Loley Christina
- Loos Ruth
- Lorbeer Roberto
- Lotery Andrew
- Lourdes Sampietro M.
- Luan J.
- Luben Robert
- Lucas G. (Gavin)
- Lyssenko Valeriya
- Mannucci Pier
- Maouche Seraya
- Marre Michel
- Marrugat Jaume
- Martinelli Nicola
- Matthiasson S.E. (Stefan E.)
- Matullo G.
- McArdle Wendy
- McCarroll Steve
- McCarthy Mark
- McCarthy Mark I.
- McCulloch Laura
- McKeown Pascal
- McNoe Les
- McPherson R. (Ruth)
- McPherson Ruth
- Meigs James
- Meisinger Christa
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Meitinger Thomas
- Melander O. (Olle)
- Melander Olle
- Meneton Pierre
- Merriman T.R. (Tony R.)
- Midthjell Kristian
- Mohlke Karen
- Mohlke Karen L.
- Mooser V. (Vincent)
- Mooser Vincent
- Morgan Thomas
- Morken M.A. (Mario A.)
- Morken Mario
- Morris Andrew
- Morris Andrew
- Muhlestein Joseph
- Munroe Patricia
- Munzel Thomas
- Musunuru Kiran
- März Winfried
- Mühleisen Thomas
- Nahrstaedt Janja
- Naik D.K. (Dilip K.)
- Najjar Samer
- Narisu Narisu
- Navarro Pau
- Navis Gerjan
- Nelson Christopher P.
- Newhouse Stephen
- Newton-Cheh Christopher
- Nilsson P. (Peter)
- Nilsson P. (Peter)
- Norman Paul E.
- Numans Mattijs
- Nöthen Markus
- O'Donnell Christopher
- O'Donnell Christopher J.
- O'Reilly Paul
- Olivieri O. (Oliviero)
- Onland-Moret N.C. (N. Charlotte)
- Org Elin
- Orho-Melander Marju
- Ouwehand Willem
- Owen Katharine
- Palmen Jutta
- Palmer Colin
- Panico Salvatore
- Pankow James
- Papadakis K. (Konstantinos)
- Patel Riyaz
- Patterson Chris
- Payne Felicity
- Peden John
- Pedersen Oluf
- Peltonen Leena Johanna
- Perola Markus
- Perry John
- Peters Annette
- Petersen A.K.
- Peyvandi Flora
- Pfeufer Arne
- Platou Carl
- Polidoro Silvia
- Potter Simon
- Pouta Anneli
- Powell Janet
- Pramstaller Peter Paul
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed
- Rader Daniel
- Rallidis Loukianos
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner Nigel William
- Reffelmann Thorsten
- Refstrup Mette
- Reilly M.P. (Muredach P.)
- Rettig Rainer
- Ricceri Fulvio
- Rice Catherine
- Rij Andre
- Roberts Robert
- Robertson Neil
- Rocheleau Ghislain
- Roden Michael
- Romanazzi Valeria
- Rosendaal Frits
- Rubin Diana
- Rudan Igor
- Sacerdote Carlotta
- Salomaa Veikko
- Salomaa Veikko
- Samani N.J. (Nilesh J.)
- Samani Nilesh
- Samani Nilesh
- Sampson M.J. (Michael J.)
- Sandhu Manjinder
- Sandhu Manjinder
- Sanna Serena
- Saxena Richa
- Sayers Ian
- Schadt Eric
- Scheet Paul
- Schillert Arne
- Schlessinger D. (David)
- Schouw Yvonne
- Schreiber S. (Stefan)
- Schrezenmeir J. (Jürgen)
- Schunkert Heribert
- Schwartz S.M. (Stephen M.)
- Schwartz S.M. (Stephen M.)
- Schäfer A. (Arne)
- Scott D Julian
- Scott L.J. (Laura J.)
- Scott Laura
- Scuteri Angelo
- Seedorf U. (Udo)
- Segrè Ayellet
- Shields Beverley
- Shrader Peter
- Sigurdsson G. (Gunnar)
- Sijbrands Eric
- Siscovick D.S. (David S.)
