Mecanismo civil para prevenir y resolver conflictos de intereses en el derecho privado ruso

The article studies the legal mechanism preventing and resolving a conflict of interest in civil law. The Russian public law pays much attention to the prevention of competitive interests but there are still no studies on a conflict of interest in private law. The authors have written this article to consider the relevant legal studies and draw their conclusions. Methods: The authors used the methods of comparative and systemic analysis, synthesis and scientific research to examine such a legal concept as a "conflict of interest in private law". The study aims at analyzing the category of competitive interests in relation to private law, determining its prerequisites, reasons and possible solutions. The authors have concluded that a conflict of interest often causes corporate conflicts among parties involved in corporate relations. Moreover, this type of conflicts arises due to the realization of individual property interests and the possibility of one person to influence the other, for example, a conflict between majority and minority shareholders.El artículo explora el mecanismo legal para prevenir y resolver conflictos de intereses en el derecho civil. En Rusia, a la prevención del conflicto de intereses se presta bastante atención en el derecho público, pero, desafortunadamente, no hay estudios dedicados a la investigación del conflicto de intereses en el derecho privado. Los autores han preparado un artículo analítico sobre la investigación en este campo del derecho, utilizando métodos de análisis comparativo y sistémico, síntesis, e investigación científica del aparato legal «conflicto de intereses en derecho privado». El objetivo es investigar la categoría conflicto de intereses en relación con el derecho privado, identificar dónde y en qué circunstancias ocurren con mayor frecuencia el conflicto de intereses, así como las razones determinantes del conflicto de intereses y las formas de resolverlo. Llegando a concluir que, el conflicto de intereses es una de las principales causas de conflictos corporativos entre los participantes en las relaciones corporativas; y al mismo tiempo, surge con mayor frecuencia, como consecuencia de la realización de los intereses de propiedad de las personas, así como la posibilidad de ciertas persona a ejerzer influencia sobre otra, por ejemplo, un conflicto entre accionistas mayoritarios y minoritarios

Cross-border cooperation as a component of sustainable regional development of Mongolia

The paper examines the problem of sustainable socio-economic regional development of Mongolia. Based on the analysis of the main indicators of the economy of Mongolia and its aimaks, it has been concluded, that cross-border cooperation plays a significant role in the sustainable development of the economy of Mongolia; due to heterogeneity and signifi diff entiation in terms of development, when developing a strategy for cross-border cooperation, there is a need to take into account the specifics of each individual region and aimak; the solution of the problem of sustainable socio-economic regional development of Mongolia should be implemented on the basis of an integrated approach

Mecanismo civil para prevenir y resolver conflictos de intereses en el derecho privado ruso

The article studies the legal mechanism preventing and resolving a conflict of interest in civil law. The Russian public law pays much attention to the prevention of competitive interests but there are still no studies on a conflict of interest in private law. The authors have written this article to consider the relevant legal studies and draw their conclusions. Methods: The authors used the methods of comparative and systemic analysis, synthesis and scientific research to examine such a legal concept as a "conflict of interest in private law". The study aims at analyzing the category of competitive interests in relation to private law, determining its prerequisites, reasons and possible solutions. The authors have concluded that a conflict of interest often causes corporate conflicts among parties involved in corporate relations. Moreover, this type of conflicts arises due to the realization of individual property interests and the possibility of one person to influence the other, for example, a conflict between majority and minority shareholders.El artículo explora el mecanismo legal para prevenir y resolver conflictos de intereses en el derecho civil. En Rusia, a la prevención del conflicto de intereses se presta bastante atención en el derecho público, pero, desafortunadamente, no hay estudios dedicados a la investigación del conflicto de intereses en el derecho privado. Los autores han preparado un artículo analítico sobre la investigación en este campo del derecho, utilizando métodos de análisis comparativo y sistémico, síntesis, e investigación científica del aparato legal «conflicto de intereses en derecho privado». El objetivo es investigar la categoría conflicto de intereses en relación con el derecho privado, identificar dónde y en qué circunstancias ocurren con mayor frecuencia el conflicto de intereses, así como las razones determinantes del conflicto de intereses y las formas de resolverlo. Llegando a concluir que, el conflicto de intereses es una de las principales causas de conflictos corporativos entre los participantes en las relaciones corporativas; y al mismo tiempo, surge con mayor frecuencia, como consecuencia de la realización de los intereses de propiedad de las personas, así como la posibilidad de ciertas persona a ejerzer influencia sobre otra, por ejemplo, un conflicto entre accionistas mayoritarios y minoritarios

Aberrant Ganglioside Functions to Underpin Dysregulated Myelination, Insulin Signalling, and Cytokine Expression: Is There a Link and a Room for Therapy?

