PREPARATION AND PHYSICOCHEMICAL EVALUATION OF MRIDU APAMARGA KSHARA

Ksharakalpana is one of the unique pharmaceutical preparation forms described in Ayurveda. Kshara is ashes of herbal drugs and is alkaline in nature. A detailed description of Kshara Kalpana preparation methods, types, properties and applications of different Kshara are available in Ayurvedic classics. Kshara is the substance having Ksharana and Kshanan properties. Various plants are mentioned as suitable for the preparation of Kshara viz., Apamarga, Arka (Calotropis gigantea Linn.), Mulaka (Raphanus sativus Linn.), Snuhi (Euphorbia nerifolia Linn.) etc. Among these Apamarga, Arka are the most common drugs used for the preparation of Kshara. In the present study whole plant of Apamarga (Achyranthes aspera Linn.) was used for the preparation of Kshara. Different opinions are there about the amount of water to be used, number of filtrations etc., while preparing the Kshara. Generally Apamarga kshara is prepared by decantation process in a single wash. In order to obtain increased yield and to reduce the loss during straining, in the present study it was prepared by the capillary action and three times washing. This method gave 49% more yield of Apamarga kshara and is far more when compared to traditional methods. Physicochemical evaluation of the prepared Kshara complied with the pharmacoepial standards

MANAGEMENT OF GARBHINI PANDU WITH DRAKSHA GHRITA AND LAKSHMANA LAUHA: A COMPARATIVE CLINICAL STUDY

Anaemia during pregnancy is a major public health problem throughout the world, particularly in the developing countries. According to WHO, prevalence of anaemia in pregnant women is estimated as 14 per cent in developed and 51 percent in developing countries. In India the prevalence is 65-75 percent. Acharya Kashyapa explained that like other disorders Samprapti of Pandu is also similar in Garbhini. So all narration mentioned in Ayurvedic classics regarding Pandu is applicable to Garbhini- Pandu. In the present study total 37 patients were recruited under the study and distributed into two groups Group-A (Draksha ghrita) and Group-B (Lakshmana lauha). After completion of trial 30 patients data was only available for assessment and 07 patients were dropped out from the study due to their irregular follow-up. On analysis of results, none of the patient has showed excellent relief. 10.00% and 30.00% patient has showed moderate relief in group A & B respectively. 06.00% and 10.00% patient in A and B group showed marked relief while 06.66% and 00.00% patient in has showed mild relief in A and B group and also the 26.66% and 16.66% patient has showed no relief. When the two groups A and B were compared with each other, the percentage of relief is found higher in group B, so it implies that group B is more clinically significant than group A. Overall conclusion of this study is that Draksha Gritha and Lakshmana lauha both drugs are effective, but Lakshmana lauha is comparatively better to cure the Subjective and Objective parameter of Garbhini Pandu

Evaluation of Japakusumadi Yoga for safety profile - Acute Toxicity Profile

Japakusumadi Yoga is an Ayurvedic formulation, indicated for contraception in Ayurveda. This study determines acute toxicity of ‘Japakusumadi Yoga’ an oral formulation in wister albino rats. Single dose acute toxicity was assessed by employing OECD guidelines 425 using AOT software. Test formulations was administered to overnight fasted animals and 14 days observation of dosed (up down as per requirement) rats was done for general appearance, cage side behaviour including increased or decreasing motor activity, convulsions, straub’s reaction, catatonia, muscle spasm, spasticity, ophisthotonus, hyperesthesia, muscle relaxation, anaesthesia, arching and rolling, lacrimation, salivation, diarrhoea, writhing movement, mode of respiration and changes in skin colour etc., with mortality and autopsy finding in case of dead animal. Based on the observation made and recorded it can be concluded that the test drug is without any toxic potential even at the dose of 2000 mg/kg in animals equivalent to 22.4g for human being

Effect of Kshara Karma with Apamarga Pratisaraniya Kshara in Cervical Erosion - A Case Report

Cervical erosion is the commonest causes of vaginal discharge in females, where ectocervix is covered by columnar epithelium, that means natural squamous epithelium is later replaced by columnar epithelium and appears like a Karnikakara granthi or Vrana depending upon the chronicity. The condition of cervical erosion is commonly treated in contemporary system of medicine with invasive therapies such as electric cauterization, cryosurgery etc. Kshara karma is a minimal invasive procedure that helps to destroy the ectopic columnar epithelium. So in the present study, a 40 year old woman diagnosed with cervical erosion (Karnini yonivyapad) was treated with Kshara karma using Apamarga Pratisarainiya kshara for 3 sittings each on alternate days for two cycles, starting from fifth day of the menstruation. After treatment significant reduction in the extent of cervical erosion was observed and the patient got relief in associated complaints. From this case study, it can be concluded that Kshara karma with Apamarga pratisaraniya kshara may be used as a safe and economical option for treating the cervical erosion

APPLICATIONS OF THERMAL AND MICROWAVE-ASSISTED SYNTHESIS OF XANTHONE DERRIVATIVE: A NEW METHODOLOGY

Abstract: An efficient and green procedure has been developed for the synthesis of hydroxyxanthones from 2, 6 dihydroxybenzoic acid via acid-catalyzed cyclization. This method provides excellent yields of products in a short time, making it a useful strategy for the synthesis of structurally diverse hydroxyxanthones. The relative efficiencies of thermal and microwave-assisted cyclization approaches have also been examined

Hexagonal Microstrip Patch Antenna Design for UWB Application

Microstrip patch antennas is one of the most used antennas for wireless communication. Its key features include a limited bandwidth, low cost, and ease of manufacture. This paper describes about the design of microstrip patch antenna over the frequency range of 3.1 GHz to 10.6 GHz for UWB applications. The substrate material chosen is FR4, having a loss tangent of 0.02, dielectric constant of 4.4, and substrate thickness of 1.59 mm. This work presents design of microstrip antenna with hexagonal shaped radiating patch. An antenna is modelled and analysed using HFSS 2021 R2 software. The antenna structure provides return loss which is less than -10 dB and a VSWR less than 2 over the specified frequency range. The simulated results of proposed hexagonal shaped microstrip patch antenna provides a peak gain of 5.32 dB with radiation efficiency of 90.88%. The planned antennas can be used for UWB applications

Lossless and Reversible Data Hiding using Public Key Cryptography

In today’s world, the internet is a platform, where large amount of data can be obtained and transferred. Different technologies and internet access are used to transfer the data which can be accessed by authorized and unauthorized users.The major drawback of these technologies are that any unauthorized person can access it.Hence encryption and decryption is perform on Message/Data .In encryption the plain text/image is converted into cipher text/image.The technique of data hiding is used to hide the data that has to be transferred from the source to the destination.The process involves insertion of secret message in the cover image which is encrypted with the help of AES algorithm. This algorithm generates public/private key. All this process can be performed in lossless and reversible manner