Cross-Generational Occupation-Based Interventions for Upper Extremity Injuries

Decreased adherence to therapy protocols after upper extremity injury has been correlated with increased risk of re-injury and decreased general therapy outcomes. Occupation-based therapy has been shown to increase adherence to therapy protocol. To date, there have been several occupation-based protocols in upper-extremity musculoskeletal rehabilitation, but never one that addresses occupation across the lifespan and attempts to develop a tool to assist therapist in developing occupation based protocols specific to the developmental group. The main theoretical background for the development of the clinical tool was the Model of Human Occupation (MOHO) and Erickson\u27s Developmental Stages Model. An extensive literature review was completed to discover the needs of the population. Once the literature was completed we began compiling the final product. The final product defines each development group in Erickson\u27s theory group using terminology from MOHO. Using this description, we organized activities into each developmental group. Each activity was analyzed and organized by the motions required to perform each activity. The final product is a book of sections covering all upper extremity movements. Each movement is described in terms of starting position, ending position, and normal range of motion. Each page has a section with example activities that incorporate the motion, with activities being organized by developmental group. The appendix of the book contains copies of the pages with streamlined explanations to be utilized as patient handouts. This product incorporates a more client-centered approach with a variety of occupation-based activities in order to address upper extremity musculoskeletal injuries across a person\u27s lifespan. Our hope is that the clinical aid will be utilized to usher in a paradigm shift in upper extremity therapy that is less protocol based and more client-centered and occupation-based. The finished product is to be utilized by an occupational therapist and the client to benefit the recovery process of musculoskeletal injuries and incorporate occupation-based interventions into the recovery process. Further research must be completed to assess the efficacy of the clinical aid and to make adjustments based on results to maximize the effectiveness and increase patient outcomes

To promote Pekan Nabalu as one of the tourism attraction in Malaysia by redesigning corporate / Sweney Simbeh

This section is an overview of background research based on literature review. Chapter one is about the Pekan Nabalu. From this academic writing, I have study about the Pekan Nabalu view besides to get solution for this research. Chapter two is about research and methodology. In this chapter ,1 want to propose my research objectives. Research objective are important to us to know the objective by doing this research. This chapter also including different kind of research to get information on this project. Research methodology focus on what type of method that we using that suitable for our issues. It is also help us to get more data and also evidence for the issues. This is the way to getting more detail about this place. Chapter three is analysis and finding. In this chapter I’m using the method of interview, and questionnaire to gain information. This section provide the discussion based on the original data obtained from the research method.lnterview review that I’m doing is to get know about Pekan Nabalu with interviewing with face to face. It is a useful to obtain detail with knowing the information, perception and opinion. Questionnaire used to get back the respond others to this research. After finished distributes a questionnaire, I made analysis to get a result from questionnaire. Finding have to be made to know the result from the data analysis. The final is describe the conclusion and recommendation. This section describe the conclusion for research that I’ve done. This is also explain the recommendation which is the way that should be doing to obtain the purpose of this research. This is describe with objective and the development of practical recommendations based on relevant research

Convergence calls: multimedia storytelling at British news websites

This article uses qualitative interviews with senior editors and managers from a selection of the UK's national online news providers to describe and analyse their current experimentation with multimedia and video storytelling. The results show that, in a period of declining newspaper readership and TV news viewing, editors are keen to embrace new technologies, which are seen as being part of the future of news. At the same time, text is still reported to be the cornerstone for news websites, leading to changes in the grammar and function of news video when used online. The economic rationale for convergence is examined and the article investigates the partnerships sites have entered into in order to be able to serve their audience with video content. In-house video is complementing syndicated content, and the authors examine the resulting developments in newsroom training and recruitment practices. The article provides journalism and interactive media scholars with case studies on the changes taking place in newsrooms as a result of the shift towards multimedia, multiplatform news consumption

Research conference summary from the 2014 International Task Force on

OBJECTIVE: METHODS: In 2014, the Alternating Hemiplegia of Childhood Foundation hosted a multidisciplinary workshop intended to address fundamental challenges surrounding the diagnosis and management of individuals with RESULTS: Workshop attendees were charged with the following: (1) to achieve consensus on expanded diagnostic criteria to facilitate the identification of additional patients, intended to supplement existing syndrome-specific diagnostic paradigms; (2) to standardize definitions for the broad range of paroxysmal manifestations associated with AHC to disseminate to families; (3) to create clinical recommendations for common recurrent issues facing families and medical care providers; (4) to review data related to the death of individuals in the Alternating Hemiplegia of Childhood Foundation database to guide future efforts in identifying at-risk subjects and potential preventative measures; and (5) to identify critical gaps where we most need to focus national and international research efforts. CONCLUSIONS: This report summarizes recommendations of the workshop committee, highlighting the key phenotypic features to facilitate the diagnosis of possibl

