The Prometheus Bomb

During World War II, the lives of millions of Americans lay precariously in the hands of a few brilliant scientists who raced to develop the first weapon of mass destruction. Elected officials gave the scientists free rein in the Manhattan Project without understanding the complexities and dangers involved in splitting the atom. The Manhattan Project was the first example of a new type of choice for congressmen, presidents, and other government officials: life and death on a national scale. From that moment, our government began fashioning public policy for issues of scientific development, discoveries, and inventions that could secure or threaten our existence and our future. But those same men and women had no training in such fields, did not understand the ramifications of the research, and relied on incomplete information to form potentially life-changing decisions. Through the story of the Manhattan Project, Neil J. Sullivan asks by what criteria the people in charge at the time made such critical decisions. He also ponders how similar judgments are reached today with similar incomprehension from those at the top as our society dives down the potential rabbit hole of bioengineering, nanotechnology, and scientific developments yet to come

The Prometheus Bomb

During World War II, the lives of millions of Americans lay precariously in the hands of a few brilliant scientists who raced to develop the first weapon of mass destruction. Elected officials gave the scientists free rein in the Manhattan Project without understanding the complexities and dangers involved in splitting the atom. The Manhattan Project was the first example of a new type of choice for congressmen, presidents, and other government officials: life and death on a national scale. From that moment, our government began fashioning public policy for issues of scientific development, discoveries, and inventions that could secure or threaten our existence and our future. But those same men and women had no training in such fields, did not understand the ramifications of the research, and relied on incomplete information to form potentially life-changing decisions. Through the story of the Manhattan Project, Neil J. Sullivan asks by what criteria the people in charge at the time made such critical decisions. He also ponders how similar judgments are reached today with similar incomprehension from those at the top as our society dives down the potential rabbit hole of bioengineering, nanotechnology, and scientific developments yet to come

IMPACT OF MEAT IMPORTS ON LEAST-COST UNITED STATES BEEF PRODUCTION

International Relations/Trade,

Real-world clinical experience in the Connect® chronic lymphocytic leukaemia registry: a prospective cohort study of 1494 patients across 199 US centres.

The clinical course of chronic lymphocytic leukaemia (CLL) is heterogeneous, and treatment options vary considerably. The Connect® CLL registry is a multicentre, prospective observational cohort study that provides a real-world perspective on the management of, and outcomes for, patients with CLL. Between 2010 and 2014, 1494 patients with CLL and that initiated therapy, were enrolled from 199 centres throughout the USA (179 community-, 17 academic-, and 3 government-based centres). Patients were grouped by line of therapy at enrolment (LOT). We describe the clinical and demographic characteristics of, and practice patterns for, patients with CLL enrolled in this treatment registry, providing patient-level observational data that represent real-world experiences in the USA. Fluorescence in situ hybridization (FISH) analyses were performed on 49·3% of patients at enrolment. The most common genetic abnormalities detected by FISH were del(13q) and trisomy 12 (45·7% and 20·8%, respectively). Differences in disease characteristics and comorbidities were observed between patients enrolled in LOT1 and combined LOT2/≥3 cohorts. Important trends observed include the infrequent use of genetic prognostic testing, and differences in patient characteristics for patients receiving chemoimmunotherapy combinations. These data represent experiences of patients with CLL in the USA, which may inform treatment decisions in everyday practice

Bose glass and Mott glass of quasiparticles in a doped quantum magnet

The low-temperature states of bosonic fluids exhibit fundamental quantum effects at the macroscopic scale: the best-known examples are Bose-Einstein condensation (BEC) and superfluidity, which have been tested experimentally in a variety of different systems. When bosons are interacting, disorder can destroy condensation leading to a so-called Bose glass. This phase has been very elusive to experiments due to the absence of any broken symmetry and of a finite energy gap in the spectrum. Here we report the observation of a Bose glass of field-induced magnetic quasiparticles in a doped quantum magnet (Br-doped dichloro-tetrakis-thiourea-Nickel, DTN). The physics of DTN in a magnetic field is equivalent to that of a lattice gas of bosons in the grand-canonical ensemble; Br-doping introduces disorder in the hoppings and interaction strengths, leading to localization of the bosons into a Bose glass down to zero field, where it acquires the nature of an incompressible Mott glass. The transition from the Bose glass (corresponding to a gapless spin liquid) to the BEC (corresponding to a magnetically ordered phase) is marked by a novel, universal exponent governing the scaling on the critical temperature with the applied field, in excellent agreement with theoretical predictions. Our study represents the first, quantitative account of the universal features of disordered bosons in the grand-canonical ensemble.Comment: 13+6 pages, 5+6 figures; v2: Fig. 5 update

Characterizing the efficacy of methods to subtract terrestrial transient noise near gravitational wave events and the effects on parameter estimation

We investigate the impact of transient noise artifacts, or {\it glitches}, on gravitational wave inference, and the efficacy of data cleaning procedures in recovering unbiased source properties. Due to their time-frequency morphology, broadband glitches demonstrate moderate to significant biasing of posterior distributions away from true values. In contrast, narrowband glitches have negligible biasing effects owing to distinct signal and glitch morphologies. We inject simulated binary black hole signals into data containing three common glitch types from past LIGO-Virgo observing runs, and reconstruct both signal and glitch waveforms using {\tt BayesWave}, a wavelet-based Bayesian analysis. We apply the standard LIGO-Virgo-KAGRA deglitching procedure to the detector data - we subtract the glitch waveform estimated by the joint {\tt BayesWave} inference before performing parameter estimation with detailed compact binary waveform models. We find that this deglitching effectively mitigates bias from broadband glitches, with posterior peaks aligning with true values post deglitching. This provides a baseline validation of existing techniques, while demonstrating waveform reconstruction improvements to the Bayesian algorithm for robust astrophysical characterization in glitch-prone detector data.Comment: 22 pages, 17 figure