Gangliosides are molecules widely present in the plasma membranes of mammalian cells, participating in a variety of processes, including protein organization, transmembrane signalling and cell adhesion. Gangliosides are abundant in the grey matter of the brain, where they are critically involved in postnatal neural development and function. The common precursor of the majority of brain gangliosides, GM3, is formed by the sialylation of lactosylceramide, and four derivatives of its a- and b-series, GM1, GD1a, GD1b and GT1b, constitute 95% of all the brain gangliosides. Impairments in ganglioside metabolism due to genetic abnormalities of GM-synthases are associated with severe neurological disorders. Apart from that, the latest genome-wide association and translational studies suggest a role of genes involved in brain ganglioside synthesis in less pervasive psychiatric disorders. Remarkably, the most recent animal studies showed that abnormal ganglioside functions result in dysregulated neuroinflammation, aberrant myelination and altered insulin receptor signalling. At the same time, these molecular features are well established as accompanying developmental psychiatric disorders such as attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD). This led us to hypothesize a role of deficient ganglioside function in developmental neuropsychiatric disorders and warrants further gene association clinical studies addressing this question. Here, we critically review the literature to discuss this hypothesis and focus on the recent studies on ST3GAL5-deficient mice. In addition, we elaborate on the therapeutic potential of various anti-inflammatory remedies for treatment of developmental neuropsychiatric conditions related to aberrant ganglioside functions. Keywords: insulin receptor signalling; major brain gangliosides; mice; myelination; neurodevelopmental disorders; neuroinflammatio

Алгоритмы балансирования нагрузки в Грид-системах

Проведено аналіз стратегій балансування навантаження в Грід-системах та порівняльний аналіз наявних алгоритмів розподілу потоку завдань між обчислювальними ресурсами Грід-середовища.The analysis of strategies of balancing load in the Grid-systems and comparative analysis of existing algorithms of the distribution of flow of the tasks between computing resources of a Grid environment are shown.Проведен анализ стратегий балансирования нагрузки в Грид-системах и сравнительный анализ имеющихся алгоритмов распределения потока заданий между вычислительными ресурсами Грид-среды

Super-mandatory rules in private international law

The article studies the concept and the need to apply super-mandatory rules in international private relations. The concept of super-mandatory rules emerged in international law in the 20th century. However, different countries provide various definitions of such rules and develop different practices of their application. The diversification of this concept hinders the effective protection of violated rights and obligations of parties to international relations. Analyzing different acts of international law, the authors of the article offer their vision of super-mandatory rules. Methods: The topic was studied through general scientific methods and special scientific methods, including system-structural, historical, technical-legal analysis, comparative jurisprudence, etc. The objective is to examine the application of super-mandatory rules (in particular, their possible application in international private relations), as well as determine and formulate their essence. Results: The authors have studied the application of super-mandatory rules in various countries, including Russia. They have also formed the definition of super-mandatory rules and considered the possibility of their application in Russia

Ethical standards and rights in the regulation of high technology

The study aims at considering the ethical and legal regulation of high technology in the sphere of medicine and identifying problems and determine developmental prospects. The methodological basis was the theory of cognition. To overcome problems in this area, the following algorithm of actions is proposed: to adopt ethical norms in the field of science and certain high-tech areas of professional activity; to consolidate the order, as well as features of adopting ethical norms, changing and canceling them; to determine the functioning of special bodies adopting regulations and other procedures (for example, ethical councils); to authorize the application of norms and procedure of ethical responsibility to individuals who are subject to ethical norms of the sphere (area) of their activity; to establish control and supervisory measures for the activities of specially created bodies; to ensure the proper application of ethical standards

Predation stress causes excessive aggression in female mice with partial genetic inactivation of Tryptophan hydroxylase-2: evidence for altered myelination-related processes

© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The interaction between brain serotonin (5-HT) deficiency and environmental adversity may predispose females to excessive aggression. Specifically, complete inactivation of the gene encoding tryptophan hydroxylase-2 (Tph2) results in the absence of neuronal 5-HT synthesis and excessive aggressiveness in both male and female null mutant (Tph2-/-) mice. In heterozygous male mice (Tph2+/-), there is a moderate reduction in brain 5-HT levels, and when they are exposed to stress, they exhibit increased aggression. Here, we exposed female Tph2+/- mice to a five-day rat predation stress paradigm and assessed their emotionality and social interaction/aggression-like behaviors. Tph2+/- females exhibited excessive aggression and increased dominant behavior. Stressed mutants displayed altered gene expression of the 5-HT receptors Htr1a and Htr2a, glycogen synthase kinase-3 β (GSK-3β), and c-fos as well as myelination-related transcripts in the prefrontal cortex: myelin basic protein (Mbp), proteolipid protein 1 (Plp1), myelin-associated glycoprotein (Mag), and myelin oligodendrocyte glycoprotein (Mog). The expression of the plasticity markers synaptophysin (Syp) and cAMP response element binding protein (Creb), but not AMPA receptor subunit A2 (GluA2), were affected by genotype. Moreover, in a separate experiment, naïve female Tph2+/- mice showed signs of enhanced stress resilience in the modified swim test with repeated swimming sessions. Taken together, the combination of a moderate reduction in brain 5-HT with environmental challenges results in behavioral changes in female mice that resemble the aggression-related behavior and resilience seen in stressed male mutants; additionally, the combination is comparable to the phenotype of null mutants lacking neuronal 5-HT. Changes in myelination-associated processes are suspected to underpin the molecular mechanisms leading to aggressive behavior.The authors’ animal work reported here was supported by Deutsche Forschungsgemeinschaft (DFG:CRC TRR58A1/A5), the European Union’s Seventh Framework Programme (FP7/2007–2013) under Grant No. 602805 (Aggressotype), the Horizon 2020 Research and Innovation Programme under Grant No. 728018 (Eat2beNice) (to K.-P.L. and T.S.) and Grant No. 101007642 (PhytoAPP) (to D.C.A. and T.S.), and Swiss-Russian Cooperation grant RPG Russia 2020 (to S.W. and K.-P.L.). Molecular data analysis was supported by RAS N0520-2019-0031 (to E.S. and T.S.).info:eu-repo/semantics/publishedVersio

Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes

The interaction between brain serotonin (5-HT) deficiency and environmental adversity may predispose females to excessive aggression. Specifically, complete inactivation of the gene encoding tryptophan hydroxylase-2 (Tph2) results in the absence of neuronal 5-HT synthesis and excessive aggressiveness in both male and female null mutant (Tph2-/-) mice. In heterozygous male mice (Tph2+/-), there is a moderate reduction in brain 5-HT levels, and when they are exposed to stress, they exhibit increased aggression. Here, we exposed female Tph2+/- mice to a five-day rat predation stress paradigm and assessed their emotionality and social interaction/aggression-like behaviors. Tph2+/- females exhibited excessive aggression and increased dominant behavior. Stressed mutants displayed altered gene expression of the 5-HT receptors Htr1a and Htr2a, glycogen synthase kinase-3 β (GSK-3β), and c-fos as well as myelination-related transcripts in the prefrontal cortex: myelin basic protein (Mbp), proteolipid protein 1 (Plp1), myelin-associated glycoprotein (Mag), and myelin oligodendrocyte glycoprotein (Mog). The expression of the plasticity markers synaptophysin (Syp) and cAMP response element binding protein (Creb), but not AMPA receptor subunit A2 (GluA2), were affected by genotype. Moreover, in a separate experiment, naïve female Tph2+/- mice showed signs of enhanced stress resilience in the modified swim test with repeated swimming sessions. Taken together, the combination of a moderate reduction in brain 5-HT with environmental challenges results in behavioral changes in female mice that resemble the aggression-related behavior and resilience seen in stressed male mutants; additionally, the combination is comparable to the phenotype of null mutants lacking neuronal 5-HT. Changes in myelination-associated processes are suspected to underpin the molecular mechanisms leading to aggressive behavior. Keywords: 5-HT receptors; female aggression; glycogen synthase kinase-3 β (GSK-3β); myelination; predation stress; tryptophan hydroxylase-2 (Tph2)

Safety of dabigatran etexilate for the secondary prevention of venous thromboembolism in children

This open-label, single-arm, prospective cohort trial is the first phase 3 safety study to describe outcomes in children treated with dabigatran etexilate for secondary venous thromboembolism (VTE) prevention. Eligible children aged 12 to <18 years (age stratum 1), 2 to <12 years (stratum 2), and >3 months to <2 years (stratum 3) had an objectively confirmed diagnosis of VTE treated with standard of care (SOC) for ‡3 months, or had completed dabigatran or SOC treatment in the DIVERSITY trial (NCT01895777) and had an unresolved clinical thrombosis risk factor requiring further anticoagulation. Children received dabigatran for up to 12 months, or less if the identified VTE clinical risk factor resolved. Primary end points included VTE recurrence, bleeding events, and mortality at 6 and 12 months. Overall, 203 children received dabigatran, with median exposure being 36.3 weeks (range, 0-57 weeks); 171 of 203 (84.2%) and 32 of 203 (15.8%) took capsules and pellets, respectively. Overall, 2 of 203 children (1.0%) experienced on-treatment VTE recurrence, and 3 of 203 (1.5%) experienced major bleeding events, with 2 (1.0%) reporting clinically relevant nonmajor bleeding events, and 37 (18.2%) minor bleeding events. There were no on-treatment deaths. On-treatment postthrombotic syndrome was reported for 2 of 162 children (1.2%) who had deep vein thrombosis or central-line thrombosis as their most recent VTE. Pharmacokinetic/pharmacodynamic relationships of dabigatran were similar to those in adult VTE patients. In summary, dabigatran showed a favorable safety profile for secondary VTE prevention in children aged from >3 months to <18 years with persistent VTE risk factor(s). This trial was registered at www.clinicaltrials.gov as #NCT02197416. (Blood. 2020;135(7):491-504