- Siscovick David
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Smith A. (Alberto)
- Smith A.J.P.
- Smith Albert Vernon
- Smith T.B. (Tamara B.)
- Snieder Harold
- Snoep Jaapjan
- Sohrabi Soroush
- Song Kijoung
- Soranzo N. (Nicole)
- Soranzo Nicole
- Sparsø Thomas
- Spector Timothy
- Spertus John
- Stark K. (Klaus)
- Stefansson K. (Kari)
- Stefansson K. (Kari)
- Stein Lincoln
- Steinthorsdottir Valgerdur
- Stewart Alexandre F.
- Stirrups Kathy
- Stoll Monika
- Strachan David
- Strassburger Klaus
- Stringham H.M. (Heather M.)
- Stringham Heather
- Subirana Isaac
- Sun Qi
- Susan Burnett Mary
- Swift Amy
- Sylvius Nicolas
- Syvänen A.C.
- Tanaka Toshiko
- Tang W.
- Teijink J. A W
- Tennstedt Stephanie
- Teumer Alexander
- Thompson John
- Thompson John
- Thompson Matthew
- Thomson I.A. (Ian A.)
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorleifsson Gudmar
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir Unnur
- Tichet Jean
- Tobin Martin
- Tognoni G. (Giovanni)
- Tomaszewski Maciej
- Topless Ruth
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tuomilehto Jaakko
- Tybjaerg-Hansen A.
- Uda Manuela
- Uiterwaal Cuno
- Uitterlinden A. (Andre)
- Uitterlinden André
- Valle T.T. (Timo T.)
- van Rij A. (Andre)
- Vasudevan Thodur
- Vicky Phillips L.
- Vineis Paolo
- Vliet-Ostaptchouk Jana
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin F.)
- Voight Benjamin
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Waeber Gérard
- Wain Louise
- Walker M. (Mark)
- Wallace Chris
- Waltham Matthew
- Wareham N.J. (Nicholas J.)
- Wareham Nick
- Wareham Nick
- Watanabe R.M. (Richard M.)
- Waterworth Dawn
- Watkins Hugh
- Webster J. (John)
- Weedon Michael
- Welch Ryan
- Wells George
- Wichmann H.E. (H. Erich)
- Wichmann Heinz Erich
- Wichmann Heinz Erich
- Wijmenga C. (Cisca)
- Wijmenga Cisca
- Wild John
- Wild Philipp
- Willenborg Christina
- Willer C.J. (Cristen J.)
- Willer Cristen
- Williams Frances
- Wilson J.F. (James F.)
- Witteman J. (Jacqueline)
- Witteman Jacqueline
- Wright Benjamin
- Wright Benjamin
- Wu Guanming
- Ye S. (Shu)
- Yu Grace
- Yuan Xin
- Zeggini Eleftheria
- Zeggini Eleftheria
- Zelenika Diana
- Zeller Tanja
- Zhai Guangju
- Zhang Feng
- Ziegler A. (Andreas)
- Zwart John-Anker
- Publication venue
- Elsevier
- Publication date
- 01/01/2011
- Field of study
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10−5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 × 10−5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10−10, odds ratio 1.15 [1.10–1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04–1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression
Empagliflozin in Patients with Chronic Kidney Disease
- Author
- Aamir Navivala
- Abdulwahab Arbi
- Abegail Hernandez Pena
- Abraham Hanburry
- Adedolapo Adeleke
- Adeera Levin
- Adil Hazara
- Adline Ghazi
- Agnes Masengu
- Ahmad Tuffaha
- Ahmed Awad
- Ahmed Ghanem
- Ai Fukasawa
- Aik Kheng Lee
- Aiko Terakawa
- Aiko Tomita
- Aiko Yamada
- Ailsa Geddes
- Airi Sato
- Akane Katanosaka
- Akane Yamamoto