Early Radio and X-Ray Observations of the Youngest Nearby Type Ia Supernova PTF 11kly (SN 2011fe)

On 2011 August 24 (UT) the Palomar Transient Factory (PTF) discovered PTF11kly (SN 2011fe), the youngest and most nearby Type Ia supernova (SN Ia) in decades. We followed this event up in the radio (centimeter and millimeter bands) and X-ray bands, starting about a day after the estimated explosion time.We present our analysis of the radio and X-ray observations, yielding the tightest constraints yet placed on the pre-explosion mass-loss rate from the progenitor system of this supernova. We find a robust limit of Ṁ ≾ 10^(−8)(w/100 km s^(−1))M_☉ yr^(−1) from sensitive X-ray non-detections, as well as a similar limit from radio data, which depends, however, on assumptions about microphysical parameters. We discuss our results in the context of single-degenerate models for SNe Ia and find that our observations modestly disfavor symbiotic progenitor models involving a red giant donor, but cannot constrain systems accreting from main-sequence or sub-giant stars, including the popular supersoft channel. In view of the proximity of PTF11kly and the sensitivity of our prompt observations, we would have to wait for a long time (a decade or longer) in order to more meaningfully probe the circumstellar matter of SNe Ia

Improving garden soils with organic matter

This publication will help you understand the importance of soil organic matter levels to good plant performance. It also contains suggestions for suitable soil amendments. Any soil, no matter how compacted, can be improved by the addition of organic matter. The result will be a better environment for almost any kind of plant.Published May 2003. Reviewed August 2013. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalo

Rates and predictors of risk of stroke and its subtypes in diabetes: a prospective observational study

Background Small vessel disease is reported to be a more common cause of ischaemic stroke in people with diabetes than in others. However, population based studies have shown no difference between those with and those without diabetes in the subtypes of stroke. We determined the rates and predictors of risk of stroke and its subtypes in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial. Methods 9795 patients aged 50–75 years with type 2 diabetes were followed up for a median of 5 years. Annual rates were derived by the Kaplan–Meier method and independent predictors of risk by Cox proportional hazards regression analyses. Results The annual rate of stroke was 6.7 per 1000 person years; 82% were ischaemic and caused by small artery disease (36%), large artery disease (17%) and embolism from the heart (13%); 10% were haemorrhagic. Among the strongest baseline predictors of ischaemic or unknown stroke were age (60–65 years, HR 1.98; >65 years, HR 2.35) and a history of stroke or transient ischaemic attack (TIA) (HR 2.06). Other independent baseline predictors were male sex, smoking, history of hypertension, ischaemic heart disease, nephropathy, systolic blood pressure and blood low density lipoprotein (LDL) cholesterol, HbA1c and fibrinogen. A history of peripheral vascular disease, low high density lipoprotein, age and history of hypertension were associated with large artery ischaemic stroke. A history of diabetic retinopathy, LDL cholesterol, male sex, systolic blood pressure, smoking, diabetes duration and a history of stroke or TIA were associated with small artery ischaemic stroke. Conclusions Older people with a history of stroke were at highest risk of stroke, but the prognosis and prognostic factors of subtypes were heterogeneous. The results will help clinicians quantify the absolute risk of stroke and its subtypes for typical diabetes patients.FIELD trial sponsored by Laboratoires Fournier SA, Dijon, France (part of Abbott

A reassuring presence: An evaluation of Bradford District Hospice at Home service

Within the United Kingdom, a developing role for primary care services in cancer and palliative care has resulted in an increase in palliative home care teams. The provision of professional care in the home setting seeks to provide necessary services and enhanced choice for patients whose preference is to die at home. A mismatch between patient preference for home death and the actual number of people who died at home was identified within Bradford, the locality of this study. In response to this mismatch, and reflecting the policy environment of wishing to enhance community service provision, the four Primary Care Trusts (PCTs) in the city sought to offer support to patients who wished to remain in their own homes through the final stages of a terminal illness. To offer this support they set up a dedicated hospice at home team. This would provide services and support for patients in achieving a dignified, symptom free and peaceful death, allowing families to maximise time spent together. The aim of the study was to evaluate the Bradford hospice at home service from the perspective of carers, nurses and General Practitioners. Postal questionnaires were sent to carers (n = 289), district nurses (n = 508) and GP's (n = 444) using Bradford's hospice at home service. Resulting quantitative data was analysed using the Statical Package for Social Sciences (SPSS) and qualitative data was analysed using grounded theory techniques. The data from carers, district nurses and GPs provide general support for the Bradford hospice at home service. Carers valued highly the opportunity to 'fulfil a promise' to the individual who wished to be cared for at home. District nurses and GPs cited the positive impact of access to specialist expertise. This was a 'reassuring presence' for primary healthcare teams and offered 'relief of carer anxiety' by providing prompt, accessible and sensitive care. Carers and health professionals welcomed the increased possibility of patients being cared for at home. The study identified the need to focus on improving skill levels of staff and on ensuring continuity of care