High circulating levels of sICAM-1 and sVCAM-1 in the patients with Hashimoto's thyroiditis

Objective: To investigate whether soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels are increased in euthyroid patients with Hashimoto's thyroiditis (HT) and whether they are associated with thyroid autoimmunity and metabolic parameters. Design: Cross-sectional. Subjects and Methods: In total, 80 euthyroid patients with HT and 80 age- and body mass index (BMI)-matched control participants were included. Serum sICAM-1, sVCAM-1, free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (anti-TPO), thyroglobulin antibody (anti-TG), fasting blood glucose (FBG), insulin, and lipid levels and homeostasis model assessment for insulin resistance (HOMA-IR) were assessed in all participants. Results: The patients with HT had significantly higher levels of sICAM-1 and sVCAM-1 than controls (both p < 0.001). The difference was sustained after adjustment for TSH and levothyroxine use. Regression analysis demonstrated that sICAM-1 was related to anti-TPO (p < 0.001), and sVCAM-1 was related to both anti-TPO and-TG (p < 0.001 and p = 0.03, respectively); this relationship was sustained after adjustment for age and BMI. Although FBG and HOMA-IR were higher in the HT group, logistic regression analysis revealed that there was no effect of anti-TPO, anti-TG, sICAM-1, sVCAM-1, and C-reactive protein (CRP) on the occurrence of high FBG and high HOMA-IR. Conclusion: sICAM-1 and sVCAM-1 levels were significantly elevated in the patients with euthyroid HT and correlated closely with thyroid autoimmunity. However, soluble adhesion molecules had no relation with glucose metabolism parameters in the HT patients

Osteoporosis development and vertebral fractures after abdominal irradiation in patients with gastric cancer

Abstract Background Decrease in bone mineral density, osteoporosis development, bone toxicity and resulting insufficiency fractures as late effect of radiotherapy are not well known. Osteoporosis development related to radiotherapy has not been investigated properly and insufficiency fractures are rarely reported for vertebral bones. Methods Ninety-seven patients with gastric adenocarcinoma were evaluated for adjuvant treatment after surgery. While 73 out of 97 patients treated with adjuvant chemoradiotherapy comprised the study group, 24 out of 97 patients with early stage disease without need of adjuvant treatment comprised the control group. Bone mineral densities (BMD) of lumbar spine and femoral neck were measured by dual energy x-ray absorptiometry after surgery, and one year later in both groups. Results There was statistically significant decline in BMDs after one year in each group itself, however the decline in BMDs of the patients in the irradiated group was more pronounced when compared with the patients in the control group; p values were 0.02 for the decline in BMDs of lumbar spine, and 0.01 for femoral neck respectively. Insufficiency fractures were observed only in the irradiated patients (7 out of 73 patients) with a cumulative incidence of 9.6%. Conclusions Abdominal irradiation as in the adjuvant treatment of gastric cancer results in decrease in BMD and osteoporosis. Insufficiency fracture risk in the radiation exposed vertabral bones is increased. Calcium and vitamin D replacement and other measures for prevention of osteoporosis and insufficiency fractures should be considered after abdominal irradiation

Voice characteristics associated with polycystic ovary syndrome

Objectives/HypothesisTo test the assumption that voice is changed in polycystic ovary syndrome (PCOS) and identify changes that occur

Evaluation of the Relationship between Insulin Resistance and Selenoprotein P in Patients with Polycystic Ovary Syndrome