- Akihiro Fujimoto
- Akihiro Katayama
- Akihito Tanaka
- Akiko Fujita
- Akiko Hashimoto
- Akiko Ishiguro
- Akiko Omata
- Akimasa Asai
- Akinwande Akinfolarin
- Akio Kanazawa
- Akiyo Nishiyama
- Akiyo Tanabe
- Alastair Rankin
- Alastair Woodman
- Albert Hing
- Albert Power
- Alberto Rosati
- Aldo P Maggioni
- Aldo Peixoto
- Aleksandra Murawska
- Alessandro D'Amelio
- Alex Aguilera
- Alex Baxter
- Alex Howson
- Alexa Wonnacott
- Alexander Hadley
- Alexander Hodakowski
- Alexander Paliege
- Alexis Africano
- Alexis Stevenson
- Alfio Giuffrida
- Alfred K Cheung
- Alia Hasan
- Alia Zubaidah Bahtar
- Alice Aitken
- Alice Guerini
- Aliseiya Garza
- Alison Cowley
- Alison Jenkins
- Alison Timadjer
- Allen Young
- Allison Leslie
- Amalia Caamano
- Amanda Aliu
- Amanda Axler
- Amanda Davis
- Amanda Scott
- Amanda Tyler
- Amar Ali
- Amber Avery
- Amber Hurst
- Amelia Te
- Ami Inamori
- Amin Oomatia
- Amir Kazory
- Amret Hawfield
- Amritanshu Pandey
- Amy Hudson
- Amy Hunter
- Amy Mottl
- Ana Moncada
- Anand Srivastava
- Anastassiya Reisler
- Anca Gherman
- Andre Valleteau
- Andrea Lorimer
- Andrea Schwab
- Andrea Webster
- Andrea Wilson
- Andreas Schneider
- Andrew Breach
- Andrew Connor
- Andrew Frankel
- Andrew Gordon
- Andrew Lewington
- Andrew Shepherd
- Andrew Steele
- Andy Burke
- Andy Measor
- Angela Bergner
- Angela Chamberlain
- Angela Field
- Angela Moon
- Angeline Mbuyisa
- Angharad Williams
- Anil George
- Anita Hepditch
- Anita Kamarzarian
- Anja Knoppe
- Anju Oommen
- Anke Torp
- Ankit Mehta
- Ann Bennett
- Ann Cooper
- Ann Vasseur
- Anna Brewer
- Anna Liew
- Anna Postal
- Anna Romo
- Anna Sampson
- Annalisa Aloisi
- Anne Froment
- Anne Grace
- Anne Schreiber
- Anne-Marie Beneat
- Annegret Fleischer
- Annette Kraemer-Guth
- Annie Saillant
- Annika Küpper
- Anoushka Bhatt
- Anthony Lambert
- Anthony Torres
- Anthoula Apostolidi
- Antonia Schuster
- Antonio Cardone
- Aoife O'Sullivan
- Aparna Padiyar
- Arash Rashidi
- Archie Maskill
- Arelis Madera
- Arif Khwaja
- Arihiro Kiyosue
- Asako Takesada
- Ashlee Morris
- Ashleigh Wheeler
- Ashley Lawson
- Ashwathy Varughese
- Ashwini Gore
- Asma Sabarai
- Astrid Maselli
- Atsuko Nakatsuka
- Atsuyuki Tokuyama
- Auguste Kutschat
- Autumn Wood
- Aya Kawase
- Aya Tanaka
- Aya Yamanaka
- Ayako Imai
- Ayana Tatsuzawa
- Aydin Er
- Ayesha Ali
- Ayesha Irtiza-Ali
- Aziee Sudin
- Bader Al-Zeer
- Baigent Colin
- Bak Leong Goh
- Balwinder Gill
- Ban Chai Peng
- Baochun Guo
- Barbara Bartolomei Mecatti
- Barbara Tucky
- Barbara Winter-Goodwin
- Barbara Zander
- Barry Johns
- Beate Schumacher
- Bellovich Keith
- Ben Bagwell
- Ben Caplin
- Bernd Hohenstein
- Bernd Kruger
- Bernd Schroppel
- Bernd Stratmann
- Bernhard Banas
- Bernhard Kraemer
- Bernhard Winkelmann
- Bethelihem Gebeyehu
- Bhavya Kothapalli
- Bhrigu Sood
- Bhupinder Grewal
- Bianca Weber
- Bianka Rettenmaier
- Binbin Jin
- Bob Goodenough
- Bradley Eilerman
- Brandy Caudill
- Brenner Susanne
- Brian Camilleri
- Brigitte Fuchs
- Britta Brettschneider
- Britta Zemann
- Brittany Cleveland
- Brittany Golson
