131 research outputs found
Influence of inert gases on the reactive high power pulsed magnetron sputtering process of carbon-nitride thin films
The influence of inert gases (Ne, Ar, Kr) on the sputter process of carbon and carbon-nitride (CNx)
thin films was studied using reactive high power pulsed magnetron sputtering (HiPIMS). Thin solid
films were synthesized in an industrial deposition chamber from a graphite target. The peak target
current during HiPIMS processing was found to decrease with increasing inert gas mass. Time
averaged and time resolved ion mass spectroscopy showed that the addition of nitrogen, as reactive
gas, resulted in less energetic ion species for processes employing Ne, whereas the opposite was
noticed when Ar or Kr were employed as inert gas. Processes in nonreactive ambient showed
generally lower total ion fluxes for the three different inert gases. As soon as N2 was introduced
into the process, the deposition rates for Ne and Ar-containing processes increased significantly.
The reactive Kr-process, in contrast, showed slightly lower deposition rates than the nonreactive.
The resulting thin films were characterized regarding their bonding and microstructure by x-ray
photoelectron spectroscopy and transmission electron microscopy. Reactively deposited CNx thin
films in Ar and Kr ambient exhibited an ordering toward a fullerene-like structure, whereas carbon
and CNx films deposited in Ne atmosphere were found to be amorphous. This is attributed to an
elevated amount of highly energetic particles observed during ion mass spectrometry and indicated
by high peak target currents in Ne-containing processes. These results are discussed with respect to
the current understanding of the structural evolution of a-C and CNx thin films. VC 2013 American
Vacuum Society. [http://dx.doi.org/10.1116/1.4769725
Electronic Properties and Bonding in ZrHx Thin Films Investigated by Valence-Band X-ray Photoelectron Spectroscopy
The electronic structure and chemical bonding in reactively magnetron
sputtered ZrHx (x=0.15, 0.30, 1.16) thin films with oxygen content as low as
0.2 at% are investigated by 4d valence band, shallow 4p core-level and 3d
core-level X-ray photoelectron spectroscopy. With increasing hydrogen content,
we observe significant reduction of the 4d valence states close to the Fermi
level as a result of redistribution of intensity towards the H 1s - Zr 4d
hybridization region at about 6 eV below the Fermi level. For low hydrogen
content (x=0.15, 0.30), the films consist of a superposition of hexagonal
closest packed metal (alpha-phase)and understoichiometric delta-ZrHx (CaF2-type
structure) phases, while for x=1.16, the film form single phase ZrHx that
largely resembles that of stoichiometric delta-ZrH2 phase. We show that the
cubic delta-ZrHx phase is metastable as thin film up to x=1.16 while for higher
H-contents, the structure is predicted to be tetragonally distorted. For the
investigated ZrH1.16 film, we find chemical shifts of 0.68 and 0.51 eV towards
higher binding energies for the Zr 4p3/2 and 3d5/2 peak positions,
respectively. Compared to the Zr metal binding energies of 27.26 and 178.87 eV,
this signifies a charge-transfer from Zr to H atoms. The change in the
electronic structure, spectral line shapes, and chemical shifts as function of
hydrogen content is discussed in relation to the charge-transfer from Zr to H
that affects the conductivity by charge redistribution in the valence band.Comment: 11 pages, 6 figure
The Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease
Many neuromuscular disease entities possess a significant disease burden and therapeutic options remain limited. Innovative human preclinical models may help to uncover relevant disease mechanisms and enhance the translation of therapeutic findings to strengthen neuromuscular disease precision medicine. By concentrating on idiopathic inflammatory muscle disorders, we summarize the recent evolution of the novel in vitro models to study disease mechanisms and therapeutic strategies. A particular focus is laid on the integration and simulation of multicellular interactions of muscle tissue in disease phenotypes in vitro. Finally, the requirements of a neuromuscular disease drug development workflow are discussed with a particular emphasis on cell sources, co-culture systems (including organoids), functionality, and throughput.Peer Reviewe
Treatment with higher dosages of heart failure medication is associated with improved outcome following cardiac resynchronization therapy
