Perhekuntoutus puntarissa : Kelan psykiatrisen perhekuntoutuksen kehittämishankkeen arviointi

Kelan moniammatillisen perhekuntoutuksen tavoitteena oli lapsen ja nuoren toiminta- ja opiskelukyvyn parantaminen ja turvaaminen sekä yhteistyön tiivistäminen paikallisten tahojen, kuten päivähoidon, koulujen, perheneuvoloiden ja sairaanhoitopiirien, kanssa. Lapsilla ja nuorilla tuli olla lääkärin toteama psykiatrinen sairaus sekä hoitosuhde ennen kuntoutuksen aloitusta. Yhteensä 1 514 lasta ja nuorta perheineen 12:sta eri perhekuntoutushankkeesta osallistui kuntoutukseen vuosina 2005–2008. Lapset olivat hyvin heterogeeninen ryhmä iältään ja diagnooseiltaan. Lapin yliopisto ja Kuntoutussäätiö vastasivat kehittämishankkeen ulkoisesta arvioinnista. Arvioinnin tehtävänä oli kuntoutuksen kohderyhmän kuvauksen ohella tutkia, millaisia muutoksia lasten tilanteissa tapahtui kuntoutusintervention myötä. Tarkoitus oli selvittää, kokivatko lapset ja vanhemmat saaneensa tukea kuntoutuksesta. Tehtävänä oli myös selvittää, mitkä tekijät ennustivat lapsissa tapahtuneita myönteisiä muutoksia tai lasten ja vanhempien saamaa tukea sekä millaiset kuntoutuksen toimintamuodot osoittautuivat perheille hyödyllisiksi. Tiedot kerättiin kuntoutuksen alussa ja lopussa lapsille ja vanhemmille sekä perhekuntoutushankkeille suunnattujen kyselyiden avulla. Vanhempien arvioiden perusteella lasten oireet vähenivät lähes kahdella kolmesta, pysyivät ennallaan viidesosalla ja lisääntyivät vajaalla viidenneksellä. Vanhempien huoli lapsesta, perheen koherenssi ja kuntoutuksen kesto ennustivat lapsen oireilun vähenemistä. Kuntoutuksen kesto ja toimintamuoto puolestaan ennustivat vanhempien ja lasten kuntoutuksesta saamaa tukea. Lapset hyötyivät yksilö- ja perhepainotteisesta kuntoutuksesta ja vanhemmat perheterapeuttisesti ja ryhmätoimintaan painottuneesta kuntoutuksesta. Lähipiiristä saatu apu lisäsi vanhempien voimavaroja. Lasta auttoi se, että vanhemmat saivat kuntoutuksesta voimavaroja.15,00 euro

EFFECT OF CARBON CONTENT ON THE PHASE TRANSFORMATION CHARACTERISTICS, MICROSTRUCTURE AND PROPERTIES OF 500 MPa GRADE MICROALLOYED STEELS WITH NONPOLYGONAL FERRITE MICROSTRUCTURES

The influence of C in the range of 0.011-0.043 wt-% on the phase transformation characteristics, mechanical properties andmicrostructure of Fe-2.0Mn-0.25Mo-0.8Ni-0.05Nb-0.03Ti steel was investigated. In the dilatometric experiments, it wasfound that a reduction in the C content increased the phase transformation temperatures, decreased the hardness andpromoted quasi-polygonal ferrite (QF) formation over granular bainitic ferrite (GBF) and bainitic ferrite (BF), but at the sametime the sensitivity of the phase transformation temperatures and hardness to cooling rates was reduced. Mechanical testingof laboratory hot rolled plates revealed that the targeted yield strength of 500 MPa was reached even in the steel withthe lowest C content (0.011wt-%). An increase in C content did not considerably increase the yield strength, although thetensile strength was more significantly increased. Impact toughness properties, in turn, were markedly deteriorated due to thisC content increment. Microstructural analysis of the hot rolled plates showed that an increase in C content decreased thefraction of QF and consequently increased the fraction of GBF and BF, as well as the size and fraction of C-enriched secondarymicroconstituents. In addition, the size of the coarsest crystallographic packets seemed to be finer in the low C steelwith QF dominated microstructure than in its higher C counterparts with higher fractions of GBF-BF, even thought theaverage crystallographic packet size was slightly finer in these higher C steels.Mechanical testing of the simulated CGHAZ’s showed that their toughness properties are not strongly dependenton C content, although there exists a general trend for toughness to slightly weaken with increasing C content. Itcould be concluded that HAZ toughness properties of these types of steels are acceptable. On the basis of dilatometricexperiments, mechanical testing and microstructural analysis it can be stated that a good combination of strength,toughness and weldability as well as microstructural stability can be reached in very low C steels with QF dominatedmicrostructures. Finally, an example of this type of microstuctural concept, which has been successfull

Preterm birth and subsequent timing of pubertal growth, menarche, and voice break

Background: We evaluated pubertal growth and pubertal timing of participants born preterm compared to those born at term. Methods: In the ESTER Preterm Birth Study, we collected growth data and measured final height of men/women born very or moderately preterm (<34 gestational weeks, n = 52/55), late preterm (34–<37 weeks, 94/106), and term (≥37 weeks, 131/151), resulting in median 9 measurements at ≥6 years. Timing of menarche or voice break was self-reported. Peak height velocity (PHV, cm/year) and age at PHV (years) were compared with SuperImposition by Translation And Rotation (SITAR) model (sexes separately). Results: Age at PHV (years) and PHV (cm/year) were similar in all gestational age groups. Compared to term controls, insignificant differences in age at PHV were 0.1 (95% CI: −0.2 to 0.4) years/0.2 (−0.1 to 0.4) for very or moderately/late preterm born men and −0.0 (−0.3 to 0.3)/−0.0 (−0.3 to 0.2) for women, respectively. Being born small for gestational age was not associated with pubertal growth. Age at menarche or voice break was similar in all the gestational age groups. Conclusions: Timing of pubertal growth and age at menarche or voice break were similar in participants born preterm and at term