- Brittany Whitmore
- Brueckmann Martina
- Camille Galloway
- Cara Healy
- Carina Krieger
- Carl-Philipp Roesch
- Carlo Castillo
- Carlo Garofalo
- Carlos Hernandez-Cassis
- Carlos Martinez
- Carly McDonald
- Carol Buckman
- Carol Knott
- Caroline Blake
- Carolyn Hutchinson
- Cashmere Hardy
- Cassandra Johnson
- Cassandra Kimber
- Cat Guest
- Cath Byrne
- Cathy Jackson
- Cecilia Barnini
- Cesira Cafiero
- Chakradhar Velagapudi
- Charalampos Kriatselis
- Charles Daniels
- Charles Herzog
- Charlotte Kamundi
- Chee Koon Low
- Chek Loong Loh
- Chelsia Bao Tyng Chan
- Chen Cheng
- Chen Hua Ching
- Cheng Beng Goh
- Cherney David
- Chetna Tailor
- Cheung Alfred K
- Chiara Saccà
- Chiara Salviani
- Chidambaram Nethaji
- Chie Hashimoto
- Chie Saito
- Chigusa Higuchi
- Chigusa Yamashita
- Chiho Murakami
- Chika Kuribayashi
- Chimaki Unekawa
- Chintankumar Barot
- Chloe Bird
- Chong Men Leong
- Chris Bowler
- Chrissie Ambrose
- Christian Albert
- Christian Hartner
- Christian Hugo
- Christina Büttner
- Christina Reith
- Christine Bond
- Christine Braun
- Christine Brown
- Christine McClary-Wright
- Christine Meshykhi
- Christine Pötz
- Christoph Stellbrink
- Christoph Wanner
- Christopher Goldsmith
- Christopher Hill
- Christopher Marshall
- Christopher Provenzano
- Christopher Sze Bing Sim
- Christopher Wong
- Chuanwen Xu
- Chukwuma Chukwu
- Chun Leong Low
- Chye Chung Gan
- Cindy Castro
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- Claire Burston
- Claire Sharpe
- Claire Shenton
- Clare Hui Hong Tan
- Clare Macdonald
- Claudia Donhauser
- Claudia Foellinger
- Claudia Hanf
- Claudia Schmidt
- Claudia Schneider-Danwitz
- Clorinda Falcone
- Cole Valletta
- Conception Pugay
- Concetta Gangemi
- Conor Moran
- Cristina Badin
- Cristina Calvi
- Curtis Knight
- Cynthia Mohandas
- Daisuke Sato
- Daisy Arteaga
- Damini Jeyarajah
- Daniel Kraus
- Daniel Pinto
- Daniel Steffl
- Daniela Farrugia
- Danijela Bovan
- Danny Sugimoto
- Daria Motta
- Darya Hosein
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- David Cherney
- David Loader
- David MacLean
- David Preiss
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- Davina Hewitt
- Debasish Banerjee
- Debbie Domingo
- Debbie Griffin
- Deborah Glowski
- Deborah Lund
- Deirdre Fottrell-Gould
- Denise Donaldson
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- Denise Laurienti
- Dennis Karounos
- Deo Rajat
- Derrick Bennett
- Devasmita Dev
- Dheeptha Radhakrishnan
- Diane Campbell
- Diane Watkins
- Diethelm Tschope
- Diliana Draganova
- Divya Birudaraju
- Dolores Rijos
- Domenico Santoro
- Dominic Fellowes
- Dominik Alscher
- Dominik Stoffler
- Donald Fraser
- Donata Lucci
- Donatella Bilucaglia
- Doo Yee Mah
- Doreen Zhu
- Doris Poehler
- Dorleena Gowen
- Duncan Browne
- Eason Chang
- Edmond Limon
- Edward Kinsella-Perks
- Edward Pereira
- Edwin Wong
- Egbert Schulz
- Eiichiro Kanda
- Eilbracht Jens
- Eirini Lioudaki
- Eitaro Nakashima
- Ekaterina Stellbrink
- Elaine Fung
- Eleanor Damian
- Elena Brioni
- Elias Ugwu
- Elif Turan
- Elisa Joye Petr