Implementing The Prison Rape Elimination Act: A Toolkit for Jails

Minor edits. “The goal of this Toolkit is to provide jails of all sizes, political divisions, and geographic locations with a step-by-step guide for preventing, detecting, and eliminating sexual abuse of inmates in their custody – and for responding effectively to abuse when it occurs. Prison rape includes all forms of inmate sexual abuse within a correctional facility, including state and federal prisons, county and municipal jails, police lock-ups, holding facilities, inmate transportation vehicles, juvenile detention facilities, and community corrections facilities. Protecting arrestees, detainees, and inmates from sexual violence is part of a jail’s core mission. This toolkit will help assess your jail’s operations with an eye to improvements.” The Toolkit is divided into folders holding materials related to: introductory information about PREA [Prison Rape Elimination Act] and it Standards; a Self-Assessment Checklist with supporting forms “to provide a step-by-step process for jails to review and assess policies, procedures, and practices in light of the PREA Standards and accepted best practices”; and additional resources to assist you in PREA-readiness

Alternating hemiplegia of childhood: Retrospective genetic study and genotype-phenotype correlations in 187 subjects from the US AHCF registry

Mutations in ATP1A3 cause Alternating Hemiplegia of Childhood (AHC) by disrupting function of the neuronal Na+/K+ ATPase. Published studies to date indicate 2 recurrent mutations, D801N and E815K, and a more severe phenotype in the E815K cohort. We performed mutation analysis and retrospective genotype-phenotype correlations in all eligible patients with AHC enrolled in the US AHC Foundation registry from 1997-2012. Clinical data were abstracted from standardized caregivers' questionnaires and medical records and confirmed by expert clinicians. We identified ATP1A3 mutations by Sanger and whole genome sequencing, and compared phenotypes within and between 4 groups of subjects, those with D801N, E815K, other ATP1A3 or no ATP1A3 mutations. We identified heterozygous ATP1A3 mutations in 154 of 187 (82%) AHC patients. Of 34 unique mutations, 31 (91%) are missense, and 16 (47%) had not been previously reported. Concordant with prior studies, more than 2/3 of all mutations are clustered in exons 17 and 18. Of 143 simplex occurrences, 58 had D801N (40%), 38 had E815K (26%) and 11 had G937R (8%) mutations. Patients with an E815K mutation demonstrate an earlier age of onset, more severe motor impairment and a higher prevalence of status epilepticus. This study further expands the number and spectrum of ATP1A3 mutations associated with AHC and confirms a more deleterious effect of the E815K mutation on selected neurologic outcomes. However, the complexity of the disorder and the extensive phenotypic variability among subgroups merits caution and emphasizes the need for further studies

Alternating Hemiplegia of Childhood-Related Neural and Behavioural Phenotypes in Na+,K+-ATPase α3 Missense Mutant Mice

Missense mutations in ATP1A3 encoding Na(+),K(+)-ATPase α3 have been identified as the primary cause of alternating hemiplegia of childhood (AHC), a motor disorder with onset typically before the age of 6 months. Affected children tend to be of short stature and can also have epilepsy, ataxia and learning disability. The Na(+),K(+)-ATPase has a well-known role in maintaining electrochemical gradients across cell membranes, but our understanding of how the mutations cause AHC is limited. Myshkin mutant mice carry an amino acid change (I810N) that affects the same position in Na(+),K(+)-ATPase α3 as I810S found in AHC. Using molecular modelling, we show that the Myshkin and AHC mutations display similarly severe structural impacts on Na(+),K(+)-ATPase α3, including upon the K(+) pore and predicted K(+) binding sites. Behavioural analysis of Myshkin mice revealed phenotypic abnormalities similar to symptoms of AHC, including motor dysfunction and cognitive impairment. 2-DG imaging of Myshkin mice identified compromised thalamocortical functioning that includes a deficit in frontal cortex functioning (hypofrontality), directly mirroring that reported in AHC, along with reduced thalamocortical functional connectivity. Our results thus provide validation for missense mutations in Na(+),K(+)-ATPase α3 as a cause of AHC, and highlight Myshkin mice as a starting point for the exploration of disease mechanisms and novel treatments in AHC