The microstructure and technological properties of ultra high strength 1100MPa grade strip steel

The article describes the microstructure and the technological properties of a direct quenched ultrahighstrength strip steel with the minimum specific yield strength of 1100MPa. The microstructure of thislow carbon, Mn-Cr-Mo-Cu-Ni alloyed steel consists mainly of auto-tempered lath martensite. Due to thesophisticated thermo-mechanical controlled processing schedule, the martensite transformation takesplace from a fine and uniform austenite grain structure. State-of-the-art steelmaking and continuous castingoperations guarantee a good inclusion cleanness and low level of segregation. The steel has excellent impactand fracture toughness properties with respect to its ultra-high strength level. The determined transitiontemperature for 28J in Charpy-V test and fracture toughness characteristic temperature, T0, were below-100°C. The weldability tests indicated that the impact toughness of the heat affected zone (HAZ) is excellentand there is no significant softening in the HAZ or in the welded joint in the wide range of t8/5 cooling times.The steel allows crack-free bending with a minimum inside bending radius equal to 3 times material thicknessirrespective of the bending direction. In addition, the steel has a good resistance to atmospheric corrosion

Vesicular Egress of Non-Enveloped Lytic Parvoviruses Depends on Gelsolin Functioning

The autonomous parvovirus Minute Virus of Mice (MVM) induces specific changes in the cytoskeleton filaments of infected permissive cells, causing in particular the degradation of actin fibers and the generation of “actin patches.” This is attributed to a virus-induced imbalance between the polymerization factor N-WASP (Wiscott-Aldrich syndrome protein) and gelsolin, a multifunctional protein cleaving actin filaments. Here, the focus is on the involvement of gelsolin in parvovirus propagation and virus-induced actin processing. Gelsolin activity was knocked-down, and consequences thereof were determined for virus replication and egress and for actin network integrity. Though not required for virus replication or progeny particle assembly, gelsolin was found to control MVM (and related H1-PV) transport from the nucleus to the cell periphery and release into the culture medium. Gelsolin-dependent actin degradation and progeny virus release were both controlled by (NS1)/CKIIα, a recently identified complex between a cellular protein kinase and a MVM non-structural protein. Furthermore, the export of newly synthesized virions through the cytoplasm appeared to be mediated by (virus-modified) lysomal/late endosomal vesicles. By showing that MVM release, like entry, is guided by the cytoskeleton and mediated by vesicles, these results challenge the current view that egress of non-enveloped lytic viruses is a passive process

Why de dicto desires are fetishistic

Ratio, Volume 34, Issue 4, Page 303-311, December 2021

On Imprimitive Representations of Finite Reductive Groups in Non-defining Characteristic

In this paper, we begin with the classification of Harish-Chandra imprimitive representations in non-defining characteristic. We recall the connection of this problem to certain generalizations of Iwahori-Hecke algebras and show that Harish-Chandra induction is compatible with the Morita equivalence by Bonnaf\'{e} and Rouquier, thus reducing the classification problem to quasi-isolated blocks. Afterwards, we consider imprimitivity of unipotent representations of certain classical groups. In the case of general linear and unitary groups, our reduction methods then lead to results for arbitrary Lusztig series

Future HAB science: Directions and challenges in a changing climate

There is increasing concern that accelerating environmental change attributed to human-induced warming of the planet may substantially alter the patterns, distribution and intensity of Harmful Algal Blooms (HABs). Changes in temperature, ocean acidification, precipitation, nutrient stress or availability, and the physical structure of the water column all influence the productivity, composition, and global range of phytoplankton assemblages, but large uncertainty remains about how integration of these climate drivers might shape future HABs. Presented here are the collective deliberations from a symposium on HABs and climate change where the research challenges to understanding potential linkages between HABs and climate were considered, along with new research directions to better define these linkages. In addition to the likely effects of physical (temperature, salinity, stratification, light, changing storm intensity), chemical (nutrients, ocean acidification), and biological (grazer) drivers on microalgae (senso lato), symposium participants explored more broadly the subjects of cyanobacterial HABs, benthic HABs, HAB effects on fisheries, HAB modelling challenges, and the contributions that molecular approaches can bring to HAB studies. There was consensus that alongside traditional research, HAB scientists must set new courses of research and practices to deliver the conceptual and quantitative advances required to forecast future HAB trends. These different practices encompass laboratory and field studies, long-term observational programs, retrospectives, as well as the study of socioeconomic drivers and linkages with aquaculture and fisheries. In anticipation of growing HAB problems, research on potential mitigation strategies should be a priority. It is recommended that a substantial portion of HAB research among laboratories be directed collectively at a small sub-set of HAB species and questions in order to fast-track advances in our understanding. Climate-driven changes in coastal oceanographic and ecological systems are becoming substantial, in some cases exacerbated by localized human activities. That, combined with the slow pace of decreasing global carbon emissions, signals the urgency for HAB scientists to accelerate efforts across disciplines to provide society with the necessary insights regarding future HAB trends