- Elisabeth Bahlmann-Kroll
- Elisabeth Laundy
- Elissa Williams
- Elizabeta Matvienko
- Elizabeth Newman
- Elizabeth Swanson
- Elke Preiss
- Elke Schettler
- Elliyyin Katiman
- Emberson Jonathan R
- Emi Kuroda
- Emily Chang
- Emily Harding
- Emily Laity
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- Emma McHaffie
- Emma Sadler
- Emmie Cole
- Enric Vilar
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- Eric Wines
- Erika Perez
- Eriko Takahira
- Erin Latore
- Ester Baldini
- Esther Zhao Zhi Tan
- Etsuo Yoshidome
- Eunice Doctolero
- Eva Voigt
- Eve Miller-Hodges
- Evelina Grobovaite
- Evelyn Nadar
- Ewelina Eckrich
- Exodus Edmerson
- Fadia Boreky
- Fairol Huda Ibrahim
- Fang Chen
- Fang Feng
- Farah Amalina Mohamed Affandi
- Farah Hanis Zulkipli
- Farah Latif
- Farid Ghalli
- Fariz Safhan Mohamad Nor
- Federica Tripodi
- Federico Alberici
- Fengmin Shao
- Filippo Aucella
- Filippo Fani
- Filippo Farnia
- Florian Sonntag
- Fortunata Zirino
- France Samson
- Frances Morris
- Francesca Bianchini
- Francesco Pesce
- Francesco Russo
- Francesco Scolari
- Francesco Totaro
- Francisco Aguilar
- Francois Dube
- Francois Madore
- Frank McCarroll
- Frank Strutz
- Franz Putz
- Franziska Klauser
- Franziska Scheidemantel
- Freda Driver
- Frederic Rahbari-Oskoui
- Fujiko Hasegawa
- Fulvia Zappulo
- Fuye Yang
- Gabriele Eden
- Gaetano La Manna
- Gagandeep Dhillon
- Gail Evans
- Gail Makos
- Genesis Naverrete
- Genielle Brewer
- Gennaro Santorelli
- Georg Rainer Schlieper
- George Thomas
- Georges Nakhoul
- Geraldine Hernandez
- Gerard Martins
- Gerhard Klausmann
- Gerhard Schmidt
- Gianna Fabbri
- Gianni Carraro
- Gillian Whalley
- Gina Morig
- Giorgio Gentile
- Giovanna Leoncini
- Giovanni Gambaro
- Giovanni Piccinni
- Girish Shivashankar
- Giulia Nobili
- Giuseppe Cianciolo
- Giuseppe Grandaliano
- Giuseppe Spatoliatore
- Giuseppe Vezzoli
- Giuseppina Pessolano
- Godson Oguchi
- Golriz Jafari
- Goto Shinya
- Green Jennifer B
- Gregory Greenwood
- Guanguo Cui
- Guillermo Jimenez
- Gunnar Heine
- Gunter Wolf
- Guylaine Marcotte
- Haitao Zhang
- Haiyan Lin
- Hajar Ahmad Rosdi
- Hajime Nagasu
- Hamish Woodhouse
- Hanako Hase
- Hanna Reiner
- Hannah Kingston
- Hannah Turner
- Hans Schmidt-Gurtler
- Hao Dai
- Harald Darius
- Hari Dukka
- Hari Nair
- Harish Pariani
- Harold Szerlip
- Harpreet Bajaj
- Haruhito Uchida
- Haruka Sasajima
- Hasnah Yahaya
- Hasnain Khandwala
- Hauske Sibylle J
- Haynes Richard
- Heather Edwards
- Heather Henderson
- Heba Nosseir
- Helen Clarke
- Helen Eldon
- Helen French
- Helen Lochhead
- Helen Sparks
- Henry Brown
- Hermann Haller
- Herrington William G
- Hesham Ammar
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- Hideki Kamiya
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- Mahboob Rahman
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- Shintaro Nunokawa
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- Shiva Ugni
- Shivinder Jolly
- Shizuka Higashi
- Shogo Banno
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- Shoichi Maruyama