Polikistik Over Sendromlu Hastalarda İnsülin Direnci ve Selenoprotein P İlişkisinin DeğerlendirilmesiAyşenur Özderya1, İbrahim Yılmaz2, Şevin Demir3, Şule Temizkan1, Mehmet Sargın4, Mehmet Ali Ustaoğlu2, Kadriye Aydın11Sağlık Bilimleri Üniversitesi, Kartal Dr. Lütfi Kırdar Eğitim Ve Araştırma Hastanesi, Endokrinoloji Ve Metabolizma Hastalıkları Bölümü,i̇stanbul, Türkiye2Sağlık Bilimleri Üniversitesi, Kartal Dr. Lütfi Kırdar Eğitim Ve Araştırma Hastanesi, İç Hastalıkları Kliniği, İstanbul, Türkiye3Sağlık Bilimleri Üniversitesi, Kartal Dr Lütfi Kırdar Eğitim ve Araştırma Hastanesi, Aile Hekimliği Kliniği, İstanbul, Türkiye4Medeniyet Üniversitesi Tıp Fakültesi, Aile Hekimliği Kliniği, İstanbul, TürkiyeGİRİŞ ve AMAÇ: Polikistik over sendromu (PKOS) doğurganlık çağındaki kadınlarda en sık görülen ve insülin direnci (IR) ile karakterize bir bozukluktur. Selenoprotein P(SeP) de, insülin direnciyle ilişkili bir hepatokindir. Bu çalışmada PKOS’da SeP düzeylerini belirlemeyi ve IR ile ilişkisini araştırmayı amaçladık.&nbsp;YÖNTEM ve GEREÇLER: Çalışmada 27 hastayla yaş ve vücut kitle indeksi (VKI) eşleştirilmiş 27 sağlıklı kontrolün demografik özellikleri, antropometrik ölçümleri ve biyokimyasal parametreleri değerlendirildi. IR ve serbest androjen indeksi (FAI) hesaplandı. SeP ile biyokimyasal ve antropometrik parametrelerin korelasyonu yapıldı.BULGULAR: Hasta ve kontroller arasında açlık insülini ve HOMA-IR anlamlı farklıyken (her iki p&lt;0.05), SeP düzeyleri benzerdi (sırasıyla, 1.05±0.7ng/mL ve 1.61±1.9ng/mL, p=0.7). Her iki grupta da SeP ile HOMA-IR arasında korelasyon saptanmadı. PCOS grubunda SeP ile bel çevresi arasında negatif korelasyon mevcutken (p=0.03, r=-0.485), kontrol grubunda izlenmedi. Kontrol grubunda ise SeP ile VKI ve yağ yüzdesi arasında negatif korelasyon mevcutken (sırasıyla r=-0.506, p=0.007 ve r=-0.643, p=0.024), PCOS grubunda izlenmedi. Ayrıca hastalarda testosteron ile SeP arasında anlamlı pozitif korelasyon saptandı (r=0,456, p=0,017).&nbsp;TARTIŞMA ve SONUÇ: Hasta ve kontroller arasında SeP düzeyleri benzer bulundu ve PKOS’da SeP ile IR arasında bir ilişki saptanmadı. Ancak PKOS'da SeP’nin bel çevresi ve testosteron ile korelasyonu olası bir metabolik ilişkiyi akla getirmektedir.&nbsp;Anahtar Kelimeler:&nbsp;İnsülin direnci, polikistik over sendromu, selenoprotein P, vücut kitle indeksi, vücut yağ yüzdesi.</p

High circulating levels of sICAM-1 and sVCAM-1 in the patients with Hashimoto’s thyroiditis

Objective: To investigate whether soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels are increased in euthyroid patients with Hashimoto's thyroiditis (HT) and whether they are associated with thyroid autoimmunity and metabolic parameters. Design: Cross-sectional. Subjects and Methods: In total, 80 euthyroid patients with HT and 80 age- and body mass index (BMI)-matched control participants were included. Serum sICAM-1, sVCAM-1, free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (anti-TPO), thyroglobulin antibody (anti-TG), fasting blood glucose (FBG), insulin, and lipid levels and homeostasis model assessment for insulin resistance (HOMA-IR) were assessed in all participants. Results: The patients with HT had significantly higher levels of sICAM-1 and sVCAM-1 than controls (both p < 0.001). The difference was sustained after adjustment for TSH and levothyroxine use. Regression analysis demonstrated that sICAM-1 was related to anti-TPO (p < 0.001), and sVCAM-1 was related to both anti-TPO and-TG (p < 0.001 and p = 0.03, respectively); this relationship was sustained after adjustment for age and BMI. Although FBG and HOMA-IR were higher in the HT group, logistic regression analysis revealed that there was no effect of anti-TPO, anti-TG, sICAM-1, sVCAM-1, and C-reactive protein (CRP) on the occurrence of high FBG and high HOMA-IR. Conclusion: sICAM-1 and sVCAM-1 levels were significantly elevated in the patients with euthyroid HT and correlated closely with thyroid autoimmunity. However, soluble adhesion molecules had no relation with glucose metabolism parameters in the HT patients

Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey

Objective: Vitamin D deficiency is a common health problem around the world. This study aimed to evaluate the nationwide prevalence of vitamin D status in tertiary care hospitals in Turkey