Site Communication in Direct Formation of H2O2 over Single-Atom Pd@Au Nanoparticles

Single atom alloy catalysts offer possibilities to obtain turnover frequencies and selectivities unattainable by their monometallic counterparts. One example is direct formation of H2O2 from O2 and H2 over Pd embedded in Au hosts. Here, a first-principles-based kinetic Monte Carlo approach is developed to investigate the catalytic performance of Pd embedded in Au nanoparticles in an aqueous solution. The simulations reveal an efficient site separation where Pd monomers act as active centers for H2 dissociation, whereas H2O2 is formed over undercoordinated Au sites. After dissociation, atomic H may undergo an exothermic redox reaction, forming a hydronium ion in the solution and a negative charge on the surface. H2O2 is preferably formed from reactions between dissolved H+ and oxygen species on the Au surface. The simulations show that tuning the nanoparticle composition and reaction conditions can enhance the selectivity toward H2O2. The outlined approach is general and applicable for a range of different hydrogenation reactions over single atom alloy nanoparticles

Digital communications between VIDA and their suppliers

The Swedish forest industry has put a lot of resources in the development of digital communications in hopes of improving collaboration with suppliers. The purpose of this study was to investigate whether VIDA would benefit from using digital communication with suppliers. The survey was conducted as a questionnaire study among the company’s staff and its suppliers. The result indicated needs and interests to use digital communications in both groups. Young suppliers and suppliers on a distance showed the most interest in using digital communication. In terms of using these digital communications, the staffs and suppliers were most interested in information regarding transaction and forestmanagement plans. Anyway it´s not particularly important in terms of choosing where to sell their timber. The conclusion of the study implies that VIDA can use digital communication in order to strengthen their relationship with suppliers, attract new suppliers and to streamline their overall communication

Modulatory effects on dendritic cells by human herpesvirus 6

Human herpesvirus 6A and 6B are β-herpesviruses approaching 100% seroprevalance worldwide. These viruses are involved in several clinical syndromes and have important immunomodulatory effects. Dendritic cells (DC) are key players in innate and adaptive immunity. Accordingly, DC are implicated in the pathogenesis of many human diseases, including infections. In this review the effects of HHV-6 infection on DC will be discussed

Lighting and perceived safety : lighting design for a part of a forest path in Stadsskogen, Uppsala

Många upplever otrygghet när de rör sig utomhus nattetid, inte minst i grönområden. Få studier undersöker belysning och upplevd trygghet i skogsstråk, därav är det relevant att undersöka frågorna: Vilka belysningsstrategier kännetecknar upplevd trygghet i skogsstråk? Hur kan ett skogsstråk i teorin ljusgestaltas för att främja upplevd trygghet? För att besvara första frågan gjordes en bakgrund om perception och ljus, följt av en tematisk litteraturöversikt om belysningsstrategier som påverkar upplevd trygghet. För att besvara andra frågan användes dataprogram till att ta fram ett ljusgestaltningsförslag för en del av ett skogsstråk. Till grund för ljusgestaltningen ligger, förutom litteraturen, två platsanalysmetoder. Den första ger verktyg för att analysera delstråkets utseendemässiga egenskaper. Den andra ger verktyg för att koppla utseendemässiga egenskaper till upplevd trygghet. Svaret på första frågan tyder på att följande aspekter är särskilt viktiga beakta vid ljussättning i trygghetssyfte: öppenhet, slutenhet, sikt, återgivning av omgivningen, ljuskontraster och ljusfärg. Vidare bör kombinationen av nämnda aspekter säkerställa läsbarhet och visuell kontroll. Svaret på andra frågan är att stolpbelysning, LED-bollar, upplysta träd, vitt ljus och varma ljusfärger är lämpliga i delstråket i syfte att främja den upplevda tryggheten. För att avgöra om en ljusgestaltning ökar den upplevda tryggheten rekommenderas att den omsätts i praktiken och testas genom enkäter.It is common to feel unsafe outdoors during night, not least in green areas. Few publications investigate lighting and perceived safety in forest paths, hence it is relevant to investigate the questions: What lighting strategies characterize perceived safety in forest paths? In theory, how can a forest path be designed with lighting to favor perceived safety? To answer the first question a background about perception and light was made, followed by a thematic literature overview about lighting strategies affecting perceived safety. To answer the second question a lighting design proposal for a part of a forest path was made using software. The lighting design is based, in addition to the literature, on two site-based analysis methods. The first provides tools for analyzing aesthetic qualities. The second aims to connect aesthetic qualities to perceived safety. The answer to the first question suggests that the following aspects are particularly important to consider in a lighting design of a forest path: openness, enclosure, prospect, rendering of the environment, light-dark contrast and color temperature of light. The use of these aspects should assure readability of space and visual control. The answer to the second question suggests that lamp posts, LED-balls, illuminated trees, white light and warm color temperature of light, are suitable for the chosen forest path in order to favor perceived safety. To determine whether a lighting design enhances perceived safety, it is recommended that the lighting design is tested on site by questionnaires

Temperature and concentration dependence of the electrochemical PtHg4 alloy formation for mercury decontamination

New and improved methods to remove toxic mercury from contaminated waters and waste streams are highly sought after. Recently, it was shown that electrochemical alloy formation of PtHg4 on a platinum surface with mercury ions from solution can be utilized for decontamination, with several advantages over conventional techniques. Herein, we examine the alloy formation process in more detail by mercury concentration measurements using inductively coupled plasma mass spectrometry in batch measurements as well as electrochemical quartz crystal microbalance analysis both in batch and in flowing water with initial mercury concentrations ranging from 0.25 to 75000 \ub5g L−1 Hg2+. Results show that mercury is effectively removed from all solutions and the rate of alloy formation is constant over time, as well as for very thick layers of PtHg4. The apparent activation energy for the electrochemical alloy formation was determined to be 0.29 eV, with a reaction order in mercury ion concentration around 0.8. The obtained results give new insights that are vital in the assessment and further development of electrochemical alloy formation as a method for large scale mercury decontamination

A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues

BACKGROUND: Analogues of vitamin D3 are extensively used in the treatment of various illnesses, such as osteoporosis, inflammatory skin diseases, and cancer. Functional testing of new vitamin D3 analogues and formulations for improved systemic and topical administration is supported by sensitive screening methods that allow a comparative evaluation of drug properties. As a new tool in functional screening of vitamin D3 analogues, we describe a genomically integratable sensor for sensitive drug detection. This system facilitates assessment of the pharmacokinetic and pharmadynamic properties of vitamin D3 analogues. The tri-cistronic genetic sensor encodes a drug-sensoring protein, a reporter protein expressed from an activated sensor-responsive promoter, and a resistance marker. RESULTS: The three expression cassettes, inserted in a head-to-tail orientation in a Sleeping Beauty DNA transposon vector, are efficiently inserted as a single genetic entity into the genome of cells of interest in a reaction catalyzed by the hyperactive SB100X transposase. The applicability of the sensor for screening purposes is demonstrated by the functional comparison of potent synthetic analogues of vitamin D3 designed for the treatment of psoriasis and cancer. In clones of human keratinocytes carrying from a single to numerous insertions of the vitamin D3 sensor, a sensitive sensor read-out is detected upon exposure to even low concentrations of vitamin D3 analogues. In comparative studies, the sensor unveils superior potency of new candidate drugs in comparison with analogues that are currently in clinical use. CONCLUSIONS: Our findings demonstrate the use of the genetic sensor as a tool in first-line evaluation of new vitamin D3 analogues and pave the way for new types of drug delivery studies in sensor-transgenic animals

Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals

peer-reviewedH.D.D., A.J.C., P.J.B. and B.J.H. would like to acknowledge the Dairy Futures Cooperative Research Centre for funding. H.P. and R.F. acknowledge funding from the German Federal Ministry of Education and Research (BMBF) within the AgroClustEr ‘Synbreed—Synergistic Plant and Animal Breeding’ (grant 0315527B). H.P., R.F., R.E. and K.-U.G. acknowledge the Arbeitsgemeinschaft Süddeutscher Rinderzüchter, the Arbeitsgemeinschaft Österreichischer Fleckviehzüchter and ZuchtData EDV Dienstleistungen for providing genotype data. A. Bagnato acknowledges the European Union (EU) Collaborative Project LowInputBreeds (grant agreement 222623) for providing Brown Swiss genotypes. Braunvieh Schweiz is acknowledged for providing Brown Swiss phenotypes. H.P. and R.F. acknowledge the German Holstein Association (DHV) and the Confederación de Asociaciones de Frisona Española (CONCAFE) for sharing genotype data. H.P. was financially supported by a postdoctoral fellowship from the Deutsche Forschungsgemeinschaft (DFG) (grant PA 2789/1-1). D.B. and D.C.P. acknowledge funding from the Research Stimulus Fund (11/S/112) and Science Foundation Ireland (14/IA/2576). M.S. and F.S.S. acknowledge the Canadian Dairy Network (CDN) for providing the Holstein genotypes. P.S. acknowledges funding from the Genome Canada project entitled ‘Whole Genome Selection through Genome Wide Imputation in Beef Cattle’ and acknowledges WestGrid and Compute/Calcul Canada for providing computing resources. J.F.T. was supported by the National Institute of Food and Agriculture, US Department of Agriculture, under awards 2013-68004-20364 and 2015-67015-23183. A. Bagnato, F.P., M.D. and J.W. acknowledge EU Collaborative Project Quantomics (grant 516 agreement 222664) for providing Brown Swiss and Finnish Ayrshire sequences and genotypes. A.C.B. and R.F.V. acknowledge funding from the public–private partnership ‘Breed4Food’ (code BO-22.04-011- 001-ASG-LR) and EU FP7 IRSES SEQSEL (grant 317697). A.C.B. and R.F.V. acknowledge CRV (Arnhem, the Netherlands) for providing data on Dutch and New Zealand Holstein and Jersey bulls.Stature is affected by many polymorphisms of small effect in humans1. In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes2,3. Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 × 10−8) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP–seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals

Biopolis : A Game Project about Climate- and Behavior Change

Klimatförändring är något som sker naturligt på vår planet. Vad man dock har upptäckt under de senaste 100 åren, är att vi människor har påskyndat denna process och därmed satt planetens naturliga cykel ur balans. Forskare förutspår drastiska förändringar i framtiden. Torka och begränsad åtkomst till dricksvatten. Höjning av havsnivån. Extremaväder. M.m. Ändå händer det inte så mycket som man tycker att det borde göra. En förändring måste ske. Så vad kan jag, som grafisk designer, göra för världen? Ett av de stora problemen inom detta ämne är attdetta är något man inte vill tala om i samhället. Det är ett tungt ämne och det är förståeligt att mangärna vänder ryggen till. Därför har jag anpassatmitt projekt till att tackla detta dilemma genom attutnyttja ett medium som har möjlighet att fångauppnärksamhet på ett öppensinnat sätt. Genom rolig aktivitet och lättsam stämning hoppas jag att fler ska vara öppna till förändring. För att uppnå detta har grafisk formgivning använts för att gestala projektets identitet med stöd från färgteori och beteendevetenskap. Även teorierna om nudging och learning by doing har spelat en rolli arbetet som mynnat ut i ett  brädspel med fokus på användarupplevelsen.Climate change is something that happens naturally on our planet. What has been discovered over the last 100 years, however, is that us humans have accelerated this process and put the planet’s natural cycle out of balance. Researchers predict drastic changes in the future. Drought and limited access to drinking water. Increasing sea level. Extreme weather. Etc. Despite this not as much happens as you think it should. A change must happen. So what can I, as a graphic designer, do for the world? One of the big problems about this topic, is that this is something people avoid talking about in society. It’s a heavy subject and it’s understandable that people would rather turn their back on it. Therefore, I have adapted my project to tackle this dilemma by using a medium that has the opportunity to capture attention in an open minded way. Through fun activity and light-hearted atmosphere, I hope that more people will be open to change. To achieve this, graphic design has been used to shape the project’s identity with the support of color theory and behavioral science. The theories of nudging and learning by doing have also played a role in the work, which resulted in a board game with a focus on user experience

Contextualizing Customer Feedback: A Research-through-Design Approach - Alternative Approaches and Dialogical Engagement in Survey Design

Providing context behind customer feedback remains a challenge for company’s who rely on approaching Customer Experience (CX) through standardized Customer Satisfaction (CS) metrics like Net Promoter Score (NPS), Customer Satisfaction Score (CSAT), and Customer Effort Score (CES). Practical guidelines for monitoring CS throughout the customer journey are limited, creating a gap in academic research. This study addresses this gap by offering practical guidelines for CS, actionable insights, and alternative survey design strategies within the context of invoicing. Utilizing a Research-through-Design (RtD) approach guided by the Double Diamond design model, the study consists of four phases: Discover, Define, Develop, and Deliver. From a service design perspective using qualitative methods, the study acquires and analyzes both organizational and customer insights. Synthesized empirical findings emphasize the need for a more comprehensive approach that targets specific phases of the customer journey utilizing a more customer- centric approach, paving the way for alternative methods that reaches beyond just simply measuring CS. Introducing the concept of a personal companion, the study presents a dialogical approach where surveys are experienced as ongoing interactions rather mere tasks. By highlighting the importance of contextualization, alternative survey approaches, and a dialogical approach, this research aims to guide company’s in managing customer feedback strategies

Compiler for an Embedded Extension Language on Android

Bytecode interpreters are a common implementation strategy for scripting languages. Source code is translated to bytecode to improve time and memory performance. The Android platform includes the Dalvik virtual machine, which typically executes bytecode compiled from Java source code. This thesis describes how this virtual machine can be reused to execute bytecode compiled from a scripting language. A compiler is written for a test bed scripting language and the time and memory performance is evaluated. The Dalvik virtual machine, designed for a statically typed object-oriented language, was flexible enough to successfully host a dynamically typed scripting language that allows for objects to be transported cheaply between scripts and Java code. The compiled code executes one to two orders of magnitude faster than with a naive interpreting implemetation. Numeric performance is lacking in general, though simpler cases are optimized