- Shoji Saito
- Shoko Hayashi
- Shoko Otomo
- Shona Murray
- Shota Hashimoto
- Shraddha Shah
- Shuai Tang
- Shuang Xia
- Shuhan Zhou
- Shunichiro Asahara
- Shunsuke Goto
- Shweta Bansal
- Sian Griffin
- Sibylle J Hauske
- Silke Markau
- Simona Barberi
- Simona Bianco
- Simone Boedecker
- Simone Hagge
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- Simone Vettoretti
- Sina Rolfsmeier
- Sion Roy
- Siti Munirah Jaafar
- Siti Nabilah Mohamad Zaini
- Smeeta Sinha
- Smita Gunda
- Sodai Kubota
- Sofia Dayi
- Sonja Grotjahn
- Sonoka Yamamoto
- Soo Kun Lim
- Soon Yi Sor
- Sorcha Mulligan
- Sri Yarlagadda
- Sridhar Ramanaidu
- Srinivasan Beddhu
- Stacey-Ann Villaruel
- Stacie Hitchcock
- Stacy Gillham
- Staplin Natalie
- Stefan Degenhardt
- Stefan Haack
- Stefan Hantel
- Stefanie Jones
- Stefanie Kuhn
- Stephan Matthias
- Stephanie Bolton
- Stephanie Estcourt
- Stephanie Evans
- Stephanie Martinez
- Stephanie Rosenberg
- Stephanie Watson
- Stephanie Whittaker
- Stephany Topping
- Stephen Aronoff
- Steubl Dominik
- Steven Nagelberg
- Stevens Will
- Stewart Moffat
- Subash Somalanka
- Subha Clarke
- Subrata Debnath
- Sucharit Joshi
- Sue Ann Lee
- Sue Hewins
- SueAnn Squyres
- Sui Phin Kon
- Sunil Bhandari
- Sunita Bavanandan
- Suresh Ramadoss
- Suria Junus
- Susan Haskett
- Susan Hurley
- Susan McLaughlin
- Susannah Pajak
- Susanne Bodine
- Susanne Brenner
- Susumu Nakatani
- Suzannah Dorey
- Sybille Merscher
- Tabbatha Duck
- Tabinda Dugal
- Tadahiro Tomita
- Taeko Uchida
- Tai Meng Chen
- Takahiro Ishikawa
- Takahiro Kato
- Takahiro Matsunaga
- Takahiro Yamano
- Takako Kuramae
- Takako Ozawa
- Takanori Hyo
- Takashi Funayama
- Takashi Kadowaki
- Takashi Kobayashi
- Takashi Udagawa
- Takatoshi Otani
- Takayuki Katsuno
- Takehiko Wada
- Takehiro Sugiyama
- Takeshi Kurose
- Takeshi Miyatsuka
- Takeshi Ogihara
- Takuji Ishimoto
- Takuma Kojo
- Takuya Haraguchi
- Takuya Yokoyama
- Tamaki Sasaki
- Tamara Isakova
- Tammi Glider
- Tammy Ross
- Tanaji Dasgupta
- Taneera Ghate
- Taniya Nimbkar
- Tanvi Talsania
- Tara Johnson
- Tasuku Nagasawa
- Tatsuhito Himeno
- Tatyana Chavagnon
- Tejas Patel
- Teresa Kozlowski
- Teresa McKinley
- Terri Chant
- Tetsuya Hosooka
- Tetsuya Shigehara
- Thahir Abdul-Samad
- The EMPA-KIDNEY Collaborative Group: Colin Baigent
- Theresa McCarthy
- Thiemo Pfab
- Thisun Saram
- Thomas Arnold
- Thomas Jones
- Thomas Phillips
- Thomas Pickett
- Thomas Sitter
- Thomas Walters
- Thomas Weinreich
- Tim Doulton
- Tim Williams
- Timothy Ellam
- Tina Harding
- Tina Ramsey
- Ting Meng
- Tingting Kan
- Tobias Bergler
- Toluleyi Sobande
- Tomoe Sato
- Tomohide Hayami
- Tomohito Gohda
- Tomohito Izumi
- Tomoka Nakamura
- Tomoki Kosugi
- Tomoko Hisatake
- Tomoko Morisaki
- Tomoko Takahashi
- Tomoko Takai
- Tomonori Hasegawa
- Tomoya Mita
- Torsten Schramm
- Toru Ikeda
- Toshiki Kano
- Toshimasa Yamauchi
- Toshiya Yamamoto
- Toshiyuki Komiya
- Toyoyoshi Uchida
- Tracey Cummins
- Tracy Fuller
- Tracy Spinola
- Trevor Greene
- Tricia Young
- Tristan Daniels
- Tsukasa Iwakura
- Tuttle Katherine R