Background Cardiac resynchronization therapy (CRT) is associated with improved morbidity and mortality in patients with chronic heart failure (CHF) on optimal medical therapy. The impact of CHF medication optimization following CRT, however, has never been comprehensively evaluated. In the current study, we therefore investigated the effect of CHF medication dosage on morbidity and mortality in CHF patients after CRT implantation. Methods and results Chronic heart failure medication was assessed in 185 patients after CRT implantation. During an overall mean follow-up of 44.6 months, 83 patients experienced a primary endpoint (death, heart transplantation, assist device implantation, or hospitalization for CHF). Treatment with higher dosages of angiotensin-converting enzyme inhibitor (ACE-I) or angiotensin receptor blockers (ARBs) (P = 0.001) and beta-blockers (P < 0.001) as well as with lower dosages of loop diuretics (P < 0.001) was associated with a reduced risk for the primary combined endpoint as well as for all-cause mortality. Echocardiographic super-responders to CRT were treated with higher average dosages of ACE-I/ARBs (68.1 vs. 52.4%, P < 0.01) and beta-blockers (59 vs. 42.2%, P < 0.01). During follow-up, the average dosage of loop diuretics was decreased by 20% in super-responders, but increased by 30% in non-super-responders (P < 0.03). Conclusion The use of higher dosages of neurohormonal blockers and lower dosages of diuretics is associated with reduced morbidity and mortality following CRT implantation. Our data imply a beneficial effect of increasing neurohormonal blockade whenever possible following CRT implantatio
The small giant clam, Tridacna maxima exhibits minimal population genetic structure in the Red sea and genetic differentiation from the Gulf of Aden
The Red Sea serves as a natural laboratory to investigate mechanisms of genetic differentiation and population dynamics of reef organisms due to its high species endemism. Giant clams, important yet understudied coral reef engineering species, are ideal candidates for such study in this region. This paper presents the first population genetics study of giant clams covering the entire East coast of the Red Sea. Our study aimed to investigate the population structure of the small giant clam, Tridacna maxima, based on 501-bp fragment of the cytochrome c oxidase I gene from 194 individuals (126 new sequences from this study plus 68 sequences from GenBank), collected from 14 locations in the Red Sea and Gulf of Aden (RSGA). For the genetic analysis, each sampling site was treated as a population. T. maxima showed high genetic diversity, with high gene flow in almost all sampling sites. The insignificant global #ST-value of 0.02 (p > 0.05) suggests the presence of one large, panmictic population across a wide range of temperature and salinity gradients in the RSGA. Despite this, the population in Djibouti was genetically differentiated from the other 11 populations in the Red Sea, suggesting a connectivity break between the Red Sea and the Gulf of Aden. These results could be explained by the oceanographic features facilitating wide larval transport inside the Red Sea, and creating a dispersal barrier to the Gulf of Aden. Besides larval dispersal by currents, apparent successful establishment following dispersal is probably facilitated by the mode and time of reproduction as well as the ability of T. maxima to achieve high fitness in the highly variable environmental conditions of the Red Sea.King Abdullah University of Science & Technology: BAS/1/1071-01-01info:eu-repo/semantics/publishedVersio
Белорусская энергетика: современное состояние и перспективы
Материалы III Междунар. науч. конф. студентов, аспирантов и молодых ученых, Гомель, 20 мая 2010 г
Тенденции развития регионального туризма
Материалы IV Междунар. науч.-практ. конф., Гомель, 17–18 нояб. 2005 г
Neanderthals in changing environments from MIS 5 to early MIS 4 in northern Central Europe:Integrating archaeological, (chrono)stratigraphic and paleoenvironmental evidence at the site of Lichtenberg
Reduction of the thermal conductivity of the thermoelectric material ScN by Nb alloying
ScN-rich (Sc,Nb)N solid solution thin films have been studied, motivated by the promising thermoelectric properties of ScN-based materials. Cubic Sc1-xNbxN films for 0 amp;lt;= x amp;lt;= 0.25 were epitaxially grown by DC reactive magnetron sputtering on a c-plane sapphire substrate and oriented along the (111) orientation. The crystal structure, morphology, thermal conductivity, and thermoelectric and electrical properties were investigated. The ScN reference film exhibited a Seebeck coefficient of -45 mu V/K and a power factor of 6 x 10(-4) W/m K-2 at 750K. Estimated from room temperature Hall measurements, all samples exhibit a high carrier density of the order of 10(21) cm(-3). Inclusion of heavy transition metals into ScN enables the reduction in thermal conductivity by an increase in phonon scattering. The Nb inserted ScN thin films exhibited a thermal conductivity lower than the value of the ScN reference (10.5W m(-1) K-1) down to a minimum value of 2.2 Wm(-1) K-1. Insertion of Nb into ScN thus resulted in a reduction in thermal conductivity by a factor of similar to 5 due to the mass contrast in ScN, which increases the phonon scattering in the material. Published by AIP Publishing.Funding Agencies|European Research Council under the European Community [335383]; Swedish Foundation for Strategic Research (SSF) through the Future Research Leaders 5 program; Swedish Research Council (VR) [621-2012-4430, 2016-03365]; Knut and Alice Wallenberg Foundation through the Wallenberg Academy Fellows program; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009 00971]; project NanoCaTe (FP7-NMP) [604647]; project CTEC [1305-00002B]</p
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