- Tze Jian Ng
- Ulla Ludwig
- Ulrike Giebeln-Hudnell
- Ulrike Schmidt
- Urs Benck
- Ursula Hohenstatt
- Usah Lilavivat
- Vahid Mahabadi
- Vanessa Rivers
- Verlaine Stewart-Ray
- Veronica Poma
- Veronica Yousif
- Vesta Lai
- Vicki Adell
- Vicki Brindle
- Vicki Dodds
- Vicki Donley
- Vickie Jones
- Victoria Carnall
- Victoria Gonce
- Vimal Derebail
- Vinay Varad
- Vittorio Ortalda
- Vivian Yiu
- Vladimir Cejka
- Volker Schettler
- Volker Vielhauer
- Wael Eid
- Wagdy Basily
- Wakako Isari
- Wallendszus Karl
- Waltraud Kmietschak
- Wan Ahmad Faizal Alaidin Razali
- Wan Hazlina Wan Mohamad
- Wanner Christoph
- Waqar Ayub
- Waseem Karsan
- Wasim Deeb
- Wasim Hanif
- Wataru Ogawa
- Wei Wang
- Wei Wei
- Weijing Bian
- Weiping Hou
- Weixin Kong
- Wen Jiun Liu
- Wen Liu
- Wendy Arriaga
- Wiebke Kaluza-Schilling
- Will Stevens
- William Durham
- William G Herrington
- William G Herrington
- William Hodge
- William Petchey
- Wolf-Adam Seeger
- Wolfgang Seeger
- Wuhanbilige Hundei
- Xavier Rossello
- Xia Song
- Xiangcheng Xiao
- Xiaojing Jiao
- Xiaojue Li
- Xiaoliang Wang
- Xinzhou Zhang
- Xiumei Hu
- Xuejiao Liu
- Xueying Wang
- Yan Li
- Yanmei Xu
- Yanping Wang
- YanRu Qiao
- Yanwu Yu
- Yanyun Xie
- Yao Weng
- Yao Yao
- Yasemin Kavak
- Yasuhiko Furukawa
- Yasuhiko Ito
- Yasuhiko Kanaguchi
- Yasuhiro Suzuki
- Yasushi Iwaita
- Ye Mun Low
- Yee Yan Lee
- Yew Fong Liew
- Yi Loon Tye
- Yik Hong Wong
- Yik Shen Lim
- Ying Hu
- Ying Jiang
- Ying Kuan
- Ying Lu
- Yinghua Chen
- Yohei Ejima
- Yoko Inukai
- Yolanda Miller
- Yong Chieh Chan
- Yonghong Bu
- Yoshiaki Morishita
- Yoshie Shibata
- Yoshifumi Tamura
- Yoshihiko Yamasaki
- Yoshihisa Wada
- Yoshikazu Tamori
- Yoshiki Suzuki
- Yoshimitsu Yamasaki
- Yoshinari Yasuda
- Yoshinori Osaki
- Yoshiro Kato
- Yoshiyuki Hamamoto
- Yosuke Hirakawa
- Yosuke Nakagawa
- Youcef Mostefai
- Young Lee-Barkey
- Yu An
- Yu Chen
- Yu Chen Ong
- Yu Yamanouchi
- Yuana Mohd Yusoff
- Yuichiro Munakata
- Yuji Oe
- Yuka Sato
- Yuka Ueda
- Yukari Miura
- Yuki Fujita
- Yuki Fukao
- Yuki Omori
- Yukihiro Shimizu
- Yukihiro Yamaji
- Yukiko Nakayama
- Yukiko Toyonaga
- Yukiko Wakita
- Yuko Katsuda
- Yuko Makita
- Yuko Okada
- Yuko Orimo
- Yumi Osawa
- Yushi Hirota
- Yusuke Suzuki
- Yutaka Kamimura
- Yuya Nishida
- Yvette Webley
- Yvonne Ehrl
- Yvonne Jackson
- Zabrina Lozon
- Zaid Azhari
- Zaiha Harun
- Zainab Sheriff
- Zanaida Cooper
- Zay Htet
- Zhang Duan Tham
- Zhi-Hong Liu
- Zhirui Zhao
- Zhu Doreen
- Zhuo Tang
- Zohreh Forghani
- Zuber Patel
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2023
- Field of study
Background The effects of empagliflozin in patients with chronic kidney disease who are at risk for disease progression are not well understood. The EMPA-KIDNEY trial was designed to assess the effects of treatment with empagliflozin in a broad range of such patients. Methods We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m(2) of body-surface area, or who had an eGFR of at least 45 but less than 90 ml per minute per 1.73 m(2) with a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of at least 200. Patients were randomly assigned to receive empagliflozin (10 mg once daily) or matching placebo. The primary outcome was a composite of progression of kidney disease (defined as end-stage kidney disease, a sustained decrease in eGFR to < 10 ml per minute per 1.73 m(2), a sustained decrease in eGFR of & GE;40% from baseline, or death from renal causes) or death from cardiovascular causes. Results A total of 6609 patients underwent randomization. During a median of 2.0 years of follow-up, progression of kidney disease or death from cardiovascular causes occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% confidence interval [CI], 0.64 to 0.82; P < 0.001). Results were consistent among patients with or without diabetes and across subgroups defined according to eGFR ranges. The rate of hospitalization from any cause was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.86; 95% CI, 0.78 to 0.95; P=0.003), but there were no significant between-group differences with respect to the composite outcome of hospitalization for heart failure or death from cardiovascular causes (which occurred in 4.0% in the empagliflozin group and 4.6% in the placebo group) or death from any cause (in 4.5% and 5.1%, respectively). The rates of serious adverse events were similar in the two groups. Conclusions Among a wide range of patients with chronic kidney disease who were at risk for disease progression, empagliflozin therapy led to a lower risk of progression of kidney disease or death from cardiovascular causes than placebo
Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Aflori Laura
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Amri Khalid
- Al Hussaini Sabah
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alias Raja Liza Raja
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angel Miguel Paludi
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Anizi Mashel Al
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Araujo Daniela Marques
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Aribawa Mahaalit Alit
- Arkalaki Eleni
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam M
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azam Ummi Azmira Ahmad
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beattie Scott
- Beattie Scott
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- Delgado García David R
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- Greaves K. E.
- Greaves Rosanna
- Green Garyth M
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- Harrichandparsad R
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- Hodgkiss Tracey
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- Hodzovic Emil
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- Weatherill J
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- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zin Nor Hafizah Mohd
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- åkring Irene
- Ögren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally